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The complications caused by metallic orthopaedic bone screws like stress-shielding effect, screw loosening, screw migration, higher density difference, painful reoperation and revision surgery for screw extraction can be overcome with the bioabsorbable bone screws. This study aims to use additive manufacturing (AM) technology to fabricate orthopaedic biodegradable cortical screws to reduce the bone-screw-related-complications.

The fused filament fabrication technology (FFFT)-based AM technique is used to fabricate orthopaedic cortical screws. The influence of various process parameters like infill pattern, infill percentage, layer height, wall thickness and different biological solutions were observed on the compressive strength and degradation behaviour of cortical screws.

The porous lattice structures in cortical screws using the rapid prototyping technique were found to be better as porous screws can enhance bone growth and accelerate the osseointegration process with sufficient mechanical strength. The compressive strength and degradation rate of the screw is highly dependent on process parameters used during the fabrication of the screw. The compressive strength of screw is inversely proportional to the degradation rate of the cortical screw.

The present study is focused on cortical screws. Further different orthopaedic screws can be modified with the use of different rapid prototyping techniques.

The use of rapid prototyping techniques for patient-specific bone screw designs is scantly reported. This study uses FFFT-based AM technique to fabricate various infill patterns and porosity of cortical screws to enhance the design of orthopaedic cortical screws.

The purpose of this study was to evaluate in vivo the bioavailability of the Ilex paraguariensis polyphenols due to total polyphenols and changes in antioxidant capacity (AOC) in human plasma after an acute intake of 300 ml of an infusion of yerba maté (YM) for 120 minutes. Also, we evaluated the variation of plasma protein or plasma uric acid after the acute intake of YM infusion.

Seventeen healthy young volunteers participated in the determining plasma of total polyphenols concentration (TPC, Folin-Ciocalteu method), plasma AOC for ferric reducing antioxidant power (FRAP) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid diammonium salt [ABTS] methods), plasmatic uric acid and plasma total protein over the 120 minutes test.

It was found that the bioavailability of YM polyphenols during 120 minutes was 49.3 ± 11.9 per cent, the TPC was increased to 6.0 ± 1.5 per cent, the plasma AOC was increased by FRAP 8.3 ± 3.3 per cent and by ABTS 6.0 ± 2.0 per cent and no significant variation of plasma protein or plasma uric acid was found.

Maté polyphenols has a thrifty effect on the natural antioxidant defenses of the body, which are beneficial to human health.

There was no information on the bioavailability of polyphenols in YM infusions prepared in its traditional form as “hot mate”.

This study was carried out to examine the effect of cocoa extract (CE) on plasma glucose levels in hyperglycaemic rats induced with streptozotocin. Three concentrations of CE were used to study its effect on oral glucose tolerance test (OGTT). In the normal group, CE at 0.5 per cent concentration had significantly reduced the glucose level (p<0.05) at 0 and 60 min, 1.0 per cent at 0 (p<0.05), 60 (p<0.01) and 180 min (p<0.01), 3.0 per cent at 60 (p<0.05) and 180 min (p<0.01) as compared to control. In hyperglycaemic group, 3.0 per cent CE had reduced the glucose level significantly (p<0.05) at 60 as compared to control. Based on the results from OGTT, 3.0 per cent concentration was used to evaluate the effect of CE in a 2‐week study. There was no significant difference in reduced plasma glucose levels and lipid profiles in hyperglycaemic and normal rats, which were given basal diet enriched with 3.0 per cent CE extracted from cocoa powder as compared to the control (basal diet).

The purpose of the study is to highlights the conceptual and scientific knowledge regarding bioavailability of food bioactive components which is essential for the thorough understanding of their role in disease prevention and factors that limit their absorption.

Nutrikinetics is an extended version of pharmacokinetics that is used for studying the bioavailability and bioaccessibility of components through different techniques such as metabolic profiling, multi-level data analysis and population-based modeling.

There are different phases of nutrikinetics study of the bioactive components. The initial stage of nutrikinetics is starting from simplest in-vitro assay which is applicable in the early stage of functional foods development. Thereafter, the next stage of nutrikinetics studies are related to human intervention studies as designed by European Food Safety Authority. The aim of such studies are to develop dose-exposure and exposure response study of a bioactive component.

This paper will enlighten the concept of nutrikinetics, its requirement and the future perspectives of nutrikinetics study including long-term efficacy studies and multi-compartmental analysis of the different bioactive components.

Based on DNase I and reduced graphene oxide (rGO)-magnetic silicon microspheres (MNPS), a highly sensitive and selective fluorescent probe for the detection of PD-L1 was developed.

