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Article
Publication date: 12 March 2018

Bruna Luísa Radavelli, Priscila Berti Zanella, Amanda Souza Silva and Valesca Dall’Alba

The purpose of this paper is to verify the possible associations between dietary components and the intestinal microbiota in clinical parameters of inflammatory bowel disease.

Abstract

Purpose

The purpose of this paper is to verify the possible associations between dietary components and the intestinal microbiota in clinical parameters of inflammatory bowel disease.

Design/methodology/approach

In this review, a search in PubMed and Bireme databases was performed. The authors included randomized clinical trials published between 2005 and 2017, only in adult humans with Crohn’s disease or ulcerative colitis.

Findings

Six articles were included by the end of the search. The most widely used intervention was the use of prebiotics, including fructooligosaccharides or fructooligosaccharides with inulin, followed by probiotics. The main findings regarding the microbiota were the increase in the total amount of bacteria and variability (phyla). Clinically, there was improvement in inflammation seen in parameters such as C-reactive protein, interleukins and tumor necrosis factor alpha.

Originality/value

Dietary interventions, especially from symbiotics, can modulate the microbiota, mainly in relation to time, when compared pre- and post-supplementation, and this positively interferes with clinical parameters of inflammatory bowel diseases. However, the studies were quite heterogeneous in population, methodology, intervention, mycobiota analysis and inflammatory markers.

Details

Nutrition & Food Science, vol. 48 no. 2
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 8 May 2017

Cassiana Ganem Achtschin and Aytan Miranda Sipahi

Titanium is a naturally occurring mineral in the form of titanium dioxide (TiO2) and is one of the most widely used food additives. The purpose of this review article is…

Abstract

Purpose

Titanium is a naturally occurring mineral in the form of titanium dioxide (TiO2) and is one of the most widely used food additives. The purpose of this review article is to show the importance of the accumulation of this mineral in the gut and its relation with inflammatory processes.

Methodology

This is a literature review study from 2002 to 2016, focusing on studies with TiO2 and its relation with inflammatory bowel diseases.

Findings

Articles describe that TiO2 is resistant to gastrointestinal degradation, as it has high stability, and that its particles, ingested daily, may bind to biomolecules in the lumen or be absorbed by the intestinal mucosa, accumulating in the macrophages of lymphoid tissue in the gut, thus causing or aggravating the inflammatory response in the inflamed bowel.

Limitations/implications

There is a limited number of studies on the long-term impact of dietary microparticles in animal models, in healthy subjects and in patients with inflammatory bowel diseases.

Practical implications

It is necessary to regulate the amount of TiO2 used in industrialized products.

Social implications

The high consumption of processed foods, as opposed to a healthy diet based on the balanced consumption of nutrients, is relevant, as it may lead to or exacerbate intestinal inflammation.

Originality/value

This review indicates that titanium particles may mediate toxicological processes leading to an abnormal increase in intestinal permeability, which may be particularly aggravating in patients with inflammatory bowel diseases.

Details

Nutrition & Food Science, vol. 47 no. 3
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 21 October 2013

S. Sarkar

Increased evidence for the health benefits of probiotics for health restoration coupled with the consumer's inclination towards a safe, natural and cost-effective…

Abstract

Purpose

Increased evidence for the health benefits of probiotics for health restoration coupled with the consumer's inclination towards a safe, natural and cost-effective substitute for drugs have led application of probiotics as a pharmaceutical agent and are rapidly moving in clinical usage. In this context, this article attempts to highlight the potential of probiotics as a pharmaceutical agent.

Design/methodology/approach

Endeavor has been made to explore the significance of probiotics for the modulation of gut ecology and their action. Potentiality of probiotics for their exploitation as a pharmaceutical agent has also been justified. Limitations of probiotic therapy and the various considerations for probiotic therapy have also been delineated.

Findings

Probiotic organisms influence the physiological and pathological process of the host by modifying the intestinal microbiota, thereby affecting human health. Beneficial effects of probiotics as a pharmaceutical agent seem to be strain and dose dependent and more efficacious with their early introduction. Combination of various probiotics proved to be more efficacious than single strain for exhibiting prophylactic activities.

Research limitations/implications

Reviewed literature indicated that it is difficult to generalize for the beneficial effect of all probiotics for all types of diseases as efficacy of probiotics is strain-dependent and dose-dependent and its clinical application needs long-term investigations.

Practical implications

Clinical trials have displayed that probiotics may alleviate certain disorders or diseases in humans especially those related to gastro-intestinal tract.

