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The main objective of this paper is to illustrate an analytical view of different methods of 3D bioprinting, variations, formulations and characteristics of biomaterials. This review also aims to discover all the areas of applications and scopes of further improvement of 3D bioprinters in this era of the Fourth Industrial Revolution.

This paper reviewed a number of papers that carried evaluations of different 3D bioprinting methods with different biomaterials, using different pumps to print 3D scaffolds, living cells, tissue and organs. All the papers and articles are collected from different journals and conference papers from 2014 to 2022.

This paper briefly explains how the concept of a 3D bioprinter was developed from a 3D printer and how it affects the biomedical field and helps to recover the lack of organ donors. It also gives a clear explanation of three basic processes and different strategies of these processes and the criteria of biomaterial selection. This paper gives insights into how 3D bioprinters can be assisted with machine learning to increase their scope of application.

The chosen research approach may limit the generalizability of the research findings. As a result, researchers are encouraged to test the proposed hypotheses further.

This paper includes implications for developing 3D bioprinters, developing biomaterials and increasing the printability of 3D bioprinters.

This paper addresses an identified need by investigating how to enable 3D bioprinting performance.

Reconstructing multi-layer tissue structure using cell printing to repairing complex tissue defect is a challenging task, especially using in situ bioprinting. This study aims to propose a method of in situ bioprinting multi-tissue layering and path planning for complex skin and soft tissue defects.

The scanned three-dimensional (3D) point cloud of the skin and soft tissue defect is taken as the input data, the depth value of the defect is then calculated using a two-step grid division method, and the tissue layer is judged according to the depth value. Then, the surface layering and path planning in the normal direction are performed for different tissue layers to achieve precise tissue layering filling of complex skin soft tissue defects.

The two-step grid method can accurately calculate the depth of skin and soft tissue defects and judge the tissue layer accordingly. In the in situ bioprinting experiment of the defect model, the defect can be completely closed. The defect can be reconstructed in situ, and the reconstructed structure is basically the same as the original skin tissue structure, proving the feasibility of the proposed method.

This study proposes an in situ bioprinting multi-tissue layering and path planning method for complex skin and soft tissue defects, which can directly convert the scanned 3D point cloud into a multi-tissue in situ bioprinting path. The printed result has a similar structure to that of the original skin tissue, which can make cells or growth factors act on the corresponding tissue layer targets.

Bioprinting is a promising technology, which has gained a recent attention, for application in all aspects of human life and has specific advantages in different areas of medicines, especially in ophthalmology. The three-dimensional (3D) printing tools have been widely used in different applications, from surgical planning procedures to 3D models for certain highly delicate organs (such as: eye and heart). The purpose of this paper is to review the dedicated research efforts that so far have been made to highlight applications of 3D printing in the field of ophthalmology.

In this paper, the state-of-the-art review has been summarized for bioprinters, biomaterials and methodologies adopted to cure eye diseases. This paper starts with fundamental discussions and gradually leads toward the summary and future trends by covering almost all the research insights. For better understanding of the readers, various tables and figures have also been incorporated.

The usages of bioprinted surgical models have shown to be helpful in shortening the time of operation and decreasing the risk of donor, and hence, it could boost certain surgical effects. This demonstrates the wide use of bioprinting to design more precise biological research models for research in broader range of applications such as in generating blood vessels and cardiac tissue. Although bioprinting has not created a significant impact in ophthalmology, in recent times, these technologies could be helpful in treating several ocular disorders in the near future.

This review work emphasizes the understanding of 3D printing technologies, in the light of which these can be applied in ophthalmology to achieve successful treatment of eye diseases.

The 3 D bioprinting technology is used to prepare the tissue engineering scaffold with precise structures for the cell proliferation and differentiation.

According to the characteristics of the ideal tissue engineering scaffold, the microstructural design of the tissue engineering scaffold is carried out. The bioprinter is used to fabricate the tissue engineering scaffold with different structures and spacing sizes. Finally, the scaffold with good connectivity is achieved and used to cell PC12 culture.

The results show that the pore structure with the line spacing of 1 mm was the best for cell culture, and the survival rate of the inoculated cells PC12 is as high as 90%. The influence of the pore shape on the cell survival is not evidence.

