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Dietary inflammatory potential (DIP) is a novel dietary index designed to evaluate individuals’ diets with considering inflammation and anti-inflammation score. In addition, adhesion molecules including soluble intracellular adhesion molecules-1 (sICAM-1), soluble cellular adhesion molecules-1 (sVCAM-1) and E-selectin are important biomarkers to assess endothelium dysfunction which are related to atherosclerosis and cardiovascular complications. Also, there is no study for assessing the association between adhesion molecules and DIP until now as well as other studies that assessed the relationship between dietary inflammatory index or DIP has controversy. The purpose of this cross-sectional study was to determine the correlation between DIP and endothelial markers such as E-selectin, sICAM-1 and sVCAM-1 among female nurses from Isfahan. In this study, DIP was used instead of DII.

This study was performed on 420 healthy nurses. The nurses were selected by random cluster sampling method from private and public Isfahan hospitals. A validated food frequency questionnaire (FFQ) was applied to assess the DIP. A fasting blood sample was collected for measuring the plasma levels of the endothelial markers and other variables.

After adjusting different potential confounders, no statistical association was found between DIP and sICAM-1, E–selectin and sVCAM-1 in Model I (P = 0.57, 0.98 and 0.45), Model II (P = 0.57, 0.98 and 0.45) and Model III (P = 0.67, 0.92 and 0.50) in comparison to the crude group (P = 0.35, 0.83 and 0.49, respectively).

The results revealed that the plasma levels of endothelial markers including E-selectin, sICAM-1 and sVCAM-1 were not significantly associated with DIP in female nurses.

This paper aims to evaluate the effect of consumption of a high-fat diet (HFD) rich with total saturated fats on adiposity and serum levels of vascular cell adhesion molecule (sVCAM-1), a biomarker of endothelial inflammation/dysfunction. Another aim is to evaluate whether supplementation of a phytosomal formulation of curcumin would reduce adiposity measures and sVCAM-1 levels in HFD rats.

The study was conducted on 17 male rats which were allocated to one of three feeding regimen groups: normal diet (ND); HFD, or HFD with dietary phytosomal curcumin (HFD-C). Anthropometric measures were recorded weekly up to 20 weeks of feeding intervention, at the end of which, sVCAM-1 levels were also compared with one-way ANOVA and Tukey post-hoc analysis.

The HFD group had the greatest values for raw anthropometric data, and there was a group difference in anthropometric measures, however there was no significant difference between HFD and HFD-C for any measure. The gain at 20 weeks from initial values did reveal significant differences in weight and abdominal circumference between HFD and HFD-C groups. There were significant group differences in sVCAM-1 levels, with only HFD-C displaying significant lower levels than HFD group.

This is the first study that shows the capacity of a phytosomal formulation of curcumin in reducing adiposity and sVCAM-1 levels during daily intake of saturated fats above the recommended level. The results are promising in that this formulation can protect against endothelial inflammation/dysfunction, and can be used as complimentary therapy to suppress dyslipidemia/obesity-related cardiovascular complications.

The purpose of this chapter is to review and synthesise the available evidence for the health benefits of walking. It follows a non-systematic evidence review and finds that the evidence base for the health benefits of walking is growing. Increasingly we are finding strong evidence for the beneficial effects of walking for both individuals and populations. More evidence is required on how to better understand the health outcomes associated with walking and how to promote long term increases in walking behaviour. Systematic reviews of specific health benefits remain rare. Walking should be promoted in all population groups regardless of age or sex. There are currently few existing integrative syntheses of the physical and mental health outcomes associated with walking and this chapter aims to help fill that gap.

Type 2 diabetes mellitus (T2DM) is a worldwide health problem. Blood pressure (BP) and inflammation are well-established risk factors for the cardiovascular complications of T2DM. Genistein is known to improve endothelial dysfunction. The purpose of this study is to investigate the effects of genistein supplementation on BP, high-sensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in postmenopausal women with T2DM.

This randomized, double-blind, placebo-controlled clinical trial is conducted on postmenopausal women with T2DM. A total of 54 subjects aged between 47 and 69 years are divided into two groups. Participants in the genistein group (n = 28) are given two genistein capsules (each capsule contained 54 mg genistein) and those in the placebo group (n = 26) received two placebo capsules (each capsule contained 54 mg maltodextrin) daily for 12 weeks. General characteristics, BP, hs-CRP and Hcy levels are measured at the baseline and at the end of the trial.

