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Taurine (2-aminoethane sulfonic acid; C2H7NO3S) is a nonprotein sulfur-containing β-amino acid present in nearly all mammalian tissues and the most ubiquitous free endogenous biomolecule in human cells. Taurine is commonly known as a conditionally essential amino acid because taurine is one of the few amino acids that are not incorporated in protein synthesis. The purpose of this study is to review the existing articles related to taurine and to give an account how useful is taurine to the different body systems. In this thorough overview, taurine is covered in terms of its essentiality, sources, advantages for neonates and the elderly, the effects of taurine deficiency, and the safety and toxicity of taurine supplements.

This is a narrative review into the subject matter. Published articles were searched on different portals like PubMed, EMBASE, Scopus, Google Scholar, PubChem etc. The authors also evaluated the availability of taurine in commercially available energy drinks.

This comprehensive review, presents the potential clinical benefits and functional properties of taurine as a conditionally essential amino acid. Energy drinks containing taurine (and their concentration) are also reported in this review.

This is the first data that the authors are aware of that shows taurine content in a variety of energy drinks on the market.

In the recent decades, energy drinks consumption has increased dramatically. Many researches found their adverse effects on the structure and function of organs and systems, with nervous and cardiovascular systems most studied. Liver is one of the priority target organs in case of beverages consumption. The purpose of this paper is to explore the effects of energy drink consumption on morphofunctional conditions of liver.

A search in PubMed, Web of Science, Scopus and eLIBRARY.ru databases was performed using relevant keywords.

Both clinical and experimental data concerning effects of energy drink use on structure and function of liver are summarized and systematized in this review. Most of them documented hepatotoxicity after prolonged over-consumption of energy drinks. Probable mechanisms of action of their basic ingredients (sugars, caffeine, taurine, D-glucuronolactone, vitamin B3) on morphology and functioning of liver as well as combined use of energy drinks with alcohol are described.

This review paper represents evidential information about the negative impact of energy drink consumption on morphofunctional conditions of liver.

Renal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.

Experimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.

The following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.

SAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.

Infant formula is the sole nutrition and food source for many infants. Information on the free amino acid (FAA) content of formulas, particularly those that are protein hydrolysate based, is limited, despite emerging evidence for the role of FAAs in regulating eating behaviour. The purpose of this paper is to measure levels of essential, semi‐essential, and nonessential FAAs in commercially available infant formulas to provide a foundation for future research examining the influence of FAAs on infant development.

Using an automatic amino acid analyzer, we measured the concentrations of FAAs in four types of formula: two cow milk (CMF); three soy protein (SPF); and three protein hydrolysate (PHF), one of which was a partial hydrolysate (pPHF) and two of which were extensive hydrolysate (ePHF).

It was found that the amount and number of FAAs varied significantly across formula types: for CMF, total FAAs ranged from 523‐864 μmol/L, with taurine being the most prominent; SPF, 1933‐2450, methionine; pPHF, 2329, taurine; and ePHF, 80375‐85445, leucine. ePHF had the highest levels and the most diversified profiles of FAAs.

Striking discrepancies exist for FAA profiles of infant formulas. Comparison of these data to published psychophysical data on the taste qualities of individual FAAs provides insights into the unique flavor profiles of infant formulas. Overall, the data from this study provide a necessary foundation for future research examining the influence of FAAs in formulas on infant growth and development.

Published data on the FAA content of PHF is limited, despite their increased availability and use. This research is the first to report the FAA content of partial and extensive PHF, and to compare these values to CMF and SPF.

The purpose of this paper is to explore the health effects and safety aspects regarding the consumption of energy drink (ED).

A wide variety of publications was identified through electronic databases (ScienceDirect, PubMed, SciELO, Google Scholar, Link springer and ResearchGate) on the basis of different keyword such as composition, market status, consumption pattern, health effects, consequences and policies related to ED consumption.

