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This study aims to perform flow simulations inside the acinus with fine alveolar pores (Kohn pores) using hexagonal cells and bottom-up geometric modeling, which enabled the elimination of invalid voids using previous top-bottom methods and spherical or circular cells.

Regular hexagonal cells were used to construct alveoli with no gaps via tessellation. Some hexagonal cells were fused to eliminate the inner boundaries to represent the structure of the bronchial tree. For the remaining hexagonal cells, the side lengths of the shared walls were adjusted to construct alveolar pores. Periodic moving boundaries with the same phase were set for all walls to describe synchronous contraction and expansion of the bronchi and alveoli.

More realistic flow characteristics in the distal lung were obtained. The effects of pore size and the mechanism of auxiliary ventilation of alveolar pores were revealed.

To the best of the authors’ knowledge, this is the first numerical simulation study on the function of multiple alveolar pores at the level of pulmonary acini, which will be helpful for simulating the dynamic process of cough and sputum excretion in the future.

The purpose of this paper is to study the mechanism of efficient sputum excretion from the distal lung by using a tessellationally distal lung model with alveolar pores.

First, a two-dimensional tessellational composite structure of the bronchus, alveoli and alveolar pores (Kohn pore) is constructed with the tessellational splitting and fusion of regular hexagonal elements. Then, the level set method is used to study the effects of alveolar pores and their sizes, expiratory cycles and respiratory intensity.

The existence of alveolar pores is the prerequisite for sputum excretion, and there is an optimal size of alveolar pores for sputum excretion. Strong asymmetric respiration can break the reversibility of the flow at a low Reynolds number and causes significant net displacement of sputum. The expiratory cycle is negatively correlated with the net displacement of sputum. The respiratory intensity is positively correlated with the net displacement of sputum.

This research is helpful for understanding the complex sputum excretion process in diseases, such as pneumonia, and developing corresponding adjuvant therapy.

The purpose of this study is to obtain an effective implant with porous structures on its surface, named porous-surfaced implant, which helps to improve the overall stability of the implant and promote the combination of implant and alveolar bone.

Porous-surfaced implants with a porosity of 16%, 21%and 32% were designed and the effect of porosity on the strength of the implant was analyzed by ABAQUS software. Porous-surfaced implants with different porosity were printed by selective laser melting and the surface morphology was observed. Animal experiments of implants with porous structures and coating were carried out in healthy beagle dogs. The experimental group was treated with hydroxyapatite coating and the control group was not treated. Bone volume (BV) and total volume (TV) of the implant surface of the experimental group and control group were calculated by Skyscan CTvol software.

With the increase of porosity of porous-surfaced implants, the neck stress of the porous-surfaced implants increased and their strength decreased. In addition, in animal vivo experiments, the ratio value of BV to TV of the porous-surfaced implants was between 55.38% and 79.86%, which was the largest when the porosity of porous-surfaced implants was 16%. The internal and surrounding bone formation content of porous-surfaced implants with hydroxyapatite coating was higher than porous-surfaced implants without coating.

The results of this study show that the pores on the surface of implants can be filled with the new bone and porous-surfaced implants with 16% porosity provide better space for the growth of new bone. The porous structures with hydroxyapatite coating are beneficial to the growth of new bone around implants. The results of this study are helpful to improve the overall stability of implants and to promote the combination of implant and alveolar bone.

The purpose of this paper is to establish a chair-side design and production method for a tooth-supported fixed implant guide and to evaluate its accuracy.

Three-dimensional (3D) data of the alveolar ridge, adjacent teeth and antagonistic teeth were acquired from models of the edentulous area of 30 patients. The implant guides were then constructed using self-developed computer-aided design software and chair-side fused deposition modelling 3D-printing and positioned on a dental model. A model scanner was used to acquire 3D data of the positioned implant guides, and the overall error was then evaluated.

