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Adipose tissue accumulation by trapping vitamin D and reducing its level may cause serious side effects. The purpose of this study is to determine the effects of vitamin D supplementation on dehydroepiandrosterone (DHEA), paraoxonase 1 (PON 1), insulin, free fatty acid (FFA), apolipoprotein-AI (Apo-AI) and apolipoprotein B (Apo-B) concentration in obese and overweight participants under low-calorie diet (LCD) program.

Healthy overweight and obese individuals (n = 70) with vitamin D deficiency were randomly assigned into 2 groups to receive either vitamin D supplements (an oral 2,000 IU vitamin D supplement) or placebo for 8 weeks.

All the participants were given an LCD program during the intervention. Vitamin D supplementation led to a significant increase in the levels of 25(OH)D (vitamin D vs placebo groups: 36.6 ± 9.8 vs 19.9 ± 3.5 ng/mL, p < 0.001), PON 1 levels (vitamin D vs placebo groups: 80 ± 25 vs 58 ± 23.2 ng/mL, p = 0.001), DHEA concentration (vitamin D vs placebo groups: 2.3 ± 0.7 vs 1.5 ± 0.6 ng/mL, p < 0.001) and Apo-AI levels (vitamin D vs placebo groups 3.7 ± 0.5 vs 3 ± 0.5 mg/dL, p < 0.001). Besides, intake of vitamin D supplements led to a significant decrease in FFA (vitamin D vs placebo groups: 3.1 ± 0.75 vs 3.5 ± 0.5 ng/mL, p = 0.001). After adjusting the analyses based on baseline levels, age and baseline body mass index measures, significant changes were observed in the insulin levels (0.03 ± 0.06 vs −1.7 ± 0.6 µIU/ml, p = 0.04). But the authors did not find any significant difference in the concentration of Apo-B between groups (vitamin D vs placebo groups: 71.5 ± 35.5 vs 66.6 ± 28.5 mg/dL, p = 0.05).

Overall vitamin D supplementation for eight weeks among vitamin D-deficient obese and overweight participants had beneficial effects on serum DHEA PON 1 FFA insulin and Apo- AI while it did not affect the Apo-B concentration.

The purpose of this study was to determine the effects of whole oat, oat bran and refined oat incorporation in a high-fat diet (HFD) on cardio-metabolic risk biomarkers in rats with type 2 diabetes mellitus (T2DM).

T2DM was induced by feeding male rats with an HFD for 10 weeks, followed by a low dose of streptozotocin. T2DM rats were then divided into four homogeneous groups. Three groups consumed an HFD containing 45 per cent (g/100 g diet) whole oat, oat bran or refined oat. The fourth untreated group (control) received the HFD.

The results showed that whole oat and oat bran, compared with refined oat and control, effectively reduced food intake (p < 0.007), arterial blood pressure (p = 0.0001), glycemia (p < 0.001), insulinemia (p < 0.01), glycosylated haemoglobin (p < 0.001) as well as homeostasis insulin resistance (HOMA-IR) (p < 0.001). They also improved blood lipid levels and reverse cholesterol transport by reducing serum total cholesterol (p = 0.0001), triacylglycerols (p < 0.05), very-low- (p = 0.0001) and low-density lipoproteins cholesterol contents (p < 0.02) increasing lipids (p < 0.002) and cholesterol excretion (p = 0.0001), and high-density lipoprotein cholesteryl esters (HDL₂-CE) concentrations (p = 0.0001) and stimulating lecithin: cholesterol acyltransferase (LCAT) activity (p = 0.0001). Moreover, they attenuated lipid peroxidation by increasing paraoxonase-1 (PON-1) atheroprotective activity (p < 0.05).

In T2DM rats, whole oat and particularly, its bran incorporated into an HFD improves arterial blood pressure, glycemic balance and lipid metabolic pathway by reducing hypertriglyceridemia and hypercholesterolemia and increasing atheroprotective activities of LCAT and PON-1. In contrast, refined oat accentuates the risk factors associated with diabetes.

This paper aims to evaluate the protective potential of prickly pear cactus fresh cladodes (opuntia ficus indica (OFI)) on glycemic disorders, dyslipidemia, prooxidant/antioxidant stress biomarkers and reverse cholesterol transport (by evaluating the activity of lecithin-cholesterol acyltransferase (LCAT)) and paraoxonase (PON1) in rats prematurely exposed to cafeteria diet (CD).

Sixteen young rats were divided into two groups fed CD containing 50 per cent of hyperlipidic diet (HLD) and 50 per cent of junk food mix supplemented or not with 50 g of fresh young cladodes of OFI to 100 g of CD, during 30 days.

