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The study purposes were to investigate the knowledge, attitude and practice of pesticide use and to determine the levels of serum cholinesterase among rice farmers in Nakhon Nayok province, Thailand.

A cross-sectional study was carried out in communities in Nakhon Nayok Province, Thailand. Multistage random sampling was employed, selecting one person per each rice farmer household. Data was collected from 188 rice farmers using a structured face-to-face interview questionnaire. A reactive-paper finger-blood test was used to determine SChE levels. Chi-square test was used to determine the relationship between the practice of pesticide use and SChE levels.

The results indicated that the rice farmers had a fairly good knowledge and a neutral attitude toward the practice of pesticide use. Most of the respondents had a fairly proper practice of pesticide use. However, serum cholinesterase levels of the farmers were unsafe and risky. It signified that 68.1% of the farmers had a health risk from using pesticides. The prevalence of abnormal SChE levels among rice farmers with improper use was significantly higher than that among rice farmers who had a proper use.

The result provided a guideline for operational planning and control and prevention of health effects from pesticides use in farmers or other agriculturists who use pesticides in cultivation.

Concerned local agencies especially health-related agencies are able to conduct a training to educate and build safety awareness including monitoring continuously the safety behaviors toward pesticides use. It can be implemented by establishing leaders from health promoting hospitals led by village health volunteers, community leaders and participation from farmers to collaboratively monitor proper use of pesticides beginning with health surveillance in the abnormal SChE group to be screened for pesticide exposure every six months or one year.

Farmers gained knowledge and understanding of pesticides use and used it properly, which resulted in a reduction of pesticide residues in body as well as in the environment. In addition, the government policy should legislate measures for related agencies to promote proper use of pesticides. For instance, Department of Agriculture, Minister of Agriculture and Cooperatives should regularly supervise, monitor and inspect the production and distribution of pesticides in local shops and also systematically encourage agriculturists to adopt using pesticides that are less harmful.

Having knowledge, understanding and proper practices toward pesticides use, farmers can reduce health effects of pesticides use in themselves and family members.

Children living in agricultural areas are exposed to pesticides in their living areas and through activities of daily living. These exposures may lead to adverse health effects. The purpose of this paper is to investigate household environmental and behavioural factors associated with chlorpyrifos exposure and resultant adverse health effects in children living in an agricultural community.

A cross-sectional study was conducted including 65 toddlers (age of 12–36 months) and their parents were face-to-face interviewed from January to February 2016. Toddler’s hands and feet, toys and floors were wiped for chlorpyrifos residue analysis. The wipes were extracted and analysed by gas chromatography with a flame photometric detector, and blood cholinesterase activity was measured by the EQM Test-mate (model 400).

The average age (± standard deviation) of children was 19.9 (±5.9) months. Chlorpyrifos detections were 61.5 per cent (hands), 57.1 per cent (toys), 53.8 per cent (floors) and 30.8 per cent (feet). The highest chlorpyrifos residue concentration was detected on toy surface (3.022 µg/m²). Chlorpyrifos residues on hands and feet were positively correlated with concentrations on floors and toys (Spearman’s ρ, p<0.01). Multiple linear regression analysis revealed that more frequent hand washing (β=−0.236, p=0.067) and showering (β=−0.240, p=0.056) was negatively associated with chlorpyrifos residue on children’s body. House cleaning frequency was significantly associated with an increase in haemoglobin-adjusted erythrocyte cholinesterase (β=0.251, p<0.05).

Chlorpyrifos exposures found in the children household area through their activities and behaviours can cause several adverse health effects. The circumstances associated with chlorpyrifos exposure should be mitigated and reduced to improve the household environment of children living agricultural areas.

“It is generally accepted that the food industry must be scientifically based to cope with the problems, particularly of public health, which arise as new processes of growing, manufacturing, packaging and preserving food depart even further from traditional ways.”

Presents a summary of the research literature on the title topics, performed in the countries of Asia and the pacific rim. Mentions for occupational medicine a series of Chinese clinical trials on the use of drug agents for the treatment of silicosis, and the possible use of herbal remedies for a variety of skin disease problems. Discusses the use of biological techniques for the monitoring of heavy metal, organic solvents and pesticide induces toxicology, Reviews under the heading of environmental health some of the lessons learnt from the Bhopal methyl isocyanate disaster, and notes the health risks associated with rubbish dump sites. Comments finally under the head of occupational hygiene on some research on the effects of indoor air quality. Calls for an increase in safety research within the region’s countries.