Here °C we present a feasibility of biosensor to detection of PD-L1 in lung tumors plasma. In the absence of PD-L1°C the PD-L1 aptamer is absorbed on the surface of graphene oxide modified magnetic nanoparticles °8rGO-MNPS°9 and leading to effective fluorescence quenching. Upon adding PD-L1°C the aptamer sequences could be specifically recognized by PD-L1 and the aptamer/PD-L1 complex is formed°C resulting in the recovery of quenched fluorescence.

This sensor can detect PD-L1 with a linear range from 100 pg mL⁻¹ to 100 ng mL⁻¹, and a detection limit of 10 pg•m⁻¹ was achieved.

This method provides an easy and sensitive method for the detection of PD-L1 and will be beneficial to the early diagnosis and prognosis of tumors.

Human health is strongly affected by diet. By the increased use of food industries products, public knowledge about health factors and side effects of chemical additives, the concepts of human health founded an important aspect during past years, and application of natural-based ingredients such as coloring, flavoring, texturizing and anti-oxidative agents was increased.

The aim of the present paper is to review the published scientific research studies about lycopene health benefits in different human disease or disorders and bold the necessity of study the health effects of lycopene after its formulation in food industrial products. About 190 papers were searched in Google Scholar, PubMed, Web of Science databases and 72 relevant papers were used. It was found that in medical studies, the lycopene oleoresin or powder is used directly to the subjects. However, it is necessary to study the effectiveness of lycopene in diet food products.

According to the literature, it has beneficial effects on cancers, glands, reproductive system, bone, gastric system, liver and fat reduction in the body. Also, it was concluded from the literature that lycopene oxidative cleavages make also its chemo protective effects which is a lost key element to study different food processing on lycopene products or its isomers in final food products and on human health.

Many ingredients in food formulations are substituted by natural products. Lycopene is a colorant but also, according to the literature, has a strong antioxidative and anti-inflammatory effect to reduce the risk of most important human disease and disorders. Future research in food science can emphasize the effect of different unit operations or formulations on lycopene effects on human health.

In recent decades, oxytocin (OT) has been extensively studied across disciplines. Yet, the role of OT has been discussed little in the context of politics. This chapter proposes that studying the role of this hormone can enrich and advance the study of politics. The chapter reviews the previous findings on OT categorized into two sections: one that focuses on the biological mechanisms and therapeutic potentials and another that focuses on the effects on social behaviors. This review is not exhaustive but is intended to bring political scientists up to date with the progress in OT studies. Next, this chapter highlights that studying the role of OT in political context will benefit both the OT and political science literature, since there is currently a great interest in the context-dependent nature of OT. I highlight several research questions that can be answered at this intersection. Rather than waiting for other disciplines to complete unfolding the precise role of OT, students of biopolitics can make important contributions. Political science can further understand the biological underpinnings of concern for others and partisan behaviors, while OT applied to real-world settings would demonstrate how different contexts shape its effects.

The main occupational safety measure in factories is monitoring workers exposed to various types of contaminations. The main environmental concern of governments about copper industries is emission of dust, metals, metal compounds and volatile organic compounds in air. The purpose of this paper is to evaluate the immune system status of workers in a copper concentration factory in Iran by placing the emphasis on oxidative stress biomarkers.

A comparative cross-sectional study was performed on 40 workers of the copper concentration factory and 40 unexposed individuals. White blood cell count, plasma interleukin 2 and 4, oxidative burst of neutrophils, oxidative damages of DNA and RNA, lipid and protein, total antioxidant capacity of plasma, and antioxidant enzymes activities were measured.

A significant decrease in the white blood cell count and interleukin 2 and an increase in the interleukin 4 were observed in the workers and these changes represented the possibility of inflammation and weakening of the immune system. The elevation of oxidative damages, total antioxidant capacity and the activity of antioxidant enzymes are indicative of the change in oxidative stress status.

The oxidative stress induction and immune system changes might be useful biomarkers in screening and surveillance for occupational hazard. More studies are needed to find out the type and the concentration of pollutants and to evaluate the protective effects of natural antioxidants.

The body has an elaborate antioxidant defence system to protect against excessive free radical attack. Such attack has been implicated in the development process of several degenerative diseases.

The term “medical” will be interpreted broadly to include both basic and clinical sciences, related health fields, and some “medical” elements of biology and chemistry. A reference book is here defined as any book that is likely to be consulted for factual information more frequently than it will be picked up and read through in sequential order. Medical reference books have a place in public, school, college, and other non‐medical libraries as well as in the wide variety of medical libraries. All of these libraries will be considered in this column. A basic starting collection of medical material for a public library is outlined and described in an article by William and Virginia Beatty that appeared in the May, 1974, issue of American Libraries.