The overall error was 0.599 ± 0.146 mm (n = 30). One-way ANOVA revealed no statistical differences among the 30 implant guides. The gap between the occlusal surface of the teeth covering and the tissue surface of the implant guide was measured. The maximum gap after positioning of the implant guide was 0.341 mm (mean, 0.179 ± 0.019 mm). The implanted axes of the printed implant guide and designed guide were compared in terms of overall, lateral and angular error, which were 0.104 ± 0.004 mm, 0.097 ± 0.003 mm, and 2.053° ± 0.017°, respectively.

The results of this study demonstrated that the accuracy of a new chair-side tooth-supported fixed implant guide can satisfy clinical requirements.

Identifying stone decay forms is an essential first step in stone conservation. In this study a visually based geomorphological approach was used to provide a rapid assessment of the general weathering characteristics displayed by building sandstones in Stoke‐on‐Trent. Stone decay was found to be largely caused by the mechanical disruption of the sandstone and its occurrence was extremely variable in both space and time. The study demonstrates the close interrelationship between stone properties, environmental conditions, morphology of weathering features, and building characteristics. It is important that these close and dynamic interrelationships are recognised when seeking to explain or predict stone behaviour for management purposes.

This study examines the osteoconductive and healing capabilities of locally implanted synthetic hydroxyapatite (sHAp) derived from eggshells in the central incisor sockets of rats.

Toxicity experiments were conducted in vitro and in vivo, to testify the safety dosage of sHAp. Around 24 mature male Sprague–Dawley (SD) rats had their upper central incisors extracted. The rats were placed into three groups of eight rats each: Group 1: the sockets of extracted central incisors were left unfilled (control), Group 2: filled up with commercially available hydroxyapatite (HAp) and Group 3: implanted with sHAp locally retrieved from eggshells. After extraction, four rats from each group were sacrificed at 2nd and 4th weeks. Maxillary tissue sections were obtained and stained with hematoxylin and eosin (H&E) and Masson’s trichome (MT) staining. Anti-osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used primary antibodies for immunohistochemistry (IHC) special labeling.

The results showed that the locally implanted sHAp was non-toxic and safe in cell lines (human osteoblast and fibroblast) and animals. Histological analysis of H&E, MT and IHC showed that the sockets treated with locally implanted sHAp from eggshells were filled with new bone tissue of comparable thickness to other groups.

This unique technique uses locally implanted eggshell-derived sHAp with osteoconductive characteristics. In an in vivo model, sHAps increased OCN and PCNA expression to improve bone repair.

This paper aims to present a new design in the area of basal osseointegrated implant (BOI) for oral and maxillofacial surgery using a patient-specific computer-aided design (CAD) and additive manufacturing (AM) approach. The BOI was designed and fabricated according to the patient’s specific requirement, of maxilla stabilisation and dental fixation, a capacity not currently available in conventional BOI. The combination of CAD and AM techniques provides a powerful approach for optimisation and realisation of the implant in a design which helps to minimise blood loss and surgery time, translating into better patient outcomes and reduced financial burdens on healthcare providers.

The current study integrates the capabilities of conventional medical imaging techniques, CAD and metal AM to realise the BOI. The patient’s anatomy was scanned using a 128-slice spiral computed tomography scanner into a standard Digital Imaging and Communication in Medicine (DICOM) data output. The DICOM data are processed using MIMICS software to construct a digital representative patient model to aid the design process, and the final customised implant was designed using Creo software. The final, surgically implanted BOI was fabricated using direct metal laser sintering in titanium (Ti-64).

The current approach assisted us to design BOI customised to the patient’s unique anatomy to improve patient outcomes. The design realises a nerve relieving option and placement of porous structure at the required area based up on the analysis of patient bone structural data.

