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Olfaction plays a very important role in daily life. The olfactory system has the ability to recognize, discriminate and identify thousands of odorant compounds with extremely high sensitivity and specificity. The research on olfactory system has very important values in exploring the mechanisms of information processing in the other sensory nervous systems and brain. Recently, with the development of molecular biological and microelectronics technology research, the study of olfactory cell-based sensors has made great progress. The purpose of this paper is to provide details of recent developments in olfactory cell-based sensors.

Following an introduction, this paper first discusses some olfactory cell-based biosensors, which focus on the light-addressable potentiometric sensors and the microelectrode arrays. Second, surface modification, microfabrication and microfluidic technology which can improve the efficiency of cell immobilization will be summarized. The research trends of olfactory cell-based sensor in future will be proposed.

This paper shows that the biosensors’ performance is expected to be greatly improved due to the fast development of nanotechnology, optical technology and microelectronics. More and more emerging intelligent olfactory sensors will have a promising prospect in many application fields, including food quality and safety assessment, environmental monitor and human diseases detection.

This paper provides a detailed and timely review of the rapidly growing research in the olfactory cell-based sensors.

Using the remarkable olfaction ability, insects can sense trace amounts of host plant volatiles that are notorious for causing severe damage to fruits and vegetables and in consequence the industry. The purpose of the paper is to investigate the interactions between olfactory proteins, odorant-binding proteins (OBPs) and host plant volatiles through the developed olfactory biosensors. It might be helpful to develop novel pest control strategies.

Using the successfully expressed and purified OBPs of the oriental fruit fly Bactrocera dorsalis, a biosensor was developed by immobilizing the proteins on interdigitated electrodes through nitrocellulose membrane. Based on electrochemical impedance sensing, benzaldehyde emitted by the host plants, such as Beta vulgaris, was detected, which could be used to investigate and analyze the mechanisms of pests’ sense of chemical signals. The relative decreases of charge transfer resistances of the sensor were proportional to the odorant concentrations from 10⁻⁷ M to 10⁻³ M. Meanwhile, the interactions between OBPs and benzaldehyde were studied through the process of molecular docking.

The paper provides a pest OBPs-based biosensor that could sensitively detect the host odorants benzaldehyde. Meanwhile, the most related amino acids of OBPs that bind to host plant volatiles can be distinguished with molecular docking.

An olfactory biosensor was developed to explore interactions and mechanism between the pest OBPs and benzaldehyde, which showed promising potentials for small organic molecule sensing. Simultaneously, it might be helpful for novel pest control strategies.

This paper aims to provide a detailed review of weak interaction biosensors and several common biosensor methods for magnifying signals, as well as judiciously guide readers through selecting an appropriate detecting system and signal amplification method according to their research and application purpose.

This paper classifies the weak interactions between biomolecules, summarizes the common signal amplification methods used in biosensor design and compares the performance of different kinds of biosensors. It highlights a potential electrochemical signal amplification method: the G protein signaling cascade amplification system.

Developed biosensors which, based on various principles, have their own strengths and weaknesses have met the basic detection requirements for weak interaction between biomolecules: the selectivity, sensitivity and detection limit of biosensors have been consistently improving with the use of new signal amplification methods. However, most of the weak interaction biosensors stop at the research stage; there are only a minority realization of final commercial application.

This paper evaluates the status of research and application of weak interaction biosensors systematically. The G protein signaling cascade amplification system proposal offers a new avenue for the research and development of electrochemical biosensors.

The purpose of this paper is to review recent progress in electronic nose technologies, focusing on hybrid systems combining biological elements with physical transducers.

Electronic nose technologies are moving rapidly towards hybrid bioelectronic systems, where biological odour-recognition elements from the olfactory pathways of vertebrates and insects are being utilised to construct new “bionic noses” that can be used in industrial applications.

With the increased understanding of how chemical senses and the brain function in biology, an emerging field of “neuromorphic olfaction” has arisen.

