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The aim of this paper is to identify factors (i.e. age, gender, ethnicity, type of medical facility, geographical location, etc.) associated with physicians' prescribing behavior when treating influenza in the USA. The study aims to examine why the number of antiviral prescriptions remains substandard.

Data were obtained from the National Ambulatory Medical Care Survey for each influenza season between the years of 2005-2008. Bivariate analyses and two models of multivariate logistic regression analyses (one with no fixed effect and the other including year as a fixed effect) were used to analyze the data.

The results from this study revealed that among family practice physicians, 40.5 percent prescribed antiviral medications to patients presenting with influenza while 59.5 percent prescribed another form of medication. Antibiotics comprised 41.3 percent of the prescriptions for treatment of influenza. Multivariable logistic regression analyses revealed that race (White; p=0.023), type of health setting (private solo/group practice; p=0.041), employment status (owner; p=0.046), and metropolitan location (metropolitan statistical area; p=0.032) were all significantly associated with prescribing antivirals. Patients' expected source of payment (private insurance) and geographical location (Midwest) of health facility were marginally associated with prescribing antivirals.

By identifying factors associated with physicians' prescribing practices of antiviral medications, a more timely diagnosis and treatment of influenza can occur. Efforts should be targeted to improve physician education and awareness of the illness. Interventions may be implemented to improve the prescribing of antiviral medications and potentially inappropriate prescribing.

This paper aims to fabricate a polymer-based polyethylene glycol (PEG) coating with acrylic resin as a binder that can show antiviral activity against the feline coronavirus (FCov) on the glass substrate.

The PEG/acrylic coating systems of different weight percentages were coated on the glass substrates using the spray-coating method and cured at room temperature for 24 h.

The coating system containing 20 Wt.% of PEG exhibits the highest antiviral activities as high as 99.9% against FCov compared with other samples.

Findings will be useful in the development of antiviral coating for PPE fabrics by using the simple synthesis method.

Application of PEG as an antiviral agent in the antiviral coating system with high antiviral activities about 99.9%.

The COVID-19 pandemic emphasises the need for antiviral materials that can reduce airborne and surface-based virus transmission. This study aims to propose the use of additive manufacturing (AM) and surrogate modelling for the rapid development and deployment of novel copper-tungsten-silver (Cu-W-Ag) microporous architecture that shows strong antiviral behaviour against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

The research combines selective laser melting (SLM), in-situ alloying and surrogate modelling to conceive the antiviral Cu-W-Ag architecture. The approach is shown to be suitable for redistributed manufacturing by representing the pore morphology through a surrogate model that parametrically manipulates the SLM process parameters: hatch distance (h_d), scan speed (S_s) and laser power (L_p). The method drastically simplifies the three-dimensional (3D) printing of microporous materials by requiring only global geometrical dimensions solving current bottlenecks associated with high computed aided design data transfer required for the AM of porous materials.

The surrogate model developed in this study achieved an optimum parametric combination that resulted in microporous Cu-W-Ag with average pore sizes of 80 µm. Subsequent antiviral evaluation of the optimum architecture showed 100% viral inactivation within 5 h against a biosafe enveloped ribonucleic acid viral model of SARS-CoV-2.

The Cu-W-Ag architecture is suitable for redistributed manufacturing and can help reduce surface contamination of SARS-CoV-2. Nevertheless, further optimisation may improve the virus inactivation time.

The study was extended to demonstrate an open-source 3D printed Cu-W-Ag antiviral mask filter prototype.

The evolving nature of the COVID-19 pandemic brings new and unpredictable challenges where redistributed manufacturing of 3D printed antiviral materials can achieve rapid solutions.

The papers present for the first time a methodology to digitally conceive and print-on-demand a novel Cu-W-Ag alloy that shows high antiviral behaviour against SARS-CoV-2.

The purpose of this study is to consider the dynamics of Casson–Walters-B alongside gyrotactic microorganisms through the investigation of antibacterial and antiviral mechanisms using silver nanoparticles (AgNPs). The Casson fluid and Walters-B flow from the penetrable plate to the boundary layer (BL) in this analysis. The antiviral and antibacterial mechanisms of AgNPs were separately examined in this study.

