Search results

The US platelet supply is almost exclusively dependent on apheresis donors who are “aging out.” As a result, blood centers and hospitals have been experiencing spot shortages and have resorted to transfusing low-dose platelets. This paper explores using whole blood–derived platelets (WB-PLTs) to supplement the apheresis platelet (APH-PLT) supply.

This paper reviews the history leading to the current state of the US platelet supply and includes the impact of recent events such as the COVID-19 pandemic and the implementation of the US Food and Drug Administration (FDA)-mandated bacterial mitigation strategies.

WB-PLTs represent a viable source of platelets that can be used to supplement the APH-PLT supply. Whole blood automation represents a new methodology to more easily prepare WB-PLTs. Advances in donor testing and screening as well as pre-storage leukoreduction have improved the safety of WB-PLTs to the same level as APH-PLTs. Blood services in the US and abroad transfuse WB-PLTs interchangeably in all patient populations.

This paper highlights how the US blood industry is essentially “sole-sourced” in terms of APH-PLTs. In this post-COVID-19 period, when most industries are building redundancies in their supply chains, blood centers should consider WB-PLTs as an additional source of platelets to bolster the US platelet supply.

The purpose of this paper is to explore the synergistic lubrication of MoS₂ particles with different morphologies.

The synergistic lubrication of MoS₂ particles with different morphologies is evaluated using a four‐fall tribometer in liquid paraffin.

Results show that the morphology of MoS₂ has an influence on the tribological properties of MoS₂. Both MoS₂ nano‐balls and nano‐platelets function as lubrication additives in liquid paraffin better than MoS₂ micro‐platelets do. It is also found that there is a synergistic lubrication between two different morphologies of MoS₂. The composite MoS₂ additives with different morphologies can improve the wear resistance and friction reduction of liquid paraffin more than each of them singly does. The synergistic lubrication between two different MoS₂ morphologies results from the cooperation of their different lubrication mechanism.

The paper reveals a synergistic lubrication between two different MoS₂ structures. It is very advantageous and practical to partly displace nano‐MoS₂ with micro‐MoS₂.

This paper aims to present the dielectrophoresis (DEP) force (FDEP), defined as microelectrofluidics mechanism capabilities in performing selective detection and rapid manipulation of blood components such as red blood cells (RBC) and platelets. The purpose of this investigation is to understand FDEP correlation to the variation of dynamic dielectric properties of cells under an applied voltage bias.

In this paper, tapered design DEP microelectrodes are used and explained. To perform the characterization and optimization by analysing the DEP polarization factor, the change in dynamic dielectric properties of blood components are observed according to the crossover frequency (f_xo) and adjustment frequency (f_adj) variation for selective detection and rapid manipulation.

Experimental observation of dynamic dielectric properties change shows clear correlation to DEP polarization factor when performing selective detection and rapid manipulation. These tapered DEP microelectrodes demonstrate an in situ DEP patterning efficiency more than 95%.

The capabilities of tapered DEP microelectrode devices are introduced in this paper. However, they are not yet mature in medical research studies for various purposes such as identifying cells and bio-molecules for detection, isolation and manipulation application. This is because of biological property variations that require further DEP characterization and optimization.

The introduction of microelectrofluidics using DEP microelectrodes operate by selective detecting and rapid manipulating via lateral and vertical forces. This can be implemented on precision health-care development for lab-on-a-chip application in microfluidic diagnostic and prognostic devices.

This study introduces a new concept to understand the dynamic dielectric properties change. This is useful for rapid, label free and precise methods to conduct selective detection and rapid manipulation of mixtures of RBC and platelets. Further, potential applications that can be considered are for protein, toxin, cancer cell and bacteria detections and manipulation. Implementation of tapered DEP microelectrodes can be used based on the understanding of dynamic dielectric properties of polarization factor analysis.

Polymer substrates with micron size roughness features have been found to play an important role in the mechanical performance of thin functional films which are used extensively in stretchable and flexible micro electromechanical systems. The purpose of this study is to report the stretchability and flexibility limits of micro size silver nano platelet films on a soft polymer substrate having two different orientations of micro grating with respect to the applied load.

Parallel and perpendicular micro gratings on the surface of a soft polymer substrate polydimethylsiloxane were patterned using a carefully machined master aluminum block and thin aluminum foils. Silver nano platelet-based films were rod coated on the substrate surface containing the micro gratings. These films were dried in ambient air and were tested for their stretchability and flexibility limits using homemade tools. Finite element modeling has also been performed and was found to support the experimental observations.

