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This study aims to report the phytochemical screening and anti-diarrhoea properties of methanol extract of Diodia sarmentosa Swartz (DSS) leave (at 200, 400 and 600 mg/kg) in albino rats.

Three types of diarrhoea models (castor oil-induced diarrhoea, castor oil-induced gastrointestinal motility and castor oil-induced enteropooling), as well as an assay for serum and faecal electrolyte concentrations, were used. Acute toxicity study and phytochemical screening of the extract were carried out using standard techniques.

The percentage inhibition of diarrhoea by DSS 200, 400 and 600 mg/kg was obtained as 25.7%, 55% and 84.6%, respectively, compared with loperamide that had 87.6% inhibition. DSS dose dependently modulated the number and frequency of defecation, the weight of the faeces of the diarrhoea rats, the distance that was travelled by charcoal meal, mean differences in the full lengths of the intestines and the distance travelled by charcoal meal, weight and volume of intestinal contents, serum and faecal concentrations of potassium, sodium, chloride, magnesium, bicarbonate, iron and zinc relative to the negative control and in a manner akin to loperamide (for the extract at 600 mg/kg). DSS or loperamide attenuated the loss of calcium in the faeces of the rats. DSS possesses anti-diarrhoea properties, which may be attributed to the phytochemicals in it. Finally, the study showed the safety in the usage of DSS.

DSS exerted its anti-diarrhoea action in castor oil-induced diarrhoea rats, by modulating their intestinal secretory and motile activity in a manner akin to loperamide (for DSS at 600 mg/kg).

In 1988 there were in England and Wales 28,714 laboratory‐diagnosed cases of campylobacter enteritis (diarrhoea), 24,123 cases of salmonella diarrhoea and 291 cases of listeria infection. Actual numbers of cases of food‐borne infection are not known, as many cases are not recorded and not laboratory‐confirmed, either because people do not consult their doctor because symptoms are very mild, or because the doctor does not send specimens to the laboratory.

Excessive drinking of fluids occurs across the autism spectrum but despite the detrimental and potentially hazardous consequences very few studies of this phenomenon have been published. Literature on the topic is sparse. The purpose of this paper is to explore the issues via a large on-line survey and a clinic sample. It is hoped this study will encourage further interest in and investigation including exploration of the links with the neurology underlying autistic conditions.

Results were obtained via a large on-line survey of autistic individuals and parents and carers (n=637) and data from referrals to a single diagnostic assessment and diagnostic clinic.

Of 634 respondents of the on-line survey 474 reported excessive drinking of fluids in severe form. Almost two-thirds stated that this started before the age of five years. Of the children and adults seen at the clinic approximately one-third had dunk fluids excessively in the past. The effects of gender, type of autism condition, intellectual disability, reported stress and associated conditions were examined as were the type of fluids drunk and rate of drinking. The response to having to wait for a drink and the occurrence of vomiting and diarrhoea were also examined.

This is a preliminary study but with a large sample size. Limitations lie in the sparse amount of literature on this topic as it affects autism and reliance on parental and self-reports from an on-line survey, the majority of whom responded to an appeal for participants for whom excessive drinking of fluids was an established problem. The clinic sample comprised children and adults who had not been referred for reasons connected to excessive drinking of fluids but for whom this was still a significant problem. A further limitation concerns the absence of data on sensory profiles. This would be worth including in any follow up.

It is important to be aware of the implications of excessive drinking of fluids on the health and well-being of children and adults on the autism spectrum. As there are potentially lethal consequences associated with such behaviours it is essential that they are recognised, understood and responded to.

Excessive drinking of fluids has implications for the development of the child and far reaching consequences for physical and social well-being.

This is an original paper that draws on the limited literature available but is primarily based on the results of a unique on-line survey and evaluation of a clinic sample.

This chapter studies the link between urban planning and health. Access to safe drinking water is already a very serious issue for large urban populations in fast-growing economies such as India. Water availability is further being impacted by climate change, leading to the drastically increased spread of water-related diseases.

Leh Town, which is located in an ecologically vulnerable semi-arid region of the Himalayas in Ladakh, has been considered for this study because it is undergoing large-scale transformation due to rapid growth in its tourism industry. In 2012–2013 our interdisciplinary group comprising researchers from Germany and India conducted field surveys, including geographic information system-based (GIS) mapping of point sources of water pollution, questionnaire surveys of 200 households and 70 hotels and guesthouses and semi-structured interviews. We also reviewed secondary medical data.