This study shows that tissue engineering scaffolds prepared by 3 D bioprinting have graded structure for three-dimensional cell culture, which lays the foundation for the later detection of drug resistance.

Although many researchers have widely studied additive manufacturing (AM) as one of the most important industrial revolutions, few have presented a bibliometric analysis of the published studies in this area. This paper aims to evaluate AM research trends based on 4607 publications most cited from year 2010 to 2020.

The research methodology is bibliometric indicators and network analysis, including analysis based on keywords, citation analysis, productive journal, related published papers and authors indicators. Two free available software were employed VOSviewer and Bibexcel.

Keywords analysis results indicate that among the AM processes, Selective Laser Melting and Fused Deposition Modeling techniques, are the two processes ranked on top of the techniques employed and studied with 35.76% and 20.09% respectively. The citation analysis by VOSviewer software, reveals that the medical applications field and the fabrication of metal parts are the areas that interest researchers greatly. Different new research niches, as pharmaceutical industry, digital construction and food fabrication are growing topics in AM scientific works. This study reveals that journals “Materials & design”, “Advanced materials”, “Acs applied materials & interfaces”, “Additive manufacturing”, “Advanced functional materials” and “Biofabrication” are the most productive and influential in AM scientific research.

The results and conclusions of this work can be used as indicators of trends in AM research and/or as prospects for future studies in this area.

Extrusion-based additive manufacturing (AM) has been considered as a promising technique to fabricate scaffolds for tissue engineering due to affordability, versatility and ability to print porous structures. The reliability and controllability of the printing process are necessary to produce 3D-printed scaffolds with desired properties and depend on the geometric characteristics such as porosity and pore diameter. The purpose of this study is to develop an analytical model and explore its effectiveness in the prediction of geometric characteristics of 3D-printed scaffolds.

An analytical model was developed to simulate the geometric characteristics of scaffolds produced by extrusion-based AM using fluid mechanics. Polycaprolactone (PCL) was chosen as a scaffold material and was assumed to be a non-Newtonian fluid for the model. The effectiveness of the model was verified through comparison with the experimental results.

A comparison study between simulation and experimental results shows that strut diameter, pore size and porosity of scaffolds can be predicted by using extrusion pressure, temperature, nozzle diameter, nozzle length and printing speed. Simulation results demonstrate that geometric characteristics have a strong relationship with processing parameters, and the model developed in this study can be used for predicting the scaffold properties for the extrusion-based 3D bioprinting process.

The present study provides a prediction model that can simulate the printing process by a simple input of processing parameters. The geometric characteristics can be predicted prior to the experimental verification, and such prediction will reduce the process time and effort when a new material or method is applied.

Intense interest has been shown in creating new and effective biocide agents as a result of changes in bacterial isolates, bacterial susceptibility to antibiotics, an increase in patients with burns and wounds and the difficulty of treating infections and antimicrobial resistance. Woven, nonwoven and knitted materials are used to make dressings; however, nonwoven dressings are becoming more popular because of their softness and high absorption capacity. Additionally, textiles have excellent geometrical, physical and mechanical features including three-dimensional structure availability, air, vapor and liquid permeability, strength, extensibility, flexibility and diversity of fiber length, fineness and cross-sectional shapes. It is necessary to treat every burn according to international protocol and along with it has to focus on particular problems of patients and the best possible results.

The objective of this paper is to conduct a thorough examination of research pertaining to the utilization of textiles, as well as alternative materials and innovative techniques, in the context of burn wound dressings. Through a critical analysis of the findings, this study intends to provide valuable insights that can inform and guide future research endeavors in this field.

In the past years, there have been several dressings such as xeroform petrolatum gauze, silver-impregnated dressings, biological dressings, hydrocolloid dressings, polyurethane film dressings, silicon-coated nylon dressings, dressings for biosynthetic skin substitutes, hydrogel dressings, newly developed dressings, scaffold bandages, Sorbalgon wound dressing, negative pressure therapy, enzymatic debridement and high-pressure water irrigation developed for the fast healing of burn wounds.

This research conducts a thorough analysis of the role of textiles in modern burn wound dressings.

