Search results

This study aims to assess the effect of both apigenin-loaded zinc oxide nanoparticles (ZnONPs) and apigenin only against cisplatin (CP)-induced experimental cardiotoxicity.

A total of 32Wister rats (male) were randomly divided (n = 8) into four groups. Normal control group, CP group received CP (20 mg/kg); treated group I received CP and then received apigenin (0.78 mg/kg/day) orally; treated group II received CP and then received apigenin loaded ZnONPs. At the end of the experiment (10 days), samples were extracted from each rat for the assessment of complete blood picture, lipid profile, atherogenic indices, oxidative status, inflammatory and cardiotoxicity markers as well as histological examination.

The results indicated that CP produced significant alterations in the complete blood picture, lipidemic profile, atherogenic indices, antioxidation capacity and cardiac inflammatory markers as well as function enzymes as compared with the control group. Administration of apigenin only showed a non-significant change in the atherogenic indices, oxidative status and cardiotoxicity parameters, indicating incomplete cardio-protection against CP upon. Additionally, all the observed alterations in CP group were reversed when apigenin nanoparticle at lower dose was used with ZnONPs which was also confirmed by histopathological investigation.

The apigenin loaded ZnONPs exert protective effects against CP-induced experimental cardiotoxicity and improved cardiac function, suggesting a potential adjuvant role of apigenin nanoparticles against cardiotoxicity.

This study examines and estimates the relationship among identified factors or determinants for the adoption of water ionizers by customers.

To this end, the questionnaire is prepared to have the preferences of customers based on the factors or enablers identified for the analysis of customers' perceptions toward the adoption of water ionizers. Recipients are identified to collect their preferences for the factors responsible for the adoption. The convenience sampling method is used in administering the questionnaire for the study. The structural equation modeling (SEM) technique is used to construct the model for defining the relationship between measured and latent variables using the lavaan, haven, psych and semPlot libraries in R software.

The study reveals that product features, which include pH value, oxidation-reduction potential (ORP) and micro-clustering (MC), are influenced by environmental sustainability (ES), and as a result, product features and product outcomes (brand value (BV), customer recommendation (CR) and perceived usefulness (PU)) together influence the adoption of water ionizers by customers.

Water ionizers have appeared as consumer electronic appliances designed to alter the pH and ORP of water through an electrolysis process. There are proven benefits to improved water quality across different pHs for its health benefits (HB) and other commercial and household uses. The study recommends that potential HB perceived through water ionizers and product features, which are supported by ES, and helps customers decide on the adoption of water ionizers.

The study supports comprehending the relationships between consumer behavior, sustainable practices and innovative technologies like water ionizers as society places a greater emphasis on environmentally conscious living and sustainable living. This study aims to clarify the elements affecting the adoption and perception of water ionizers from a sustainability perspective through an extensive assessment of the literature and empirical analysis.

This study aimed to evaluate the compositional changes and bioaccessibility of phenolics and antioxidants in propolis during in vitro digestion as well as the cytotoxic effects of digested propolis on various cancer cell lines.

Six propolis samples were obtained and subjected to in vitro oral, gastric and intestinal digestion. Both digested and undigested samples were analyzed for their total phenolic, flavonoid and antioxidant activities. Additionally, changes in phenolic composition in the in vitro digestion system were revealed by the HPLC-DAD system. The cytotoxic effects of the digested samples were assessed on lung (A549, H1299), skin (A431), liver (Hep-G2) and colon (Caco-2) cancer cells as well as on fibroblast (Bj) cells.

The mean bioaccessibility values of phenolic and flavonoid compounds were found to be less than 35 and 24%, respectively, while the TEAC and CUPRAC antioxidant results ranged between 225.08–649.04 and 398.68–1552.28 µmol TE/g, respectively. The release of p-coumaric, ferulic, 3,4-dimethoxycinnamic acids, naringenin, pinocembrin and chrysin increased progressively from the oral to the intestinal stage. The cytotoxic effects of samples on cell lines were ranked, based on IC50 results, as A431 > Hep-G2 > Caco-2 > A549 > H1299 > Bj.

Propolis has been recognized for centuries as a natural remedy, and numerous studies have explored its bioactive components. However, no studies have previously examined the changes in the phenolic compositions of propolis samples during digestion or their cytotoxic effects on cancer cells. Therefore, this study provides novel insights and an approach to the existing literature on this topic.

