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Being an interdisciplinary research area, biomechanics has gained interest among researchers. Biomechanics deals with integration of mechanical phenomenon with the structural and functional aspects of biological systems. Biological systems being very much complex provide a very intricate platform for their analysis. In case of damages created by accidents or sport malfunctions, artificial implants are used for the replacement of bones. These implants may cause incompatibility with the human body, depending on their design and characterization. So, this research aims to analyze the vibrational characteristics of a human femur bone and to predict the safe ranges of frequencies of operation.

The current research is aimed at vibrational characterization of a human femur bone. The model of the femur bone is prepared using SOLIDWORKS software. The material properties of the femur are collected from the available literature and provided with the CAD model. The model is imported to the ANSYS software. Loading patterns as applied on the human body are also applied to the prepared model. Suitable boundary conditions are chosen for normal sitting and standing positions. The natural frequencies of the femur bone and other vibrational parameters are found out.

The first data obtained from the ANSYS software are the natural frequencies and mode shapes of vibration. Other data include the stress distributions, strain distributions, deformation patterns and potential zones of damage. The frequencies and mode shapes enable the safe ranges of human operation and the frequency range to be followed in the designing of implants. The stress distributions enable to know the potential zones of damage so that those areas can be given focus during strength considerations.

The current investigations take into account only normal sitting and walking conditions. This work can be included under static loadings. This can also be extended toward dynamic loading conditions. In the dynamic loading, walking and running conditions can be taken into account. This work focuses on the safe designing of the artificial implants and their compatibility with the human body. This can also be extended toward role of dynamic forces in the damaged bone formation and the role of implant’s characteristics for healing of bones.

Bone damage and ligament fracture are common nowadays due to increasing number of accidents, which may be vehicular or sports. In case of any damage to the skeletal parts, some artificial implant is used to support the damaged part and to help in the process of healing. The designing of the implants must be compatible with the human body. The natural frequencies and mode shapes give an idea that the vibrational parameters of the implant material must fall in the same range as the actual bone. The stress distribution and potential zone damage emphasize on strength considerations.

The current method is a novel approach toward implant designing. Here an analysis of vibrational parameters of the human femur bone is performed. Those parameters include natural frequencies, mode shapes, principal normal stress distributions, principal shear stress distributions, maximum shear elastic strains and total deformation. These parameters reflect an idea about behavior of the femur bone under actual loading conditions. This analysis enables an implant designer to focus on material properties and strength considerations of the implants which are to be used in case of bone damage.

Traditional standard bone substitutes cannot realize the individualized matching for the bones of different patients. In order to make a bone substitute match the shape of a patient's bone easily, a technology based on reverse engineering (RE) and rapid prototyping (RP) is put forward to design and fabricate a customized bone substitute. By RE, the customized bone substitute is designed according to the CT sectional pictures, and the customized localizer is designed to locate the customized bone substitute in the patient's body at the right position. A customized mandible substitute designed and fabricated by RE and RP has been put into clinical use and is discussed in detail. The results confirm that the advantage of RP in the field of bone restoration is that it can fabricate the customized bone substitute rapidly and accurately.

The purpose of this paper is to present a new method for representing heterogeneous materials using nested STL shells, based, in particular, on the density distributions of human bones.

Nested STL shells, called Matryoshka models, are described, based on their namesake Russian nesting dolls. In this approach, polygonal models, such as STL shells, are “stacked” inside one another to represent different material regions. The Matryoshka model addresses the challenge of representing different densities and different types of bone when reverse engineering from medical images. The Matryoshka model is generated via an iterative process of thresholding the Hounsfield Unit (HU) data using computed tomography (CT), thereby delineating regions of progressively increasing bone density. These nested shells can represent regions starting with the medullary (bone marrow) canal, up through and including the outer surface of the bone.

The Matryoshka approach introduced can be used to generate accurate models of heterogeneous materials in an automated fashion, avoiding the challenge of hand-creating an assembly model for input to multi-material additive or subtractive manufacturing.

This paper presents a new method for describing heterogeneous materials: in this case, the density distribution in a human bone. The authors show how the Matryoshka model can be used to plan harvesting locations for creating custom rapid allograft bone implants from donor bone. An implementation of a proposed harvesting method is demonstrated, followed by a case study using subtractive rapid prototyping to harvest a bone implant from a human tibia surrogate.

