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Agonistic antagonistic system theory and praxis were born in the medical field, but may be defined now from an epistemological and biomathematical point of view. Describes new developments in agonistic antagonistic (AA) theory and presents new applications. These include new mathematical approaches that involve variable parameters and partial derivatives in models for the regulation of AA couples (MRAAC). Gives new biomedical applications and, in explanation, a mechanism called “pathological homeostasis” (PH) is introduced. Also provides details of therapeutical trials. Suggests systems science or cybernetical strategies which are likely to have a broad field of application, particularly among decision makers in general.

This paper aims to assess the impact of curcumin supplementation body mass index and glycemic indices in women with polycystic ovary syndrome (PCOS).

A systematic search of the literature was conducted in PubMed, Scopus and ISI web of science to identify all randomized controlled trials (RCTs) published from the earliest record up to February 2021. The authors used a random-effects model to estimate pooled effect sizes.

A total of four potentially related clinical trials met the inclusion criteria which included a total of 198 participants. Random-effects meta-analysis showed significant effects of curcumin on fasting blood sugar (FBS) (−3.62 mg/dl, 95% CI [−5.65, −1.58], p-value < 0.001, I² = 0.0%), insulin level (−1.67 µU/mL, 95% CI [−3.06, −0.28], p-value = 0.018, I² = 0.0%) and homeostasis model of assessment insulin resistance (HOMA-IR) (−0.42, 95% CI [−0.76, −0.09], p-value < 0.01, I² = 0.0%). No evidence of publication bias was discovered in the meta-analyses.

Present systematic review and meta-analysis of RCTs showed beneficial effects of curcumin consumption on FBS, insulin level and HOMA-IR in patients with PCOS. However, further large-scale studies are needed to confirm these results.

The purpose of this study was to investigate the effects of prickly pear (Opuntia ficus indica (OFI)) nopalitos on body weight, food consumption, arterial blood pressure, glucidic homeostasis, cholesterol metabolic pathway and tissues redox status in type 2 diabetic (T2D) rats fed a high-fat diet (HFD).

Rats were fed by a HFD containing 30 per cent sheep fat for 10 weeks, after which they were rendered diabetic by an injection of a low dose of streptozotocin (STZ) (35 mg/kg). The diabetic rats were then divided into two groups. The first group consumed the HFD supplemented with 5 per cent (g/100 g diet) of freeze-dried OFI nopalitos (HFD-OFI), and the second group received the HFD without supplementation (HFD).

OFI nopalitos treatment decreased significantly arterial diastolic (−20%; p = 0.0001) and systolic (−16%; p = 0.0001) pressures, glycemia (−14%; p = 0.03), insulinemia (−50%; p = 0.04), glycated hemoglobin (−49%; p = 0.003), homeostasis model assessment insulin resistance (−67%; p = 0.03), cholesterolemia (−31%; p = 0.003), very-low and low-density lipoprotein cholesterol (−38%; p = 0.002 and −63% p = 0.0002, respectively); thiobarbituric acid reactive substances and lipid hydroperoxide contents, respectively, in liver (−26% p = 0.02, −20% p = 0.02), adipose tissue (−30% p = 0.002, −25% p = 0.001), muscle (−29% p = 0.003, −25% p = 0.008) and kidney (lipid hydroperoxides only (−28%; p = 0.001) but increased high-density lipoprotein (HDL₂) cholesteryl esters (+61%; p = 0.0001), serum lecithin: cholesterol acyltransferase activity (+21%; p = 0.006) and antioxidant enzymes activities (superoxide dismutase, glutathione peroxidase and catalase) of some tissues (liver, adipose tissue, muscle and kidney).

Freeze-dried OFI nopalitos improves arterial blood pressure, glycemic control, metabolic pathway of cholesterol and redox status in T2D rats.

The purpose of this paper is to provide a framework for understanding value‐added and abuse prevention activities in business processes.

The paper considers business processes as a regulation mechanism that an organization uses to survive and flourish in its environment. It proposes a theoretical framework based on the concept of homeostasis, the maintenance of identity in a changing world. In this framework the paper classifies business processes into three levels (strategic, operational, regulative) and analyse the relationships between these three levels. Based on this framework, the paper extends the “Use and Misuse Cases” technique to support modelling of value‐added and abuse prevention activities.

The main finding is the importance of considering business processes as regulation mechanisms. Traditionally, business processes are analysed through the goals they are designed to achieve. This paper analyses what the organization aims at maintaining. This makes it possible to explicitly model the potential abuses (threats) to business processes and their associated corrective measures (regulative processes).

Use of this framework enables process designers to explicitly model abuse prevention activities, even though they are traditionally considered as not participating in customer value creation. This should lead to better‐fitting business processes.

The framework is useful because it provides a theoretical justification for the value creation and abuse prevention activities that can be found in business processes. The three levels that we use to analyse business processes (strategic, operational and regulative) constitute an innovation in business process modelling where only two levels (strategic and operational) have been considered thus far. Few, if any, business process theoretical frameworks provide this kind of rationale for abuse prevention activities.

Drive and motivation are central to affective neuroscience. Here, we describe the development of conceptualizations from early behaviorist theories to contemporary theories linking motivation closely to reward. Current experimental data suggest key roles of drive and motivation in the wanting, liking, and learning processes underlying the pleasure cycle supporting survival of individuals and species. In particular, the underlying functional neuroanatomy of drive and motivation is now becoming clearer in humans and other mammals, which provides hope for novel more effective interventions for the pervasive problems of drive and motivation in affective and addictive disorders.