OFI cladodes supplementation decreased significantly body weight (p < 0.001), food intake (p < 0.05), adipose tissue weight (p < 0.01), fasting glycemia and glycosylated hemoglobin (p < 0.01), homeostasis model assessment (HOMA-IR) and insulinemia (p < 0.001), levels of cholesterol (C) (p < 0.05) and triacylglycerols (TG) (p < 0.01) in serum and in very low-density lipoproteins (VLDL-C p < 0.05 and VLDL-TG p < 0.01) and improves reverse cholesterol transport by increasing high-density lipoprotein cholesteryl-esters concentrations (p < 0.001) and by stimulating LCAT activity. Moreover, they attenuated lipid peroxidation in VLDL and low-density lipoproteins by increasing atheroprotective activity of PON-1 and in liver and adipose tissue by enhancing enzymatic antioxidant defence.

The young cladodes of OFI because of their antiobesity benefits could constitute a novel functional ingredient in pharmaceutical and nutraceutical applications.

Young cladodes of OFI in rat precociously submitted to a hyperlipidic diet/junk food (cafeteria model) seem to prevent metabolic disorders associated with obesity.

This paper aims to study the effects of Zygophyllum album (Za) (Z. album) in hypercholesterolemic-diabetic rats.

Male Wistar rats (n = 36) weighing 200 ± 10 g, consumed an experimental diet containing 20 per cent casein were divided into three groups (n = 12). The first group consumed the diet enriched with 1 per cent cholesterol (CH), the second group is rendered diabetic by intraperitoneal injection of streptozotocin (STZ) (35 mg/kg body weight) (D) (DM). The third group is hypercholesterolemic and STZ-induced diabetic (CH-DM); each group was subdivided into two groups (n = 6), non-treated groups (CH, DM and CH-DM) and treated groups supplemented with 1 per cent Z. album lyophilized aqueous extract (CH-Z, DM-Z and CH-DM-Z).

In CH-DM group, Z. album decreases glycemia (−15 per cent) and inversely increases insulinemia (+28 per cent) and Homeostasis Model Assessment of Insulin Resistance (+19 per cent). In liver, total cholesterol (TC) and triacyglycerols (TAG) levels were reduced by −57 per cent and −29 per cent, respectively. In plasma, TC concentration was increased by +20 per cent, whereas those of TAG level were lowered by −56 per cent. Lecithin cholesterol acyl transferase and paraoxonase 1 activities were raised by +45 and +59 per cent, respectively. Inversely, thiobarbituric acid reactive substance levels were lowered significantly in liver, heart, kidney and adipose tissue (p < 0.05). Superoxide dismutase activity was enhanced in liver (+54 per cent), heart (+36 per cent), kidney (+45 per cent) and adipose tissue (59 per cent). Liver glutathione peroxidase (GSH-Px) activity was enhanced by +38 per cent and heart activities of GSH-Px, and glutathione reductase (GSSH-Red) were increased by +25 and +18 per cent. In kidney, GSH-Px activity was reduced by −26 per cent; in reverse, GSSH-Red activity was increased by +14 per cent. In adipose tissue, GSH-Px and GSSH-Red activities were augmented by +35 and +15 per cent.

These results suggest that Z. album aqueous extract has antihyperglycemic and antihyperlipemic actions. Also, Z. album protects against tissue oxidative damage; therefore, it can help to prevent cardiovascular complications of diabetes combined with hypercholesterolemia.

This paper aims to identify the characteristics that a crisis unit should have to achieve effective learning after crisis. Literature has identified many relations between learning organizations and crisis; yet, there is a dearth of research on specific studies about crisis units and their post-crisis learning features. Thus, this paper aims to fill such a gap by giving some practical answers to this question: How can the crisis unit reduce defensiveness phase and extend openness and forgetfulness while learning after the crisis?

This research mobilizes a framework composed by three theoretical grids: the post-crisis learning cycle (Kovoor-Misra and Nathan, 2000); the characteristics of a learning organization (Senge, 1990); and the mechanisms of crisis learning (Mitki and Herstein, 2011). A qualitative investigation is conducted to study a crisis within an oil company (PON).

This paper shows that the duration of the learning cycle depends not only on the organization context but also on the characteristics of the crisis unit. Along with the cognitive, structural and procedural mechanisms, which contributed differently in each phase, the mixed framework allowed operationalizing Senge’s dimensions.

The elaboration of a single case study could be considered as a limitation, although it allows a deeper analysis of events within the organization.

This paper pinpoints the characteristics that organizations should have as well as the learning mechanisms they should use during each phase of the post-crisis learning cycle.

This paper analyzes crisis units as learning structures, which has not been seen yet in known literature.