Purpose – Description of the effects of the revolution in neuroscience and other areas of biology that can help to explain the roots of some portion of violent crime. The chapter reconsiders the role of brain chemistry in social behavior and violent behavior. To illustrate the interdisciplinary complexities entailed when linking brain chemistry to policy decisions concerning violent crime, this analysis has four main stages: first, why might SiFs (H2SiF6 and Na2SiF6, jointly called “silicofluorides” or SiFs) be dangerous? Second, what biochemical effects of SiF could have toxic consequences for humans? Third, on this basis a research hypothesis predicts children in communities using SiF should have increased uptake of lead from environmental sources and higher rates of behavioral dysfunctions known to be caused by lead neurotoxicity.

Design/methodology/approach – To illustrate the implications of the new issues involved, this chapter focuses on a public policy that inadvertently seems to increase rates of violent crime. Since violent behavior is one of the effects of lead neurotoxicity, the hypothesis is tested using multiple sources of data including rates of violent crime studied using a variety of multivariate statistical techniques (including analysis of variance, multiple regression, and stepwise regression).

Findings – Various data sources point to greater violence among individuals with greater exposure to SiFs.

Originality/value – Testing hypotheses linking neurotoxins to violent behavior reveals the generally unsuspected value of analyzing human social behavior and public policy from the perspective of evolutionary psychology.

The purpose of this paper is to focus on the antioxidant properties of two phenolic-rich varieties of Nigerian local rice and their anti-cholinesterase potential after in vitro-simulated gastrointestinal digestion, with the aim of establishing their actual antioxidant and nutraceutical potential after their passage through the gastrointestinal tract upon consumption.

Two local rice varieties, commonly referred to as “Gboko” and “Ofada” rice commonly grown in Benue State, a middle belt region of Nigeria and south western regions of Nigeria, respectively, were locally processed. Each of the processed grains were divided into two portions; one portion was left uncooked, while the second portion was boiled conventionally as eaten, dried and subsequently milled into powder. The milled samples of the raw and boiled rice were treated with acidified methanol to obtain the methanol extracts; another portion of each samples was subjected to in vitro enzyme digestion using standard methods to mimic human digestion; and the third portion was treated using the same scheme of in vitro digestion without the sets of enzyme which was used to serve as a control for enzyme treatment. The quali-quantitative phenolic profiles of the two local varieties were carried out with the aid of high-performance liquid chromatography with diode-array detection (HPLC-DAD) method. The antioxidant potential and anti-cholinesterase action of the methanolic extracts, the simulated in vitro digested model and the enzyme-treated controls of the rice samples were determined using standard methods and data obtained were subjected to ANOVA; the differences of means were separated using Duncan’s multiple range test (DMRT).

The quali-quantitative assessment of phenolic compounds in the two studied local varieties revealed the presence of some phenolic acids and flavonoids, with a decreased level of most of the identified phenolic compounds after boiling. In vitro enzyme-digested rice for both raw and boiled rice samples showed significantly higher total phenolic content, total flavonoid content, ferric-reducing antioxidant power, 2, 2′-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS+) scavenging and NO− inhibitory activities than the aqueous-methanolic extracts and the enzyme-treated controls. The aqueous-methanolic extracts displayed a higher 1, 1 diphenyl-2-picrylhdrazyl radical scavenging activity and inhibited Fe2+-induced lipid oxidation in rat’s brain and liver homogenate than that displayed by the in vitro enzyme-digested samples. In vitro enzyme-digested and boiled “Gboko” and “Ofada” rice and raw “Ofada” rice have the potential of inhibiting acetylcholine esterase (AChE) activity. While methanolic extracts of raw and boiled “Ofada” and “Gboko” rice exhibited the potential to inhibit butrylcholinesterase activity. The result of this paper indicates that the selected rice varieties possess antioxidant capacities which are better released after the simulated in vitro enzyme digestion; the result also showed the anti-cholinesterase potential of the studied rice grains and, therefore, they can be considered as nutraceutical health supplements.

The paper has demonstrated the antioxidant potentials of the phenolic-containing two Nigerian local rice varieties and established their anti-cholinesterase potential after simulated in vitro enzyme digestion.

This study contributes to the understanding of the health effects of pesticides exposure and of how pesticides have been and should be regulated.

