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Three-dimensional (3D) printing is highly dependent on printing process parameters for achieving high mechanical strength. It is a time-consuming and expensive operation to experiment with different printing settings. The current study aims to propose a regression-based machine learning model to predict the mechanical behavior of ulna bone plates.

The bone plates were formed using fused deposition modeling (FDM) technique, with printing attributes being varied. The machine learning models such as linear regression, AdaBoost regression, gradient boosting regression (GBR), random forest, decision trees and k-nearest neighbors were trained for predicting tensile strength and flexural strength. Model performance was assessed using root mean square error (RMSE), coefficient of determination (R²) and mean absolute error (MAE).

Traditional experimentation with various settings is both time-consuming and expensive, emphasizing the need for alternative approaches. Among the models tested, GBR model demonstrated the best performance in predicting both tensile and flexural strength and achieved the lowest RMSE, highest R2 and lowest MAE, which are 1.4778 ± 0.4336 MPa, 0.9213 ± 0.0589 and 1.2555 ± 0.3799 MPa, respectively, and 3.0337 ± 0.3725 MPa, 0.9269 ± 0.0293 and 2.3815 ± 0.2915 MPa, respectively. The findings open up opportunities for doctors and surgeons to use GBR as a reliable tool for fabricating patient-specific bone plates, without the need for extensive trial experiments.

The current study is limited to the usage of a few models. Other machine learning-based models can be used for prediction-based study.

This study uses machine learning to predict the mechanical properties of FDM-based distal ulna bone plate, replacing traditional design of experiments methods with machine learning to streamline the production of orthopedic implants. It helps medical professionals, such as physicians and surgeons, make informed decisions when fabricating customized bone plates for their patients while reducing the need for time-consuming experimentation, thereby addressing a common limitation of 3D printing medical implants.

The implications of metallic biomaterials involve stress shielding, bone osteoporosis, release of toxic ions, poor wear and corrosion resistance and patient discomfort due to the need of second operation. This study aims to use additive manufacturing (AM) process for fabrication of biodegradable orthopedic small locking bone plates to overcome complications related to metallic biomaterials.

Fused deposition modeling technique has been used for fabrication of bone plates. The effect of varying printing parameters such as infill density, layer height, wall thickness and print speed has been studied on tensile and flexural properties of bone plates using response surface methodology-based design of experiments.

The maximum tensile and flexural strengths are mainly dependent on printing parameters used during the fabrication of bone plates. Tensile and flexural strengths increase with increase in infill density and wall thickness and decrease with increase in layer height and wall thickness.

The present work is focused on bone plates. In addition, different AM techniques can be used for fabrication of other biomedical implants.

Studies on application of AM techniques on distal ulna small locking bone plates have been hardly reported. This work involves optimization of printing parameters for development of distal ulna-based bone plate with high mechanical strength. Characterization of microscopic fractures has also been performed for understanding the fracture behavior of bone plates.

The internal fixation plate of bone fractures by using polylactic acid (PLA) has attracted the attention of many researchers, as it is biodegradable and biocompatible to the human body. However, its brittleness has led to implant fracture. On the contrary, polypropylene carbonate (PPC), which is also biodegradable and biocompatible, has an excellent elongation at break. The purpose of this paper is to compare the PLA fixation plate with the new fixation plate made up of PLA/PPC blends by using finite element analysis (FEA).

The mandible bone from CT data set and fixation plate was designed by using the MIMICS, Amira and Solidworks softwares. Abaqus software was used for FEA of PLA/PPC fixation plate applied on the fractured mandible bone. A model of mandibular bone with a fracture in the body was subjected to incisor load. The analysis was run to determine the von Mises stress, elongation of the fixation plate and the displacement of the fractured gap of PLA/PPC blends fixation plate.

