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Article
Publication date: 21 July 2022

Bjorn John Stephen, Surabhi Suchanti, Devendra Jain, Harshdeep Dhaliwal, Vikram Sharma, Ramandeep Kaur, Rajeev Mishra and Abhijeet Singh

Neglected tropical diseases (NTDs) are a set of infectious diseases that primarily affect low-income countries situated near the equator. Effective diagnostic tools hold…

Abstract

Purpose

Neglected tropical diseases (NTDs) are a set of infectious diseases that primarily affect low-income countries situated near the equator. Effective diagnostic tools hold the key to stemming the spread of these infectious diseases. However, specificity is a major concern associated with current diagnostic protocols. In this regard, electrochemical deoxyribonucleic acid (DNA) biosensors could play a crucial role, as highlighted by renewed interest in their research. The purpose of this study was to highlight the current scenario for the design and development of biosensors for the detection of NTDs related pathogens. This review highlights the different types of factors involved and the modifications used to enhance sensor properties.

Design/methodology/approach

The authors discuss the potential of electrochemical DNA biosensors as efficient, affordable diagnostic tools for the detection of pathogens associated with NTDs by reviewing available literature. This study discusses the biosensor components, mainly the probe selection and type of electrodes used, and their potential to improve the overall design of the biosensor. Further, this study analyses the different nanomaterials used in NTD-based electrochemical DNA biosensors and discusses how their incorporation could improve the overall sensitivity and specificity of the biosensor design. Finally, this study examines the impact such techniques could have in the future on mass screening of NTDs.

Findings

The findings provide an in-depth analysis of electrochemical DNA biosensors for the detection of pathogens associated with NTDs.

Originality/value

This review provides an update on the different types and modifications of DNA biosensors that have been designed for the diagnosis of NTD-related pathogens.

Details

Sensor Review, vol. 42 no. 5
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 19 January 2015

Xingya Wang and Guangchang Pang

This paper aims to provide a detailed review of weak interaction biosensors and several common biosensor methods for magnifying signals, as well as judiciously guide…

Abstract

Purpose

This paper aims to provide a detailed review of weak interaction biosensors and several common biosensor methods for magnifying signals, as well as judiciously guide readers through selecting an appropriate detecting system and signal amplification method according to their research and application purpose.

Design/methodology/approach

This paper classifies the weak interactions between biomolecules, summarizes the common signal amplification methods used in biosensor design and compares the performance of different kinds of biosensors. It highlights a potential electrochemical signal amplification method: the G protein signaling cascade amplification system.

Findings

Developed biosensors which, based on various principles, have their own strengths and weaknesses have met the basic detection requirements for weak interaction between biomolecules: the selectivity, sensitivity and detection limit of biosensors have been consistently improving with the use of new signal amplification methods. However, most of the weak interaction biosensors stop at the research stage; there are only a minority realization of final commercial application.

Originality/value

This paper evaluates the status of research and application of weak interaction biosensors systematically. The G protein signaling cascade amplification system proposal offers a new avenue for the research and development of electrochemical biosensors.

Content available
Article
Publication date: 23 June 2020

Pankaj Mandpe, Bala Prabhakar, Hunny Gupta and Pravin Shende

The present study aims to summarize different non-invasive techniques for continuous glucose monitoring (CGM) in diabetic patients using glucose-oxidase biosensors. In…

1805

Abstract

Purpose

The present study aims to summarize different non-invasive techniques for continuous glucose monitoring (CGM) in diabetic patients using glucose-oxidase biosensors. In diabetic patients, the self-monitoring of blood glucose (BG) levels through minimally invasive techniques provides a quick method of measuring their BG concentration, unlike conventional laboratory measurements. The drawbacks of minimally invasive techniques include physical pain, anxiety and reduced patient compliance. To overcome these limitations, researchers shifted their attention towards the development of a pain-free and non-invasive glucose monitoring system, which showed encouraging results.

Design/methodology/approach

This study reviews the development of minimally and non-invasive method for continuous glucose level monitoring in diabetic or hyperglycemic patients. Specifically, glucose monitoring using non-invasive techniques, such as spectroscopy-based methods, polarimetry, fluorescence, electromagnetic variations, transdermal extraction-based methods and using body fluids, has been discussed. The various strategies adopted for improving the overall specificity and performance of biosensors are discussed.

