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Tunisia has been living a decade of democratic transition since 2011. In this new context, the civil society has been fervently expressing claims for democracy and social justice through creating thousands of non-for-profit organisations (NPOs) (23,456 NPOs in 2020 against 9,000 established in 30 years up to 2010). However, this shift seems to be misleading, as only 3,000 NPOs are actually active, indicating that NPOs are struggling to sustain their activities and ensure their survival. The purpose of this study is to uncover the factors hindering NPOs’ activities and survival.

Semi-structured interviews were carried out using a purposive sample of 32 NPOs members in two main economic and touristic cities – Tunis and Sousse – selected using the snowball method. A considerable amount of qualitative data was produced (400 pages of text). This seems representative of Tunisian citizens’ inclination to protest in the new prevailing political and social context. The data collection benefited from the freedom of speech gained after the 2011 civilian uprising as interviewees were enthusiastic in voicing their opinions.

Two main categories of inhibitors were identified. First, endogenous inhibitors including inhibitors under the control of the NPO (i.e. use of illegal and foreign sources of funding, limited financial resources, unavailability of NPOs’ members, short term planning, conflicts between managers, autocratic leadership, organisational support, activities diversification and organisational justice, leadership and communication skills, “NPO culture”, members’ opportunistic behaviour and generation gap), inhibitors related to NPOs inter-relationships: stiff competition, unfair and dishonest competition, lack of collaboration, trust and communication between NPOs. Second, exogenous inhibitors i.e. perceived unethical practices and image transfer, economic crisis, foreign funding sources and the media.

This study has some limitations mainly due to the sample size and characteristics of the selected interviewees. In addition, data was collected in only two regions (Tunis and Sousse). Therefore, the results may lack generalisability.

The findings highlight the critical impact of the inhibitors under the control of NPOs compared to those out of their control. NPOs in a crisis context could overcome these inhibitors by ensuring congruence between the NPOs’ mission, objectives and activities and designing suitable marketing strategies.

This study contributes to elucidating this complex circular system of exchange and its inhibitors in a challenging and understudied context. It offers support to Bagozzi’s (1974, 1975, 1994, 2011) calls for uncovering the factors constraining or facilitating exchanges that have an impact going beyond the relationship between three or more partners and the conditions that govern these exchanges. Moreover, and to the best of the authors’ knowledge, this is the first empirical attempt to support Bagozzi’s (1994) conceptualisation. It also brings an update to NPOs’ data and marketing strategy in a region near the crossroads of Middle Eastern, North African and Western influences.

The purpose of this paper is to screen for iron bioavailability and absorption-promoting activity in selected herbs. Evidence is needed to promote and practice food-based strategies such as use of plants or their parts for treating iron deficiency anemia.

Eight Indian herbs, considered to be iron rich and/or hematinic, namely, Boerhavia diffusa, Trachyspermum ammi, Amaranthus paniculatus, Lepidium sativum, Medicago sativa, Asparagus racemosus, Sesamum indicum and Piper longum, were selected. Their mineral composition and phytate and tannin contents were analyzed. Endogenous iron bioavailability was assessed in human enterocyte cell line model, Caco-2 cells, using cellular ferritin induction. Iron absorption-promoting activity was tested similarly in two herbs and their mineral extract by the addition of exogenous iron or ascorbic acid.

Based on compositional analysis, B. diffusa, L. sativum and T. ammi had high iron (> 40 mg/100 g) and tannin/phytate. A. paniculatus, M. sativa, P. longum, S. indicum had low iron (10-15 mg/100 g) with high phytate and tannin. A. racemosus had 38 mg/100 g iron and low phytate and tannin. None of the herbs induced Caco-2 cell ferritin, indicating poor endogenous iron bioavailability. Mineral solutions of, two contrasting herbs (inhibitor content), B. diffusa and A. racemosus induced ferritin with ascorbic acid and not with exogenous iron, suggesting that these are devoid of iron absorption-promoting activity.

Incorporation of such herbs in diets may enhance iron content but not its bioavailability.

Selected edible herbs have been screened for iron bioavailability and its absorption-promoting activity. This has implications in planning evidence-based strategies to correct iron deficiency in general population.

Wearable health technologies (WHTs) show promise in improving the health and well-being of the aging population because they promote healthy lifestyles. They can be used to collect health information from users and encourage them to be physically active. Despite potential benefits of WHTs, recent studies have shown that older people have low continued use intention toward WHTs. Previous work on this topic is disjointed, and new theoretical viewpoints are required.

The authors propose an enablers and inhibitors perspective to model factors influencing continued use intention of WHTs among the elderly. To test the model, we collected data from Chinese elderly (N = 295) who had prior experience using WHTs.

The study results show that social value is the strongest enabler of continued WHT use, and emotional and epistemic values and device quality also increase use continuance. Inertia and technology anxiety were identified as significant inhibitors. A post hoc importance performance map analysis revealed that while emotional value is a highly significant predictor of continued WHT use, existing WHTs do not stimulate such value in our sample.

