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The purpose of this study is to develop an efficient prediction model using vital signs and standard medical score systems, which predicts the clinical severity level of the patient in advance based on the quick sequential organ failure assessment (qSOFA) medical score method.

To predict the clinical severity level of the patient in advance, the authors have formulated a training dataset that is constructed based on the qSOFA medical score method. Further, along with the multiple vital signs, different standard medical scores and their correlation features are used to build and improve the accuracy of the prediction model. It is made sure that the constructed training set is suitable for the severity level prediction because the formulated dataset has different clusters each corresponding to different severity levels according to qSOFA score.

From the experimental result, it is found that the inclusion of the standard medical scores and their correlation along with multiple vital signs improves the accuracy of the clinical severity level prediction model. In addition, the authors showed that the training dataset formulated from the temporal data (which includes vital signs and medical scores) based on the qSOFA medical scoring system has the clusters which correspond to each severity level in qSOFA score. Finally, it is found that RAndom k-labELsets multi-label classification performs better prediction of severity level compared to neural network-based multi-label classification.

This paper helps in identifying patient' clinical status.

The healthcare sector in India is witnessing phenomenal growth, such that by the year 2022, it will be a market worth trillions of INR. Increase in income levels, awareness regarding personal health, the occurrence of lifestyle diseases, better insurance policies, low-cost healthcare services, and the emergence of newer technologies like telemedicine are driving this sector to new heights. Abundant quantities of healthcare data are being accumulated each day, which is difficult to analyze using traditional statistical and analytical tools, calling for the application of Big Data Analytics in the healthcare sector. Through provision of evidence-based decision-making and actions across healthcare networks, Big Data Analytics equips the sector with the ability to analyze a wide variety of data. Big Data Analytics includes both predictive and descriptive analytics. At present, about half of the healthcare organizations have adopted an analytical approach to decision-making, while a quarter of these firms are experienced in its application. This implies the lack of understanding prevalent in healthcare sector toward the value and the managerial, economic, and strategic impact of Big Data Analytics. In this context, this chapter on “Predictive Analytics in Healthcare” discusses sources, areas of application, possible future areas, advantages and limitations of the application of predictive Big Data Analytics in healthcare.

This study aims to analyze a conspicuous corpus of literature related to the field of technology-based intensive care research and to develop an architecture model of the future smart intensive care unit (ICU).

Papers related to the topics of electronic health record (EHR), big data, data flow and clinical decision support in ICUs were investigated. These concepts have been analyzed in combination with secondary use of data, prediction models, data standardization and interoperability challenges. Based on the findings, an architecture model evaluated using MIMIC III is proposed.

Research identified issues regarding implementation of systems, data sources, interoperability, management of big data and free text produced in ICUs and lack of accuracy of prediction models. ICU should be treated as part of a greater system, able to intercommunicate with other entities.

The research examines the current needs of ICUs in interoperability and data management. As environment changes dynamically, continuous assessment and evaluation of the model with other ICU databases is required.

The proposed model improves ICUs interoperability in national health system, ICU staff intercommunication, remote access and decision support. Its modular approach ensures that ICUs can have their own particularities and specialisms while ICU functions provide ongoing expertise and training to upgrade its staff.

The purpose of this paper is to develop evident-based predictive no-show models considering patients’ each past appointment status, a time-dependent component, as an independent predictor to improve predictability.

A ten-year retrospective data set was extracted from a pediatric clinic. It consisted of 7,291 distinct patients who had at least two visits along with their appointment characteristics, patient demographics, and insurance information. Logistic regression was adopted to develop no-show models using two-thirds of the data for training and the remaining data for validation. The no-show threshold was then determined based on minimizing the misclassification of show/no-show assignments. There were a total of 26 predictive model developed based on the number of available past appointments. Simulation was employed to test the effective of each model on costs of patient wait time, physician idle time, and overtime.

The results demonstrated the misclassification rate and the area under the curve of the receiver operating characteristic gradually improved as more appointment history was included until around the 20th predictive model. The overbooking method with no-show predictive models suggested incorporating up to the 16th model and outperformed other overbooking methods by as much as 9.4 per cent in the cost per patient while allowing two additional patients in a clinic day.