Originality/value

Ingestion of fermented dairy products containing probiotic cultures may provide health benefits in certain clinical conditions such as antibiotic-associated diarrhoea, rotavirus-associated diarrhoea, inflammatory bowel disease, inflammatory bowel syndrome, allergenic diseases, cancer, Helicobacter pylori infection and lactose-intolerance. Application of probiotics as a pharmaceutical agent is recommended.

Details

British Food Journal, vol. 115 no. 11
Type: Research Article
ISSN: 0007-070X

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Article
Publication date: 7 September 2018

Nasim Abedimanesh, Alireza Ostadrahimi, Saeed Abedimanesh, Behrooz Motlagh and Mohammad Hossein Somi

The purpose of this study is to explore the association of serum retinol and number of circulating inflammatory cells and disease activity in patients with ulcerative colitis.

Abstract

Purpose

The purpose of this study is to explore the association of serum retinol and number of circulating inflammatory cells and disease activity in patients with ulcerative colitis.

Design/methodology/approach

A total of 60 patients with ulcerative colitis were enrolled in a cross-sectional pilot study. Patients were recruited from specialized clinic of Tabriz University of Medical Sciences, Iran between April and August 2015. Mayo clinic index was used to assess clinical disease activity score. Blood samples were collected. Serum retinol was assessed using HPLC to determine vitamin A status. Complete blood count and lymphocyte phenotyping were performed by automated hematology analyzer and flow-cytometric analysis, respectively.

Findings

According to Mayo scoring, 68.33 per cent of patients had mild and 31.66 per cent had moderate or severe disease activity. About 43.33 per cent of patients were vitamin A deficient, with 23.33 per cent having moderate to severe deficiency (serum retinol < 20 µg/dl). Lower levels of serum retinol and higher count and percentages of CD3+, CD8+ T cells and neutrophil to lymphocyte ratio were statistically associated with disease activity according to univariate analysis (p = 0.002, 0.037, <0.001, 0.031, 0.002 and 0.039); however, in binary logistic regression, only lower levels of serum retinol were independently associated with disease activity with a OR of 0.564 (p = 0.021; 95 per cent CI 0.35-0.92).

Originality/value

Vitamin A deficiency was detected in this study population. Patients with moderate to severe disease activity demonstrated lower serum retinol, higher CD8+ T cells and neutrophil to lymphocyte ratio compared to patients with mild disease activity.

Details

Nutrition & Food Science, vol. 49 no. 2
Type: Research Article
ISSN: 0034-6659

Keywords

Content available
Article
Publication date: 17 July 2009

Abstract

Details

Nutrition & Food Science, vol. 39 no. 4
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 9 November 2015

Darla D. O'Dwyer and Ray L. Darville

The purpose of this paper was to investigate the impact of specific carbohydrate restriction (polysaccharides and disaccharides) in the form of the specific carbohydrate…

Abstract

Purpose

The purpose of this paper was to investigate the impact of specific carbohydrate restriction (polysaccharides and disaccharides) in the form of the specific carbohydrate diet (SCD) in treating irritable bowel syndrome (IBS).

Design/methodology/approach

A female patient diagnosed with diarrhea predominant IBS was assigned to the SCD for six months. The diet occurred in phases and was advanced based on the individual’s tolerance level under the guidance of a registered dietitian. Quality of life was measured by a pre- and post-IBS severity score questionnaire. Gastrointestinal symptoms were measured by self-assessment of IBS symptoms using a seven-point Likert-like scale, with −3 = substantially worse to +3 = substantially better. Probiotics were consumed throughout the duration of the study.

Findings

The quality of life severity score significantly improved from a severity of 315 (with 500 being the most severe) to 15. The initial symptoms from the first day on the diet compared to the total period for bloating, abdominal pain/discomfort, flatulence/wind, diarrhea, bowel urgency, stool consistency, stool frequency, energy levels, incomplete evacuation and abdominal rumbling were improved significantly (p < 0.0005). The SCD diet significantly improved the quality of life and IBS symptoms in a female patient with IBS-diarrhea.

Originality/value

This study is the first of its kind to evaluate the efficacy of the SCD to treat IBS. The SCD should be considered a therapeutic option to treating IBS after fermentable carbohydrate restriction.

