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National differences in the demand for voluntary external audits have been linked to multiple factors, such as differences in a country's rate of growth, access to external credit, and institutional quality. Audits, however, also have a psychological cost, whose intensity is genetically and culturally hereditary. Using a sample of 3,072 private firms across 34 industries in seven countries, including five countries or regions from the former Soviet Comecon, we find that a country's share of firms choosing to undergo external audits is negatively related to the prevalence of carriers of the G allele in the mu-opioid receptor gene's A118G polymorphism, also known as the “social sensitivity” gene. Furthermore, the relationship between the prevalence of the social sensitivity gene and audits is fully mediated by a national culture's degree of collectivism. The results are statistically and economically highly significant and remain robust to the introduction of a set of confounding factors at the firm and country levels. Our results have practical relevance in recognizing psychological diversity when conducting audits and, more generally, preventing burnout in the workplace.

Diagnosing pain and pain inflicting diseases are crucial issues in the health care of individuals with intellectual and developmental disabilities. The purpose of this paper is to delineate possible peculiarities in pain perception, characterizing a syndrome-specific spectrum of pain causing diseases as well as particular features of pain expression in Rett syndrome (RTT).

A selective review of the literature on pain, dolorous disorders and diseases, molecular aspects of pain transduction, pain perception, and expression of painful conditions in RTT was undertaken.

RTT causing mutations in the methyl-CpG-binding protein 2 (MECP2) have an impact on various endogenous molecules modulating pain transmission. Individuals with RTT are specifically prone to numerous pathological states which can cause pain. By thorough observation/application of proper tools, it is possible to recognize painful states in persons with RTT.

This paper imparts empirical/evidence-based data on pain perception/transmission, possible syndrome-specific causes of pain and pain expression/assessment in RTT, with the objective of promoting the quality of clinical practice in this crucial issue.