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Purpose: The world has been impacted distinctively by the Covid-19 outbreak. The economic recession in 2020 and 2021 is predicted to become the most intense since World War II. This chapter explores the effects of the Covid-19 epidemic crisis on entrepreneurship and different activities, emphasizing developing economies.

Design/methodology/approach: The work aims first on the major crises that could impact entrepreneurial activity triggered by the pandemic. The authors briefly study the literature on the previous health crisis and its impacts on entrepreneurship. Then, under Covid-19, the authors illustrated the navigational prospects for creativity and entrepreneurship.

Findings: Our research indicates that the pandemic’s impact on creativity and entrepreneurship would be adverse but not hugely harmful. A new opportunity ecosystem under COVID-19 is respected and researched for innovation and entrepreneurship. Simultaneously, the incentives provided by the COVID-19 pandemic for consumer e-commerce adoption in Saudi Arabia are being addressed.

Originality/value: This is probably the first chapter of the book focusing on the impact on the Covid-19 pandemic entrepreneurship. It directly discusses the effects of the Covid-19 pandemic on both the global economy and entrepreneurship dynamics. It also recommends fascinating future-oriented, relevant research areas about helping entrepreneurs solve it and what new prospects are developing for them.

Purpose: Economic development agendas usually drive innovation, and it is an essential tool for government institutions to promote economic growth. The Quadruple Helix Model of Innovation captures the process by integrating and overlapping knowledge and technology, forming an aggregate output invested in producing more products and services, innovation, and technology. This chapter focuses on how the quadruple helix supports the linkage between knowledge creation, innovation output, and enhancing regional and national competitiveness.

Design/methodology/approach: The chapter also illustrates the triple helix concept and then the quadruple helix model of innovation, focusing on the four main aspects, i.e., Government, Universities, Industry, and Civil society. The authors aim to simulate the economic significance of evolving, rapidly adaptive, and interdisciplinary knowledge and innovation ecosystems.

Findings: The findings and examples stated in several different MENA regions can boost the economy as various platforms provide digital transformation, encourage culture awareness in schools, encourage youth empowerment, and support tech start-ups. They can drive forward the index of creativity and innovation within entrepreneurs and the general members of society. Recommendations include a further study to modify the model and customize it based on the country’s needs.

Originality/value: This chapter of the book focuses on the four main aspects of the quadruple helix model of innovation with specific examples in several countries. The chapter would be beneficial for the upcoming entrepreneurs and students who progress in developing tech start-ups and digitization.

Purpose: The best way of improving youth entrepreneurs’ success rates is to provide youth entrepreneurs with quality support, skills, and resources to be better equipped and willing to make any decision that makes them creative with time. This chapter explores youth entrepreneurship in the MENA region as educating young people about entrepreneurship is crucial today and is about developing new businesses in the region.

Design/methodology/approach: The chapter mainly aims at the role of academia in boosting entrepreneurship among young people in the UAE. Then the literature provides insights on the substantial gender effect on becoming an entrepreneur and the region’s job market.

Findings: Our research indicates that the global economy is witnessing a sudden rise in entrepreneurship in all life areas, based on current world dynamics. Thus, young people must learn and accomplish skills that promote creativity for doing business. For young people to have the requisite skills to start their businesses, educational programs must be in line with industry requirements.

Originality/value: This chapter of the book focuses on youth entrepreneurship, which would help upcoming researchers and students grasp good knowledge about entrepreneurship’s importance. It also recommends relevant research areas on MENA youth entrepreneurship support programs.