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The purpose of this study is to systematically review the existing literature on the blood supply chain (BSC) from a network design perspective and highlight the research gaps in this area. Moreover, it also aims to pinpoint new research opportunities based on the recent innovative technologies for the BSC network design.

The study gives a comprehensive systematic review of the BSC network design studies until October 2021. This review was carried out in accordance with preferred reporting items for systematic reviews and meta-analyses (PRISMA). In the literature review, a total of 87 studies were analyzed under six main categories as model structure, application model, solution approach, problem type, the parties of the supply chain and innovative technologies.

The results of the study present the researchers’ tendencies and preferences when designing their BSC network models.

The study presents a guide for researchers and practitioners on BSC from the point of view of network design and encourages adopting innovative technologies in their BSC network designs.

The study provides a comprehensive systematic review of related studies from the BSC network design perspective and explores research gaps in the collection and distribution processes. Furthermore, it addresses innovative research opportunities by using innovative technologies in the area of BSC network design.

Ineffective management inventory of medical products such as blood and vaccines can create severe repercussions for hospitals, clinics or medical enterprises, such as surgery delays and postponements. Inventory sharing is a form of horizontal collaboration that can provide solutions to key actors of the healthcare supply chain (HSC), yet no prior study reviewed this topic.

This study conducts a systematic literature review of thirty-nine inventory-sharing studies in the context of HSCs published from 2012 until early 2022. The descriptive and thematic analyses include chronological distribution, geographical location, comparison between developed/developing regions, stakeholder and incident analysis.

Thematic analysis classified inventory sharing among five product supply chains (blood, medical supplies, medicines, vaccines and generic medical products). Benefits include shortage reduction, cost minimisation, and wastage mitigation. Barriers include (1) IT infrastructure, (2) social systems, (3) cost and (4) supply chain operations. Perishable inventory policies include Fresher-First (FF), Last-Expire-First-Out (LEFO), First-In-First-Out (FIFO) and First-Expire-First-Out (FEFO). The analysis also showed differences between developed and developing countries. The study identifies several future research opportunities that include (1) product utilisation rate, (2) cost reductions, (3) shortage mitigation and (4) waste reduction.

No prior study has systematically reviewed inventory sharing in HSCs to reveal benefits, barriers, patterns and gaps in the current literature. It makes five propositions and develops a research model to guide future research. The study concludes with theoretical and managerial implications.

This study aims to minimize the cost and time of blood delivery in the whole blood supply chain network (BSCN) in disaster conditions. In other words, integrating all strategic, tactical and operational decisions of three levels of blood collection, processing and distribution leads to satisfying the demand at the right time.

This paper proposes an integrated BSCN in disaster conditions to consider four categories of facilities, including temporary blood collection centers, field hospitals, main blood processing centers and medical centers, to optimize demand response time appropriately. The proposed model applies the location of all permanent and emergency facilities in three levels: blood collection, processing and distribution. Other essential decisions, including multipurpose facilities, emergency transportation, inventory and allocation, were also used in the model. The LP metric method is applied to solve the proposed bi-objective mathematical model for the BSCN.

The findings show that this model clarifies its efficiency in the total cost and blood delivery time reduction, which results in a low carbon transmission of the blood supply chain.

The researchers proposed an integrated BSCN in disaster conditions to minimize the cost and time of blood delivery. They considered multipurpose capabilities for facilities (e.g. field hospitals are responsible for the three purposes of blood collection, processing and distribution), and so locating permanent and emergency facilities at three levels of blood collection, processing and distribution, support facilities, emergency transportation and traffic on the route with pollution were used to present a new model.

The objective of this study is to mitigate the risks of a blood shortage. The authors designed two simulation studies to identify the superior methodology that can decrease the impact of a massive national donor shortage.

The simulation designs are triggered by the COVID-19 pandemic. The first simulation examines the company’s choice of strategic partners (regionally and nationally), and the second inspects creating a national coordinated effort to organize a pooled blood inventory that would require blood centers to contribute a small percentage of their monthly donations to become a member.

The results indicate that both methods can significantly manage the risk of stockouts regardless of the availability of safety inventory in a blood center; however, although more effective in reducing the number of shortages per month, creating a national blood pool causes the shortages to be recognized earlier than desired.

The authors contribute to the literature by focusing on the potential risk of blood shortage because it directly impacts healthcare, hospitals’ costs and their ability to provide care. Though a handful of researchers have targeted the study of the blood supply chain, there is not any article that is similar to this study.

Blood availability is critical for saving lives in various healthcare services. Ensuring blood availability can only be achieved through efficient management of the blood supply chain (BSC). A key component of the BSC is bloodmobiles, which are responsible for a significant portion of blood donation collections. The most crucial factor affecting the efficacy of bloodmobiles is their location selection. Therefore, detailed decision analyses are essential for the location selection of bloodmobiles. This study proposes a comprehensive approach to bloodmobile location selection for resilient BSCs.

