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Cactus young cladodes improves unbalanced glycemic control, dyslipidemia, prooxidant/antioxidant stress biomarkers and stimulate lecithin-cholesterol acyltransferase and paraoxonase activities in young rats after cafeteria diet exposure

Hadjera Chekkal (Laboratory of Clinical and Metabolic Nutrition (LNCM), Department of Biology, Faculty of Nature and Life Sciences, University Oran 1, Oran, Algeria)
Nour el Imane Harrat (Laboratory of Clinical and Metabolic Nutrition (LNCM), Department of Biology, Faculty of Nature and Life Sciences, University Oran 1, Oran, Algeria)
Fouad Affane (Laboratory of Clinical and Metabolic Nutrition (LNCM), Department of Biology, Faculty of Nature and Life Sciences, University Oran 1, Oran, Algeria)
Fatima Bensalah (Laboratory of Clinical and Metabolic Nutrition (LNCM), Department of Biology, Faculty of Nature and Life Sciences, University Oran 1, Oran, Algeria)
Sabrine Louala (Laboratory of Clinical and Metabolic Nutrition (LNCM), Department of Biology, Faculty of Nature and Life Sciences, University Oran 1, Oran, Algeria)
Myriem Lamri-Senhadji (Laboratory of Clinical and Metabolic Nutrition (LNCM), Department of Biology, Faculty of Nature and Life Sciences, University Oran 1, Oran, Algeria)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 5 August 2019

Issue publication date: 5 March 2020

Abstract

Purpose

This paper aims to evaluate the protective potential of prickly pear cactus fresh cladodes (opuntia ficus indica (OFI)) on glycemic disorders, dyslipidemia, prooxidant/antioxidant stress biomarkers and reverse cholesterol transport (by evaluating the activity of lecithin-cholesterol acyltransferase (LCAT)) and paraoxonase (PON1) in rats prematurely exposed to cafeteria diet (CD).

Design/methodology/approach

Sixteen young rats were divided into two groups fed CD containing 50 per cent of hyperlipidic diet (HLD) and 50 per cent of junk food mix supplemented or not with 50 g of fresh young cladodes of OFI to 100 g of CD, during 30 days.

Findings

OFI cladodes supplementation decreased significantly body weight (p < 0.001), food intake (p < 0.05), adipose tissue weight (p < 0.01), fasting glycemia and glycosylated hemoglobin (p < 0.01), homeostasis model assessment (HOMA-IR) and insulinemia (p < 0.001), levels of cholesterol (C) (p < 0.05) and triacylglycerols (TG) (p < 0.01) in serum and in very low-density lipoproteins (VLDL-C p < 0.05 and VLDL-TG p < 0.01) and improves reverse cholesterol transport by increasing high-density lipoprotein cholesteryl-esters concentrations (p < 0.001) and by stimulating LCAT activity. Moreover, they attenuated lipid peroxidation in VLDL and low-density lipoproteins by increasing atheroprotective activity of PON-1 and in liver and adipose tissue by enhancing enzymatic antioxidant defence.

Social implications

The young cladodes of OFI because of their antiobesity benefits could constitute a novel functional ingredient in pharmaceutical and nutraceutical applications.

Originality/value

Young cladodes of OFI in rat precociously submitted to a hyperlipidic diet/junk food (cafeteria model) seem to prevent metabolic disorders associated with obesity.

Keywords

Acknowledgements

Conflicts of interest statement: The authors declare no conflict of interest.

This study was funded by the Ministry of Higher Education and Scientific Research, Algeria (CNEPRU number D01N01UN310120150023).

Citation

Chekkal, H., Harrat, N.e.I., Affane, F., Bensalah, F., Louala, S. and Lamri-Senhadji, M. (2020), "Cactus young cladodes improves unbalanced glycemic control, dyslipidemia, prooxidant/antioxidant stress biomarkers and stimulate lecithin-cholesterol acyltransferase and paraoxonase activities in young rats after cafeteria diet exposure", Nutrition & Food Science, Vol. 50 No. 2, pp. 288-302. https://doi.org/10.1108/NFS-01-2019-0025

Publisher

:

Emerald Publishing Limited

Copyright © 2019, Emerald Publishing Limited