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Incorporation of whole oat, especially bran, into a high-fat diet, improves cardio-metabolic risk factors in type 2 diabetic rats

Fatima Bensalah (Laboratory of Clinical and Metabolic Nutrition, Department of Biology, Faculty of Nature and Life Sciences, Université d’Oran 1, Oran, Algeria)
Nour el Imane Harrat (Laboratory of Clinical and Metabolic Nutrition, Department of Biology, Faculty of Nature and Life Sciences, Université d’Oran 1, Oran, Algeria)
Fouad Affane (Laboratory of Clinical and Metabolic Nutrition, Department of Biology, Faculty of Nature and Life Sciences, Université d’Oran 1, Oran, Algeria)
Hadjera Chekkal (Laboratory of Clinical and Metabolic Nutrition, Department of Biology, Faculty of Nature and Life Sciences, Université d’Oran 1, Oran, Algeria)
Myriem Lamri-Senhadji (Laboratory of Clinical and Metabolic Nutrition, Department of Biology, Faculty of Nature and Life Sciences, Université d’Oran 1, Oran, Algeria)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 27 November 2018

Issue publication date: 12 August 2019

Abstract

Purpose

The purpose of this study was to determine the effects of whole oat, oat bran and refined oat incorporation in a high-fat diet (HFD) on cardio-metabolic risk biomarkers in rats with type 2 diabetes mellitus (T2DM).

Design/methodology/approach

T2DM was induced by feeding male rats with an HFD for 10 weeks, followed by a low dose of streptozotocin. T2DM rats were then divided into four homogeneous groups. Three groups consumed an HFD containing 45 per cent (g/100 g diet) whole oat, oat bran or refined oat. The fourth untreated group (control) received the HFD.

Findings

The results showed that whole oat and oat bran, compared with refined oat and control, effectively reduced food intake (p < 0.007), arterial blood pressure (p = 0.0001), glycemia (p < 0.001), insulinemia (p < 0.01), glycosylated haemoglobin (p < 0.001) as well as homeostasis insulin resistance (HOMA-IR) (p < 0.001). They also improved blood lipid levels and reverse cholesterol transport by reducing serum total cholesterol (p = 0.0001), triacylglycerols (p < 0.05), very-low- (p = 0.0001) and low-density lipoproteins cholesterol contents (p < 0.02) increasing lipids (p < 0.002) and cholesterol excretion (p = 0.0001), and high-density lipoprotein cholesteryl esters (HDL2-CE) concentrations (p = 0.0001) and stimulating lecithin: cholesterol acyltransferase (LCAT) activity (p = 0.0001). Moreover, they attenuated lipid peroxidation by increasing paraoxonase-1 (PON-1) atheroprotective activity (p < 0.05).

Originality/value

In T2DM rats, whole oat and particularly, its bran incorporated into an HFD improves arterial blood pressure, glycemic balance and lipid metabolic pathway by reducing hypertriglyceridemia and hypercholesterolemia and increasing atheroprotective activities of LCAT and PON-1. In contrast, refined oat accentuates the risk factors associated with diabetes.

Keywords

Acknowledgements

This study was funded by Research Initiative Grant Scheme (RIGS 15-033-0033), International Islamic University Malaysia. The funder has no role in the study design; data collection, analysis and interpretation; manuscript writing and submission. The authors declare that there is no conflict of interest pertaining to this study. The authors were grateful to the elderly people who have been involved in this research. The authors thank the FELDA representatives for extending full cooperation in recruiting the participants.

Citation

Bensalah, F., Harrat, N.e.I., Affane, F., Chekkal, H. and Lamri-Senhadji, M. (2019), "Incorporation of whole oat, especially bran, into a high-fat diet, improves cardio-metabolic risk factors in type 2 diabetic rats", Nutrition & Food Science, Vol. 49 No. 4, pp. 600-616. https://doi.org/10.1108/NFS-05-2018-0150

Publisher

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Emerald Publishing Limited

Copyright © 2018, Emerald Publishing Limited