The von Mises stress predicted that all the blend compositions were safe to be used as a fixation plate since the stress values were less than the yield strength. In addition, the stress value of the fixation plate was gradually decreased up to 20 percent when the amount of PPC increased to 30 percent. This indicates that the stress shielding effect was successfully reduced. The elongation of the fixation plate was gradually increased from 11.54 to 12.55 µm as the amount of PPC in the blends increased from 0 to 30 percent, thereby illustrating that the flexibility of the fixation plate was improved by the addition of PPC. Finally, the measured displacement of the fractured gap for all compositions of PLA/PPC blends fixation plate is less than 150 µm, which proves the likely success of fracture fixation by using the PLA/PPC blends.

An optimum solution of PLA/PPC blends and another new material such as compatibilizer need to be introduced in the blends in order to improve the performance of PLA/PPC blends as a new material for a fixation plate. Besides, by using the same method of producing PLA/PPC blends, longer durations for in vitro degradation of PLA/PPC blends are essential to further understand the degradation behavior of the blends applied in the human body. Finally, it is also important to further test the mechanical strength of PLA/PPC blends during the degradation period to know the current strength of the implant in the healing process of the bone.

PLA fixation plate and screw can commercially be used in CMF surgery since they reduce cost because of the elimination of secondary surgery to remove the fixation plate and screw after the healing process.

It is hoped that the advantages of this research will ensure the market of PLA product to continue expanding in medical application.

This study is one of the alternative ways for the biomedical researchers to improve the elongation break of PLA. Currently, many researchers focus on polymeric materials such as PLA, poly(glycolic) acid and polydioxanone blends, which were extensively being used in CMF surgery. However, the work on PLA/PPC blends to be used as one of the materials for the CMF fixation plate is very limited, if any. PPC, the proposed material for this research, will improve the mechanical performance of PLA fixation plate and screw to become more sustainable and flexible when applied on human mandible bone.

An important challenge of the osteotomy procedures, particularly in the case of large and complex corrections, is the fixation of the osteotomy site. The purpose of this study is to propose a practical and cost-effect methodology for the plate adapting problem of osteotomy surgery.

A novel patient-specific plate contouring methodology, based on rapid prototyping (RP) and multi-point forming (MPF) techniques, was developed and evaluated. In this methodology, a female mold is fabricated by RP, based on the geometry of the osteotomy site and estimation of the plate spring back. The mold is then used to configure a MPF die, which is then used for press forming of the factory-made locking plate. The applicability of the methodology was assessed in two case studies.

The results of implementing the methodology on a femoral and a tibial locking plate indicated very good conformity with the underlying bone, in both the frontal and sagittal planes. The surgical application of the pre-operatively contoured tibial plate facilitated the plate locating and screw inserting procedures, and provided a secure fixation for bone fragments.

The results are promising and provide a proof of concept for the feasibility and applicability of the proposed methodology in clinical practice, as a complementary to the existing surgical preplanning and patient-specific instrument preparations.

The advantageous features of RP and the MPF were used to provide a solution for the plate adapting problem of osteotomy surgery.

This bibliography is offered as a practical guide to published papers, conference proceedings papers and theses/dissertations on the finite element (FE) and boundary element (BE) applications in different fields of biomechanics between 1976 and 1991. The aim of this paper is to help the users of FE and BE techniques to get better value from a large collection of papers on the subjects. Categories in biomechanics included in this survey are: orthopaedic mechanics, dental mechanics, cardiovascular mechanics, soft tissue mechanics, biological flow, impact injury, and other fields of applications. More than 900 references are listed.

Fracture characterization of human cortical bone under pure mode I loading was performed in this work. The purpose of this paper is to validate the proposed test and procedure concerning fracture characterization of human cortical bone under pure mode I loading.

A miniaturized version of the double cantilever beam (DCB) test was used for the experimental tests. A data reduction scheme based on crack equivalent concept and Timoshenko beam theory is proposed to overcome difficulties inherent to crack length monitoring during the test. The application of the method propitiates an easy determination of the Resistance-curves (R-curves) that allow to define the fracture energy under mode I loading from the plateau region. The average value of fracture energy was subsequently used in a numerical analysis with element method involving cohesive zone modelling.

The excellent agreement obtained reveals that the proposed test and associated methodology is quite effective concerning fracture characterization of human cortical bone under pure mode I loading.

