Search results

Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. Most genetic studies have focused on risk associated with single variants, a strategy which has so far only yielded small (often non-replicable) risks for depressive disorders. In this paper we argue that more substantial risks are likely to emerge from genetic variants acting in synergy within and across larger neurobiological systems (polygenic risk factors). We show how knowledge of major integrated neurobiological systems provides a robust basis for defining and testing theoretically defensible polygenic risk factors. We do this by describing the architecture of the overall stress response. Maladaptation via impaired stress responsiveness is central to the aetiology of depression and anxiety and provides a framework for a systems biology approach to candidate gene selection. We propose principles for identifying genes and gene networks within the neurosystems involved in the stress response and for defining polygenic risk factors based on the neurobiology of stress-related behaviour. We conclude that knowledge of the neurobiology of the stress response system is likely to play a central role in future efforts to improve genetic prediction of depression and related disorders.

Bankruptcy is a financial failure of a business or an organization. Different kinds of bankruptcy prediction techniques are proposed to predict it. But, they are restricted as techniques in predicting the bankruptcy and not addressing the associated activities like acquiring the suitable data and delivering the results to the user after processing it. This situation demands to look for a comprehensive solution for predicting bankruptcy with intelligence. The paper aims to discuss these issues.

To model Business Intelligence (BI) solution for BP the concept of reference model is used. A Reference Model for Business Intelligence to Predict Bankruptcy (RMBIPB) is designed by applying unit operations as hierarchical structure with abstract components. The layers of RMBIPB are constructed from the hierarchical structure of the model and the components, which are part of the reference model. In this model, each layer is designed based on the functional requirements of the Business Intelligence System (BIS).

This reference model exhibits the non functional software qualities intended for the appropriate unit operations. It has flexible design in which techniques are selected with minimal effort to conduct the bankruptcy prediction. The same reference model for another domain can be implemented with different kinds of techniques for bankruptcy prediction.

This model is designed using unit operations and the software qualities exhibited by RMBIPB are limited by unit operations. The data set which is applied in RMBIPB is limited to Indian banks.

A comprehensive bankruptcy prediction model using BI with customized reporting.

Neuroscience is providing new tools to potentially improve diagnosis and classification of autism spectrum disorder (ASD) based on biomarkers. The purpose of this paper, is to describe certain applications of fractal analysis, a tool used to measure information complexity observed within electroencephalograph (EEG) signals and neurogenetic code. It is argued here that a better method of diagnosis of ASD may exist based on these new tools.

Selective review of literature focused on the diagnosis of ASD and recent technological advances in scientific approaches to diagnosis of ASD. It is argued that higher levels of complex, coherent data are inversely related to pathology; in biological systems, lower complexity EEG during specific tasks may reveal pathology.

Clinicians and researchers are exploring new ways to describe mental illness based on biomarkers to improve reliability and validity of diagnostic methods. Specific application of chaos theory in the form of fractal analysis shows promise as one possible method.

This is a conceptual paper addressing the advantages of employing fractal analysis of EEG and genomics for the diagnosis of ASD.

This study aims to examine the research productivity of Pakistan Agricultural Research Council’s (PARC’s) researchers published during 2001–2020 by using scientometric indicators. The study explored the growth and collaborative trends along with authorship and institutional collaborative patterns at the national and international levels.

The study was conducted in four phases. Firstly, a search strategy was designed to retrieve reliable data sets. During the second phase, data from PARC research was retrieved from Scopus and Web of Science (WoS). In the third phase, the data were combined, and duplications were removed. Finally, the data were analysed using RStudio and VOSviewer.

The study identified 2,868 research publications from 16 communication channels spanning over the period of 2001–2020. The growth rate varied during the study period and the year 2020 was the most productive year of the organization. Most of the research was produced in multi-authorship and five authors were dominant. Pakistan Journal of Botany was the most preferred and cited source. Moreover, PARC research collaboration with Pakistani researchers was more than their international counterparts.

Like other research, this research has some limitations. For example, this research is based on secondary data extracted from WoS and Scopus databases, world-renowned online academic. However, researchers should keep in mind while interpreting the results of this study. Secondly, the research publications published by PARC researchers during 2001–2020 were considered. Finally, this research considered English language literature only.

The study’s key theoretical contribution is its strategy for merging WoS and Scopus in RStudio, while its findings could assist agriculture research stakeholders in identifying new areas of research, awards, promotions and identification of research gaps.