This chapter explores the ways in which cybernetics influenced the works of F. A. Hayek from the late 1940s onward. It shows that the concept of negative feedback, borrowed from cybernetics, was central to Hayek’s attempt to explain the principle of the emergence of human purposive behavior. Next, the chapter discusses Hayek’s later uses of cybernetic ideas in his works on the spontaneous formation of social orders. Finally, Hayek’s view on the appropriate scope of the use of cybernetics is considered.

This conceptual article presents a schematic for use with extended cybernetic recursion in living systems and applies it to the issue of hyper vigilance as a demonstration of its utility.

The test-operate-test-exit (TOTE) schematic of Miller et al. (1960) is critically evaluated along with other schematics, including those of ordered cybernetics, and a new schematic is proposed, a recursive test-operate-test (rTOT), which emphasizes teleological purpose and hierarchical structure. The background psychophysiology of trauma is reviewed and then rTOT is applied to hyper vigilance, a cardinal component of post-traumatic stress disorder (PTSD).

Once the schematic was developed, it was applied to the behavior of hyper vigilance. Other applications are suggested.

As demonstrated, the rTOT schematic has potentially wide application because of its pragmatic and detailed structure.

The rTOT requires careful consideration of teleological purposes for its application and is simple enough, but also complex enough, for relevant utilization. Its compact nature and adjustable hierarchy scope are good mini-max complexity solutions for cybernetic, information modeling schematics.

The revealed teleological purpose of the trauma adaptation of hyper vigilance presents significant alternative formulation options for prevention and intervention.

While the rTOT schematic is derived from previous schematics, it is original in its emphasis on information processing, the teleological aspects of extended recursion and on the provision of a hierarchical structure for those recursions. It is considerably more compact than other schematics associated with the ordered cybernetics literature. The explication of the adaptation model for post-trauma consequences is significantly enhanced by the rTOT application.

Homeostatics is a new science, which, it is considered, advances at a rate which may supersede cybernetics. It reveals the informational laws that govern the living matter and projects them on to all systems. Homeostasis (Gk: homoios – “similar” and stasis – “state” or “standing”) can be represented as a dynamic maintenance of assigned values, parameters, functions and trends of development (decay).

The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. The deterioration of endoplasmic reticulum (ER) homeostasis is called ER stress. Glucose-regulated protein-78 (GRP-78) and X-box binding protein-1 (XBP-1) are key markers of ER stress and the therapeutic targets of diseases. Sterol regulatory element binding protein-1c (SREBP-1c) is the most important transcription factor that regulates the expression of enzymes for fatty acid synthesis. The purpose of this paper is to research the effects of L-carnitine and trans-chalcone on ER stress and oxidative stress parameters, and to explore the therapeutic potential of L-carnitine and trans-chalcone molecules.

Forty male wistar albino rats randomly selected were divided into five groups. All groups are fed with standard chow (ad libitum). While Group I was fed with drinking water, Group II, III, IV and V were fed with water containing 15% HFCS. L-carnitine was given to Group IV and trans-chalcone to Group V, and both were dissolved with DMSO and given intraperitoneally. Group III was not given anything additional.

While the amount of water consumption of HFCS-fed rats has increased, the amount of feed consumption has decreased. The weights of rats in Group II and Group III have increased significantly compared to Group I (p = 0.001, p = 0.001 respectively). In Group III, GRP78, XBP-1; malondialdehyde level (p < 0.001, p = 0.001, p = 0.041); total cholesterol, triglyceride, LDL levels (p = 0.001, p < 0.001, p = 0.009, p = 0.001, respectively) have increased significantly.

To the best of the authors’ knowledge, this study is the first report to show that excessive HFCS consumption causes oxidative stress and ER stress. The antioxidant and antiobesity properties of trans chalcone have been demonstrated. Extensive experimental and clinical studies should be conducted.

This paper aims to depict the mechanistic role of vitamin D on dementia prevention, relief of the severity and the complication of the disease. All papers indexed in scientific databases, including Scopus, Elsevier, PubMed, Embase and Google Scholar between 2000 and 2021 were extracted and discussed. To present the mechanistic role of vitamin D in declining the severity of dementia, keywords including dementia, vitamin D, oxidative stress, inflammation, amyloid beta-Peptides were used.

Dementia is a prevalent cognitive disorder worldwide, especially in elderly people, which is accompanied by serious disabilities. Besides genetic, biological and lifestyle factors are involved in the incidence of dementia. An unhealthy diet along with micronutrient deficiencies are among modifiable factors. Vitamin D is one of the important micronutrients in brain health. Besides the involvement in gene expression, bone mineralization, apoptosis, inflammation, skeletal maturation, neurotropic action and hemostasis of phosphate and calcium, vitamin D also exerts neuroprotective effects via genomic and non-genomic pathways.

Vitamin D up-regulates the expression of various genes involved in dementia incidence via various mechanisms. Decreasing oxidative stress and the neuro-inflammatory cytokines levels, regulation of the expression of alternated Proteins including Tau and Amyloid-ß, calcium homeostasis in the central nervous system and also vascular are considered main mechanisms.

Considering the importance of diet in preventing dementia, adherence to a healthy diet that provides essential nutrients to brain function seems to be urgent. Controlling serum levels of vitamin D periodically and providing vitamin D by related sources or supplements, if there is a deficiency, is recommended. Future studies are needed to clarify other related mechanisms.