Details

Nutrition & Food Science, vol. 45 no. 6
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 1 August 1997

Mabel Blades

Notes that people with food allergies and intolerances may not always receive great sympathy from health professionals. Underlines the importance of treating these…

Abstract

Notes that people with food allergies and intolerances may not always receive great sympathy from health professionals. Underlines the importance of treating these problems seriously and sets out definitions of intolerance, allergy and aversion. Outlines a range of disorders such as asthma and rheumatoid arthritis where food allergy or intolerance may be implicated, and also looks at a range of foods which seem to cause problems. Lists methods of diagnosis for food allergy and intolerance and concludes that the number of sufferers is increasing.

Details

Nutrition & Food Science, vol. 97 no. 4
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 29 May 2007

Emily A. Wilson and Barbara Demmig‐Adams

The purpose of this paper is to provide a comprehensive overview of multiple functions and their underlying mechanisms for two common spices, garlic and onion, containing…

Abstract

Purpose

The purpose of this paper is to provide a comprehensive overview of multiple functions and their underlying mechanisms for two common spices, garlic and onion, containing organosulphur compounds.

Design/methodology/approach

Literature review of chemistry, physiology, molecular biology, clinical studies.

Findings

Both garlic and onions exert their effects on human health via multiple different functions, including antioxidant, anti‐inflammatory, and antibacterial properties. The organosulphur compounds in these spices scavenge oxidizing agents, inhibit the oxidation of fatty acids, thereby preventing the formation of pro‐inflammatory messengers, and inhibit bacterial growth, via interaction with sulphur‐containing enzymes.

Research limitations/implications

Currently available information on the optimal amount for consumption for each spice is insufficient.

Originality/value

This review is unique in its comprehensive nature, considering multiple different effects of the spices examined as well as multiple studies from molecular to clinical approaches.

Details

Nutrition & Food Science, vol. 37 no. 3
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 28 April 2020

Mina Movahedian, Jamal Rahmani, Zahra Yari, Samaneh Rashvand and Azita Hekmatdoost

The purpose of this paper is to evaluate the possible relationship of dietary glycemic index (GI) and glycemic load (GL) with ulcerative colitis (UC) risks because there…

Abstract

Purpose

The purpose of this paper is to evaluate the possible relationship of dietary glycemic index (GI) and glycemic load (GL) with ulcerative colitis (UC) risks because there is insufficient evidence on the association of GI and GL with UC incidences.

Design/methodology/approach

In this case–control study, dietary GI and GL of 62 patients with histology-confirmed UC and 124 controls were assessed using a validated semi-quantitative food frequency questionnaire. The primary outcome measure was the association between dietary GI and GL and UC risk.

Findings

In age-adjusted and unadjusted models, there was no statistically significant association between dietary GI and GL and UC risk. However, after adjusting for all known covariates, the odds ratio of UC in third tertile of GI was 2.86 folds higher than first tertile (95% CI: 1.02–8.00, p for trend = 0.04). In the case of GL, when the confounders were adjusted, although subjects in the third tertile were at 2.70 times higher risk of having UC than those in the first tertile (95% CI: 0.72–10.15, p for trend = 0.15), the association was not statistically significant.

Originality/value

In conclusion, the findings indicate a positive relationship between dietary GI and risk of UC. Further prospective studies are needed to elucidate if the findings are consistent, in addition to experimental studies to explore the potential mechanisms of this association.

Details

Nutrition & Food Science , vol. 51 no. 1
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 13 June 2008

M.S. Sajid, A. Tonsi and M.K. Baig

The purpose of this article is to discuss the value of health‐related quality of life (HR‐QOL) measurement and describe its development with a few examples.

Abstract

Purpose

The purpose of this article is to discuss the value of health‐related quality of life (HR‐QOL) measurement and describe its development with a few examples.

Design/methodology/approach

The methodology is a literature review of various articles published in the last 25 years on health‐related quality of life.

Findings

HR‐QOL tools are health status instruments, which are utilized to assess the changes in the health status of patients. These surveys are of increasingly importance as healthcare providers are challenged to justify treatment approaches and rationale for any intervention. Objective criteria can be used to determine whether there is clinical evidence of disease. However, the impact of disease on the individual's life is not included in such a clinical assessment. The use of validated and reliable health instruments is directed at measuring this impact in a reproducible and valid fashion. In patient‐centred research, “experimental” conditions are constantly changing because human beings with values, feelings, perspectives and social relationships are being treated. It is especially important to use valid measurement tools when assessing these impacts.

Originality/value

This article is written from the authors' own experience and knowledge and adds those benefits to the literature already available.

Details

International Journal of Health Care Quality Assurance, vol. 21 no. 4
Type: Research Article
ISSN: 0952-6862

Keywords

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