The physical phenomenon of this problem was analyzed with partial differential equations (PDEs). These PDEs were changed into ordinary differential equations (ODEs) to further explain the significance of pertinent control parameters. The set of equations is solved numerically by implementing the spectral relaxation method (SRM). SRM is a numerical technique that uses the basic techniques of Gauss-Seidel. The SRM first decouples and linearizes the coupled nonlinear set of ODEs.

In this finding, it is found that the thermal radiation parameter produces higher temperatures within the BL to cause blockage in viral replications. It is found in this study that the magnetic parameter assisted in disinfection by lowering the antiviral and antibacterial mechanisms within the momentum BL. This is evident from the reduction in the velocity and momentum BL as the Casson and Walters-B parameters increase.

This paper is unique because it examined the antiviral and antibacterial mechanisms by using AgNPs. Prior to the authors’ understanding, no study of this type was conducted in the past. To the best of the authors’ knowledge, no other study in the past has examined the mechanisms of antiviral and antibacterial separately within the BL. Also, the simultaneous flow of Casson (honey) and Walters-B fluids were considered flowing through the vertical porous plate to the BL.

The purpose of this paper is to provide a comprehensive overview of the current knowledge regarding chronic hepatitis C (CHC) infection, antiviral therapy, depression, and gender.

CHC and its treatment options were reviewed examining their relationship with depression and gender.

CHC is a high prevalent chronic infection worldwide, being similar in men and women. However, the infection shows many gender differences in terms of innate response, genetic variability (i.e. IL-28B), route of transmission (i.e. intravenous drug use), disease progression (i.e. fibrosis), lifetime period (i.e. pregnancy), and risk factors (i.e. HIV). Both the hepatitis C infection and antiviral treatment (especially when using the pro-inflammatory cytokine interferon α), are highly associated with depression, where female gender constitutes a risk factor. It seems that the new direct-acting antiviral combinations produce fewer neuropsychiatric side effects. In fact, the presence of depression at baseline is no longer a limitation for the initiation of antiviral treatment. Antidepressant drugs have been recommended as current depression and prophylactic treatment in risk subgroups. However, caution should be exercised due to the risk of drug-drug interactions with some antiviral drugs. Women should be counselled prenatal, during and after pregnancy, taking into account the clinical situation, and the available evidence of the risks and benefits of antiviral and antidepressant treatments. Multidisciplinary approach shows cost-efficacy results.

The paper clarifies the complex management of CHC therapy and the importance of individualizing treatment. The results also underline the need for an integrated multidisciplinary approach.

This study aims to focus on the preparation and characterization of the silver nanowire (AgNWs), as well as their application as antimicrobial and antivirus activities either with incorporation on the waterborne coating formulation or on their own.

Prepared AgNWs are characterized by different analytical instruments, such as ultraviolet-visible spectroscope, scanning electron microscope and X-ray diffraction spectrometer. All the paint formulation's physical and mechanical qualities were tested using American Society for Testing and Materials, a worldwide standard test procedure. The biological activities of the prepared AgNWs and the waterborne coating based on AgNWs were investigated. And, their effects on pathogenic bacteria, antioxidants, antiviral activity and cytotoxicity were also investigated.

The obtained results of the physical and mechanical characteristics of the paint formulation demonstrated the formulations' greatest performance, as well as giving good scrub resistance and film durability. In the antimicrobial activity, the paint did not have any activity against bacterial pathogen, whereas the AgNWs and AgNWs with paint have similar activity against bacterial pathogen with inhibition zone range from 10 to 14 mm. The development of antioxidant and cytotoxicity activity of the paint incorporated with AgNWs were also observed. The cytopathic effects of herpes simplex virus type 1 (HSV-1) were reduced in all three investigated modes of action when compared to the positive control group (HSV-1-infected cells), suggesting that these compounds have promising antiviral activity against a wide range of viruses, including DNA and RNA viruses.