The challenge now is to actually implement the no-show predictive model systematically to further demonstrate its robustness and simplicity in various scheduling systems.

This paper provides examples of how to build the no-show predictive models with time-dependent components to improve the overbooking policy. Accurately identifying scheduled patients’ show/no-show status allows clinics to proactively schedule patients to reduce the negative impact of patient no-shows.

The incidence of prostate cancer is increasing from the past few decades. Various studies have tried to determine the survival of patients, but metastatic prostate cancer is still not extensively explored. The survival rate of metastatic prostate cancer is very less compared to the earlier stages. The study aims to investigate the survivability of metastatic prostate cancer based on the age group to which a patient belongs, and the difference between the significance of the attributes for different age groups.

Data of metastatic prostate cancer patients was collected from a cancer hospital in India. Two predictive models were built for the analysis-one for the complete dataset, and the other for separate age groups. Machine learning was applied to both the models and their accuracies were compared for the analysis. Also, information gain for each model has been evaluated to determine the significant predictors for each age group.

The ensemble approach gave the best results of 81.4% for the complete dataset, and thus was used for the age-specific models. The results concluded that the age-specific model had the direct average accuracy of 83.74% and weighted average accuracy of 79.9%, with the highest accuracy levels for age less than 60.

The study developed a model that predicts the survival of metastatic prostate cancer based on age. The study will be able to assist the clinicians in determining the best course of treatment for each patient based on ECOG, age and comorbidities.

Existing descriptions of trust in health care largely assume a straightforward association between a patient’s relationship with a regular provider and his or her trust in health care. I extend status characteristics theory (SCT) and social identity theory (SIT) to suggest greater variability in this association by investigating the role of social differences between patients and their regular providers. Whereas the SIT extension predicts lower trust in dissimilar than similar dyads, the predictions from the SCT extension depend on status in dissimilar dyads. Further, research examining how social differences in patient–provider dyads shape trust largely emphasizes racial differences, but the theories implicate gender differences too.

I analyze a longitudinal dataset of patient–provider dyads offering a conservative test of the extensions.

Results generally support predictions from the SCT extension. Specifically, patients’ status based on differences in either race or gender: (1) is inversely related to their trust in health care and (2) influences the resiliency of their trust, whereby the degree health care met prior expectations matters less (more) for the trust of low (high) status patients than equal status patients.

When patients and providers differ on both race and gender, findings sometimes depart from predictions. This indicates differences in two social categories is a unique situation where the contributions of each category are distinct from that of the other.

This research extends SCT to explain greater variability in the connection between patient–provider dyads and trust in health care, while also showing how gender compares to race.

The purpose of this paper is to formulate a framework to construct a patient-specific risk score and therefore to classify these patients into various risk groups that can be used as a decision support mechanism by the medical decision makers to augment their decision-making process, allowing them to optimally use the limited resources available.

A conventional statistical model (logistic regression) and two machine learning-based (i.e. artificial neural networks (ANNs) and support vector machines) data mining models were employed by also using five-fold cross-validation in the classification phase. In order to overcome the data imbalance problem, random undersampling technique was utilized. After constructing the patient-specific risk score, k-means clustering algorithm was employed to group these patients into risk groups.

Results showed that the ANN model achieved the best results with an area under the curve score of 0.867, while the sensitivity and specificity were 0.715 and 0.892, respectively. Also, the construction of patient-specific risk scores offer useful insights to the medical experts, by helping them find a trade-off between risks, costs and resources.

The study contributes to the existing body of knowledge by constructing a framework that can be utilized to determine the risk level of the targeted patient, by employing data mining-based predictive approach.

Patient treatment trajectory data are used to predict the outcome of the treatment to particular disease that has been carried out in the research. In order to determine the evolving disease on the patient and changes in the health due to treatment has not considered existing methodologies. Hence deep learning models to trajectory data mining can be employed to identify disease prediction with high accuracy and less computation cost.

Multifocus deep neural network classifiers has been utilized to detect the novel disease class and comorbidity class to the changes in the genome pattern of the patient trajectory data can be identified on the layers of the architecture. Classifier is employed to learn extracted feature set with activation and weight function and then merged on many aspects to classify the undetermined sequence of diseases as a new variant. The performance of disease progression learning progress utilizes the precision of the constituent classifiers, which usually has larger generalization benefits than those optimized classifiers.

