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Early prediction of any type of cancer is important for the treatment of this type of disease, therefore, our target to evaluate whether monitoring early changes in plasma human epidermal growth factor receptor 2 (HER2) levels (using EIS), could help in the treatment of breast cancer or not? Human epidermal growth factor receptor 2 (HER2) overexpression is an important biomarker for treatment selection in earlier stages of cancers. The combined detection of the HER2 gene in plasma for blood cancer provides an important reference index for the prognosis of metastasis to other tissues. For this purpose, the authors fabricated and characterized a model wireless biosensor-based electrochemical impedance spectroscopy (EIS) for detecting HER2 plasma as therapeutics.

Most sensors generally are fabricated based on a connection between component of the sensors and the external circuits through wires. Although these types of sensors provide suitable sensitivities and also quick responses, the connection wires can be limited to the sensing ability in various devices approximately. Therefore, the authors designed a wireless sensor, which can provide the advantages of in vivo sensing and also long-distance sensing, quickly.

The biosensor structure was designed for detection of HER2, HER3 and HER-4 from lab-on-chip approach with six units of screen-printed electrode (SPE), which is built of an electrochemical device of gold/silver, silver/silver or carbon electrodes. The results exhibited that the biosensor is completely selective at low concentrations of the plasma and HER2 detection via the standard addition approach has a linearity plot, therefore, by using this type of biosensors HER2 in plasma can be detected.

This is then followed by detecting HER2 in real plasma using standard way which proved to have great linearity (R² = 0.991) proving that this technique can be used to detect HER2 solution in real patients.

Field-effect transistor (FET) has excellent electronic properties and inherent signal amplification, and with the development of nanomaterials technology, FET biosensors with nanomaterials as channels play an important role in the field of heavy metal ion detection. This paper aims to review the research progress of silicon nanowire, graphene and carbon nanotube field-effect tube biosensors for heavy metal ion detection, so as to provide technical support and practical experience for the application and promotion of FET.

The article introduces the structure and principle of three kinds of FET with three kinds of nanomaterials, namely, silicon nanowires, graphene and carbon nanotubes, as the channels, and lists examples of the detection of common heavy metal ions by the three kinds of FET sensors in recent years. The article focuses on the advantages and disadvantages of the three sensors, puts forward measures to improve the performance of the FET and looks forward to its future development direction.

Compared with conventional instrumental analytical methods, FETs prepared using nanomaterials as channels have the advantages of fast response speed, high sensitivity and good selectivity, among which the diversified processing methods of graphene, the multi-heavy metal ions detection of silicon nanowires and the very low detection limit and wider detection range of carbon nanotubes have made them one of the most promising detection tools in the field of heavy metal ions detection. Of course, through in-depth analysis, this type of sensor has certain limitations, such as high cost and strict process requirements, which are yet to be solved.

This paper elaborates on the detection principle and classification of field-effect tube, investigates and researches the application status of three kinds of FET biosensors in the detection of common heavy metal ions. By comparing the advantages and disadvantages of each of the three sensors in practical applications, the paper focuses on the feasibility of improvement measures, looks forward to the development trend in the field of heavy metal detection and ultimately promotes the application of field-effect tube development technology to continue to progress, so that its performance continues to improve and the application field is constantly expanding.

This study aims to improve detection efficiency of fluorescence biosensor or a graphene field-effect transistor biosensor. Graphene field-effect transistor biosensing and fluorescent biosensing were integrated and combined with magnetic nanoparticles to construct a multi-sensor integrated microfluidic biochip for detecting single-stranded DNA. Multi-sensor integrated biochip demonstrated higher detection reliability for a single target and could simultaneously detect different targets.