The research findings illustrate the importance of incorporating user resistance in technology acceptance studies in general and WHT usage studies in particular. This study contributes by providing an integrative model of technology continued use intention for the elderly along with practical implications for policymakers.

A limited number of prior studies have taken both enablers and inhibitors into account when explaining continued WHT use intention among the elderly. This paper fills this research gap and contributes to the WHT literature by considering both enablers and inhibitors in the same model. Moreover, this study contributes to the ongoing research on WHT, and more broadly, gerontechnology use among the elderly.

The purpose of this paper is to examine why large firms often fail to develop disruptive innovations. This study identifies several key inhibitors or barriers that hinder those developments. A conceptual model is presented that examines the interrelationship and interdependence of these inhibiting factors, in an effort to provide a better understanding of how companies can improve their disruptive innovation capabilities.

This paper focuses on disruptive innovation rather than incremental innovation and is limited to research findings on large corporations. Recently published works (1990‐2004) have examined success factors as the determinants of disruptive innovation capability. A complementary approach is to examine the inhibitors of disruptive innovation and investigate their interrelationship and interdependence. The study is based on an extensive review of literature available, and examines both internal and external inhibiting factors to develop a conceptual model of disruptive innovation capabilities.

Many large corporations fail to develop disruptive innovations. It is argued that the basic constraints to creating successful disruptive innovation stem in large part from several inhibiting factors, and we have identified different clusters of interrelated and partly‐interdependent inhibitors: the inability to unlearn obsolete mental models, a successful dominant design or business concept, a risk‐averse corporate climate, innovation process mismanagement, lack of adequate follow‐through competencies and the inability to develop mandatory internal or external infrastructure. The conceptual disruptive innovation capability model provides a better understanding of the interrelationship among these limiting factors. There is still a vast gap between intention and actual disruptive innovation capability. Developing distinctive capabilities to bridge this gap should be an integral part of a company's strategy for growth.

This paper is based on an extensive review of literature on disruptive innovation barriers. In it is proposed a conceptual interrelationship model of innovation inhibitors as a basis for determining and improving a company's disruptive innovation capability. It is suggested that, in addition to the theory presented in this paper, further empirical research studies be carried out to validate the key inhibitors of our conceptual model, their interrelationship and interdependence, and the impact on disruptive innovation development.

The study is intended to provide practical insight into clusters of inhibiting factors that prevent large organisations from improving their disruptive innovation capability. The conceptual model facilitates the development of distinctive competencies and mindsets to improve these capabilities.

Advanced glycation end products (AGEs) are continuously formed in the body during normal metabolism and ageing through a non‐enzymatic glycosylation reaction between proteins and carbohydrates, known as the Maillard's reaction. Many AGEs are capable of forming cross‐links between proteins and most of them have fluorescent properties. Production of AGEs is markedly increased in diabetes mellitus where they play a pathological role. The aim of the present study is to investigate the possible inhibitory effects of urea, metformin and ascorbic acid on in vitro formation of fluorescent AGE products by comparing their inhibitory capacity with a well‐known AGEs inhibitor, aminoguanidine.

Experiments were carried out using bovine serum albumin and D (+) glucose to produce glycated bovine serum albumin, a fluorescent AGE. Fluorometer analysis was then performed to measure AGEs production and fluorescent intensity was compared between glycated samples with and without the inhibitors.

Aminoguanidine which is known to form guanidine‐carbonyl adduct, reversing the glycation process. was found to inhibit AGEs formation by 57 per cent. Although urea and metformin inhibits glycation by the same route, it was the most effective inhibitor among all four inhibiting agents used. Ascorbic acid, an antioxidant, also inhibits fluorescent AGEs by 52 per cent. It was also a good cross‐link inhibitor. Urea showed an inhibitory effect of 27 per cent. It is suggested that urea formed in the body might be a possible natural protector of AGEs formation. Finally, metformin, an antidiabetic drug inhibits AGEs production by only 12 per cent. It is known to rather increase peripheral sensitivity to insulin and lower blood‐glucose level.

The paper shows that aminoguanidine is the most efficient inhibitor and ascorbic acid supplementation could prove useful in diabetic patients to remove reactive species generated in the Maillard's reaction.

The purpose of this study is to explore the exogenous and endogenous drivers of the high-growth of Unicorn start-ups along their life cycle, with a particular focus on Unicorns in the fintech industry.

The study employs an explorative longitudinal analysis with a matched-pair of two cases of Unicorns start-ups with similar antecedent features to understand holistically drivers over the longer term.

High-growth patterns over the longer term are the result of a combined industry- and company-life cycle perspective. Drivers and growth patterns vary significantly according to the time of entry in the industry and its development status. The findings are systematised within a set of propositions to be tested in future research.

The limitations lie in empirical evidence, as the analysis is limited to one-matched-pair. The revealed Unicorns' drivers for long-term growth might encourage future research to further investigate these drivers on a larger scale.

The study offers practical recommendations for start-ups with high-growth ambitions and advice to policy makers regarding the development of tailor-made support programs.

