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Iron deficiency anemia (IDA) is the most common form of anemia in the world, affecting children, women and the elderly, while also being a common comorbidity in several medical conditions. Several studies have suggested a possible association between IDA and neurological dysfunction. Epilepsy, one of the common neurological disorders, has an unknown association with IDA. This pa per aims to investigate whether there is a causal relationship between IDA and epilepsy using a two-sample Mendelian randomization (MR) design.

This paper obtained summary data on IDA and epilepsy from the FinnGen consortium. Genetic variants significantly associated with IDA were used as instrumental variables (IVs). Epilepsy, focal epilepsy and generalized epilepsy were the outcomes. This paper used inverse variance weighted (IVW) as the primary estimate, and other MR methods were used as supplementary measures. Sensitivity analysis was also performed to assess heterogeneity and pleiotropy.

IVW estimates genetically predicted a causal relationship between IDA and the risk of epilepsy [odds ratio (OR), 1.15; 95% confidence interval (95% CI), 1.05–1.26; p = 0.002] and focal epilepsy (OR, 1.978, 95% CI, 1.58–2.48, p ≤ 0.0001), while no significant causal relationship was found with generalized epilepsy (OR, 1.1, 95% CI, 0.94–1.3, p = 0.24). There was no evidence of horizontal pleiotropy and heterogeneity in the sensitivity analysis.

This two-sample MR study found that IDA has a negative effect on the development of epilepsy. Clinical control of IDA may be helpful in the prevention of epilepsy. There is a need for further studies to explain the underlying mechanisms of this association.

The epoxy resins need to be added with flame retardant to ensure safety in practical applications. There were a lot of highly toxic substances in the flame retardant used in the past, which caused greater harm to human body and the environment. Therefore, this study aims to propose a research on the synthesis of new phosphorous-containing flame retardant and the properties of flame retardant epoxy resins.

The flame retardant intermediate DOPO was synthesized using o-phenylphenol as the substrate. The intermediate was mixed with D4Vi under certain conditions to synthesize a new phosphorous-containing flame retardant. The flame retardant was added to the epoxy resins to prepare the flame retardant epoxy resins.

The experimental results show that the synthetic new phosphorous-containing flame retardant is far less harmful than the flame retardant used in the past and has extremely low toxicity, which is suitable for use in practical projects.

The new phosphorus-containing flame retardant synthesized by forms a more uniform and dense carbon layer in the combustion process, which well protects the underlying materials, thus improving the flame retardancy of epoxy resin materials. The harm of the new phosphorus-containing flame retardant is far less than that of ordinary flame retardant. The flame retardant used in the past has very low toxicity and is suitable for practical engineering.

The purpose of this paper is to extend prior supply chain research by describing the process of innovation knowledge increase in supply chain network. More specifically, this study investigates the role of network density, and views the knowledge increase as the process of knowledge diffusion and knowledge innovation.

A multi-agent model, which demonstrates the process of knowledge increase in supply chain network, was established, and simulated by using NetLogo simulation platform.

The results indicate that the network density will promote the knowledge increase of the supply chain when it is high or low. In the meantime, these results show that the inhibition of knowledge diffusion and knowledge innovation will appear when network density is moderate.

Although previous research has identified the importance of knowledge increase in promoting sustainable development of supply chain, far less attention was given to the study of the effect of network structure on the knowledge increase in supply chain. This study thus fulfills the research gap by providing a description of the process of knowledge increase with the consideration of network density. The conclusion is of great significance for the choice of network density for sustainable development of supply chain.

This study aims to comprehensively investigate the relationship between government subsidies and innovation performance in Chinese enterprises listed on the SSE STAR Market.

An unbalanced sample, covering 285 observations in 215 enterprises listed on the SSE STAR Market from 2019 to 2020, was used to explore the relationships between government subsidies, R&D investment, CEO shareholding and innovation performance. Counterfactual analysis is added for robustness testing.

Empirical evidence confirms that government subsidies have an inverted U-shaped relationship with R&D investment and innovation performance. Meanwhile, R&D investment is a mediating variable between government subsidies and innovation performance. Moreover, CEO shareholding plays a moderating role between government subsidies and R&D investment. The higher the CEO ownership, the steeper the inverted U-shaped relationship.

The government should introduce a dynamic mechanism to reasonably control subsidy amounts and strengthen the supervision of subsidy use. Enterprise managers should be aware of how incentives affect the firm’s innovation and implement a coordinated development of government subsidy policies and internal enterprise governance.

This study adds new empirical evidence for the relationship between government subsidies and enterprise innovation performance. The risk incentive provided by stock options is an important micro mechanism to compensate for the lack of government subsidies. The study identifies ways to promote firm innovation based on the synergistic effect of internal and external mechanisms.