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In recent decades, oxytocin (OT) has been extensively studied across disciplines. Yet, the role of OT has been discussed little in the context of politics. This chapter proposes that studying the role of this hormone can enrich and advance the study of politics. The chapter reviews the previous findings on OT categorized into two sections: one that focuses on the biological mechanisms and therapeutic potentials and another that focuses on the effects on social behaviors. This review is not exhaustive but is intended to bring political scientists up to date with the progress in OT studies. Next, this chapter highlights that studying the role of OT in political context will benefit both the OT and political science literature, since there is currently a great interest in the context-dependent nature of OT. I highlight several research questions that can be answered at this intersection. Rather than waiting for other disciplines to complete unfolding the precise role of OT, students of biopolitics can make important contributions. Political science can further understand the biological underpinnings of concern for others and partisan behaviors, while OT applied to real-world settings would demonstrate how different contexts shape its effects.