This study provides a novel integration of the spherical fuzzy analytical hierarchy process (SF-AHP) and spherical fuzzy complex proportional assessment (SF-COPRAS) methodologies. In this framework, the criteria are weighted using SF-AHP. The alternatives are then evaluated using SF-COPRAS, employing criteria weights obtained from SF-AHP without defuzzification.

The results show that supply conditions and resilience are the most important criteria for a bloodmobile location selection. Additionally, the validation analyses confirm the stability of the solution.

This study presents several managerial implications that can aid mid-level managers in the BSC during the decision-making process for bloodmobile location selection. The critical factors revealed, along with their importance in choosing bloodmobile locations, serve as a comprehensive guide. Additionally, the framework proposed in this study offers decision-makers (DMs) an effective method for ranking potential bloodmobile locations.

This study presents the first application of multi-criteria decision-making (MCDM) for bloodmobile location selection. In this manner, several aspects of bloodmobile location selection are considered for the first time in the existing literature. Furthermore, from the methodological aspect, this study provides a novel SF-AHP-integrated SF-COPRAS methodology.

The purpose of this study is to comprehensively explore the impact of digitalization on healthcare supply chains (HcSCs). It seeks to understand how digital technologies enhance efficiency, transparency and responsiveness within these complex logistical systems. The study aims to provide a holistic view of the transformative potential of digitalization in the healthcare sector, with a particular focus on improving patient care and streamlining operational processes.

This research employs a systematic review methodology, carefully curating a selection of 45 relevant articles from 66 articles rigorously screened using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to provide a holistic view. It follows established systematic review protocols, incorporating a meticulous search strategy and precise keyword selection. The chosen research design enables a comprehensive examination of the existing body of knowledge concerning digital platforms, real-time tracking technologies, transparency and responsiveness in the context of HcSCs.

The findings of this study emphasize the pivotal role of digital technologies in reshaping HcSCs. Digital platforms, real-time tracking systems and technological integrations substantially enhance efficiency, transparency and responsiveness. Data-driven decision-making, improved communication and agile responses to dynamic demands are key aspects. These findings underscore the transformative impact of digitalization on healthcare logistics, emphasizing the potential for streamlined operations, enhanced patient care and more efficient resource allocation.

Despite the systematic methodology, this study is subject to certain limitations. It relies on existing literature, which may not cover the most recent developments in the rapidly evolving field of digital HcSCs. Furthermore, the study may be influenced by publication bias. The implications suggest the need for continued research to explore emerging digital technologies and their effects on healthcare logistics, ensuring that supply chains remain agile and responsive.

The practical implications of this research are significant for HcSC managers with insights into digital technologies to enhance transparency and collaboration and improve resource visibility. The integration of data analytics can lead to more effective inventory management and demand forecasting. Blockchain (BC) technology can ensure transparent and secure transactions, fostering trust among stakeholders. For practitioners, this research offers actionable guidance for navigating the digital age, promoting operational efficiency and ensuring a consistent supply of essential medical products. Researchers can use these insights as a foundation for further exploration into the potential of digitalization in HcSCs.

The social implications of digitalization in HcSCs are far-reaching. They encompass improved patient care, as digital technologies enhance the efficiency, transparency and responsiveness of supply chains. This translates to better access to critical medical supplies, potentially reducing healthcare disparities and benefiting underserved populations. Enhanced patient safety is a significant social outcome, as transparent and secure transactions enabled by technologies like BC mitigate the risks associated with counterfeit medications. Furthermore, digitalization builds trust among stakeholders, promotes accountability and fosters resilient healthcare systems, which are capable of responding effectively to crises. It also has the potential to make healthcare more affordable, contributing to increased healthcare access and transparency in decision-making.

The originality and value of this study lie in its comprehensive synthesis of diverse findings related to digitalization in HcSCs. While prior studies have examined isolated facets of digital technology adoption, this research provides a comprehensive overview. It contributes to a deeper understanding of the transformative potential of digitalization within the healthcare sector, offering practical approaches to enhance patient care and streamline operations.

The US platelet supply is almost exclusively dependent on apheresis donors who are “aging out.” As a result, blood centers and hospitals have been experiencing spot shortages and have resorted to transfusing low-dose platelets. This paper explores using whole blood–derived platelets (WB-PLTs) to supplement the apheresis platelet (APH-PLT) supply.

This paper reviews the history leading to the current state of the US platelet supply and includes the impact of recent events such as the COVID-19 pandemic and the implementation of the US Food and Drug Administration (FDA)-mandated bacterial mitigation strategies.

