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The purpose of this paper is to design an Internet-of-Things (IoT) architecture-based Diabetic Retinopathy Detection Scheme (DRDS) proposed for identifying Type-I or Type-II diabetes and to specifically advise the Type-II diabetic patients about the possibility of vision loss.

The proposed DRDS includes the benefits of automatic calculation of clip limit parameters and sub-window for making the detection process completely adaptive. It uses the advantages of extended 5 × 5 Sobels operator for estimating the maximum edges determined through the convolution of 24 pixels with eight templates to achieve 24 outputs corresponding to individual pixels for finding the maximum magnitude. It enhances the probability of connecting pixels in the vascular map with its closely located neighbourhood points in the fundus images. Then, the spatial information and kernel of the neighbourhood pixels are integrated through the Robust Semi-supervised Kernelized Fuzzy Local information C-Means Clustering (RSKFL-CMC) method to attain significant clustering process.

The results of the proposed DRDS architecture confirm the predominance in terms of accuracy, specificity and sensitivity. The proposed DRDS technique facilitates superior performance at an average of 99.64% accuracy, 76.84% sensitivity and 99.93% specificity.

DRDS is proposed as a comfortable, pain-free and harmless diagnosis system using the merits of Dexcom G4 Plantinum sensors for estimating blood glucose level in diabetic patients. It uses the merits of RSKFL-CMC method to estimate the spatial information and kernel of the neighborhood pixels for attaining significant clustering process.

The IoT architecture comprises of the application layer that inherits the DR application enabled Graphical User Interface (GUI) which is combined for processing of fundus images by using MATLAB applications. This layer aids the patients in storing the capture fundus images in the database for future diagnosis.

This proposed DRDS method plays a vital role in the detection of DR and categorization based on the intensity of disease into severe, moderate and mild grades. The proposed DRDS is responsible for preventing vision loss of diabetic Type-II patients by accurate and potential detection achieved through the utilization of IoT architecture.

The performance of the proposed scheme with the benchmarked approaches of the literature is implemented using MATLAB R2010a. The complete evaluations of the proposed scheme are conducted using HRF, REVIEW, STARE and DRIVE data sets with subjective quantification provided by the experts for the purpose of potential retinal blood vessel segmentation.

The purpose of this work is to present an approach for autonomous detection of eye disease in fundus images. Furthermore, this work presents an improved variant of the Tiny YOLOv7 model developed specifically for eye disease detection. The model proposed in this work is a highly useful tool for the development of applications for autonomous detection of eye diseases in fundus images that can help and assist ophthalmologists.

The approach adopted to carry out this work is twofold. Firstly, a richly annotated dataset consisting of eye disease classes, namely, cataract, glaucoma, retinal disease and normal eye, was created. Secondly, an improved variant of the Tiny YOLOv7 model was developed and proposed as EYE-YOLO. The proposed EYE-YOLO model has been developed by integrating multi-spatial pyramid pooling in the feature extraction network and Focal-EIOU loss in the detection network of the Tiny YOLOv7 model. Moreover, at run time, the mosaic augmentation strategy has been utilized with the proposed model to achieve benchmark results. Further, evaluations have been carried out for performance metrics, namely, precision, recall, F1 Score, average precision (AP) and mean average precision (mAP).

The proposed EYE-YOLO achieved 28% higher precision, 18% higher recall, 24% higher F1 Score and 30.81% higher mAP than the Tiny YOLOv7 model. Moreover, in terms of AP for each class of the employed dataset, it achieved 9.74% higher AP for cataract, 27.73% higher AP for glaucoma, 72.50% higher AP for retina disease and 13.26% higher AP for normal eye. In comparison to the state-of-the-art Tiny YOLOv5, Tiny YOLOv6 and Tiny YOLOv8 models, the proposed EYE-YOLO achieved 6–23.32% higher mAP.

This work addresses the problem of eye disease recognition as a bounding box regression and detection problem. Whereas, the work in the related research is largely based on eye disease classification. The other highlight of this work is to propose a richly annotated dataset for different eye diseases useful for training deep learning-based object detectors. The major highlight of this work lies in the proposal of an improved variant of the Tiny YOLOv7 model focusing on eye disease detection. The proposed modifications in the Tiny YOLOv7 aided the proposed model in achieving better results as compared to the state-of-the-art Tiny YOLOv8 and YOLOv8 Nano.

Diabetic retinopathy (DR) is a central root of blindness all over the world. Though DR is tough to diagnose in starting stages, and the detection procedure might be time-consuming even for qualified experts. Nowadays, intelligent disease detection techniques are extremely acceptable for progress analysis and recognition of various diseases. Therefore, a computer-aided diagnosis scheme based on intelligent learning approaches is intended to propose for diagnosing DR effectively using a benchmark dataset.

