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Purpose: Economic development agendas usually drive innovation, and it is an essential tool for government institutions to promote economic growth. The Quadruple Helix Model of Innovation captures the process by integrating and overlapping knowledge and technology, forming an aggregate output invested in producing more products and services, innovation, and technology. This chapter focuses on how the quadruple helix supports the linkage between knowledge creation, innovation output, and enhancing regional and national competitiveness.

Design/methodology/approach: The chapter also illustrates the triple helix concept and then the quadruple helix model of innovation, focusing on the four main aspects, i.e., Government, Universities, Industry, and Civil society. The authors aim to simulate the economic significance of evolving, rapidly adaptive, and interdisciplinary knowledge and innovation ecosystems.

Findings: The findings and examples stated in several different MENA regions can boost the economy as various platforms provide digital transformation, encourage culture awareness in schools, encourage youth empowerment, and support tech start-ups. They can drive forward the index of creativity and innovation within entrepreneurs and the general members of society. Recommendations include a further study to modify the model and customize it based on the country’s needs.

Originality/value: This chapter of the book focuses on the four main aspects of the quadruple helix model of innovation with specific examples in several countries. The chapter would be beneficial for the upcoming entrepreneurs and students who progress in developing tech start-ups and digitization.

This study aims to evaluate the potential of using the components of the quadruple helix and quintuple helix models, which are extensions of the triple helix university-private sector-public sector cooperation model. Thus, the triple helix model shaped by university-private-public sector cooperation has transformed into a quadruple helix innovation model with the inclusion of the media and culture-oriented public helix. In this context, while the triple helix emphasizes tripartite networks and hybrid organizations, the quadruple helix system focuses on intertwined collaborations, coevolution, and specialization within the framework of firms, institutions, and stakeholders. In the quadruple helix innovation system, the coevolution of art and innovation has assumed a central role in knowledge generation and innovation. In the quintuple helix innovation model, the natural environment of society is added to the quadruple helix. This study consists of three parts. In the first part, the literature on triple helix, quadruple helix, and quintuple helix models is reviewed. In the second part, digital transformation and technological innovations from Industrial Revolution 1.0 to Industry 5.0 are analyzed. In the third section, the contribution of the quintuple helix model to Industry 5.0 and Society 5.0 is explained.

This paper aims to examine the collaboration of livestock farming business with other three groups of actors and explore the gap between expectations and reality concerning biogas production as collaborative innovation for the socially responsible development of rural regions in Lithuania.

This paper is based on the concept of the Quadruple Helix, which focusses on innovation, viewed as a process involving increasingly closer interactions and coordination among the following four groups of actors of the helix: government, academia, industry and civil society. Scientific literature analysis and generalization, expert interview and focus group methods were used to generate data for analysis. Data were collected during the period of July-November 2018 in Lithuania.

The research results reveal that the greatest gap among expectations and the actual situation in collaboration for socially responsible innovation, biogas production – is observed among non‐governmental organizations as representatives of civil society and all other questioned Quadruple Helix actors, whereas the government had been recognized as a most isolated part of the collaboration for innovation in biogas in Lithuania.

This paper presents empirical findings, based on qualitative data, collected in one EU new member state, i.e. Lithuania. International comparative perspectives are given in other related papers. Research findings are promising for further research in the field of socially responsible development of rural regions using the Quadruple Helix approach to foster collaboration for modern circular economy innovation both from theoretical and empirical points of view.

The methodology might be used for practitioners to research collaboration excellence/gaps in any field of activity.

The research takes into account the public interest from a very broad point of view – how to develop rural regions in a socially responsible way by using already established innovations in biogas in livestock farms by giving another dimension of socially responsible collaboration for innovation.

The paper proposes using the original Quadruple Helix approach to foster the socially responsible development of rural regions, thus enlarging the scope of the theory of corporate social responsibility (CSR) with the newly emerged discourse in the field. Socially responsible development of rural regions with the use of collaboration for circular innovations has been absent from theoretical to empirical CSR research.

The purpose of this paper is to investigate the literature on the representation of the quadruple and quintuple helix (QQH) in innovation environments such as incubators and science and technology parks (STPs).

The authors used the integrative review as a methodological approach and systematized studies regarding the main research objectives; theoretical approaches; methodology and study object; QQH representation, by identifying actor, performance and main results; and additional contributions to the QQH model.

As a result, the authors noticed a lack of standardization on the representation of the quadruple helix, but the example of associations and community centers as representatives of the civil society. The quintuple helix does not have an actor that represents the environment, but STPs foster sustainable actions, encourage the generation of green companies and stimulate sustainable practices among established companies.

Based on changes in the economic and social scenarios, new theoretical approaches emerge to explain the innovation process, such as the QQH. Incubators and STPs are favorable settings for interactions, according to the new models; however, there is a lack of studies addressing this topic in such environments. Hence, this study contributes to understanding the existence and performance of QQH, by showing how these new helices were identified, in addition to advancing the subject in innovation environments such as incubators and STPs.