In this study, the authors integrated graphene field-effect transistor biosensing and fluorescent biosensing, combined with magnetic nanoparticles, to fabricate a multi-sensor integrated microfluidic biochip for the detection of single-stranded deoxyribonucleic acid (DNA). Graphene films synthesized through chemical vapor deposition were transferred onto a glass substrate featuring two indium tin oxide electrodes, thus establishing conductive channels for the graphene field-effect transistor. Using π-π stacking, 1-pyrenebutanoic acid succinimidyl ester was immobilized onto the graphene film to serve as a medium for anchoring the probe aptamer. The fluorophore-labeled target DNA subsequently underwent hybridization with the probe aptamer, thereby forming a fluorescence detection channel.

This paper presents a novel approach using three channels of light, electricity and magnetism for the detection of single-stranded DNA, accompanied by the design of a microfluidic detection platform integrating biosensor chips. Remarkably, the detection limit achieved is 10 pm, with an impressively low relative standard deviation of 1.007%.

By detecting target DNA, the photo-electro-magnetic multi-sensor graphene field-effect transistor biosensor not only enhances the reliability and efficiency of detection but also exhibits additional advantages such as compact size, affordability, portability and straightforward automation. Real-time display of detection outcomes on the host facilitates a deeper comprehension of biochemical reaction dynamics. Moreover, besides detecting the same target, the sensor can also identify diverse targets, primarily leveraging the penetrative and noninvasive nature of light.

This study aims to provide a microfluidic blood glucose sensing platform based on integrated interdigitated electrode arrays (IDEAs) on a flexible quartz glass substrate, adhering closely to pertinent electrochemical characterizations.

Sensors are the key elements of the modern electronics era through which all the possible physical quantities can be detected and converted into their equivalent electrical form and processed further. But to make the sensing environment better, various types of innovative architectures are being developed nowadays and among them interdigitated electrodes are quite remarkable in terms of their sensing capability. They are a well-qualified candidate in the field of gas sensing and biosensing, but even their sensitivities are getting saturated due to their physical dimensions. Most of the thin film IDEAs fabricated by conventional optical lithographic techniques do not possess a high surface-to-volume ratio to detect the target specified and that reduces their sensitivity factor. In this context, a classic conductive carbon-based highly sensitive three dimensional (3D) IDEA-enabled biosensing system has been conceived on a transparent and flexible substrate to measure the amount of glucose concentration present in human blood. 3D IDEA possesses a way better capacitive sensing behavior compared to conventional thin film microcapacitive electrodes. To transmit the target biological analyte sample property for the detection purpose to the interdigitated array-based sensing platform, the design of a microfluidic channel is initiated on the same substrate. The complex 3D Inter Digital array structure improves the overall capacitance of the entire sensing platform and the reactive surface area as well. The manufactured integrated device displays a decent value of sensitivity in the order of 5.6 µA mM⁻¹ cm⁻².

Development of a low-cost array-based integrated and highly flexible microfluidic biochip to extract the quantity of glucose present in human blood.

Potential future research opportunities in the realm of integrated miniaturized, low-cost smart biosensing systems may arise from this study.

This paper aims to numerically examine the impact of gyrotactic microorganisms and radiation on heat transport features of magnetic nanoliquid within a closed cavity. Thermophoresis, chemical reaction and Brownian motion are also considered in flow geometry for the moment of nanoparticles.

Finite element method (FEM) was depleted to numerically approximate the temperature, momentum, concentration and microorganisms concentration of the nanoliquid. The present simulation was unsteady state, and the resulting transformed equations are simulated by FEM-based Mathematica algorithm.

It has been found that isotherm patterns get larger with increasing values of the magnetic field parameter. Additionally, numerical codes for rate of heat transport impedance inside the cavity with an increasing Brownian motion parameter values.

To the best of the authors’ knowledge, the research work carried out in this paper is new, and no part is copied from others’ works.

This study aims to focuse on the flow behavior of a specific nanofluid composed of blood-based iron oxide nanoparticles, combined with motile gyrotactic microorganisms, in a ciliated channel with electroosmosis.

