Diet, microbiota and inflammatory bowel disease: review

Bruna Luísa Radavelli (Department of Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, Brazil)
Priscila Berti Zanella (Department of Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, Brazil)
Amanda Souza Silva (Department of Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, Brazil)
Valesca Dall’Alba (Department of Nutrition, Federal University of Rio Grande do Sul, Porto Alegre, Brazil)

Nutrition & Food Science

ISSN: 0034-6659

Publication date: 12 March 2018

Abstract

Purpose

The purpose of this paper is to verify the possible associations between dietary components and the intestinal microbiota in clinical parameters of inflammatory bowel disease.

Design/methodology/approach

In this review, a search in PubMed and Bireme databases was performed. The authors included randomized clinical trials published between 2005 and 2017, only in adult humans with Crohn’s disease or ulcerative colitis.

Findings

Six articles were included by the end of the search. The most widely used intervention was the use of prebiotics, including fructooligosaccharides or fructooligosaccharides with inulin, followed by probiotics. The main findings regarding the microbiota were the increase in the total amount of bacteria and variability (phyla). Clinically, there was improvement in inflammation seen in parameters such as C-reactive protein, interleukins and tumor necrosis factor alpha.

Originality/value

Dietary interventions, especially from symbiotics, can modulate the microbiota, mainly in relation to time, when compared pre- and post-supplementation, and this positively interferes with clinical parameters of inflammatory bowel diseases. However, the studies were quite heterogeneous in population, methodology, intervention, mycobiota analysis and inflammatory markers.

Keywords

Citation

Radavelli, B., Zanella, P., Silva, A. and Dall’Alba, V. (2018), "Diet, microbiota and inflammatory bowel disease: review", Nutrition & Food Science, Vol. 48 No. 2, pp. 259-271. https://doi.org/10.1108/NFS-07-2017-0156

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Publisher

:

Emerald Publishing Limited

Copyright © 2018, Emerald Publishing Limited

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