The novelty in this work is that developed BOI comprises a patient-specific design that allows for custom fabrication around the patients' nerves, provides structural support to the compromised maxilla and comprises a dual abutment design, with the capacity of supporting fixation of up to four teeth. Conventional BOIs are only available for a signal abutment capable of holding one or two teeth only. Given the customised nature of the design, the concept could easily be extended to explore a greater number of fixation abutments, abutment length/location, adjusted dental fixation size or greater levels of maxilla support. The study highlights the significance of CAD packages to construct patient-specific solution directly from medical imaging data, and the efficiency of metal AM to translate designs into a functional implant.

Fabricating functionally graded scaffolds to mimic the complex spatial distributions of the composition, micro-structure and functionality of native tissues will be one of the key objectives for future tissue engineering research. This study aims to create a scaffold to mimic functionally-graded tissue using a hybrid process, which incorporated electrospun polycaprolactone (PCL) and electrosprayed hydroxyapatite (HA) in a simple pathway.

The PCL and HA were dispensed simultaneously from different positions to form a layer on a rotational mandrel, and a gradient construct was achieved by adjusting dispensing rates of both materials.

The morphology of scaffolds changed gradually from one layer to another layer with the change of the dispensing conditions of the two materials. The elemental distribution analysis revealed that C/Ca ratio linearly increased with certain dispensing rate ratio of PCL:HA. In addition, the thickness, mechanical properties (i.e. ultimate tensile stress and Young’s modulus), surface roughness and water contact angle of each layer changed accordingly with the variation of dispensing rate of PCL and HA, and the diameter distributions of PCL fibres and HA particles did not vary significantly.

This study showed the hybrid process has the potential to be used in fabrication of scaffold with functionally graded structure for tissue engineering applications, especially for mimicking the nature of the native 3D tendon–bone interface.

The purpose of this study is the development of a global SLM-manufacturing optimization strategy taking into account material porosity and SLM process productivity. Selective laser melting (SLM) is a master forming process generating not only a near net shape geometry, but also the material with its properties. Research focuses primarily on optimal processing parameters for maximised material properties. However, the process allows also designing the material structure by internal porosity, affecting global material properties and the process productivity.

The study investigates the influence of the main SLM process parameters on material porosity and consequently on the static mechanical properties of hardened SS17-4PH material. Furthermore, a model for the SLM scanning productivity is developed based on the SLM processing parameters.

The results show a clear correlation between porosity level and mechanical properties. Thereby, the mechanical strength and material modulus can be varied in a wide range. The degree of internal material porosity can be correlated to the energy input defined by a set of SLM processing parameters, such as Laser power, powder layer thickness and scan speed, allowing pre-definition of a specific degree of porosity.

Aligning of the SLM processing parameters to the technical material requirements of the parts to be produced, e.g. maximal stresses in service, required E-modulus or lightweight aspects, enlarges the general design space significantly. In combination with the presented model for the scanning productivity, it is further possible to optimize the SLM build rate.

The purpose of this paper is to contribute to the qualitative and quantitative knowledge on ultrafine particles in air near a steel making plant located in an Italian site.

A combination of experimental methodologies was used for the online and offline monitoring and chemical characterization of particulate matter (PM) in the air near the plant. Two unfiltered twin-sampling systems were adopted, working when the plant was on/off. All condensed air samples were submitted to Ion Chromatography analysis. The same samples were submitted to acid digestion before Graphite Furnace Atomic Absorption Spectroscopy Analysis. Continuous daily PM10 samples were collected to characterize ambient air. PM10 samples were also analysed to estimate metals content. The PM size distribution was achieved by continuous online monitoring. The adopted ultrafine particulate monitor classifies particles in the range 20-200 nm. The overall size distribution was inferred from an Optical Particulate Counter able to classify particles in the range 0.3-10 µm.

The obtained results show that no causal relationship can be found between the measurements of anions and metal in the air near the plant under investigation and the presence of the steel making plant. The trend in emissions of micro-particles was found quite characteristic of similar semi-urban areas.

The paper demonstrates that a steel making plant adopting best available techniques could have a local impact compatible with the surrounding environment.