This study applies a powerful mathematical model to examine the combined impacts of bio convection and electrokinetic forces on nanofluid flow. The presence of cilia, which are described as wave-like motions on the channel walls, promotes fluid propulsion, which improves mixing and mass transport. The velocity and dispersion of nanoparticles and microbes are modified by the inclusion of electroosmosis, which is stimulated by an applied electric field. This adds a significant level of complexity.

To ascertain their impact on flow characteristics, important factors such as bio convection Rayleigh number, Grashoff number, Peclet number and Lewis number are varied. The results demonstrate that while the gyrotactic activity of microorganisms contributes to the stability and homogeneity of the nanofluid distribution, electroosmotic forces significantly enhance fluid mixing and nanoparticle dispersion. This thorough study clarifies how to take advantage of electroosmosis and bio convection in ciliated micro channels to optimize nanofluid-based biomedical applications, such as targeted drug administration and improved diagnostic processes.

First paper discussed “Numerical Computation of Cilia Transport of Prandtl Nanofluid (Blood-Fe₃O₄) Enhancing Convective Heat Transfer along Micro Organisms under Electroosmotic effects in Wavy Capillaries”.

This paper aims to apply the novel numerical model to analyze the effect of pillar material on the response of compound quartz crystal resonator (QCR) with an array of pillars. The performance of the proposed device compared to conventional QCR method was also investigated.

A finite element method model was developed to analyze the behavior of QCR coupled with an array of pillars. The model was composed of an elastic pillar, a solution and a perfectly matched layer. The validation of the model was performed through a comparison between its predictions and previous experimental measurements. Notably, a good agreement was observed between the predicted results and the experimental data.

The effect of pillar Young’s modulus on the coupled QCR and pillars with a diameter of 20 µm, a center-to-center spacing of 40 µm and a density of 2,500 kg/m³ was investigated. The results indicate that multiple vibration modes can be obtained based on Young’s modulus. Notably, in the case of the QCR–pillar in air, the second vibration mode occurred at a critical Young’s modulus of 0.2 MPa, whereas the first mode was observed at 3.75 Mpa. The vibration phase analysis revealed phase-veering behavior at the critical Young’s modulus, which resulted in a sudden jump-and-drop frequency shift. In addition, the results show that the critical Young’s modulus is dependent on the surrounding environment of the pillar. For instance, the critical Young’s modulus for the first mode of the pillar is approximately 3.75 Mpa in air, whereas it increases to 6.5 Mpa in water.

It was concluded that the performance of coupled QCR–pillar devices significantly depends on the pillar material. Therefore, choosing pillar material at critical Young’s modulus can lead to the maximum frequency shift of coupled QCR–pillar devices. The model developed in this work helps the researchers design pillars to achieve maximum frequency shift in their measurements using coupled QCR–pillar.

The increasing focus of consumers on health and environmental sustainability continues to drive the demand for organic food. Despite the recognized importance of health and environmental concerns, the differential impact of these factors on organic food purchasing decisions is evident, indicating the presence of moderating variables. This investigation attempts to delineate these contingencies within the realms of socio-environmental and individual factors, paying particular attention to subjective norms, uncertainty, and egoistic values.

Using the convenience sampling method, the primary data sample was collected by a professional market research consulting firm and included 1876 usable respondents from China. Hierarchical multiple regression analysis was utilized to verify the model and test the relationships between the constructs.

The results indicated that the path from environmental concern to organic food purchase intention was significantly influenced by subjective norms and uncertainty, both of which enhance this relationship. In contrast, egoistic values appeared to dampen this effect. Uncertainty also emerged as a key factor in the link between health concerns and organic food purchase intention, albeit with an opposite impact, weakening the relationship.

This study provides useful insights for academics and marketers to understand the complex phenomenon of organic consumer behavior. This result indicates that marketers can target reference groups to develop organic food marketing strategies.

Few studies have proposed and validated a model with these moderating factors collectively to study the purchase intention of organic food consumers in China.