Adipose tissue accumulation by trapping vitamin D and reducing its level may cause serious side effects. The purpose of this study is to determine the effects of vitamin D supplementation on dehydroepiandrosterone (DHEA), paraoxonase 1 (PON 1), insulin, free fatty acid (FFA), apolipoprotein-AI (Apo-AI) and apolipoprotein B (Apo-B) concentration in obese and overweight participants under low-calorie diet (LCD) program.
Healthy overweight and obese individuals (n = 70) with vitamin D deficiency were randomly assigned into 2 groups to receive either vitamin D supplements (an oral 2,000 IU vitamin D supplement) or placebo for 8 weeks.
All the participants were given an LCD program during the intervention. Vitamin D supplementation led to a significant increase in the levels of 25(OH)D (vitamin D vs placebo groups: 36.6 ± 9.8 vs 19.9 ± 3.5 ng/mL, p < 0.001), PON 1 levels (vitamin D vs placebo groups: 80 ± 25 vs 58 ± 23.2 ng/mL, p = 0.001), DHEA concentration (vitamin D vs placebo groups: 2.3 ± 0.7 vs 1.5 ± 0.6 ng/mL, p < 0.001) and Apo-AI levels (vitamin D vs placebo groups 3.7 ± 0.5 vs 3 ± 0.5 mg/dL, p < 0.001). Besides, intake of vitamin D supplements led to a significant decrease in FFA (vitamin D vs placebo groups: 3.1 ± 0.75 vs 3.5 ± 0.5 ng/mL, p = 0.001). After adjusting the analyses based on baseline levels, age and baseline body mass index measures, significant changes were observed in the insulin levels (0.03 ± 0.06 vs −1.7 ± 0.6 µIU/ml, p = 0.04). But the authors did not find any significant difference in the concentration of Apo-B between groups (vitamin D vs placebo groups: 71.5 ± 35.5 vs 66.6 ± 28.5 mg/dL, p = 0.05).
Overall vitamin D supplementation for eight weeks among vitamin D-deficient obese and overweight participants had beneficial effects on serum DHEA PON 1 FFA insulin and Apo- AI while it did not affect the Apo-B concentration.
Declarations Consent for publication: A written consent to publish the information and data of the participants was obtained.
Availability of data and materials: The data sets used during the current study are available from the corresponding author on reasonable request.
We want to again thank participants for completed participation in the study.
Conflicts of interest statement: The authors declare that they have no conflicts of interest.
Funding: Support for this study was given by the Iran University of Medical Science (Grant number: 28907).
Authors’ contributions: The research was designed by FSH, MZ and ECH. Additionally, ECH and BY conducted and collected all the data; AH and ECH performed the statistical analysis; MZ, ER and ECH wrote the manuscript; and the final manuscript was investigated and approved by all the authors.
Chehsmazar, E., Zarrati, M., Yazdani, B., Razmpoosh, E., Hosseini, A.F. and Shidfar, F. (2021), "The effect of vitamin D supplementation on serum concentrations of dehydroepiandrosterone, paraoxonase 1, apolipoproteins, free fatty acid and insulin in vitamin D deficient obese and overweight individuals under a low-calorie diet program: a randomized controlled trial", Nutrition & Food Science, Vol. 51 No. 5, pp. 765-780. https://doi.org/10.1108/NFS-05-2020-0176
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