We found that diarrhoeal incidence has increased in the local population in Leh in the past decade, which may be linked to water pollution: Further, we found that rapidly increasing water consumption coupled with a lack of adequate water and sanitation infrastructure is causing serious water pollution.

Further, data is needed for causal connections between water pollution and health impacts to be conclusively drawn.

This study discusses the use of GIS to support a call for the need for more integrated urban planning and decision-making that holistically addresses water and health challenges in Leh and advocates the development of a decentralized or hybrid sanitation system to support water resources conservation as a central dimension of an integrated health management approach.

GIS is also a very useful platform for supporting participatory urban planning in Leh.

With such an integrated urban planning approach, Leh would be a lighthouse example for other towns in the region.

Increased evidence for the health benefits of probiotics for health restoration coupled with the consumer's inclination towards a safe, natural and cost-effective substitute for drugs have led application of probiotics as a pharmaceutical agent and are rapidly moving in clinical usage. In this context, this article attempts to highlight the potential of probiotics as a pharmaceutical agent.

Endeavor has been made to explore the significance of probiotics for the modulation of gut ecology and their action. Potentiality of probiotics for their exploitation as a pharmaceutical agent has also been justified. Limitations of probiotic therapy and the various considerations for probiotic therapy have also been delineated.

Probiotic organisms influence the physiological and pathological process of the host by modifying the intestinal microbiota, thereby affecting human health. Beneficial effects of probiotics as a pharmaceutical agent seem to be strain and dose dependent and more efficacious with their early introduction. Combination of various probiotics proved to be more efficacious than single strain for exhibiting prophylactic activities.

Reviewed literature indicated that it is difficult to generalize for the beneficial effect of all probiotics for all types of diseases as efficacy of probiotics is strain-dependent and dose-dependent and its clinical application needs long-term investigations.

Clinical trials have displayed that probiotics may alleviate certain disorders or diseases in humans especially those related to gastro-intestinal tract.

Ingestion of fermented dairy products containing probiotic cultures may provide health benefits in certain clinical conditions such as antibiotic-associated diarrhoea, rotavirus-associated diarrhoea, inflammatory bowel disease, inflammatory bowel syndrome, allergenic diseases, cancer, Helicobacter pylori infection and lactose-intolerance. Application of probiotics as a pharmaceutical agent is recommended.

Severe bacterial infection is a major cause of neonatal morbidity and mortality worldwide. Geographical-based demographic laboratory and clinical data are required to get a conclusion about the bacterial infection and their antibiotic susceptibility for the empiric antibiotic treatment in infants who presented with suspected infection. This study was aimed to find the most prevalent bacterial infection and antibiotic sensitivity among infants in the post-neonatal period presented at a tertiary care centre in South India.

A cross-sectional study was designed among infants (29 days to 1 year old) presented with suspected infection in the paediatric department. Infants with positive culture report were analysed for the bacteriological and antibiotic profile from the medical records. Antibiotic sensitivity was determined for the isolated bacteria according to standard procedure and data statically analysed.

Total of 218 samples (138 male and 80 female) were analysed. Most of the samples (171/218, 78.4%) were throat swab (p = 0.0247). Only one sample was cerebrospinal fluid from case of meningitis. Sample from upper RTI was major (162/218, 74.3%) with male dominance followed by stool samples from cases of diarrhoea (22/218, 10.0%). Staphylococcus aureus was the major organism identified in 46/171 (26.9 %) throat swabs. The most sensitive antibiotic against bacteria isolated from throat swab and CSF was gentamicin and cloxacillin. Netilmicin and piperacillin plus tazobactam were the sensitive antibiotics against bacteria isolated from stool, ear secretion and urine samples.

Upper RTI was the prevalent bacterial infection followed by diarrhoea in infants in the post-neonatal period. Klebsiella pneumoniae was the common organism identified in the overall report followed by E. coli and S. aureus. Community-based awareness should be provided to follow good hygiene regularly in child care. Furthermore, avoid delay in seeking treatment and provide the medicine prescribed at the right time and in the right dose to limit the morbidity and bacterial resistance.

Spaniards do not have a term to define the diarrhoea and vomiting, occurring either singly or in combination, which affects British tourists to Spain. Enfermedad espanola, a generic term, explains nothing, no more than the term “Spanish ‘tummy’” and from the number of reports by returning visitors of sickness, ranging from one‐day vomiting or diarrhoea to a week or more of severe symptoms, often leading to prostration and collapse, varied pathology is indicated; a combination of causes, although how much is due to intestinal pathogens and how much to plain dietary disturbance is not known. What is certain, however, is that the incidence rate is very high; during the height of the summer anything from 80 to 100%.