The purpose of this paper is twofold. First, to investigate the documentality of human remains in museum and research collections. Second, to provide a rationale for a processual model of documentation, which can account for their repatriation and eventual burial.

This paper uses a multidisciplinary approach to examine the repatriation issue. It considers an ethical argument developed to support claims for repatriation: the nominal identification of a body as a universal criterion for its burial. Based on Igor Kopytoff’s processual model of commoditisation, it looks to cultural anthropology to help explain how objects can move between a document and non-document state.

Human remains can be understood as examples of information-as-thing. However, while document theory can readily account for the expanding realm of documentation, it cannot adequately accommodate instances where documentality is revoked, and when something ceases to be a document. When a human biological specimen is returned, the process that made it serve as a document is effectively reversed. When remains are interred, they revert to their primary standing, as people. The process of becoming a document is therefore not unidirectional, and document status not permanent.

The implications of a processual model of documentation are discussed. Such a model must be able to account for things as they move into and out of the document state, and where the characteristics of documentality change through time.

This paper explores problematic material not usually discussed in relation to document theory. The repatriation movement poses a challenge to a discourse predicated on documentation as a progressively expanding field.

Ti6Al4V alloy has received a great deal of attention in medical applications due to its biomechanical compatibility. However, the human bone stiffness is between 10 and 30 GPa while solid Ti6Al4V is several times stiffer, which would cause stress shielding with the surrounding bone, which can lead to implant and/or the surrounding bone’s failure.

In this work, the effect of selective laser melting (SLM) process parameters on the characteristics of Ti6Al4V samples, such as porosity level, surface roughness, elastic modulus and compressive strength (UCS), has been investigated using response surface method. The examined ranges of process parameters were 35-50 W for laser power, 100-400 mm/s for scan speed and 35-120 µm for hatch spacing. The process parameters have been optimized to obtain structures with properties very close to that in human bones.

The results showed that the porosity percentage of a SLM component could be increased by reducing the laser power and/or increasing the scan speed and hatch spacing. It was also shown that there was a reverse relationship between the porosity level and both the modulus of elasticity and UCS of the SLM part. In addition, the increased laser power was resulted into a substantial decrease of the surface roughness of SLM parts. Results from the optimization study revealed that the interaction between laser process parameters (i.e. laser power, laser speed, and the laser spacing) have the most significant influence on the mechanical properties of fabricated samples. The optimized values for the manufacturing of medical implants were 49 W, 400 mm/s and 99 µm for the laser power, laser speed and laser spacing, respectively. The corresponding porosity, surface roughness, modulus of elasticity and UCS were 23.62 per cent, 8.68 µm, 30 GPa and 522 MPa, respectively.

Previous investigations related to additive manufacturing of Ti alloys have focused on producing fully dense and high-integrity structures. There is a clear gap in literature regarding the simultaneous enhancement and adjustment of pore fraction, surface and mechanical properties of Ti6Al4V SLM components toward biomedical implants. This was the objective of the current study.

Bisphosphonate (BP) medications can be applied to prohibit the damage of bone density and the remedy of bone illnesses such as osteoporosis. As the metal chelating of phosphonate groups are nearby large with six O atoms possessing the high negative charge, these compounds are active toward producing the chelated complexes through drug design method. BP agents have attracted much attention for the clinical treatment of some skeletal diseases depicted by enhancing of osteoclast-mediated bone resorption.

In this work, it has been accomplished the CAM-B3LYP/6–311+G(d, p)/LANL2DZ to estimate the susceptibility of SWCNT for adsorbing alendronate, ibandronate, neridronate and pamidronate chelated to two metal cations of 2Mg²⁺, 2Ca²⁺, 2Sr²⁺ through nuclear magnetic resonance and thermodynamic parameters. Therefore, the data has explained that the feasibility of using SWCNT and BP agents becomes the norm in metal chelating of drug delivery system which has been selected through alendronate → 2X, ibandronate → 2X, neridronate → 2X and pamidronate → 2X (X = Mg²⁺/Ca²⁺/Sr²⁺) complexes.

