To read the full version of this content please select one of the options below:

Amplification systems of weak interaction biosensors: applications and prospects

Xingya Wang (Tianjin Key Laboratory of Food Biotechnology, Tianjin University of Commerce, Tianjin, China)
Guangchang Pang (Tianjin Key Laboratory of Food Biotechnology, Tianjin University of Commerce, Tianjin, China)

Sensor Review

ISSN: 0260-2288

Article publication date: 19 January 2015

Abstract

Purpose

This paper aims to provide a detailed review of weak interaction biosensors and several common biosensor methods for magnifying signals, as well as judiciously guide readers through selecting an appropriate detecting system and signal amplification method according to their research and application purpose.

Design/methodology/approach

This paper classifies the weak interactions between biomolecules, summarizes the common signal amplification methods used in biosensor design and compares the performance of different kinds of biosensors. It highlights a potential electrochemical signal amplification method: the G protein signaling cascade amplification system.

Findings

Developed biosensors which, based on various principles, have their own strengths and weaknesses have met the basic detection requirements for weak interaction between biomolecules: the selectivity, sensitivity and detection limit of biosensors have been consistently improving with the use of new signal amplification methods. However, most of the weak interaction biosensors stop at the research stage; there are only a minority realization of final commercial application.

Originality/value

This paper evaluates the status of research and application of weak interaction biosensors systematically. The G protein signaling cascade amplification system proposal offers a new avenue for the research and development of electrochemical biosensors.

Keywords

Acknowledgements

The authors would like to acknowledge the financial support of National Natural Science Foundation of China (No. 31371773), National Key Scientific and Technological Project (No. 2012BAD29B07) and Key Laboratory of Dairy Science, Ministry of Education (Northeast Agricultural University) Open Research Fund.

Citation

Wang, X. and Pang, G. (2015), "Amplification systems of weak interaction biosensors: applications and prospects", Sensor Review, Vol. 35 No. 1, pp. 30-42. https://doi.org/10.1108/SR-03-2014-629

Publisher

:

Emerald Group Publishing Limited

Copyright © 2015, Emerald Group Publishing Limited