This study aims to produce composite pigments, including SHS/ZnAl-LDHs, IDS/ZnAl-LDHs and SNND/ZnAl-LDHs, with improved coloration, enhanced photostability and thermostability and biocompatibility.

The chemical structures of the composite pigments were characterized by X-ray diffraction spectroscopy and Fourier transform infrared spectroscopy. Photostability and thermal stability were assessed using ultraviolet-visible spectroscopy and colorimetry. The coverage of the dyes was determined through black-and-white tile testing, and specific RGB values were used to indicate color expressiveness. Finally, a four-color eyeshadow was formulated, and safety tests were conducted via human patch test and cellular assays to confirm the safety and reliability of the samples.

The experimental results demonstrate an enhancement in the photo and thermal stability of the SHS/ZnAl-LDHs, IDS/ZnAl-LDHs and SNND/ZnAl-LDHs composites, along with their superior performance in terms of covering power and color saturation. These composite pigments also exhibit high safety, making them well-suited for cosmetic applications.

The composite pigments based on hydrotalcite can be used in the cosmetic industry without causing any harm to the environment and human health.

The addition of hydrotalcite enables better application of pigments in cosmetics.

The phenomenon of friction and wear in parallel groove clamps under wind vibration in 10 kV distribution networks represents a significant challenge that can lead to their failure. This study aims to elucidate the wear mechanism of parallel groove clamps under wind-induced vibration through simulation and experimentation.

FLUENT software was used to simulate the flow around the conductor and the parallel groove fixture, and the Karman vortex street phenomenon was discussed. The stress fluctuations of each component under breeze vibration conditions were investigated using ANSYS, and fretting experimentations were conducted at varying amplitudes.

The results demonstrate that the impact of breeze vibration on the internal stress of the parallel groove clamps is considerable. The maximum stress observed on the lower clamping block was found to be up to 300 MPa. As wind speed increased, the maximum vibration frequency was observed to reach 72.6 Hz. Concurrently, as the vibration amplitude increased, the damage in the contact zone of the lower clamping block also increased, with the maximum contact resistance reaching 78.0 µO at a vibration amplitude of 1.2 mm. This was accompanied by a shift in the wear mechanism from adhesive wear to oxidative wear and fatigue wear.

This study presents a comprehensive analysis of the fretting wear phenomenon associated with parallel groove clamps under wind vibration. The findings provide a reference basis for the design and protection of parallel groove clamps.

Probiotic coadministration with soy beverages has been shown to have favorable results in human health. This study aims to conduct a systematic review of randomized clinical trials to examine the effect of probiotic soy beverages (PSB) on human health aspects such as lipid profile, oxidative stress and kidney function.

The study was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Relevant articles were extracted from PubMed, SCOPUS, Web of Science, Science Direct and Google Scholar up to April 2024. This paper searched all databases using the following keywords: (“Soy milk” OR “Soy beverage” OR “Fermented soy milk” OR “Soy Fermented Beverages”) AND (“Probiotic” OR “Probiotics”). The literature search did not consider language, age and publication date restrictions.

A total of 2,183 subjects were included in this review. PSB beneficially decreased low-density lipoprotein cholesterol and total cholesterol levels and increased high-density lipoprotein cholesterol. PSB beneficially affected superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione. PSB decreased serum creatinine and increased estimated glomerular filtration rate. Cystatin-C and progranulin decreased significantly in the PSB group. PSB had no significant effect on anthropometric indices, while decreased systolic and diastolic blood pressure.

This study provides a brief overview of the effect of PSB on lipid profile, oxidative stress, inflammation and kidney function for the first time.

This review paper delves into the comprehensive understanding of Ashwagandha, spanning its botanic occurrence, conventional applications, extraction techniques and pivotal role in addressing various disorders.

Introduction Ashwagandha, also known as Withania somnifera, is a remarkable botanical resource with a rich history of use in traditional medicine.

In botany, Withania somnifera thrives in diverse ecosystems, particularly in tropical and subtropical regions. Its extensive distribution across regions, the Canary Islands, South Africa, the Middle East, Sri Lanka, India and China underscores its adaptability and resilience. The traditional uses of Ashwagandha in Ayurvedic and indigenous medicine systems have persisted for over 3,000 years. With over 6,000 plant species utilized historically, India, often regarded as the “botanical garden of the world,” has firmly established Ashwagandha as a cornerstone in traditional healing practices.