This study presents literature reviews for the period 2000–2013 on (i) the health effects of pesticides and on (ii) preference valuation of health risks related to pesticides, as well as a discussion of the role of benefit-cost analysis applied to pesticide regulatory measures.

This study indicates that the health literature has focused on individuals with direct exposure to pesticides, i.e. farmers, while the literature on preference valuation has focused on those with indirect exposure, i.e. consumers. The discussion highlights the need to clarify the rationale for regulating pesticides, the role of risk perceptions in benefit-cost analysis, and the importance of inter-disciplinary research in this area.

This study relates findings of different disciplines (health, economics, public policy) regarding pesticides, and identifies gaps for future research.

Human performance, particularly that of the warfighter, has been the subject of a large amount of research during the past few decades. For example, in the Medline database of medical and psychological research, 1,061 papers had been published on the topic of “military performance” as of October 2003. Because warfighters are often pushed to physiological and mental extremes, a study of their performance provides a unique glimpse of the interplay of a wide variety of intrinsic and extrinsic factors on the functioning of the human brain and body. Unfortunately, it has proven very difficult to build performance models that can adequately incorporate the myriad of physiological, medical, social, and cognitive factors that influence behavior in extreme conditions. The chief purpose of this chapter is to provide a neurobiological (neurochemical) framework for building and integrating warfighter performance models in the physiological, medical, social, and cognitive areas. This framework should be relevant to all other professionals who routinely operate in extreme environments. The secondary purpose of this chapter is to recommend various performance metrics that can be linked to specific neurochemical states and can accordingly strengthen and extend the scope of the neurochemical model.

Although first rank symptoms focus on positive symptoms of psychosis they are shared by a number of psychiatric conditions. The difficulty in differentiating bipolar disorder from schizophrenia with affective features has led to a third category of patients often loosely labeled as schizoaffective. Research in schizophrenia has attempted to render the presence or absence of negative symptoms and their relation to etiology and prognosis more explicit. A dichotomous population is a recurring theme in experimental paradigms. Thus, schizophrenia is defined as process or reactive, deficit or non-deficit and by the presence or absence of affective symptoms. Laboratory tests confirm the clinical impression showing conflicting responses to dexamethasone suppression and clearly defined differences in autonomic responsiveness, but their patho-physiological significance eludes mainstream theory. Added to this is the difficulty in agreeing to what exactly constitutes useful clinical features differentiating, for example, negative symptoms of a true deficit syndrome from features of depression. Two recent papers proposed that the general and specific cognitive features of schizophrenia and major depression result from a monoamine-cholinergic imbalance, the former due to a relative muscarinic receptor hypofunction and the latter, in contrast, to a muscarinic hypersensitivity exacerbated by monoamine depletion. Further development of these ideas will provide pharmacological principles for what is currently an incomplete and largely, descriptive nosology of psychosis. It will propose a dimensional view of affective and negative symptoms based on relative muscarinic integrity and is supported by several exciting intracellular signaling and gene expression studies. Bipolar disorder manifests both muscarinic and dopaminergic hypersensitivity. The greater the imbalance between these two receptor signaling systems, the more the clinical picture will resemble schizophrenia with bizarre, incongruent delusions and increasingly disorganized thought. The capacity for affective expression, by definition a non-deficit syndrome, will remain contingent on the degree of preservation of muscarinic signaling, which itself may be unstable and vary between trait and state examinations. At the extreme end of muscarinic impairment, a deficit schizophrenia subpopulation is proposed with a primary and fixed muscarinic receptor hypofunction.

The genomic profile of bipolar disorder and schizophrenia overlap and both have a common dopaminergic intracellular signaling which is hypersensitive to various stressors. It is proposed that the concomitant muscarinic receptor upregulation differentiates the syndromes, being marked in bipolar disorder and rather less so in schizophrenia. From a behavioral point of view non-deficit syndromes and bipolar disorder appear most proximate and could be reclassified as a spectrum of affective psychosis or schizoaffective disorders. Because of a profound malfunction of the muscarinic receptor, the deficit subgroup cannot express a comparable stress response. None -theless, a convergent principle of psychotic features across psychiatric disorders is a relative monoaminergic-muscarinic imbalance in signal transduction.

Dementia in older persons with learning disabilities is a growing concern for all those involved in their care. There is at present no effective treatment, but the importance of current drug treatments is reviewed. Developments in drug treatments for dementia remain an active area of ongoing research.