A miniaturized version of traditional DCB test was proposed for cortical human bone fracture characterization under mode I loading owing to size restrictions imposed by human femur. In fact, DCB specimen propitiates a longer length for self-similar crack propagation without undertaking spurious effects. As a consequence, a R-curve was obtained allowing an adequate characterization of cortical bone fracture under mode I loading.

This study aims to provide an overview of rapid prototyping (RP) and shows the potential of this technology in the field of medicine as reported in various journals and proceedings. This review article also reports three case studies from open literature where RP and associated technology have been successfully implemented in the medical field.

Key publications from the past two decades have been reviewed.

This study concludes that use of RP-built medical model facilitates the three-dimensional visualization of anatomical part, improves the quality of preoperative planning and assists in the selection of optimal surgical approach and prosthetic implants. Additionally, this technology makes the previously manual operations much faster, accurate and cheaper. The outcome based on literature review and three case studies strongly suggests that RP technology might become part of a standard protocol in the medical sector in the near future.

The article is beneficial to study the influence of RP and associated technology in the field of medicine.

The purpose of this paper is to compare fracture‐fixation and bone‐healing promotion efficacies of an intramedullary (IM) nail‐type and an external osteosynthesis plate‐type femoral trochanteric‐fracture implants using the results of a combined multi‐body dynamics and finite element analyses. For both implants, fracture fixation was obtained using a dynamic hip blade which is anchored to the femur head on one end and is connected to the IM rod/plate on the other. The analysis was carried out for two pre‐fracture conditions of the femur: healthy and osteoporotic.

The musculoskeletal dynamics portion of the analysis was used to obtain realistic physiological loading conditions (i.e. muscle forces and joint reaction forces and moments) associated with four typical everyday activities of a patient, namely, walking, lunging, cycling and egress (i.e. exiting a passenger vehicle). The subsequent structural finite element analysis of the fractured femur/implant assembly was employed to quantify fracture‐fixation efficacy (as measured by the extents of lateral (found to be minor), flexural and torsional displacements of the two femur fragments) and the bone‐healing promotion efficacy (as quantified by the fraction of the fractured surface area which experienced desirable contact pressures).

The results obtained show that, in general, the IM‐rod type of implant out‐performs the osteosynthesis plate type of implant over a large range of scenarios involving relative importance of the bone‐healing promotion and fracture‐fixation efficacies, health condition of the femur and the activity level of the patient. More specifically, the more active the patient and the larger extent of osteoporosis in the femur, the more justifiable is the use of the IM‐rod type of implant.

The present approach enables assessment of the fracture‐fixation performance of orthopedic implants under physiologically realistic loading conditions.

Traditional standard bone substitutes cannot realize the individualized matching for the bones of different patients. In order to make a bone substitute match the shape of a patient's bone easily, a technology based on reverse engineering (RE) and rapid prototyping (RP) is put forward to design and fabricate a customized bone substitute. By RE, the customized bone substitute is designed according to the CT sectional pictures, and the customized localizer is designed to locate the customized bone substitute in the patient's body at the right position. A customized mandible substitute designed and fabricated by RE and RP has been put into clinical use and is discussed in detail. The results confirm that the advantage of RP in the field of bone restoration is that it can fabricate the customized bone substitute rapidly and accurately.

This study aims to propose a visualized model of hot technology evolution to describe its development.

The basic concept is to divide a technological field into a timeline consisting of several patent clusters. Hot technology trajectories are then explored using their continuity, as well as the point in time at which they occur.

Patents in orthopaedics between 1999 and 2014 have been chosen as the research subjects and the field is divided into several hot technology trajectories. A further step is taken by interpreting high-frequency key terms. Three categories – spine-related materials, bone repairing materials and bone plates – have been identified.

The trajectories presented by evolving diagrams allow readers to understand the evolution of hot technology and help analysts to plan layout and strategies to remain competitive.

Patent clusters reflect the knowledge context of technology development. Previous studies have focused on only new technology evolution and have rarely explored the knowledge context of hot patents that have been frequently cited in recent years. Such patents often guide the development of technology.