Genistein supplementation resulted in a significant reduction in systolic BP (SBP) (p < 0.001), diastolic BP (DBP) (p = 0.020), mean arterial pressure (MAP) (p < 0.001), serum levels of hs-CRP (p = 0.005) and Hcy (p = 0.001) in genistein group compared with placebo group at the end of the study. Significant decreases are also found in SBP by 5.4%, p < 0.001, DBP by 6.7%, p < 0.001, MAP by 6.2%, p < 0.001, serum levels of hs-CRP by 47.0%, p = 0.015 and Hcy by 18.4%, p < 0.001 in the genistein supplemented group. No significant changes are observed in terms of all post-intervention values in the placebo group.

Genistein administration improved BP, hs-CRP and Hcy levels in postmenopausal women with T2DM and may be useful in control of some CVD risk factors in these subjects.

Advice about the role of eggs in the diet has changed several times over the decades. The purpose of this paper is to evaluate published evidence reporting associations between egg consumption, egg nutrients and health.

The scientific literature was searched using Medline and key words relevant to eggs and egg nutrients. In addition, a new secondary analysis of the UK National Diet and Nutrition Survey (NDNS) was undertaken to examine nutritional and health differences between consumers and non‐consumers of eggs.

Eggs are a rich source of protein and several essential nutrients, particularly vitamin D, vitamin B12, selenium and choline. Emerging evidence suggests that eating eggs is associated with satiety, weight management and better diet quality. In addition, antioxidants found in egg yolk may help prevent age‐related macular degeneration. The secondary analysis showed that regular egg consumers with a low red and processed meat (RPM) intake ate healthier diets and had a better micronutrient status than those who did not eat eggs but who had a high RPM intake. It was concluded that egg consumption, at a range of intakes, was associated with nutrition and health benefits.

More research on eggs, and egg nutrients, is needed to confirm the health benefits. Future studies should control for other dietary and lifestyle factors.

This paper develops knowledge about egg consumption beyond cholesterol content and provides new evidence from a secondary analysis of a large national dietary database.

The goal of this narrative review was to look at the link between the Mediterranean diet (MD) and the telomere length. Furthermore, this study aims to understand the impact of the MD on obesity-related telomere length.

Relevant literature was reviewed to explore the potential influence of the MD on telomere length and its association with obesity.

The MD is one of the healthiest diets of all known dietary patterns, and it is also linked to the telomere length. Except for fruits and vegetables, the main findings for other MD components are inconsistent. In terms of antioxidant and antiinflammatory properties, using the MD as a weight loss approach is a good method. For predicting changes in obesity characteristics, the initial telomere length is critical. However, there are not many studies in the field that have looked at the MD as a weight loss approach and its link to the telomere length. As a result, more research is needed to understand these connections in various groups.

This study is unique since it examines the MD, telomere length and obesity-related consequences. This study examines the MD, telomere length and obesity to determine if the MD can help lose weight while maintaining telomere length. As there are few studies on MD weight loss and telomere length, the work emphasizes the need for greater research in this area. This study fills a research gap and improves the understanding of nutrition, telomere biology and obesity-related outcomes.

Garlic supplementation may be inversely contributed to body weight and composition; however, previous results have been inconsistent. This study aims to evaluate the effect of garlic supplementation on body weight and composition using a systematic review and meta-analysis.

Online databases of PubMed, ISI Web of Science, Scopus and Google Scholar were searched up to January 2020. The random-effects model was used to calculate the effect sizes of the included studies. The risk of bias of included studies was assessed using the Cochrane collaboration’s tool. Besides, the NutriGrade scoring system was applied to judge the credibility of the evidence.

In total, 18 studies (with 1,250 participants) were included in the meta-analysis. The pooled analysis revealed that garlic supplementation has a significant increase in body weight [weighted mean difference (WMD) = 0.31 Kg, 95% CI: 0.09, 0.53 Kg, P = 0.005, n = 12 effect sizes]. Waist circumference (WC) does remarkably reduce [WMD = −1.28 cm, 95% CI: −2.08, −0.47 cm, P = 0.002, n = 4 effect size]. However, body mass index, body fat percent and fat-free mass do not dramatically change (P > 0.05). Notably, the pooled analyses on body weight and WC were sensitive to two included studies. NutriGrade’s score was rated low for this meta-analysis.