3D printing is believed to be driving the third industrial revolution. However, a scientometric visualizing of 3D printing research and an exploration its hotspots and emerging trends are lacking. This study aims to promote the theory development of 3D printing, help researchers to determine the research direction and provide a reference for enterprises and government to plan the development of 3D printing industry by a comprehensive understanding of the hotspots and trends of 3D printing.

Based on the theory of scientometrics, 2,769 literatures on the 3D printing theme were found in the Web of Science Core Collection’ Science Citation Index Expanded (SCI-EXPANDED) index between 1995-2016. These were analyzed to explore the research hotspots and emerging trends of 3D printing with the software CiteSpaceIII.

Hotspots had appeared first in 1993, grew rapidly from 2005 and peaked in 2013; hotspots in the “medical field” appeared earliest and have remained extremely active; hotspots have evolved from “drug”, “printer”, “rapid prototyping” and “3D printing” in the 1990s, through “laser-induced consolidation”, “scaffolds”, “sintering” and “metal matrix composites” in the 2000s, to the current hotspots of “stereolithography”, “laser additive manufacturing”, “medical images”; “3D bioprinting”, “titanium”, “Cstem cell” and “chemical reaction” were the emerging hotspots in recent years; “Commercial operation” and “fusion with emerging technology such as big data” may create future hotspots.

It is hard to avoid the possibility of missing important research results on 3D printing. The relevant records could be missing if the query phrases for topic search do not appear in records. Besides, to improve the quality of data, this study selected articles and reviews as the research objects, which may also omit some records.

First, this is the first paper visualizing the hotspots and emerging trends of 3D printing using scientometric tools. Second, not only “burst reference” and “burst keywords” but also “cluster” and “landmark article” are selected as the evaluation factors to judge the hotspots and trends of a domain comprehensively. Third, overall perspective of hotspots and trends of 3D printing is put forward for the first time.

The national technology accumulation pattern in three-dimensional (3D) printing technology field has not yet been studied until now. This paper is to fill this gap. To be specific, the purpose of this paper is to answer the following two questions. What is the comparative advantage of 3D printing technology among countries? What is the relative impact of 3D printing technology in the worldwide?

Patent bibliometric analysis was used for analyzing and collecting data to find critical information of 3D printing. Some indicators (RTA, FSGI, RII, CV) have been applied in analyzing the national patterns of technology accumulation in developed and developing countries by using patent statistics.

First, the USA, Japan, and Germany are the leading countries in 3D printing technology, while the technology accumulation patterns of these countries are rather different. Second, Israel and Italy have good performance in the fast-growing technology sub-fields. Third, although the number of patents owned by developing countries, such as China and Russia, is not few, the citations received by these patents are low.

A limitation of this study is that technological development can be reflected by many indicators and patent statistic is merely one reflection form. This study just analyzes the 3D printing technology development from the perspective of patent statistic, the authors would like to continue the comprehensive analysis with the other data indicators in a future study.

The national technology accumulation pattern in 3D printing technology field has not yet been studied until now. This paper is to fill this gap.

This study aims to report the development of an open-source syringe extrusion head for shear-thinning materials. The target is to adapt open-source 3D printers to be helpful in research lines that use gels, hydrogels, pastes, inks, and bio-inks.

This hardware was designed to be compatible with a Graber i3-based 3D printer; nevertheless, it can be easily adapted to other open-source 3D printers.

The extrusion head successfully deposits the material during the 3D printing process. It was validated fabricating geometries that include scaffold structures, which are a possible application of bioprinting for tissue engineering. As reported, the extruded filaments allowed the porous samples' structuration.

This system expands the applications of open-source 3D printers used at the laboratory scale. It enables low-cost access to research areas such as tissue engineering and biofabrication, energy storage devices and food 3D printing.

The open-source hardware here reported is of simple fabrication, assembly and installation. It uses a Cardan coupling and a three guides system to transfer the stepper motor motion. This approach allows continuous movement transfer to the syringe piston, producing an adequate deposition or retraction. Thus, the effect of misalignments is avoided, considering that these latter can cause skipping steps in the motor, directly affecting the deposition.