Extraction methods play a pivotal role in harnessing the therapeutic potential of Ashwagandha. Ultrasonic-assisted extraction and high-performance liquid chromatography are among the techniques employed to obtain the key bioactive compounds. Ashwagandha’s significance in modern medicine is underscored by its potential to address a spectrum of health issues. The multifaceted bioactivity of Ashwagandha is attributed to its antioxidant, anti-inflammatory, heart conditions, metabolic disorders, renal ailments, hepatic diseases and adaptogenic properties, making it a subject of increasing interest in contemporary medical research. This review synthesizes the assorted perspectives of Ashwagandha, from its botanical roots and conventional employments to its advanced extraction strategies and its intention to basic well-being challenges, advertising important bits of knowledge for analysts, specialists and healthcare experts alike.

A section of in-service PE gas pipeline in Guocun, Beijing, was found to appear gas leaking at the electrofusion (EF) joint. This study is dedicated to reveal the material cause of EF joint failure to help with a more accurate prediction of service life of PE gas pipe and further normalize the construction of PE gas pipeline.

Defect detection was carried out on the leaking EF joint using ultrasonic phased array. The mechanical degradation and structural aging behavior was studied by tension test, FTIR technology, TG test and DSC test. The organic components in the soil surrounding the PE gas pipe failure area were qualitatively identified.

The results showed that the organic surfactants in the soil environment could accelerate the aging behavior of PE material, leading to a deterioration of mechanical properties and a serious reduction in the ability of the PE pipe and EF joint, especially at the welding defect, to resist external force.

A novel study was conducted to investigate the failure cause of the EF joint of in-service PE gas pipe, incorporating the analysis of environmental factors and structural deterioration.

The purpose of this study is to evaluate the effectiveness of nanocontainer solutions in removing deteriorated and aged polymers commonly used in coating and consolidating archaeological glass.

This study focused on characterizing glass surfaces coated with two commonly used polymeric materials in archaeological glass preservation. Furthermore, the study evaluates the elimination of these coatings from the surfaces by using innovative aqueous systems composed of micellar solutions (MS) and oil-in-water (O/W) Texapon-P microemulsions (TEX). Glass samples coated with selected polymers were subjected to thermal and photochemical aging to simulate natural degradation conditions. This study aimed to evaluate the effectiveness of nanocontainer aqueous systems compared to acetone (Ac), a conventional solvent commonly used for removal procedures. The characterization procedures involved transmission electron microscopy, USB digital microscopy, scanning electron microscopy, color alteration and gravimetric measurement.

The findings indicate that the effectiveness of novel techniques using aqueous nanocontainer systems is quite promising when considering a “green approach” to preserving cultural heritage. Microscopic examination demonstrated the efficacy of MS in effectively removing acrylic and vinyl polymers from the glass surface. Furthermore, TEX proved effective in removing polyvinyl acetate (PVA) over Paraloid B72 (B-72). In addition, the measurement of color alteration values revealed a decrease after using MS compared to the standard sample before applying the polymers, with values of ΔE = 1.48 and 1.82 for B-72 polymer and PVA, respectively.

This research provides nanocontainer solutions for removing aged polymers from the glass surface. This makes the current study a promising step for treating archaeological glass.

Nanotechnology (NT) advancements in personal protective textiles (PPT) or personal protective equipment (PPE) have alleviated spread and transmission of this highly contagious viral disease, and enabled enhancement of PPE, thereby fortifying antiviral behavior.

Review of a series of state of the art research papers on the subject matter.

This paper expounds on novel nanotechnological advancements in polymeric textile composites, emerging applications and fight against COVID-19 pandemic.

As a panacea to “public droplet prevention,” textiles have proven to be potentially effective as environmental droplet barriers (EDBs).

PPT in form of healthcare materials including surgical face masks (SFMs), gloves, goggles, respirators, gowns, uniforms, scrub-suits and other apparels play critical role in hindering the spreading of COVID-19 and other “oral-respiratory droplet contamination” both within and outside hospitals.

When used as double-layers, textiles display effectiveness as SFMs or surgical-fabrics, which reduces droplet transmission to <10 cm, within circumference of ∼0.3%.

NT advancements in textiles through nanoparticles, and sensor integration within textile materials have enhanced versatile sensory capabilities, robotics, flame retardancy, self-cleaning, electrical conductivity, flexibility and comfort, thereby availing it for health, medical, sporting, advanced engineering, pharmaceuticals, aerospace, military, automobile, food and agricultural applications, and more. Therefore, this paper expounds on recently emerging trends in nanotechnological influence in textiles for engineering and fight against COVID-19 pandemic.