To the best of the author’s knowledge, this study is the first to use scientometric indicators to evaluate PARC’s research productivity. This detailed analysis provides a deeper understanding of PARC’s contribution to agriculture research and its potential implications.

In the literature there are numerous tests that compare the accuracy of automated valuation models (AVMs). These models first train themselves with price data and property characteristics, then they are tested by measuring their ability to predict prices. Most of them compare the effectiveness of traditional econometric models against the use of machine learning algorithms. Although the latter seem to offer better performance, there is not yet a complete survey of the literature to confirm the hypothesis.

All tests comparing regression analysis and AVMs machine learning on the same data set have been identified. The scores obtained in terms of accuracy were then compared with each other.

Machine learning models are more accurate than traditional regression analysis in their ability to predict value. Nevertheless, many authors point out as their limit their black box nature and their poor inferential abilities.

AVMs machine learning offers a huge advantage for all real estate operators who know and can use them. Their use in public policy or litigation can be critical.

According to the author, this is the first systematic review that collects all the articles produced on the subject done comparing the results obtained.

The proposed article is aimed at exploring the opportunities, challenges and possible outcomes of incorporating big data analytics (BDA) into health-care sector. The purpose of this study is to find the research gaps in the literature and to investigate the scope of incorporating new strategies in the health-care sector for increasing the efficiency of the system.

Fora state-of-the-art literature review, a systematic literature review has been carried out to find out research gaps in the field of healthcare using big data (BD) applications. A detailed research methodology including material collection, descriptive analysis and categorization is utilized to carry out the literature review.

BD analysis is rapidly being adopted in health-care sector for utilizing precious information available in terms of BD. However, it puts forth certain challenges that need to be focused upon. The article identifies and explains the challenges thoroughly.

The proposed study will provide useful guidance to the health-care sector professionals for managing health-care system. It will help academicians and physicians for evaluating, improving and benchmarking the health-care strategies through BDA in the health-care sector. One of the limitations of the study is that it is based on literature review and more in-depth studies may be carried out for the generalization of results.

There are certain effective tools available in the market today that are currently being used by both small and large businesses and corporations. One of them is BD, which may be very useful for health-care sector. A comprehensive literature review is carried out for research papers published between 1974 and 2021.

Biotech companies stand as key actors in pharmaceutical innovation. The high risk and long timelines inherent with their R&D investments might hinder their access to funding, potentially stifling innovation. This study aims to explore into the appeal of biotech companies to capital market investors, whose financial backing could bolster the growth of the biotechnology sector.

This paper uses a dataset of 774 US publicly listed biotech firms to investigate their risk and return characteristics by comparing them to pharmaceutical firms and a sample of matched non-biotech R&D-intensive firms over the sample period 1980–2021. Tests show that the conclusions remain consistent across diverse methodological approaches.

The paper shows that biotech companies are riskier than the average firm in the market index but outperform on a risk-adjusted basis both the market and a matched group of R&D-intensive firms. This is particularly true for large capitalization biotech, which is also shown to provide a diversification benefit by reducing the downside risk in past crisis periods.

This paper provides insight relevant to the current debate about the overall performance of the biotech industry in terms of policy changes and their impact on small, early-stage biotech firms. While small and early-stage biotech firms are playing an increasing role in scientific innovation, this study confirms their greater vulnerability to financial risks and the importance of access to capital markets in enabling those companies to survive and evolve into larger biotech.

The purpose of this paper is to explore new methods to improve supply chain management in uncertain environment, more specifically, to tackle the uncertain demand problem and the inventory optimization problem faced by most supply chain systems.

The paper develops a multi‐objective inventory optimization model, which combines the classic grey prediction GM(1,1) model with the metaheuristic method. The former is applied to achieve the forecasting mechanism in supply chain operations, and the latter is applied to optimize the model solution.

Results show that the grey‐based forecasting mechanism performs better than other prediction methods, such as the double exponential smoothing method used in this paper. The solution of the multi‐objective inventory optimization model is also improved with the integration of grey prediction method. These indicate the importance of a forecasting mechanism in supply chain management.

The paper succeeds in constructing a novel inventory optimization model and in providing a novel supply chain management framework. It shows for the first time that grey prediction method combined with metaheuristic method may be a valid approach to supply chain management under uncertain environment.