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This study aims to focuse on the flow behavior of a specific nanofluid composed of blood-based iron oxide nanoparticles, combined with motile gyrotactic microorganisms, in a ciliated channel with electroosmosis.

This study applies a powerful mathematical model to examine the combined impacts of bio convection and electrokinetic forces on nanofluid flow. The presence of cilia, which are described as wave-like motions on the channel walls, promotes fluid propulsion, which improves mixing and mass transport. The velocity and dispersion of nanoparticles and microbes are modified by the inclusion of electroosmosis, which is stimulated by an applied electric field. This adds a significant level of complexity.

To ascertain their impact on flow characteristics, important factors such as bio convection Rayleigh number, Grashoff number, Peclet number and Lewis number are varied. The results demonstrate that while the gyrotactic activity of microorganisms contributes to the stability and homogeneity of the nanofluid distribution, electroosmotic forces significantly enhance fluid mixing and nanoparticle dispersion. This thorough study clarifies how to take advantage of electroosmosis and bio convection in ciliated micro channels to optimize nanofluid-based biomedical applications, such as targeted drug administration and improved diagnostic processes.

First paper discussed “Numerical Computation of Cilia Transport of Prandtl Nanofluid (Blood-Fe₃O₄) Enhancing Convective Heat Transfer along Micro Organisms under Electroosmotic effects in Wavy Capillaries”.

This study aims to provide a microfluidic blood glucose sensing platform based on integrated interdigitated electrode arrays (IDEAs) on a flexible quartz glass substrate, adhering closely to pertinent electrochemical characterizations.

Sensors are the key elements of the modern electronics era through which all the possible physical quantities can be detected and converted into their equivalent electrical form and processed further. But to make the sensing environment better, various types of innovative architectures are being developed nowadays and among them interdigitated electrodes are quite remarkable in terms of their sensing capability. They are a well-qualified candidate in the field of gas sensing and biosensing, but even their sensitivities are getting saturated due to their physical dimensions. Most of the thin film IDEAs fabricated by conventional optical lithographic techniques do not possess a high surface-to-volume ratio to detect the target specified and that reduces their sensitivity factor. In this context, a classic conductive carbon-based highly sensitive three dimensional (3D) IDEA-enabled biosensing system has been conceived on a transparent and flexible substrate to measure the amount of glucose concentration present in human blood. 3D IDEA possesses a way better capacitive sensing behavior compared to conventional thin film microcapacitive electrodes. To transmit the target biological analyte sample property for the detection purpose to the interdigitated array-based sensing platform, the design of a microfluidic channel is initiated on the same substrate. The complex 3D Inter Digital array structure improves the overall capacitance of the entire sensing platform and the reactive surface area as well. The manufactured integrated device displays a decent value of sensitivity in the order of 5.6 µA mM⁻¹ cm⁻².

Development of a low-cost array-based integrated and highly flexible microfluidic biochip to extract the quantity of glucose present in human blood.

Potential future research opportunities in the realm of integrated miniaturized, low-cost smart biosensing systems may arise from this study.

Normal-weight obesity (NWO), characterized by normal body mass index (BMI) but excess body fat, is a potential contributor to chronic diseases. This study aims to assess the relationship between this phenomenon and some metabolic factors in a population of Iranian employees.

This cross-sectional study was conducted on Iranian employees from the baseline data of Employees Health Cohort Study, Shiraz, Iran. Anthropometric measures, including weight, height, waist circumference and percentage of body fat, were obtained from the cohort database. The participants were divided into three groups: healthy, normal-weight obese and overweight/obese. Metabolic variables including blood pressure, fasting blood sugar, lipid profile, liver function enzymes and metabolic syndrome were assessed in relation to the study groups.

A total of 985 participants aged 25–64 years were included. Males with NWO had significantly higher alanine aminotransferase (ALT) levels compared to the healthy group in the fully adjusted model. Also, high-density lipoprotein (HDL) was significantly lower among females with overweight/obesity than healthy group when adjusted for age and energy intake. Furthermore, after adjusting for age and energy intake, both genders in the overweight/obese group showed significantly elevated systolic and diastolic blood pressure, while this was not observed for the NWO group. Lastly, metabolic syndrome was more prevalent in NWO as well as overweight/obesity.