Important components are olfactory receptor proteins and soluble proteins found at the periphery of olfaction called odorant-binding proteins. The idea is that these proteins can be incorporated into transducers and function as biorecognition elements for volatile compounds of interest.

Major drivers are the security, environmental and medical applications, and the internet of things will be a major factor in implementing low-cost chemical sensing in networked applications for the future.

Widespread take up of new technologies that are cheap will minimise the impact of environmental pollution, increase food safety and may potentially help in non-invasive screening for medical ailments.

This review brings together diverse threads of research leading to a common theme that will inform a non-expert of recent developments in the field.

Vision, audition, olfactory, tactile and taste are five important senses that human uses to interact with the real world. As facing more and more complex environments, a sensing system is essential for intelligent robots with various types of sensors. To mimic human-like abilities, sensors similar to human perception capabilities are indispensable. However, most research only concentrated on analyzing literature on single-modal sensors and their robotics application.

This study presents a systematic review of five bioinspired senses, especially considering a brief introduction of multimodal sensing applications and predicting current trends and future directions of this field, which may have continuous enlightenments.

This review shows that bioinspired sensors can enable robots to better understand the environment, and multiple sensor combinations can support the robot’s ability to behave intelligently.

The review starts with a brief survey of the biological sensing mechanisms of the five senses, which are followed by their bioinspired electronic counterparts. Their applications in the robots are then reviewed as another emphasis, covering the main application scopes of localization and navigation, objection identification, dexterous manipulation, compliant interaction and so on. Finally, the trends, difficulties and challenges of this research were discussed to help guide future research on intelligent robot sensors.

The present study aims to summarize different non-invasive techniques for continuous glucose monitoring (CGM) in diabetic patients using glucose-oxidase biosensors. In diabetic patients, the self-monitoring of blood glucose (BG) levels through minimally invasive techniques provides a quick method of measuring their BG concentration, unlike conventional laboratory measurements. The drawbacks of minimally invasive techniques include physical pain, anxiety and reduced patient compliance. To overcome these limitations, researchers shifted their attention towards the development of a pain-free and non-invasive glucose monitoring system, which showed encouraging results.

This study reviews the development of minimally and non-invasive method for continuous glucose level monitoring in diabetic or hyperglycemic patients. Specifically, glucose monitoring using non-invasive techniques, such as spectroscopy-based methods, polarimetry, fluorescence, electromagnetic variations, transdermal extraction-based methods and using body fluids, has been discussed. The various strategies adopted for improving the overall specificity and performance of biosensors are discussed.

In conclusion, the technology of glucose oxidase-based biosensors for glucose level monitoring is becoming a strong competitor, probably because of high specificity and selectivity, low cost and increased patient compliance. Many industries currently working in this field include Google, Novartis and Microsoft, which demonstrates the significance and strong market potential of self-monitored glucose-oxidase-based biosensors in the near future.

This review paper summarizes comprehensive strategies for continuous glucose monitoring (CGM) in diabetic patients using non-invasive glucose-oxidase biosensors. Non-invasive techniques received significant research interest because of high sensitivity and better patient compliance, unlike invasive ones. Although the results from these innovative devices require frequent calibration against direct BG data, they might be a preferable candidate for future CGM. However, the challenges associated with designing accurate level sensors to biomonitor BG data easily and painlessly needs to be addressed.

This paper aims to focus on the development and characterization of a new electrochemical sensor, designed for the detection of methylene blue present in aqueous medium.

This sensor is obtained through the coupling of a polymeric membrane and an ion-sensitive electrode (platinum electrode). The preparation of the polymeric membrane involves the incorporation of a receptor: β-cyclodextrin (β-CD), a polymer (polyvinylchloride) and a plasticizer (dioctylphtalate). Cyclic voltammetry method (CV) was used to investigate the electrical properties of this electrochemical sensor. The effect of the experimental parameters such as dye initial concentration, scan rate, interfering elements presence and additional Nafion membrane presence was investigated in this paper.