WB-PLTs represent a viable source of platelets that can be used to supplement the APH-PLT supply. Whole blood automation represents a new methodology to more easily prepare WB-PLTs. Advances in donor testing and screening as well as pre-storage leukoreduction have improved the safety of WB-PLTs to the same level as APH-PLTs. Blood services in the US and abroad transfuse WB-PLTs interchangeably in all patient populations.

This paper highlights how the US blood industry is essentially “sole-sourced” in terms of APH-PLTs. In this post-COVID-19 period, when most industries are building redundancies in their supply chains, blood centers should consider WB-PLTs as an additional source of platelets to bolster the US platelet supply.

Background: This paper examines the relationship between determinants of blood transfusion sustainability (BTS) that is master production scheduling (MPS) and blood production (BP) of Uganda. The study was founded on four objectives. The study looked at the direct relationship between MPS and the BTS, direct relationship between MPS and BP, direct relationship between BP and BTS. It also assessed how BP mediated the direct relationship between MPS and BTS. The study used a quantitative method.

Methods: A survey questionnaire was administered to collect data from 367 staff of regional blood banks and government university teaching hospital blood banks; and 213 were found to be usable. The main analysis was done using structural equation modeling.

Results: This study found that MPS had a negative and insignificant relationship with the BTS. The study found that relationship between MPS and BP was positive and significant. The study also found that relationship between BP and BTS was positive and significant. The study concluded that the effect of MPS on BTS was fully mediated by BP. It was recommended that blood banks seeking to achieve transfusion sustainability must understand the sector in which they operate. The various stakeholders in the blood supply chain ie blood banks, hospital blood banks, funding agents, ministry of health, must also integrate to enhance the transfusion sustainability. Blood banks performance measures essentially timely delivery was very critical for saving lives of patients in need of blood.

Conclusion: The study has provided a new conceptual framework that investigate the BP mediating effect on the relationship of MPS and BTS, and thus can serve as an incentive for more research to be conducted in this regard of different developing countries. The authors also proposed identifying the effect of other BP factors such as blood donor management and hospital transfusion practices on BTS.

Supply chain risk management can effectively reduce the loss of retailers. In this regard, retailers need to consider the competition risks of competitors in addition to the disruption risks. This paper designs a resilient retail supply chain network for perishable foods under the dynamic competition to maximize retailer's profits.

A two-stage mixed-integer non-linear model is presented for designing the supply chain network. In the first stage, an equilibrium model that considers the characteristics of perishable foods is developed. In the second stage, a mixed integer non-linear programming model is presented to deal with the strategic decisions. Finally, an efficient memetic algorithm is designed to deal with large-scale problems.

The optimal the selection of suppliers, distribution centers and the order allocation are found among the supply chain entities. Considering the perishability of agri-food products, the equilibrium retail price and selling quantity are determined. Through a numerical example, the optimal inventory period under different maximum shelf life and the impact of three resilient strategies on retailer's profit, selling price and selling quantity are analyzed.

As for future research, the research can be extended in a number of directions. First, this paper studies the retail supply chain network design problem under competition among retailers. It can be an interesting direction to consider retailers competing with suppliers. Second, the authors can try to linearize the non-linear model and solve the large-scale integer programming problem by exact algorithm. Finally, the freshness of perishable foods gradually declines linearly to zero as the maximum shelf life approaches, and it would be a meaningful attempt to consider the freshness of perishable foods declines exponentially.

This paper innovatively designs the resilient supply chain network for perishable foods under dynamic competition. The retailer's dynamic competition and resilient strategies are considered simultaneously when designing supply chain network for perishable foods. In addition, this paper gives insights into how to obtain the optimal inventory period and compare the retailer's resilient strategies.

Medicine distribution logistics pattern in pharmaceutical supply chains is a hot topic, which aims to predict applicable and efficient medicine distribution patterns so that the medicine can be distributed effectively. This research aims to propose a new method, named density-distance method, that works based on Kth proximity using patient features (including age, gender, education, inherent diseases, systemic diseases and disorders); geographical features (city, state, population, density, land area) and supply chain features (destination and transportation system).

The proposed method of this research consists of two main phases where in the first phase, quantitative data analytics will be carried out to find out the significant factors and their impacts on medicine distribution. Then, in the next phase, a new Kth-proximity density-distance-based method is proposed to determine the best locations for the wholesalers while designing a supply chain.

The findings show that the proposed method can effectively design a supply chain network using realistic features. In addition, it is found that while the distance-density aggregate index is applied, the wholesalers' locations will be different compared to classic supply chain designs. The results show that age, public hygiene level and density are the most influential during designing new supply chains.

The outcomes of this research can be used in the medicine supply chains to predict appropriate medicine distribution logistics patterns.

In this research, the machine learning method based on the nearest neighbor has been used for the first time in the design of the supply chain network.