These findings further encourage identification of excess body fat, even in normal-weight individuals, to prevent chronic metabolic diseases. Special attention should be paid to subgroups with sedentary occupations, as they may be at increased risk for NWO-related health issues.

This paper aims to examine the association between the dietary inflammatory index, the consumption of Enteral Nutrition Supplemented with probiotics with certain serum inflammation markers and gastrointestinal complications among individuals diagnosed with COVID-19.

This cross-sectional investigation involved 100 COVID-19 patients who were admitted to intensive care units in hospitals. These patients were administered two different types of Enteral Nutrition, so the dietary inflammatory index (DII), gastrointestinal complications and some serum inflammation markers have been compared between two groups.

The mean DII scores in all patients were significantly pro-inflammatory (probiotic formula 2.81 ± 0.01 vs usual formula group 2.93 ± 0.14 p = 0.19). The probiotic formula consumption had an inverse association with High-sensitivity C-reactive Protein concentration (coef = −3.19, 95% CI −1.25, −5.14 p = 0.001) and lead to a reduction of 2.14 mm/h in the serum level of Erythrocyte sedimentation rate compared to normal formula. The incidence of diarrhea, abdominal pain and vomiting in probiotic formula patients was respectively 94%, 14% and 86% less than in usual formula patients (p = 0.05).

In this cross-sectional study for the first time, the authors found that probiotic formula consumption was inversely associated with serum inflammation markers and gastrointestinal complications incidence. The high DII leads to more gastrointestinal complications incidence and inflammation markers. More studies are needed to prove this relationship.

The modern fairy tale hero identity falls into a general spectrum of tropes that spans from the charming prince who seals the fate of the beautiful princess with a kiss to borderline villains with little break in this spectrum. The Witcher's Geralt of Rivia brings to light an often overlooked hero's identity by representing neither ends of this heroic spectrum but rather a different breed of hero entirely. We argue that Geralt of Rivia differs from the typical representation of the fairy tale hero by embodying the spirit of the Huntsman archetype as depicted in stories such as Snow White and Little Red Riding Hood.

This creates a new means of exploring fairy tales as genres by giving perspective to the bloodier, messier sides of these tales which have since deviated from their darker origins. Geralt exists as neither hero nor antihero, but rather a sword-for-hire who cleans up messes that ‘heroes’ otherwise cannot or will not handle themselves. Across his depictions in the books, games, and show, Geralt involves himself as a witcher; hunter of monsters. Geralt's method in overcoming this style of quest is unlike the usual hero. Standing in for the Huntsman, Geralt understands the nature and balance of man and beast and carries this responsibility while looking to accomplish his goals. In this chapter, we seek to document and bring to light this underrepresented style of hero that the witcher has to offer to show that such a hero needs not be black nor white.

Malnutrition has a significant effect on the onset and progression of infective pathology. The malnutrition status in COVID-19 cases are not understood well. Prognostic Nutritional Index (PNI) is a new and detailed assessment of nutrition and inflammation cases. This study aims to investigate the effect of PNI on mortality in COVID-19 patients.

In total, 334 patients (males, 142; females, 192; 64.5 ± 12.3 years of age) with COVID-19 bronchopneumonia were enrolled in this investigation. Cases were divided into two groups with respect to survival (Group 1: survivor patients, Group 2: non-survivor patients). Demographic and laboratory variables of COVID-19 cases were recorded. Laboratory parameters were calculated from blood samples taken following hospital admission. PNI was calculated according to this formula: PNI = 5 * Lymphocyte count (10⁹/L) + Albumin value (g/L).

When the patients were assessed with respect to laboratory values, leukocytes, neutrophils, CRP, ferritin, creatinine and D-Dimer parameters were significantly lower in Group 1 patients than Group 2 patients. Nevertheless, serum potassium value, lymphocyte count, calcium and albumin values were significantly higher in Group 1 cases than in Group 2 cases. PNI value was significantly lower in Group 2 cases than in Group 1 cases (39.4 ± 3.7 vs 53.1 ± 4.6).

In this retrospective study of COVID-19 cases, it can be suggested that PNI may be a significant risk factor for mortality. In conclusion of this research, high-risk patients with COVID-19 can be determined early, and suitable medical therapy can be begun in the early duration.

