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The purpose of this paper is establishing a general mathematical model and theoretical design rules for 3D printing of biomaterials. Additive manufacturing of biomaterials provides many opportunities for fabrication of complex tissue structures, which are difficult to fabricate by traditional manufacturing methods. Related problems and research tasks are raised by the study on biomaterials’ 3D printing. Most researchers are interested in the materials studies; however, the corresponded additive manufacturing machine is facing some technical problems in printing user-prepared biomaterials. New biomaterials have uncertainty in physical properties, such as viscosity and surface tension coefficient. Therefore, the 3D printing process requires lots of trials to achieve proper printing parameters, such as printing layer thickness, maximum printing line distance and printing nozzle’s feeding speed; otherwise, the desired computer-aided design (CAD) file will not be printed successfully in 3D printing.

Most additive manufacturing machine for user-prepared bio-material use pneumatic valve dispensers or extruder as printing nozzle, because the air pressure activated valve can print many different materials, which have a wide range of viscosity. We studied the structure inside the pneumatic valve dispenser in our 3D heterogeneous printing machine, and established mathematical models for 3D printing CAD structure and fluid behaviors inside the dispenser during printing process.

Based on theoretical modeling, we found that the bio-material’s viscosity, surface tension coefficient and pneumatic valve dispenser’s dispensing step time will affect the final structure directly. We verified our mathematical model by printing of two kinds of self-prepared biomaterials, and the results supported our modeling and theoretical calculation.

For a certain kinds of biomaterials, the mathematical model and design rules will have unique solutions to the functions and equations. Therefore, each biomaterial’s physical data should be collected and input to the model for specified solutions. However, for each user-made 3D printing machine, the core programming code can be modified to adjust the parameters, which follows our mathematical model and the related CAD design rules.

This study will provide a universal mathematical method to set up design rules for new user-prepared biomaterials in 3D printing of a CAD structure.

The main objective of this paper is to illustrate an analytical view of different methods of 3D bioprinting, variations, formulations and characteristics of biomaterials. This review also aims to discover all the areas of applications and scopes of further improvement of 3D bioprinters in this era of the Fourth Industrial Revolution.

This paper reviewed a number of papers that carried evaluations of different 3D bioprinting methods with different biomaterials, using different pumps to print 3D scaffolds, living cells, tissue and organs. All the papers and articles are collected from different journals and conference papers from 2014 to 2022.

This paper briefly explains how the concept of a 3D bioprinter was developed from a 3D printer and how it affects the biomedical field and helps to recover the lack of organ donors. It also gives a clear explanation of three basic processes and different strategies of these processes and the criteria of biomaterial selection. This paper gives insights into how 3D bioprinters can be assisted with machine learning to increase their scope of application.

The chosen research approach may limit the generalizability of the research findings. As a result, researchers are encouraged to test the proposed hypotheses further.

This paper includes implications for developing 3D bioprinters, developing biomaterials and increasing the printability of 3D bioprinters.

This paper addresses an identified need by investigating how to enable 3D bioprinting performance.

In the past decade, three-dimensional (3D) printing has gained attention in areas such as medicine, engineering, manufacturing art and most recently in education. In biomedical, the development of a wide range of biomaterials has catalysed the considerable role of 3D printing (3DP), where it functions as synthetic frameworks in the form of scaffolds, constructs or matrices. The purpose of this paper is to present the state-of-the-art literature coverage of 3DP applications in tissue engineering (such as customized scaffoldings and organs, and regenerative medicine).

This review focusses on various 3DP techniques and biomaterials for tissue engineering (TE) applications. The literature reviewed in the manuscript has been collected from various journal search engines including Google Scholar, Research Gate, Academia, PubMed, Scopus, EMBASE, Cochrane Library and Web of Science. The keywords that have been selected for the searches were 3 D printing, tissue engineering, scaffoldings, organs, regenerative medicine, biomaterials, standards, applications and future directions. Further, the sub-classifications of the keyword, wherever possible, have been used as sectioned/sub-sectioned in the manuscript.

3DP techniques have many applications in biomedical and TE (B-TE), as covered in the literature. Customized structures for B-TE applications are easy and cost-effective to manufacture through 3DP, whereas on many occasions, conventional technologies generally become incompatible. For this, this new class of manufacturing must be explored to further capabilities for many potential applications.

This review paper presents a comprehensive study of the various types of 3DP technologies in the light of their possible B-TE application as well as provides a future roadmap.

This study aims to prepare low-cost biomaterials from renewable natural resources (rosin).

Preparation of different biomaterials, ethylene glycol maleic rosin (EGMR), glycerol maleic rosin, pentaerythritol maleic rosin and sorbitol maleic rosin (SMR) esters, then evaluated by stability studies, moisture absorption, swelling index parameters, thermogravimetric analysis and skin irritation studies.

The prepared rosin derivatives had excellent moisture safety, according to the results. From EGMR to SMR, the swelling indices increase.

These rosin biomaterials were used in coating, especially in the field of pharmaceutical coating, and good results were obtained in this study.

As these biomaterials rosin derivatives have excellent moisture resistance, they are recommended for use as coating materials for moisture-sensitive drugs.

There has recently been a lot of interest in researching the effects of rosin derivatives in various drug delivery systems.

Tissue engineering (TE) involves biological, medical and engineering expertise and a current engineering challenge is to provide good TE scaffolds. These highly porous 3D scaffolds primarily serve as temporal holding devices for cells that facilitate structural and functional tissue unit formation of the newly transplanted cells. One method used successfully to produce scaffolds is that of rapid prototyping. Selective laser sintering (SLS) is one such versatile method that is able to process many types of polymeric materials and good stability of its products. The purpose of this paper is to present modeling of the heat transfer process, to understand the sintering phenomena that are experienced by powder particles in the SLS powder bed during the sintering process. With the understanding of sintering process obtained through the theoretical modeling, experimental process of biomaterials in SLS could be directed towards the appropriate sintering window, so as not to cause unintentional degradation to the biomaterials.