Experiments indicate that stretchability of silver nano platelet-based thin films tends to increase when the grating orientation remains parallel to the axis of the applied load, while its flexibility improves when the orientation becomes perpendicular to the loading axis.

The effect of grating orientation with respect to the applied load was investigated. The experiments show that micro grating roughness features are capable of enhancing the mechanical performance of nano platelet-based silver films on a soft polymer substrate and can be used in various stretchable and flexible micro electro mechanical device applications.

This paper aims to evaluate the therapeutic potential of apple extracts against thrombocytopenia, i.e. decrease in platelet count.

Male Sprague Dawley rats were used to evaluate therapeutic potential of apple extracts. Diets enriched with apple fruit and seed’s ethanolic extract were provided to normal and KBrO₃-induced thrombocytopenic rats for 60 days. KBrO₃ was administered at level of 85 mg/Kg of body weight of rats to intentionally decrease the platelet count. Platelet count and other hematological parameters were monitored at monthly intervals to evaluate therapeutic effect of apple extracts against thrombocytopenia.

The results of current research portrayed that both apple seed and fruit extracts enriched diets increased the platelet count significantly (p < 0.05) in thrombocytopenic rats. It was observed that apple fruit extract-enriched diet (AFE) raised the platelet count to 14.72 and 33.07 per cent in normal and thrombocytopenic rats, respectively. Apple seed extract-enriched diet (ASE) raised the platelet count to 11.08 and 32.90 per cent in normal and thrombocytopenic rats, respectively. Other hematological parameters including white blood cells, red blood cells and hemoglobin were also significantly increased.

Thrombocytopenia is uprising problem in developing world including India and Pakistan accompanied by different diseases especially dengue and related complications. Because of questioning on therapies against thrombocytopenia, research on diet-based therapies, as a substitute to synthetic one, is increasing. Diet rich in antioxidant compounds including apple fruit and seeds are the limelight of manuscript.

The purpose of this study is to theoretically probe the shape impacts of nano-particle on boundary layer flow of nano-fluid toward a stretching cylinder with heat-transmission effects. The base fluid used for this study is pure water, and aluminum oxide nano-particles are suspended in it. Four different shapes of nano-particle, namely, cylindrical, brick, platelets and blades, are considered to carry out the study.

The problem is modelled mathematically and the nonlinear system of equations is attained by using appropriate transmutations. The solution of transmuted equations is achieved by utilizing a shooting technique with Fourth-Fifth order Runge–Kutta Fehlberg scheme. Numerically attained results are elucidated through graphs and tables which are further compared under limiting cases with existing literature to check the validity of the results.

It is observed that fluid velocity and temperature of cylindrical shaped water nano-fluids are more than the nano-fluid having brick-shaped nano-particles. Moreover, it is seen that the nano-fluids suspended with platelets-shaped nano-particles have higher velocity and temperature than the nano-fluids containing blade-shaped nano-particles. The curvature parameter and nano-particles volume fraction have increasing effects on flow velocity and temperature of nano-fluids containing all types of nano-particle shapes.

Numerous authors have examined the impacts of nano-particle shapes on characteristics of heat transfer and fluid flow. However, to the best of the authors’ knowledge, the shape impacts of nano-particles on boundary layer flow of nano-fluid toward a stretching cylinder with heat-transmission effects have not been discussed. So, to fulfill this gap, the present paper explicates the impacts of various nano-particle shapes on Al₂O₃–water-based nano-fluid flow past a stretching cylinder with heat-transfer effects.

The purpose of this paper is to investigate the superior relationship between blood lipid- and cardiovascular disease (CVD)-related hematological parameters using superior grey relational analysis (GRA).

A total of 294 individuals who underwent simultaneous routine blood examination and blood lipid examination in the Physical Examination Center of the First Affiliated Hospital of Shantou University Medical College were included in this study. Superior GRA was performed to find out the superior factor in CVD-related hematological parameters and blood lipids. CVD-related hematological parameters included red blood cell distribution width, white cell count, and platelet count, platelet distribution width, mean platelet volume, as well as platelet crit. The indicators of blood lipids analyzed here consist of low-density lipoprotein, high-density lipoprotein, triglyceride and total cholesterol.