The purpose of this paper is to investigate the optimized setting of wire-cut electrical discharge machining (WEDM) parameters at which material removal rate (MRR) and mean roughness depth (Rz) set a compromise. The problem in the processing of Ti-6Al-4V by conventional processes is a high strength, high hardness, high tool wear. Due to which WEDM is adopted to machine Ti-6Al-4V biomedical alloy. Ti-6Al-4V alloy has a number of applications in the engineering and medical industries due to its high strength biocompatibility.

The effect of control factors (i.e. pulse on-time: Pon; pulse off-time: Poff; servo voltage: SV) on the MRR and Rz is investigated in the present research. The planning of experiments is done using a Taguchi-based L9 orthogonal array. The percentage influence of each factor on responses is also evaluated. The multi-objective optimization is done using the grey approach initially. After that, the results were also calculated using harmony search (HS). Therefore, a hybrid approach of grey and HS is used to find the optimized values of MRR and Rz.

The maximum value of grade calculated by grey-HS is 0.7879, while in the case of the experimental run the maximum value of grey grade is 0.7239. The optimized setting after improvisation at this grade value is Pon: 130 µs; Poff: 45 µs and SV: 70 V for MRR and Rz collectively. The validation of the suggested setting is completed by experimentation. The values of MRR and Rz are coming out to be 6.4 mm³/min and 13.84 µm, which represents improvised results after the implementation of the HS algorithm.

The integration of the grey approach with the HS principle in the manufacturing domain is yet to be explored. Therefore, in the present research hybrid approach of grey-HS is implemented in the manufacturing domain having applications in medical industries.

The purpose of this paper is to develop a framework for the manufacturer of a make-to-order company to simultaneously negotiate with multiple customers through mediator to achieve order acceptance decisions (OADs).

The paper developed mathematical models for the manufacturer, as well as customers to revise their offers during negotiations. Moreover, the paper also proposed a method for the mediator to carry out his assigned duties to assist in negotiation. In the decision process, mediator acts as a bridge between the manufacturer and customers to reach an agreement. A numerical example is enumerated to illustrate the working mechanism and superiority of proposed framework as compared to the framework where simultaneous negotiations are carried out without the presence of mediator.

Iterative method of negotiation conducted without mediator leads to delay in reaching agreement as the aspiration level of manufacturer offer and counter-offer of customer will never cross each other. In addition, the party who submits the offer first may suffer as the opponent can take the advantage of his/her offer during negotiation, thereby, derailing the issue of fairness. Introducing mediator between the manufacturer and the customer for their negotiations could overcome these two issues. Numerical analysis clearly illustrates that, in average, the rounds of negotiation to reach an agreement can be reduced by 22 percent using proposed negotiation framework. In addition, the fairness in negotiations can be improved by 33 percent with the incorporation of mediator.

Through continuing research efforts in this domain, certain models and strategies have been developed for negotiation. Iterative method of negotiations without mediator will help neither the manufacturer nor the customer in terms of fairness and negotiations round to reach an agreement. To the best of the author’s knowledge, so far, this is the first instance of research work in the domain of OAD and negotiation framework that attempts to incorporate mediator for simultaneous negotiation between manufacturer and customers on multiple issues simultaneously.

The purpose of this paper is first to provide a critical conceptual discussion of different use of the notion of text, especially in the case of expressions including words as well as images, second to consider the notion of document as an alternative to the notion of text, and finally to lay out a theoretical ground for a broad discipline of documentation studies.

The approach took the form of a conceptual analysis of a number of works in media and literary studies.

There were found a number of cases of contradictory use of the notion of text within the same work, talking about text in a broad overall sense covering all media as well as text as a distinctive concept separating words from images, while it was found through a conceptual history of the notion of document that the latter notion not only covers a written paper, but multiple media.

In future research, one should consider the use of document as the concept for the expressions as a whole and dedicate the notion of text solely for the verbal part of the expressions and make more empirical analysis within this conceptual framework to see if it makes a difference in practice to change the overall concept from text to document.

Having a broad concept of document, it would be possible to be more flexible regarding the choose of proper media for documentation.

By making a critique of the notion of text and suggesting a broader concept of document as well as documentation, the paper provides a ground for reconsidering the classical disciplinary structure, divided into humanities as well as the information sciences and social sciences.

This chapter focuses on policy efforts to improve college access in India and Brazil, which utilize affirmative action in higher education for historically marginalized groups. We compare structural factors impacting access to higher education for marginalized groups in India and Brazil, placing these factors in their respective historical contexts. We apply the concepts of intersectionality and interest convergence from critical race theory (CRT) not only to draw attention to how race, caste, and socioeconomic status converge to affect access for historically marginalized groups but also to further an understanding of how elites can maintain their hegemony even in the face of policies intended to achieve social justice.