SLS uses a laser as a heat source to sinter parts. A theoretical study based on heat transfer phenomena during SLS process was carried out. The study identified the significant biomaterial and laser beam properties that were critical to the sintering result. The material properties were thermal conductivity, thermal diffusivity, surface reflectivity and absorption coefficient.

The influential laser beam properties were laser power and scan speed, which were machine parameters that can be controlled by users. The identification of the important parameters has ensured that favorable sintering conditions can be achieved.

The selection of biopolymer influences the manner in which energy is absorbed by the powder bed during the SLS process. In this paper, the modeling and investigative work was validated by poly(vinyl alcohol) which is a biomaterial that has been used for many biomedical and pharmaceutical purposes.

The paper can be the foundation for extension to other types of biomaterials including biopolymers, bioceramics and biocomposites.

The formulation of the theory for heat transfer phenomena during the SLS process is of significant value to any studies in using SLS for biomedical applications.

This study aims to evaluate two bacterial cellulose (BC) films as an alternative textile surface suitable for use in the manufacture of clothing prototypes.

A combination of experiments for the production and characterization of BC films with traditional techniques for sewing fabrics was carried out. BC films were produced from the bacterum Gluconacetobacter hansenii UCP1619 and from Kombucha, a consortium of microorganisms grown on sugared tea. The BC films were then purified, characterized by scanning electron microscopy (SEM) and evaluated for mechanical strength. Two clothing prototypes were developed by combining BC films with a flat fabric composed of 70% linen and 30% polyester to assess the viability of the garment for future clothing making using biomaterials.

The results showed that the combination of flat fabric with BC-based biomaterials is a viable alternative for the innovative use of BC films in the manufacture of apparel products, especially after optimizing the mechanical properties of the artefact.

BC application studies in the textile industry are still in their early stages, although they are attracting more and more the attention of researchers around the world. The experiments carried out in this research provide new information on the handling and application of this material in innovative products for the textile industry.

The biomaterials are natural or synthetic materials used to improve quality of life either by replacing tissue/organ or assisting their function in medical field. The purpose of the study is to analyze the hydroxyapatite (HAP), HAP-TiO₂ (25 percent) composite coatings deposited on 316 LSS by High Velocity Flame Spray (HVFS) technique.

The coatings exhibit almost uniform and dense microstructure with porosity (HAP = 0.153 and HAP-TiO₂ composite = 0.138). Electrochemical corrosion testing was done on the uncoated and coated specimens in Ringer solution (SBF). As-sprayed coatings were characterized by XRD, SEM/EDS and cross-sectional X-ray mapping techniques before and after dipping in Ringer solution. Microhardness of composite coating (568.8 MPa) was found to be higher than HAP coating (353 MPa).

During investigations, it was observed that the corrosion resistance of steel was found to have increased after the deposition of HAP and HAP-TiO₂ composite coatings. Thus, coatings serve as an effective diffusion barrier to prohibit the diffusion of ions from the SBF into the substrate. Composite coatings have been found to be more corrosion resistant as compared to HAP coating in the simulated body fluid.

It has been concluded that corrosion resistance of HAP as well as composite coating is because of the desirable microstructural changes such as low porosity high microhardness and flat splat structures in coatings as compared to bare specimen.

This study is useful in the selection of biomedical implants.

This study is useful in the field of biomaterials.

No reported literature on corrosion behavior of HAP+ 25%- TiO₂ has been noted till now using flame spray technique. The main focus of the study is to investigate the HAP as well as composite coatings for biomedical applications.

The purpose of this paper is to examine the use of fused deposition modelling (FDM) models and finite element analysis (FEA) related to dysplastic hip orthopaedic surgery.

The study involved the use of Mimics and Abaqus softwares. Mimics was used to process the CT scan patient data to STL format before producing FDM models which were for before and after surgery. FEA was done to study the two different type of implant biomaterials used in dysplastic hip surgery.

The use of FDM pre models for preplanning of dysplastic hip surgery by orthopaedic surgeons and viewing of the surgery outcome via FDM post models. Different implant biomaterials used gave different results in reduction of stresses that were achieved.

This is original work involving patients in hospital, which got ethical approval and was funded by a university grant. The paper describes a new kind of research in the university.

This paper aims to analyze the corrosion behavior in Ringer solution of six commercially used Ni-based alloys that are present and commonly used as metallic biomaterials.

The specimens were received in the form of cylindrical ingots and were cut to get five samples of each brand with a cylindrical shape of 2 mm height to conduct the study. In this scientific research, the following techniques were used: open circuit potential, potentiodynamic polarization studies, and electrochemical impedance spectroscopy.

The study findings revealed the passivation tendency of the different specimens. Additionally, when the materials were compared, it was discovered that the decisive factor for high corrosion resistance was the chromium concentration. However, with similar chromium content, the stronger concentration in molybdenum increased the resistance. According to the results obtained in this investigation, the biological safety of the dental materials studied in Ringer solution was considered very high for specimens 1 and 2, and adequate for the other samples.

Metal alloys used as biomaterials in contact with the human body should be deeply investigated to make sure they are biocompatible and do not cause any harm. The corrosion resistance of an alloy is the most important characteristic for its biological safety, as all problems arise because of the corrosion process. There is scarce investigation in these Ni-based dental biomaterials, and none found in these commercially used dental materials in Ringer solution.