Findings

In conclusion, the technology of glucose oxidase-based biosensors for glucose level monitoring is becoming a strong competitor, probably because of high specificity and selectivity, low cost and increased patient compliance. Many industries currently working in this field include Google, Novartis and Microsoft, which demonstrates the significance and strong market potential of self-monitored glucose-oxidase-based biosensors in the near future.

Originality/value

This review paper summarizes comprehensive strategies for continuous glucose monitoring (CGM) in diabetic patients using non-invasive glucose-oxidase biosensors. Non-invasive techniques received significant research interest because of high sensitivity and better patient compliance, unlike invasive ones. Although the results from these innovative devices require frequent calibration against direct BG data, they might be a preferable candidate for future CGM. However, the challenges associated with designing accurate level sensors to biomonitor BG data easily and painlessly needs to be addressed.

Details

Sensor Review, vol. 40 no. 4
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 25 January 2008

Vinod Kumar Khanna

This paper aims to discover the novelties in biosensor fabrication brought about by breakthroughs in nanomaterials and process techniques, the resulting enhancement in…

6279

Abstract

Purpose

This paper aims to discover the novelties in biosensor fabrication brought about by breakthroughs in nanomaterials and process techniques, the resulting enhancement in biosensor functionalities, new applications and future possibilities.

Design/methodology/approach

The impact of nanotechnology on biosensor advancement has been examined. Different directions of biosensor research in the nano era have been highlighted. These include the efforts made through nanotechnology to improve the performance parameters of the existing biosensors, and for implementation of innovative biosensor concepts.

Findings

Nanotechnology is a key technology in biosensor development. It has permeated into the biosensor field and brought in its wake far‐reaching changes.

Practical implications

Biosensor science and engineering are central to virtually all aspects of life including medical diagnostics, environmental monitoring and biotechnological process control. Therefore, the progress in biosensors brought about by nanotechnology influences one's everyday life.

Originality/value

The study helps in understanding the applications of nanotechnology in fabricating a new generation of biosensors with improved characteristics. It provides information of value to those involved in biosensor research.

Details

Sensor Review, vol. 28 no. 1
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 1 June 1997

E.T. Powner and F. Yalcinkaya

Discusses intelligent materials, intelligent material‐based sensors, their transducing methods, and different kinds of transducers used with smart material‐based sensors…

2052

Abstract

Discusses intelligent materials, intelligent material‐based sensors, their transducing methods, and different kinds of transducers used with smart material‐based sensors. Assumes that the future of intelligent sensors will almost totally depend on intelligent chemistry and intelligent instrumentation. Molecular recognition will widen the horizons of smart systems with the help of VLSI‐based design and fabrication. Discusses different sensor mechanisms, such as ENFETs, immunoFETs, ISFETs and chemFETs and takes a detailed look at potentiometric, amperometric and optical biosensors.

Details

Sensor Review, vol. 17 no. 2
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 1 December 2005

James P. Smith

Describes the history and development of biosensors and their commercial application.

2620

Abstract

Purpose

Describes the history and development of biosensors and their commercial application.

Design/methodology/approach

Provides background information on different forms of biosensors and how they can be brought to market. This review is edited from a very detailed market research report “Medical and Biological Sensor and Sensor Systems: markets, applications and competitors worldwide”.

Findings

Finds that the commercial potential for biosensors is very large and is expected to reach US$ 2.3 billion worldwide in 2005.

Originality/value

The full market research report provides a detailed insight into biosensors and how they are made and the various application areas, together with discussion regarding a large number of vendor and research companies.

Details

Sensor Review, vol. 25 no. 4
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 20 June 2016

Yijun Teh, Asral Bahari Jambek and Uda Hashim

This paper aims to discuss a nanoscale biosensor and its signal analysis algorithms.

1071

Abstract

Purpose

This paper aims to discuss a nanoscale biosensor and its signal analysis algorithms.

Design/methodology/approach

In this work, five nanoscale biosensors are reviewed, namely, silicon nanowire field-effect-transistor biosensors, polysilicon nanogap capacitive biosensors, nanotube amperometric biosensors, gold nanoparticle-based electrochemical biosensors and quantum dot-based electrochemical biosensors.