The proposed DR diagnostic procedure involves four main steps: (1) image pre-processing, (2) blood vessel segmentation, (3) feature extraction, and (4) classification. Initially, the retinal fundus image is taken for pre-processing with the help of Contrast Limited Adaptive Histogram Equalization (CLAHE) and average filter. In the next step, the blood vessel segmentation is carried out using a segmentation process with optimized gray-level thresholding. Once the blood vessels are extracted, feature extraction is done, using Local Binary Pattern (LBP), Texture Energy Measurement (TEM based on Laws of Texture Energy), and two entropy computations – Shanon's entropy, and Kapur's entropy. These collected features are subjected to a classifier called Neural Network (NN) with an optimized training algorithm. Both the gray-level thresholding and NN is enhanced by the Modified Levy Updated-Dragonfly Algorithm (MLU-DA), which operates to maximize the segmentation accuracy and to reduce the error difference between the predicted and actual outcomes of the NN. Finally, this classification error can correctly prove the efficiency of the proposed DR detection model.

The overall accuracy of the proposed MLU-DA was 16.6% superior to conventional classifiers, and the precision of the developed MLU-DA was 22% better than LM-NN, 16.6% better than PSO-NN, GWO-NN, and DA-NN. Finally, it is concluded that the implemented MLU-DA outperformed state-of-the-art algorithms in detecting DR.

This paper adopts the latest optimization algorithm called MLU-DA-Neural Network with optimal gray-level thresholding for detecting diabetic retinopathy disease. This is the first work utilizes MLU-DA-based Neural Network for computer-aided Diabetic Retinopathy diagnosis.

The abnormalities of glaucoma have high impact on deciding and representing the causes that effects severity of blindness in human beings. The simulation experimental results would help the ophthalmologist in diagnosing of glaucoma abnormality accurately. The significant effect of glaucoma has a huge impact on the quality of human life, and its growth rate in world population tremendously increases. Glaucoma is considered as second largest cause for the blindness in the world; hence identification of it marks the importance of its detection at the earliest.

The prime objective of the work proposed is to build up a human intervention free image preparing framework for glaucoma screening. The disc calculation is assessed on retinal image dataset called retinal Image for glaucoma Analysis. The proposed method briefs a novel optic disc division calculation depending on applying a level-set strategy on a confined optic disc image. In the instance of low quality image, a twofold level set is designed, in which the principal level set is viewed as restriction for the optic disc. To keep the veins from meddling with the level-set procedure, an inpainting strategy has been applied. Also a significant commitment is to include the varieties in notion adopted by the ophthalmologists in distinguishing the disc localization and diagnosing the glaucoma. Most of the past investigations are prepared and tested depending on just a single feature, which can be thought to be one-sided for the ophthalmologist.

In continuation, the correctness has been determined depending on the quantity of image that matched with the investigation pattern adopted by the ophthalmologist. The 175 retinal images were utilized to test the results of proposed work with the manual markings of ophthalmologists. The error-free calculation in marking the optic disc region and centroid was 98.95% in comparison with the existing result of 87.34%.

In continuation, the correctness has been determined depending on the quantity of image that matched with the investigation pattern adopted by the ophthalmologist. The 175 retinal images were utilized to test the results of proposed work with the manual markings of ophthalmologists. The error-free calculation in marking the optic disc region and centroid was 98.95% in comparison with the existing result of 87.34%.

Diabetic retinopathy (DR) is one of the dangerous complications of diabetes. Its grade level must be tracked to manage its progress and to start the appropriate decision for treatment in time. Effective automated methods for the detection of DR and the classification of its severity stage are necessary to reduce the burden on ophthalmologists and diagnostic contradictions among manual readers.

In this research, convolutional neural network (CNN) was used based on colored retinal fundus images for the detection of DR and classification of its stages. CNN can recognize sophisticated features on the retina and provides an automatic diagnosis. The pre-trained VGG-16 CNN model was applied using a transfer learning (TL) approach to utilize the already learned parameters in the detection.

By conducting different experiments set up with different severity groupings, the achieved results are promising. The best-achieved accuracies for 2-class, 3-class, 4-class and 5-class classifications are 86.5, 80.5, 63.5 and 73.7, respectively.

In this research, VGG-16 was used to detect and classify DR stages using the TL approach. Different combinations of classes were used in the classification of DR severity stages to illustrate the ability of the model to differentiate between the classes and verify the effect of these changes on the performance of the model.

The study aims to enhance the detection and classification of conjunctival eye diseases' severity through the development of ConjunctiveNet, an innovative deep learning framework. This model incorporates advanced preprocessing techniques and utilizes a modified Otsu’s method for improved image segmentation, aiming to improve diagnostic accuracy and efficiency in healthcare settings.

ConjunctiveNet employs a convolutional neural network (CNN) enhanced through transfer learning. The methodology integrates rescaling, normalization, Gaussian blur filtering and contrast-limited adaptive histogram equalization (CLAHE) for preprocessing. The segmentation employs a novel modified Otsu’s method. The framework’s effectiveness is compared against five pretrained CNN architectures including AlexNet, ResNet-50, ResNet-152, VGG-19 and DenseNet-201.