The study significantly extends extant work on growth and high-growth by examining endogenous and exogenous triggers over time and by linking the Unicorn-life cycle to the industry life cycle, an approach which has, to the best of the authors’ knowledge, not yet been applied.

The main purpose of this study resides essentially in the development of a new tool to quantify the biomass in the bioreactor operating under steady state conditions.

Modeling is the most relevant tool for understanding the functioning of some complex processes such as biological wastewater treatment. A steady state model equation of activated sludge model 1 (ASM1) was developed, especially for autotrophic biomass (XBA) and for oxygen uptake rate (OUR). Furthermore, a respirometric measurement, under steady state and endogenous conditions, was used as a new tool for quantifying the viable biomass concentration in the bioreactor.

The developed steady state equations simplified the sensitivity analysis and allowed the autotrophic biomass (XBA) quantification. Indeed, the XBA concentration was approximately 212 mg COD/L and 454 mgCOD/L for SRT, equal to 20 and 40 d, respectively. Under the steady state condition, monitoring of endogenous OUR permitted biomass quantification in the bioreactor. Comparing XBA obtained by the steady state equation and respirometric tool indicated a percentage deviation of about 3 to 13%. Modeling bioreactor using GPS-X showed an excellent agreement between simulation and experimental measurements concerning the XBA evolution.

These results confirmed the importance of respirometric measurements as a simple and available tool for quantifying biomass.

The purposes of this study were to identify exogenous factors that would depress synthesis of saturated fats and enhance synthesis of unsaturated fats in the dairy cow’s mammary gland. Certain long‐chain exogenous fatty acids are known to modulate endogenous fat synthesis within tissues. We analyzed the effects of two different long‐chain monounsaturated fatty acids, namely oleic acid and trans‐vaccenic acid (TVA), on activities of acetyl‐CoA carboxylase (ACC), fatty acid synthetase (FAS) and stearoyl‐CoA desaturase (SCD) in bovine mammary epithelial cell cultures. The study was done using an established bovine mammary epithelial cell line, the MacT cells. ACC (EC 6.4.1.2) and FAS (EC 2.3.1.85) are two major enzymes involved in biosynthesis of saturated fatty acids in eucaryotic cells. SCD (EC 1.14.99.5) is the enzyme catalyzing the critical committed step in biosynthesis of unsaturated fatty acids from their saturated precursors. Data indicated depression of activity of enzymes responsible for mammary synthesis of saturated fatty acids (ACC and FAS), along with a simultaneous enhancement of mammary desaturase activity, by TVA.

It is the purpose of this paper to analyze drivers of organizational change as well as their inhibitors with a particular focus on the influence of management and the environment.

The question will be addressed with the help of the case study of the New York Stock Exchange's (NYSE) move towards electronic trading. A system dynamical analysis of underlying forces and feedback will help elucidate the strength of mechanisms that drive or impede change.

The stepwise analysis of the model in accordance with different model boundaries reveals that neither the environment nor endogenous pressures from stakeholders and management alone are able to replicate the reference behavior; all three model elements are necessary to simulate the process of the NYSE's radical move. Additionally, with only minor changes in the underlying assumptions, the model is able to show the contrasting behaviors predicted by different streams of literature.

The paper's contribution is limited by the number of but one exemplary case it provides.

The paper contributes to one of the most prominent topics in the organizational change literature and adds a valuable example of representative drivers of change. It opens the black box of organizational change by its focus on the relationship of structure and behavior as well as on the process of change.

The ability of a manufacturing system to respond to customer demand in a timely fashion is widely accepted as a source of competitive advantage. While quick response concepts at system level have been widely discussed in a range of industry sectors, such as textile, electronics and fast moving consumer goods, few studies so far have specifically investigated the responsiveness of the component supply chain. This exploratory study hence aims to reconcile the considerable ambiguity that exists around the concept of supplier responsiveness, supported by an empirical investigation into the automotive parts industry.

The study analyses the responsiveness of first‐tier automotive suppliers in Europe. The research is based on a multi‐method approach comprising of a survey, coupled with in‐depth processing mapping and complimenting interviews of production control staff at a subset of the surveyed companies.

The findings suggest that supplier responsiveness is constrained by both endogenous factors originating from within their own manufacturing operations, as well as exogenous factors related to both their respective up‐stream and downstream tiers. Furthermore, the study highlights how first‐tier suppliers are “squeezed” between demanding vehicle manufacturers on the one hand, and an unresponsive raw material supply base on the other, constraining their overall ability to respond to changing market requirements.

The conclusions derived from this research are bound by the sample these are drawn from, and additional large‐scale analyses are suggested as further research.

While the concept of “responsiveness” has been widely discussed in the supply chain literature, this debate has largely remained in the realms of qualitative description. Few studies have empirically addressed the issue of supply chain responsiveness, and if so, often focused on a subset of factors (e.g. schedule variations) only. In this paper, an holistic approach to responsiveness is adopted that aims at identifying the key variables that impact on supply chain responsiveness, as well as providing quantitative evidence to support these claims.