Owing to its popularity, various brands of EDs have been introduced in the market along with a wide variety of modifications to attract the consumers of all age groups. EDs comprise majorly active ingredients such as caffeine, taurine, guarana, L-carnitine and glucoronolactone, ginseng and sweeteners. EDs are well known to have good taste, enhance energy levels, physical alertness and performance, but they also pose risk of certain health hazards, i.e. caffeine intoxication. Because of this, different policies have been formulated by various regulatory bodies of respective countries regarding the composition, labelling, distribution and sale of EDs.

This review will provide a brief overview of composition, market status, consumption pattern, health effects, consequences and policies related to ED consumption.

This paper aims to study the effect of green lemon zest combined with sardine proteins in diabetic hypertensive rats (DHRs).

Male Wistar rats (n = 30) weighing 250 ± 10 g were divided into five groups. The first group consumed a diet containing 20 per cent casein (C). The other four groups are rendered diabetic by intraperitoneal injection of streptozotocin (40 mg/kg body weight), then hypertensive by subcutaneous implantation controlled time-release pellet containing ouabain (0.25 mg/pellet). One untreated group (DHR) consumed 20 per cent casein and the three other groups consumed the same diet supplemented with 2 per cent green lemon zest (DHR-lz), or with 20 per cent of sardine protein (group DHR-sp) or with the combination of both sardine proteins and green lemon zest (group DHR-sp + lz).

DHRs feeding on the combination of both sardine protein (sp) and lemon zest (lz) induced a significant decrease of diastolic blood pressure and heart rates values compared with DHR (p < 0.05). The HDLC values were increased by +55 per cent in DHR-sp + lz compared with DHR group. Moreover, plasma non-HDLC concentrations were decreased significantly compared to DHR, DHR-lz, DHR-sp and C groups. In DHR-sp + lzvs DHR group, TBARS values were decreased by −25 per cent in the liver. Moreover, kidney TBARS were significantly reduced by −66, −51, −65 and −67 per cent compared with C, DHR, DHR-lz and DHR-sp, respectively.

These results suggest that consumption of green lemon zest combined with sardine proteins can reduce blood pressure and tissue oxidative damage and, therefore, help to prevent cardiovascular complications in hypertensive diabetic patients.

Ethical Entrepreneurship; Internationalization of small and medium enterprises (SMEs).

Bachelor and Master courses in International Management and Entrepreneurship.

A German medical scientist developed a product which was able to absorb alcohol in blood and consequently reduced the alcohol-level. He tested it with the participation of 170 volunteers at a private party. The product was consumed after alcohol consumption and the result was an alcohol reduction by 20-70 per cent. In addition, the volunteers had either no or only small symptoms of a hangover. The students shall discuss the different business models the medical scientist could implement by taking into account ethical issues. To give them necessary working data, the case includes European environmental data (including information about the European food industry and the functional drink market), an insight into the European legal issues of starting a business in the food segment (including definitions of “food”, “food supplement” and “health claim regulation” and how these factors impact entrepreneurial decisions), current events in the European food branch and examples of possible competitors. The case is built on a real product development and on current information and facts.

To become involved with entrepreneurial thinking and entrepreneurial decision-making. To debate ethical issues in the entrepreneurial process. To become aware of the complexity of internationalization in the field of SME as well as to reflect upon and sketch appropriate strategies.

Teaching note.

This case study seeks to explore the differences between carer and professional perspectives in the assessment and treatment of a young man with intellectual disabilities, autism and mental health problems.

The opinions and perspectives of psychiatrists involved in the care and treatment of “S” and “S”'s mother about the aetiology, course, treatment and prognosis of “S”'s condition, are explored using “explanatory models”.

This paper shows the similarities and the differences of opinions and perspectives about the mental health care of a person with intellectual disabilities.

It shows how the explicit comparison of notions about a person's condition, assessment and treatment may help all involved to work together for the common ground of achieving the best outcomes for service users.