The thermodynamic results have exhibited that the substitution of 2Ca²⁺ cation by 2Sr²⁺ cation in the structure of bioactive glasses can be efficient for treating vertebral complex fractures. However, it has been observed the most fluctuation in the Gibbs free energy for BPs → 2Sr²⁺ at 300 K. Furthermore, Monte Carlo simulation has resulted by increasing the dielectric constant in the aqueous medium can enhance the stability and efficiency of BP drugs for preventing the loss of bone density and treating the osteoporosis.

According to this research, by incorporation of chelated 2Mg²⁺, 2Ca²⁺ and 2Sr²⁺ cations to BP drugs adsorbed onto (5, 5) armchair SWCNT, the network compaction would increase owing to the larger atomic radius of Sr²⁺ cation rather than Ca²⁺ and Mg²⁺, respectively.

Scaffolds are essentially required to have open porous structure for facilitating bone to grow. They are generally placed on those bone defective/fractured sites which are more prone to compressive loading. Open porous structure lacks in strength in comparison to solid. Selective laser sintering (SLS) process is prominently used for fabrication of polymer/composite scaffolds. So, this paper aims to study for fabrication of three-dimensional open porous scaffolds with enhanced strength, process parameters of SLS of a biocompatible material are required to be optimized.

Regular open porous structures with suitable pore size as per computer-aided design models were fabricated using SLS. Polyamide (PA-2200) was used to fabricate the specimen/scaffold. To optimize the strength of the designed structure, response surface methodology was used to design the experiments. Specimens as per ASTM D695 were fabricated using SLS and compressive testing was carried out. Analysis of variance was done for estimating contribution of individual process parameters. Optimized process parameters were obtained using a trust region algorithm and correlated with experimental results. Accuracy of the fabricated specimen/scaffold was also assessed in terms of IT grades. In vitro cell culture on the fabricated structures confirmed the biocompatibility of polyamide (PA-2200).

Optimized process parameters for open cell process structures were obtained and confirmed experimentally. Laser power, hatch spacing and layer thickness have contributed more in the porous part’s strength than scan speed. The accuracy of the order of IT16 has been found for all functional dimensions. Cell growth and proliferation confirmed biocompatibility of polyamide (PA-2200) for scaffold applications.

This paper demonstrates the biocompatibility of PA-2200 for scaffold applications. The optimized process parameters of SLS process for open cell structure having pore size 1.2 × 1.2 mm² with strut diameter of 1 mm have been obtained. The accuracy of the order of IT16 was obtained at the optimized process factors.

The main objective of this paper is to illustrate an analytical view of different methods of 3D bioprinting, variations, formulations and characteristics of biomaterials. This review also aims to discover all the areas of applications and scopes of further improvement of 3D bioprinters in this era of the Fourth Industrial Revolution.

This paper reviewed a number of papers that carried evaluations of different 3D bioprinting methods with different biomaterials, using different pumps to print 3D scaffolds, living cells, tissue and organs. All the papers and articles are collected from different journals and conference papers from 2014 to 2022.

This paper briefly explains how the concept of a 3D bioprinter was developed from a 3D printer and how it affects the biomedical field and helps to recover the lack of organ donors. It also gives a clear explanation of three basic processes and different strategies of these processes and the criteria of biomaterial selection. This paper gives insights into how 3D bioprinters can be assisted with machine learning to increase their scope of application.

The chosen research approach may limit the generalizability of the research findings. As a result, researchers are encouraged to test the proposed hypotheses further.

This paper includes implications for developing 3D bioprinters, developing biomaterials and increasing the printability of 3D bioprinters.

This paper addresses an identified need by investigating how to enable 3D bioprinting performance.

The purpose of this research, is to develop a nano composite deposition system (NCDS) to fabricate three dimensional functional nano composite parts.

The NCDS is a hybrid system in which material removal process by mechanical micro machining and/or the deposition process is combined.

Hybrid RP technology showed higher precision than those made by casting or deposition process. Tensile strength of the hydroxyapatite‐acrylic composite was about four times higher than that of resin‐only specimen while MWCNT composite did not show much improvement.

The paper illustrates new approaches for rapid prototyping techniques with various materials and high precision.