The new waterborne coating based on nanoparticles has the potential to be promising in the manufacturing and development of paints, allowing them to function to prevent the spread of microbial infection, which is exactly what the world requires at this time.

Repeated influenza outbreaks are surprisingly rare in prison settings worldwide, a factor that has made it superfluous, to date, to develop contingency plans for responding to prison‐based influenza epidemics. However, the influenza outbreak that occurred in an Australian prison in 2000 has highlighted the appropriateness of developing an outbreak plan, not least because of the security implications of a widespread prison influenza epidemic. Using reported attack rates and morbidity profiles of the 2000 Australian prison influenza outbreak to develop scenarios, the authors estimated the cost ‐ benefit of mass vaccination and antiviral chemotherapy approaches for the control of hypothetical widespread influenza outbreaks in New South Wales prisons, occurring at an average frequency of once every 10 years. It was concluded that, from the perspectives of maintaining prison security as well as health care services’ provision to prisoners, early antiviral chemotherapy for symptomatic individuals will have more favourable cost ‐ benefit ratios than a mass vaccination approach for controlling prison‐based influenza outbreaks that occur in line with this model.

Hepatitis C (HCV) infections are prevalent in custodial settings worldwide, yet provision of antiviral therapies is uncommon. Approximately 30,000 prisoners are held in Australian prisons at any one time, with more than 30 per cent testing positive for HCV antibodies. Prisoners have been identified in the National Hepatitis C Strategy as a priority population for assessment and treatment. The purpose of this paper is to examine the rates of HCV testing and treatment, as well as barriers and opportunities for development of infrastructure for enhanced services.

Interviews were conducted with 55 stakeholders from the correctional sector in each state and territory in Australia in two stages: service directors to gather quantitative data regarding rates of testing and treatment; and other stakeholders for qualitative information regarding barriers and opportunities.

Of more than 50,000 individuals put in in custody in Australian prisons in 2013, approximately 8,000 individuals were HCV antibody positive, yet only 313 prisoners received antiviral treatment. The barriers identified to assessment and treatment at the prisoner-level included: fear of side effects and the stigma of being identified to custodial authorities as HCV infected and a likely injecting drug user. Prisoners who came forward may be considered unsuitable for treatment because of prevalent mental health problems and ongoing injecting drug use. Provision of specialist hepatitis nurses and consultants were the most frequently recommended approaches to how prison hepatitis services could be improved.

Many personal and systems-level barriers relevant to the delivery of HCV treatment services in the custodial setting were identified. Ready access to skilled nursing and medical staff as well as direct acting antiviral therapies will allow the prison-sector to make a major contribution to control of the growing burden of HCV disease.

Nanotechnology (NT) advancements in personal protective textiles (PPT) or personal protective equipment (PPE) have alleviated spread and transmission of this highly contagious viral disease, and enabled enhancement of PPE, thereby fortifying antiviral behavior.

Review of a series of state of the art research papers on the subject matter.

This paper expounds on novel nanotechnological advancements in polymeric textile composites, emerging applications and fight against COVID-19 pandemic.

As a panacea to “public droplet prevention,” textiles have proven to be potentially effective as environmental droplet barriers (EDBs).

PPT in form of healthcare materials including surgical face masks (SFMs), gloves, goggles, respirators, gowns, uniforms, scrub-suits and other apparels play critical role in hindering the spreading of COVID-19 and other “oral-respiratory droplet contamination” both within and outside hospitals.

When used as double-layers, textiles display effectiveness as SFMs or surgical-fabrics, which reduces droplet transmission to <10 cm, within circumference of ∼0.3%.

NT advancements in textiles through nanoparticles, and sensor integration within textile materials have enhanced versatile sensory capabilities, robotics, flame retardancy, self-cleaning, electrical conductivity, flexibility and comfort, thereby availing it for health, medical, sporting, advanced engineering, pharmaceuticals, aerospace, military, automobile, food and agricultural applications, and more. Therefore, this paper expounds on recently emerging trends in nanotechnological influence in textiles for engineering and fight against COVID-19 pandemic.