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The first suspected case of zinc deficiency in man was reported from Iran and it was a knowledge of animal deficiency symptoms which first led to speculation that zinc deficiency might be responsible for the retarded growth and hypogonadism. Subsequent studies in Egypt, reported in 1963 and 1967 confirmed that such patients were zinc deficient.

The possibility that diets with high fibre levels could lead to mineral deficiency states in human populations was first recognised in Iran and other parts of the Middle East. In rural communities where the main source of energy was an unleavened, whole‐grain bread called tanok, male adolescents were observed to exhibit poor appetites, marked growth retardation and hypogonadism, all signs of zinc deficiency. The zinc content of the diets was adequate, but the availability of zinc for absorption was inhibited by the presence of dietary fibre and phytate.

Traumatic brain injuries (TBIs) are a significant public health problem that affect an estimated 1.7 million US residents yearly. TBI patients experience a variety of symptoms related to physical functioning, sensory processing, cognition, communication, behavior, and mental health, all of which differ in severity by individual. Recent evidence suggests that hypothalamic pituitary dysfunction may be impacting recovery. The purpose of this paper is to increase awareness about the frequency of hypothalamic pituitary dysfunction following a TBI and its effect on functional recovery.

The paper reviews the literature regarding hypothalamic pituitary dysfunction following TBI and discusses the potential benefits of hormone replacement therapy for individuals with hormone deficiencies.

The rate of hypothalamic pituitary dysfunction following TBI has been reported as anywhere between 25 and 80 percent. Specifically, abnormal hormone levels, both chronic and acute, are generally estimated to be approximately 5-22 percent for thyroid hormones, 15-33 percent for growth hormone (GH), and 25-80 percent for testosterone. The effect of hypopituitarism has been reported on several aspects cognitive and physical function as well as overall quality of life. In these studies, GH and testosterone deficiencies appear to underlie the observed impairments.

The paper suggests the importance of understanding and screening for hypothalamic pituitary dysfunction as hormone replacement therapy may be a beneficial intervention to promote physical and cognitive rehabilitation.

Gursh Bindra PhD describes the dietary sources of zinc and the clinical signs of deficiency, the role of the mineral in the body and ways of assessing biochemical status

Purpose: In this chapter, I analyze proceedings from 2015 when the Court of Arbitration for Sport (CAS) was asked to determine whether Dutee Chand, an Indian sprinter, could compete as a female athlete. Excluded on the basis that her naturally high testosterone levels conferred an unfair athletic advantage, Chand argued that existing policies in international sport were scientifically flawed. The purpose of the analysis is to examine whether the case led to a shift in the gender politics of sport, law, and science.

Methodology/Approach: I present a textual analysis of the arbitral award document, drawing on feminist methodology to identify where and how the adjudicating panel’s assessment of the case was gendered.

Findings: The CAS decision defined the right to compete as primarily a matter for science to decide, in the process obscuring the gendered and tilted playing field upon which scientific knowledge production takes place. Furthermore, the right to unconditional recognition as a woman was reduced to science alone.

Social Implications: My analysis reveals that Chand’s victory is a precarious one, with binary and biologized models of sex and gender prevailing when the institutions of sport, law, and science determine the policy boundaries of “fair play” for female athletes.

Originality/Value of Study: This chapter shows how the institutions of sport, law, and science work together to determine gender. As a consequence, even feminist versions of the biology of sex difference risk reifying the authority of science as the dominant knowledge form within the institutional spaces of sport and law.

In recent years there have been increasing calls for the use of anabolic androgenic steroids (AAS) and associated drugs to be recognized as a public health issue. In the domain of the competitive athlete and professional bodybuilder, recent decades have seen the diffusion of AAS from the hardcore gyms of the 1980s and 1990s to the mainstream exercise and fitness environments of the twenty-first century. Alongside the apparent increases in the use of these drugs, there is a growing evidence base in relation to harms – physical, psychological and (to some extent) social. But is this form of drug use a public health issue? What criteria should we use to make this judgement? What is the available evidence and has our understanding of the issue improved? By drawing on the authors' research in the United Kingdom and the wider international literature this chapter will explore these issues and attempt to answer the fundamental question – is the use of anabolic steroids a public health issue?

Depression is one of the most overlooked psychiatric disorders among middle-aged and elderly men. Saffron (Crocus sativus L.) stigmas are a favorite and common spice that is used as an antidepressant, an anti-inflammatory and a sexual stimulant. This systematic review aimed to provide a comprehensive survey of the effects of saffron on depression in middle-aged and elderly men.

The authors searched Web of Science, PubMed, ProQuest, Cochrane, Science Direct, Scopus and Google Scholar databases to gather any relevant studies published from 1980 to September 2022. This review included studies that examined the relationship between depression and testosterone concentration (four studies) or saffron’s effects on testosterone and depression (six studies).

Observational research showed an association between testosterone and depression in middle-aged and elderly men. Furthermore, animal studies have found that saffron increased testosterone levels and decreased depression in males. There is evidence that testosterone may contribute to the mood. Besides its antioxidant and anti-inflammatory properties, this study proposed scientific mechanisms that saffron may also play a protective role against depression through its influence on testosterone, in middle-aged and elderly men. The general use of saffron at high doses or for prolonged periods may cause side effects; therefore, it is important to consult a health-care professional before the recommended dosage and duration of saffron supplementation, especially if a person has any underlying health conditions or is taking medications.

This study provides researchers with an additional perspective for conducting clinical trials on the use of saffron to enhance the mood of elderly men with testosterone deficiency.

In this article an audit of the service provided by our osteoporosis clinic at St. Mary's Hospital, Paddington, is described. The aim was to assess the quality of the service and to identify deficiencies that could be improved upon. It extended into primary care, and included an enquiry into patient satisfaction. From April to October 1995 154 patients (of whom 150 were female) were referred to the clinic. Of these 118 required a bone density measurement and 34% of patients had osteoporosis. The general practitioners (GPs) were satisfied with the waiting time for appointments and the standard of advice and treatment (>90%) but the standard set for communication was not achieved. The inadequate premises for the clinic did not deter the patients from documenting their satisfaction with the service provided. Subsequently, improvements have been made. We conclude that an osteoporosis clinic is an important part of the shared care approach to prevention and treatment of osteoporosis.