The study finds that ConjunctiveNet significantly outperforms existing models in accuracy for detecting various severity stages of conjunctival eye conditions. The model demonstrated superior performance in classifying four distinct severity stages – initial, moderate, high, severe and a healthy stage – offering a reliable tool for enhancing screening and diagnosis processes in ophthalmology.

ConjunctiveNet represents a significant advancement in the automated diagnosis of eye diseases, particularly conjunctivitis. Its originality lies in the integration of modified Otsu’s method for segmentation and its comprehensive preprocessing approach, which collectively enhance its diagnostic capabilities. This framework offers substantial value to the field by improving the accuracy and efficiency of conjunctival disease severity classification, thus aiding in better healthcare delivery.

This paper seeks to present a novel X‐ray system and associated image segmentation algorithm for imaging the below‐ground root structures of plants.

A matched filter design for segmenting the important root structures from the background clutter in the X‐ray images was presented.

The feasibility of root imaging and the applicability of matched filters to this problem domain have been demonstrated.

This research offers a novel approach over existing methods for in situ monitoring of root structures through the application of matched filters for image segmentation.

This study evaluates machine learning (ML) classifiers for diagnosing Parkinson’s disease (PD) using subcortical brain region data from 3D T1 magnetic resonance imaging (MRI) Parkinson’s Progression Markers Initiative (PPMI database). We aim to identify top-performing algorithms and assess gender-related differences in accuracy.

Multiple ML algorithms will be compared for their ability to classify PD vs healthy controls using MRI scans of the brain structures like the putamen, thalamus, brainstem, accumbens, amygdala, caudate, hippocampus and pallidum. Analysis will include gender-specific performance comparisons.

The study reveals that ML classifier performance in diagnosing PD varies across subcortical brain regions and shows gender differences. The Extra Trees classifier performed best in men (86.36% accuracy in the putamen), while Naive Bayes performed best in women (69.23%, amygdala). Regions like the accumbens, hippocampus and caudate showed moderate accuracy (65–70%) in men and poor performance in women. The results point out a significant gender-based performance gap, highlighting the need for gender-specific models to improve diagnostic precision across complex brain structures.

This study highlights the significant impact of gender on machine learning diagnosis of PD using data from subcortical brain regions. Our novel focus on these regions uncovers their diagnostic potential, improves model accuracy and emphasizes the need for gender-specific approaches in medical AI. This work could ultimately lead to earlier PD detection and more personalized treatment.

This paper aims to propose a solution for detecting and grading diabetic retinopathy (DR) in retinal images using a convolutional neural network (CNN)-based approach. It could classify input retinal images into a normal class or an abnormal class, which would be further split into four stages of abnormalities automatically.

The proposed solution is developed based on a newly proposed CNN architecture, namely, DeepRoot. It consists of one main branch, which is connected by two side branches. The main branch is responsible for the primary feature extractor of both high-level and low-level features of retinal images. Then, the side branches further extract more complex and detailed features from the features outputted from the main branch. They are designed to capture details of small traces of DR in retinal images, using modified zoom-in/zoom-out and attention layers.

The proposed method is trained, validated and tested on the Kaggle dataset. The regularization of the trained model is evaluated using unseen data samples, which were self-collected from a real scenario from a hospital. It achieves a promising performance with a sensitivity of 98.18% under the two classes scenario.

The new CNN-based architecture (i.e. DeepRoot) is introduced with the concept of a multi-branch network. It could assist in solving a problem of an unbalanced dataset, especially when there are common characteristics across different classes (i.e. four stages of DR). Different classes could be outputted at different depths of the network.

This paper aims to understand the laser–tissue interaction mechanism during ophthalmic laser surgeries through numerical analysis. The influence of laser parameters and the multipulse technique were investigated.

The ocular fundus was simplified as a multilayered homogenous medium model. Afterward, the multilayer Monte Carlo method was used to simulate the propagation and energy deposition of laser light, and a local thermal non-equilibrium two-temperature model was established to simulate the temperature variation of chromophores and surrounding tissue with different laser wavelength.

Through the model, the selective heating of chromophore (melanin and blood vessels) was clearly illustrated: 1) neglecting the laser energy absorbance by blood in the traditional model will cause significant errors in temperature calculation; 2) the non-thermal equilibrium heat transfer model was needed to obtain an accurate description of the thermal process when the dimensionless pulse width (tp*) is <10⁵. For 532 nm Argon laser, the optimize tp* is around 10⁵ and the appropriate energy density is 5 J/cm²; 3) multipulse technique makes the energy more concentrated within the melanin, thereby reducing the thermal damage in surrounding tissue, with most appropriate pulse number and duty cycle is 10 and 1/10.

Taking the blood absorption into account, the different temperature variations of melanin/vessels and surrounding tissue caused by the selective photo-thermolysis were simulated successfully. By understanding the mechanism of laser therapy, laser parameters and multipulse technique are suggested to improve the clinical results.