Deep learning architecture uses weight function, bias function on input layers and max pooling. Outcome of the input layer has applied to hidden layer to generate the multifocus characteristics of the disease, and multifocus characterized disease is processed in activation function using ReLu function along hyper parameter tuning which produces the effective outcome in the output layer of a fully connected network. Experimental results have proved using cross validation that proposed model outperforms methodologies in terms of computation time and accuracy.

Proposed evolving classifier represented as a robust architecture on using objective function to map the data sequence into a class distribution of the evolving disease class to the patient trajectory. Then, the generative output layer of the proposed model produces the progression outcome of the disease of the particular patient trajectory. The model tries to produce the accurate prognosis outcomes by employing data conditional probability function. The originality of the work defines 70% and comparisons of the previous methods the method of values are accurate and increased analysis of the predictions.

As far as the treatment of most complex issues in the design is concerned, approaches based on classical artificial intelligence are inferior compared to the ones based on computational intelligence, particularly this involves dealing with vagueness, multi-objectivity and good amount of possible solutions. In practical applications, computational techniques have given best results and the research in this field is continuously growing. The purpose of this paper is to search for a general and effective intelligent tool for prediction of patient survival after surgery. The present study involves the construction of such intelligent computational models using different configurations, including data partitioning techniques that have been experimentally evaluated by applying them over realistic medical data set for the prediction of survival in pancreatic cancer patients.

On the basis of the experiments and research performed over the data belonging to various fields using different intelligent tools, the authors infer that combining or integrating the qualification aspects of fuzzy inference system and quantification aspects of artificial neural network can prove an efficient and better model for prediction. The authors have constructed three soft computing-based adaptive neuro-fuzzy inference system (ANFIS) models with different configurations and data partitioning techniques with an aim to search capable predictive tools that could deal with nonlinear and complex data. After evaluating the models over three shuffles of data (training set, test set and full set), the performances were compared in order to find the best design for prediction of patient survival after surgery. The construction and implementation of models have been performed using MATLAB simulator.

On applying the hybrid intelligent neuro-fuzzy models with different configurations, the authors were able to find its advantage in predicting the survival of patients with pancreatic cancer. Experimental results and comparison between the constructed models conclude that ANFIS with Fuzzy C-means (FCM) partitioning model provides better accuracy in predicting the class with lowest mean square error (MSE) value. Apart from MSE value, other evaluation measure values for FCM partitioning prove to be better than the rest of the models. Therefore, the results demonstrate that the model can be applied to other biomedicine and engineering fields dealing with different complex issues related to imprecision and uncertainty.

The originality of paper includes framework showing two-way flow for fuzzy system construction which is further used by the authors in designing the three simulation models with different configurations, including the partitioning methods for prediction of patient survival after surgery. Several experiments were carried out using different shuffles of data to validate the parameters of the model. The performances of the models were compared using various evaluation measures such as MSE.

This paper develops a robust hospital readmission prediction framework by combining the feature selection algorithm and machine learning (ML) classifiers. The improved feature selection is proposed by considering the uncertainty in patient's attributes that leads to the output variable.

First, data preprocessing is conducted which includes how raw data is managed. Second, the impactful features are selected through feature selection process. It started with calculating the relational grade of each patient towards readmission using grey relational analysis (GRA) and the grade is used as the target values for feature selection. Then, the influenced features are selected using the Least Absolute Shrinkage and Selection Operator (LASSO) method. This proposed method is termed as Grey-LASSO feature selection. The final task is the readmission prediction using ML classifiers.

The proposed method offered good performances with a minimum feature subset up to 54–65% discarded features. Multi-Layer Perceptron with Grey-LASSO gave the best performance.

The performance of Grey-LASSO is justified in two readmission datasets. Further research is required to examine the generalisability to other datasets.

In designing the feature selection algorithm, the selection on influenced input variables was based on the integration of GRA and LASSO. Specifically, GRA is a part of the grey system theory, which was employed to analyse the relation between systems under uncertain conditions. The LASSO approach was adopted due to its ability for sparse data representation.