The purpose of this chapter is to contribute to the theory building of transformative university by delivering two conceptual models for legitimizing entrepreneurial university with a transformative role in quadruple helix for sustainability governance structures as being nominated as “responsible facilitator.” This chapter draws many theoretical insights sourced from Entrepreneurial University (Etzkowitz, 1988), Institutional Theory (Scott, 1987), quadruple/quintuple helix (Carayannis & Campbell, 2009a, b) and Responsible Innovation (Owen, Macnaghten, & Stilgoe, 2012) in order to frame the resulting conceptual models of transformative university for sustainability and quadruple helix for sustainability governance. The conceptual models offer a new paradigm discussion for the changing role of universities in knowledge economy and opens up for further investigation of quadruple helix actors namely as transformative university, society, industry and government for strategic capital, social capital, economic capital and culture–human capital interventions in sustainability governance. The second model illustrates the key interventions of quadruple helix actors in four pillars of capital delivering concrete examples of activities. The originality of this chapter lies in its discourse articulating a multilayered approach for the institutionalization of entrepreneurial university embedded in a responsible innovation ecosystem based on individual, organizational and macro-level perspectives. Quadruple helix actors are nominated as “responsible facilitator,” “hybrid hub,” “agile regulator” and “pressure beneficiary” roles for their relevant place in sustainability governance structure.

By taking a micro-level perspective, this paper aims to examine the influence of the ongoing paradigm shift from technological to social innovation on principal investigators (PIs) and thereby links the two emerging research fields of entrepreneurial ecosystems and social innovation. The purpose of this paper is to build the basis for future empirical analyses.

The paper is a conceptual paper and therefore focuses on theoretical considerations. Taking a quadruple helix approach, PIs are outlined as central actors of entrepreneurial ecosystems and transformative agents of the innovation process.

PIs can proactively shape the innovation process and thus the shift from technological to social innovation, through various channels. They can affect all other actors of the quadruple helix, e.g. by exerting influence on the process of scientific change, on the public opinion and/or on the industry partners. Further, the paradigm shift might change the universities' role in the quadruple helix, substantiating their importance in the process of social change.

As PIs are influencing all other actors of the quadruple helix, they are central actors of entrepreneurial ecosystems and thus crucial players in the innovation process. Hence, they need to be supported in fulfilling their role of transformative agents, accelerating and shaping the paradigm shift from technological to social innovation. Universities should therefore reconsider their missions and vision as well as their role within the society.

This paper considers the influence of an ongoing paradigm shift from technological to social innovation on entrepreneurial ecosystems. This work focuses especially on the PIs' role as transformative agents. Therefore, it builds a bridge from entrepreneurial ecosystems to social innovation and thus contributes to both research fields. Moreover, the paper shows the great potential of PIs to influence and shape social innovation.

The purpose of this paper is to identify the most extensively studied topics with respect to the triple, quadruple and quintuple helix models developed to explain these links. The review also focusses on ascertaining future trends within this field.

Relevant documents obtained from a search in the Institute for Scientific Information’s Web of Science were submitted to bibliometric analysis using VOSviewer software.

The results of this systematic review illustrate that, despite growing concern about society and the environment, issues related to the three helixes of universities, industries and governments continue to be the most often studied. However, an additional focus on research on the quadruple and quintuple helix models has emerged in the more specialised literature. An analysis of co-citations also identified four clusters of research such as, innovation and knowledge policies; entrepreneurial universities; business innovation strategy; and triple helix stakeholders in innovation, knowledge and regional development.

Some policies are needed. Polices that undergo the mapping of the universities’ specialisations, the industry/society necessities and financial measures could foster the relations between all the stakeholders.

Altmetrics is a complementary method in scientometrics for evaluating the performance of individuals, organizations, institutions and countries in social media. Due to the large volume of data related to the interactions in science, technology and innovation, there is no choice but to develop and implement accurate models for analysis and decision making. The Quadruple Helix Model examines the scientific outcomes in four spaces of innovation, knowledge, consensus and government with a distinctive attention to the “innovation space”. In other words, it aims to find the connection between the academic space and other sectors of a society (public, media and government) to see if scientific outputs respond appropriately to their needs.

The present paper studied the impact of health-related researches in D8 countries) including Iran, Turkey, Pakistan, Bangladesh, Indonesia, Malaysia, Egypt and Nigeria) using the Altmetrics scores of their indexed journal in the Web of Science (WOS). The results demonstrated distribution of interactions of the mentioned four spaces in health science researches in terms of social media, geographical distribution and theme for D8 countries. This was conducted using content analysis, scientometric and altmetric indicators in the WOS and Altmetrics.com databases.

In D8 countries, more interaction has taken place in the knowledge and innovation spaces; however, there exist Quadruple imbalances in these countries. Moreover, some interactions have been observed in all social networks, displaying that users consider health topics in D8 countries, and clinical sciences has gotten more interaction in all the four spaces.

The application of this model using altmetrics data with current approach has been conducted for the first time.

The purpose of this paper is to question whether the emphasis placed within translational research on a linear model of innovation provides the most effective model for managing health technology innovation. Several alternative perspectives are presented that have potential to enhance the existing model of translational research. A case study is presented of innovation of a clinical decision support system. The paper concludes from the case study that an extending the triple helix model of technology transfer, to one based on a quadruple helix, present a basis for improving the performance translational research.

A case study approach is used to help understand development of an innovative technology within a teaching hospital. The case is then used to develop and refine a model of the health technology innovation system.

The paper concludes from the case study that existing models of translational research could be refined further through the development of a quadruple helix model of heath technology innovation that encompasses greater emphasis on user-led and open innovation perspectives.

The paper presents several implications for future research based on the need to enhance the model of health technology innovation used to guide policy and practice.

The quadruple helix model of innovation that is proposed can potentially guide alterations to the existing model of translational research in the healthcare sector. Several suggestions are made for how innovation activity can be better supported at both a policy and operational level.

This paper presents a synthesis of the innovation literature applied to a theoretically important case of open innovation in the UK National Health Service. It draws in perspectives from other industrial sectors and applies them specifically to the management and organisation of innovation activities around health technology and the services in which they are embedded.