Findings

Each biosensor produces a different output signal depending on its electrical characteristics. Five signal analysers are studied, with most of the existing signal analyser analyses based on the amplitude of the signal. Based on the analysis, auto-threshold peak detection is proposed for further work.

Originality/value

Suitability of the signal processing algorithm to be applied to nano-biosensors was reported.

Details

Sensor Review, vol. 36 no. 3
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 14 March 2016

Alexandra Waluszewski

The purpose of this paper is to investigate the management of the use of knowledge in interfaces stretching across company and organizational borders, including the…

Abstract

Purpose

The purpose of this paper is to investigate the management of the use of knowledge in interfaces stretching across company and organizational borders, including the negotiated monetary dimension.

Design/methodology/approach

The research approach is the IMP framework on resource interaction (Håkansson and Waluszewski, 2002), and the distinction among heterogeneous economic resources and a homogeneous monetary dimension, (Håkansson and Olsen, 2015; Perna et al., 2015). A case study on use of science based knowledge in business is utilized.

Findings

The management regime behind the creation of a user setting including a substantial monetary flow is can be characterized as “managing collective entities” (Håkansson, Bakken, Olsen, 2013) and it is argued that the knowledge management regime assumes away the most important process related to use of knowledge.

Research limitations/implications

The paper stress the theoretical need for approaching managment in general and managing use of knowledge in particular as an interactive issue.

Practical implications

The paper stress the practical need for approaching managment in general and managing use of knowledge in particular as an interactive issue.

Originality/value

The paper questions the knowledge management regime, which has a strong influence on public policy.

Details

IMP Journal, vol. 10 no. 1
Type: Research Article
ISSN: 2059-1403

Keywords

Article
Publication date: 8 October 2018

Melis Asal, Özlem Özen, Mert Şahinler, Hasan Tahsin Baysal and İlker Polatoğlu

Traditional analytical methods are often time-consuming and require bulky instruments, making their widespread implementation challenging. This paper aims to represent the…

1044

Abstract

Purpose

Traditional analytical methods are often time-consuming and require bulky instruments, making their widespread implementation challenging. This paper aims to represent the principal concepts of biosensors as an introduction of this technology to readers and offers a comprehensive understanding of its functions.

Design/methodology/approach

The authors provide descriptions of the components, characteristics and advantages of biosensors along with the immobilization methods, followed by a brief discussion.

Findings

A biosensor is an analytical device comprising a specific biomolecule and a transducer in conjunction with an output system. The biomolecule recognizes a specific target which leads to a change in physicochemical properties of a system. This biorecognition phenomenon is later converted into a detectable signal by the transducer. Biosensors can essentially serve as rapid and cost-effective devices with excellent sensitivity and specificity for critical purposes in innumerable fields, ranging from scientific research to day-to-day applications.

Originality/value

Here, the authors explain and discuss the approaches and challenges with the aim of leading to an interest in biosensor development and improving their applications.

Details

Sensor Review, vol. 39 no. 3
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 4 April 2018

Bushra Rafique, Mudassir Iqbal, Tahir Mehmood and Muhammad Ashraf Shaheen

This review aims to focus on recent reported research work on the construction and function of different electrochemical DNA biosensors. It also describes different…

1504

Abstract

Purpose

This review aims to focus on recent reported research work on the construction and function of different electrochemical DNA biosensors. It also describes different sensing materials, chemistries of immobilization probes, conditions of hybridization and principles of transducing and amplification strategies.

Design/methodology/approach

The human disease-related mutated genes or DNA sequence detection at low cost can be verified by the electrochemical-based biosensor. A range of different chemistries is used by the DNA-based electrochemical biosensors, out of which the interactions of nanoscale material with recognition layer and a solid electrode surface are most interesting. A diversity of advancements has been made in the field of electrochemical detection.

Findings

Some important aspects are also highlighted in this review, which can contribute in the creation of successful biosensing devices in the future.

Originality/value

This paper provides an updated review of construction and sensing technologies in the field of biosensing.

Details

Sensor Review, vol. 39 no. 1
Type: Research Article
ISSN: 0260-2288

Keywords

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