Research indicated that dietary antioxidants could improve immune system performance. This study aims to investigate the association of COVID-19 symptoms, total antioxidant capacity and serum inflammatory markers, with dietary antioxidants intake among angina patients.

A food frequency questionnaire was used in a cross-sectional study among 135 angina patients with COVID-19, to assess dietary antioxidants consumption. Serum levels of tumor necrosis factor, interleukin 1ß, malondialdehyde, high-sensitivity C-reactive protein and total antioxidant capacity were measured by enzyme-linked immunosorbent assay methods.

Among study angina patients, 76.67% followed unhealthy food patterns and 23.33% followed anti-inflammatory dietary patterns before hospitalization. The angina patients with anti-inflammatory food pattern had less fever (p = 0.021), cough (p = 0.018), dyspnea (p = 0.024), diarrhea (p = 0.014) and pneumonia severity index (p = 0.014) compared to patients with unhealthy food pattern. The serum levels of tumor necrosis factor, interleukin 1ß, high-sensitivity C-reactive protein and malondialdehyde, had a significantly negative association with dietary antioxidants intake (p < 0.05).

There are significant association between antioxidant intake with serum inflammation markers in COVID-19 patients. There is a need for more clinical trial studies for approval of these results.

Early prediction of any type of cancer is important for the treatment of this type of disease, therefore, our target to evaluate whether monitoring early changes in plasma human epidermal growth factor receptor 2 (HER2) levels (using EIS), could help in the treatment of breast cancer or not? Human epidermal growth factor receptor 2 (HER2) overexpression is an important biomarker for treatment selection in earlier stages of cancers. The combined detection of the HER2 gene in plasma for blood cancer provides an important reference index for the prognosis of metastasis to other tissues. For this purpose, the authors fabricated and characterized a model wireless biosensor-based electrochemical impedance spectroscopy (EIS) for detecting HER2 plasma as therapeutics.

Most sensors generally are fabricated based on a connection between component of the sensors and the external circuits through wires. Although these types of sensors provide suitable sensitivities and also quick responses, the connection wires can be limited to the sensing ability in various devices approximately. Therefore, the authors designed a wireless sensor, which can provide the advantages of in vivo sensing and also long-distance sensing, quickly.

The biosensor structure was designed for detection of HER2, HER3 and HER-4 from lab-on-chip approach with six units of screen-printed electrode (SPE), which is built of an electrochemical device of gold/silver, silver/silver or carbon electrodes. The results exhibited that the biosensor is completely selective at low concentrations of the plasma and HER2 detection via the standard addition approach has a linearity plot, therefore, by using this type of biosensors HER2 in plasma can be detected.

This is then followed by detecting HER2 in real plasma using standard way which proved to have great linearity (R² = 0.991) proving that this technique can be used to detect HER2 solution in real patients.

Fairy tales were first transmitted orally to teach the community to adapt and engage with their surroundings (Zipes, 1987, p. 1). Nonetheless, they have also contributed to reproduce traditional gender roles and stereotypes (Meland, 2020, p. 912). Indeed, they encourage ‘females to become passive self-denying, obedient, and self-sacrificial’, and males to ‘be competitive, authoritarian, and power-hungry as well as rational, abstract, and principled’ (Zipes, 1987, p. 3). Likewise, Western fairy tales are characterised by a racial dichotomy manifested through the uses of colour: purity is usually associated with white, while black is related to death. This binary opposition suggests that ‘[w]hiteness is often the invisible, privileged state, whereas any other skin colour is marked and laden with ideological judgments’ (Jorgensen, 2013, p. 56).

Carnival Row (2019–2023) is a neo-Victorian TV series created for Amazon Studios that rewrites Western fairy tales through the lens of postcolonial and gender studies. It is set in a fantastically reimagined Victorian England, where mythological creatures – e.g. fairies or centaurs – are allegorical representations of the ethnic Other. The male protagonist of this series, Philo, is a ‘half-breed’ – half human, half fairy – who passes as human to avoid racial discrimination. However, he evolves from being a male character who rejects his ethnic identity to a heroic figure who eventually embraces his racial origins at the end of Season 1. As I demonstrate in this chapter, Philo's nuanced development arguably subverts traditional depictions of white male heroes in fairy-tale narratives, where they tend to be portrayed as strong, principled and non-complex characters.