The results are interesting because the developed sensor gives a linear response in concentrations range of 10⁻¹³ M–10⁻³ M with a good correlation coefficient of 0.979 and a detection limit of 10⁻¹³ M, which reflects the sensitivity of this sensor to the target element. The sensibility value is equal to 2. 40 µA mol⁻¹ L.

The present study has shown that the modified electrode is a very good candidate in terms of price, sensibility and reproducibility for the construction of the sensitive sensor for the control of wastewater containing methylene blue.

Entomology is a useful tool when applied to engineering challenges that have been solved in nature. Especially when these special abilities of olfactory sensation, vision, auditory perception, fly, jump, navigation, chemical synthesis, exquisite structure and others were connected with mechanization, informationization and intelligentization of modern science and technology, and produced innumerable classical bionic products. The paper aims to discuss these issues.

All kinds of special abilities of insects and application status have been described and discussed in order to summarize the advanced research examples and supply bibliographic reference to the latters. Future perspectives and challenges in the use of insect bionics were also given.

In the period of life sciences and information sciences, insect bionics not only promoted the development of modern science and technology on the sides of mechanics, molecule, energy, information and control greatly but also provided new ideas and technologies for the crisis of science and technology, food, environment and ecosystem.

It may provide strategies to solve the problems and be a source of good ideas for researchers.

The purpose of this paper is to provide details of recent developments in sensors for detecting explosives and chemical warfare agents.

Following an introduction, this paper first discusses a selection of new sensing techniques aimed at detecting explosives and explosive devices. It then considers new developments in sensors for detecting chemical warfare agents. Brief concluding comments are drawn.

This paper shows that a diversity of sensor technologies is being investigated, including various advanced optical methods, nanomaterials, microelectromechanical system, electronic noses, biosensors and electrochemical techniques, several of which offer levels of sensitivity in the parts-per-trillion region. These not only have the potential to yield improved devices for detecting explosives and chemical weapons but may also play a role in health care, environmental monitoring, drug detection and industrial health and safety.

In an era of escalating terrorism and military conflicts, this provides a timely review of new technologies for detecting explosives and chemical warfare agents.

The electronic nose is an array of chemical or gas sensors and associated with a pattern-recognition framework competent in identifying and classifying odorant or non-odorant and simple or complex gases. Despite more than 30 years of research, the robust e-nose device is still limited. Most of the challenges towards reliable e-nose devices are associated with the non-stationary environment and non-stationary sensor behaviour. Data distribution of sensor array response evolves with time, referred to as non-stationarity. The purpose of this paper is to provide a comprehensive introduction to challenges related to non-stationarity in e-nose design and to review the existing literature from an application, system and algorithm perspective to provide an integrated and practical view.

The authors discuss the non-stationary data in general and the challenges related to the non-stationarity environment in e-nose design or non-stationary sensor behaviour. The challenges are categorised and discussed with the perspective of learning with data obtained from the sensor systems. Later, the e-nose technology is reviewed with the system, application and algorithmic point of view to discuss the current status.

The discussed challenges in e-nose design will be beneficial for researchers, as well as practitioners as it presents a comprehensive view on multiple aspects of non-stationary learning, system, algorithms and applications for e-nose. The paper presents a review of the pattern-recognition techniques, public data sets that are commonly referred to as olfactory research. Generic techniques for learning in the non-stationary environment are also presented. The authors discuss the future direction of research and major open problems related to handling non-stationarity in e-nose design.

The authors first time review the existing literature related to learning with e-nose in a non-stationary environment and existing generic pattern-recognition algorithms for learning in the non-stationary environment to bridge the gap between these two. The authors also present details of publicly available sensor array data sets, which will benefit the upcoming researchers in this field. The authors further emphasise several open problems and future directions, which should be considered to provide efficient solutions that can handle non-stationarity to make e-nose the next everyday device.