Although garlic supplementation could slightly increase weight and simultaneously might decrease WC, these associations were not strong enough to corroborate the findings. Also, other anthropometric indices do not significantly change. Further well-designed randomized clinical trial studies are needed to confirm the results.

The effects of Opuntia ficus indica (OFI) cladodes on uricemia level, endothelial dysfunction and oxidative damage were studied in young rats fed a cafeteria diet (CD).

A total of 16 young male Wistar rats (weighing 110 ± 20 g and four weeks old) were divided into two homogenous groups. The first group received a CD containing 50% of hyperlipidic diet and 50% of junk food mix (processed mix: hyper-fat, hyper-salted and sweetened) (CD group), and the second group (CD + OFI nopalitos) received the same diet supplemented with 50 g of fresh OFI nopalitos (young cladodes) for 30 days.

OFI nopalitos regulate the hyperuricemia, improve the endothelial dysfunction by raising the bioavailability of nitric oxide(NO) and reduce prooxidant markers by reducing lipid peroxidation and protein oxidation (p < 0.05) and boosting antioxidant capacity and enhancing the antioxidant enzymes activities (p < 0.05) in blood and aorta tissues of rats early fed with a high-fat diet /junk food.

By-products of OFI have specific functional properties that may be beneficial in metabolic disorders and offer a better alternative with an economic and sustainable development perspective.

By-products of OFI highlight potential functional properties mainly based on its potent antioxidant capacity. By-products of OFI can be used as a promising nutraceutical resource to prevent various metabolic disorders in relation with cardiovascular diseases or hyperuricemia in subjects consuming junk food and or living in the Western society to reach the objectives of health policy and maintain a sustainable health system development.

The study aims to design metabolic syndrome (MetS) ingredient mix with optimum amino acid makeup using key foods with reported functional properties and study the efficacy of this mix to alleviate the symptoms of MetS among adult men and women with MetS.

In total, 25 MetS-specific ingredient mixes that included wheat flour, common legumes, fenugreek and flaxseeds were formulated by correcting their amino acid score. The suitability of these mixes was tested for the preparation of chapati (an unleavened Indian bread). Owing to its highest lysine content, the ingredient mix of whole wheat flour, oat flour, soybean, flaxseeds and fenugreek seeds was selected for the 12-week supplementation trial among patients with MetS.

The sensory scores of chapatis made using nine ingredient mixes was comparable with those of chapati made from whole wheat flour (control). The test chapatis had a significantly (p = 0.05) higher protein, ash, fibre and fat content, and lysine was also higher (591-1,006 mg/100 g) than the control chapatis (314 mg). Positive and significant changes in the anthropometry, body composition, fasting blood glucose levels, blood pressure and lipid profile of the patients with MS was seen after consumption of the selected ingredient mix.

Keeping in view the traditional vegetarian Indian meals which usually take care of including foods from different sources to improve their protein quality, the concern for providing protein quality to prevent metabolic abnormalities is significant for a large lacto-vegetarian population in India which depends on plant foods for obtaining essential amino acids. Obtaining optimum protein quality from meals along with maintaining a physically active lifestyle may help people have the appropriate fat to lean mass proportion which may have a protective role against MetS.

The purpose of this study is to analyze markers of the progression of kidney damage by a soft computing approach.

Because markers of the progression of kidney damage, namely, plasminogen activator inhibitor-1 (PAI-1), interleukin-8 (IL-8) and highly sensitive troponin T (cTnhsT), are complex parameters, a soft computing approach was used for the assessment of functional glomerular reserves, through the use of the Modification of the Diet in Renal Disease (MDRD) formula based on serum creatinine and EPI creatinine-cystatin C formula (chronic kidney disease epidemiology collaboration).

The soft computing approach was used to detect which factors (PAI-1, IL-8 and cTnhsT) are the most important for the MDRD formula based on serum creatinine or the EPI creatinine–cystatin C formula.

Markers of the progression of kidney damage were analyzed by the soft computing approach.