The cactus cladode (Opuntia ficus indica) modulates uricemia, improves endothelial dysfunction and corrects oxidative damage in rats fed a cafeteria diet

Abstract

Purpose

The effects of Opuntia ficus indica (OFI) cladodes on uricemia level, endothelial dysfunction and oxidative damage were studied in young rats fed a cafeteria diet (CD).

Design/methodology/approach

A total of 16 young male Wistar rats (weighing 110 ± 20 g and four weeks old) were divided into two homogenous groups. The first group received a CD containing 50% of hyperlipidic diet and 50% of junk food mix (processed mix: hyper-fat, hyper-salted and sweetened) (CD group), and the second group (CD + OFI nopalitos) received the same diet supplemented with 50 g of fresh OFI nopalitos (young cladodes) for 30 days.

Findings

OFI nopalitos regulate the hyperuricemia, improve the endothelial dysfunction by raising the bioavailability of nitric oxide(NO) and reduce prooxidant markers by reducing lipid peroxidation and protein oxidation (p < 0.05) and boosting antioxidant capacity and enhancing the antioxidant enzymes activities (p < 0.05) in blood and aorta tissues of rats early fed with a high-fat diet /junk food.

Social implications

By-products of OFI have specific functional properties that may be beneficial in metabolic disorders and offer a better alternative with an economic and sustainable development perspective.

Originality/value

By-products of OFI highlight potential functional properties mainly based on its potent antioxidant capacity. By-products of OFI can be used as a promising nutraceutical resource to prevent various metabolic disorders in relation with cardiovascular diseases or hyperuricemia in subjects consuming junk food and or living in the Western society to reach the objectives of health policy and maintain a sustainable health system development.

Citation

Chekkal, H., Harrat, N.e.I., Bensalah, F., Affane, F., Louala, S. and Lamri-Senhadji, M. (2020), "The cactus cladode (Opuntia ficus indica) modulates uricemia, improves endothelial dysfunction and corrects oxidative damage in rats fed a cafeteria diet", World Journal of Science, Technology and Sustainable Development, Vol. 17 No. 4, pp. 355-365. https://doi.org/10.1108/WJSTSD-05-2019-0023