The results showed that all the grey relational degree of hematological parameters and blood lipids were over 0.8; the superior factor in hematological parameters was PLT, whereas TC was the superior factor in blood lipids.

Findings of this study suggested that hematological parameters are closely related to blood lipids and a potential role for hematological parameters in the prediction of dyslipidemia, which need further study; TC has the greatest influence on hematological parameters, whereas TG displays a minimal impact.

To the authors’ best knowledge, it was the first study to analyze the relationship between various CVD-related hematological parameters and blood lipids via superior GRA.

Natural convection in finite enclosures is a common phenomenon in various thermal applications. To provide the thermal design guidelines, this study aims to numerically explore the potential of using internal baffles and nanofluids to either enhance or suppress heat transport in a vertical annulus. Furthermore, the annular-shaped enclosure is filled with aqueous-silver nanofluid and the effects of five distinct nanoparticle shapes are examined. In addition, the influence of baffle design parameters, including baffle position, thickness and length, is thoroughly analyzed.

The finite difference method is used in conjunction with the alternating direction implicit and successive line over relaxation techniques to solve nonlinear and coupled partial differential equations. The single phase model is used for nanofluid which is considered as a homogeneous fluid with improved thermal properties. The independence tests are carried out for assessing the sufficiency of grid size and time step for obtaining results accurately.

The baffle dimension parameters and nanoparticle shape exhibit significant impact on the convective flow and heat transfer characteristics, leading to the following results: sphere- and blade-shaped nanoparticles demonstrate around 30% enhancement in the heat transport capability compared with platelet-shaped nanoparticles, which exhibit the least. When considering the baffle design parameter, either a decrease in the baffle length and thickness or an increase in baffle height leads to an improvement in heat transport rate. Consequently, a threefold increase in baffle height yields a 40% improvement in thermal performance.

Understanding the impact of nanoparticle shapes and baffle design parameters on flow and thermal behavior will enable engineers to provide valuable insight on thermal management and overall system efficiency. Therefore, the current work focuses on exploring buoyant nanofluid flow and thermal mechanism in a baffled annular-shaped enclosure. Specifically, an internal baffle that exhibits conductive heat transfer through it is considered, and the impact of baffle dimensions (thickness, length and position) on the fluid flow behavior and thermal characteristics is investigated. In addition, the current study also addresses the influence of five distinct nanoparticle shapes (e.g. spherical, cylindrical, platelet, blade and brick) on the flow and thermal behavior in the baffled annular geometry. In addition to deepening the understanding of nanofluid behavior in a baffled vertical annulus, the current study contributes to the ongoing advancements in thermal applications by providing certain guidelines to design application-specific enclosures.

The purpose of this paper is to evaluate the role of encapsulation temperature on the preparation of silica-encapsulated waterborne aluminium pigments.

The waterborne aluminium pigments were prepared with H₂O₂ as anchoring agent and siloxane used as precursors in pH = 9.0 medium at different temperatures. The anchorage and compactness of silicon which on aluminium surface were characterized by optical microscopy, scanning electron microscopy and N₂ adsorption-desorption. The anticorrosion property was characterized by the volume of produced hydrogen as a function of time.

The effect of encapsulation temperature on anticorrosion property of aluminium pigments is reflected from the anchorage and the compactness of silica on aluminium surface. Furthermore, when encapsulation temperature is 45-50°C, the silica platelets uniformly anchored on the aluminium surface as a dense film, which show the best anticorrosion property. Lower and higher encapsulation temperatures cause the silica platelets to agglomerate rather than anchor on the aluminium surface, which is unfavourable for the anchorage and the formation of compact silica film. The use of product in waterborne coatings gives a higher glossiness than that of raw material.

Only pH = 9.0 medium was explored, and the other pH medium could result in different optimum temperatures.

The investigation results provide theoretical basis for obtaining excellent waterborne aluminium pigments.

The method of investigating corrosion resistance mechanism of aluminium pigments based on anchorage and compactness is novel.

Aims to discuss Brinker Technology, the winner of the Innovative Technology category at the Offshore Achievements Awards; which helps to bring national recognition to the companies that are leading the way in all sectors of the oil industry.

Discusses the invention that won Brinker Technology the award.

Brinker Technology received the innovative technology award in recognition of their multi‐patented Platelet Technology™ that offers a unique solution to sealing costly and challenging pipeline leaks.

Keeps readers abreast of new award winning innovations and the companies that are excelling in this area.