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The purpose of this paper is to investigate epidemiology and control strategies of the four priority vector-borne diseases (VBDs) in Nepal, i.e. malaria, Kala-azar (visceral leishmaniasis), lymphatic filariasis (LF) and dengue fever/dengue hemorrhagic fever.

The study was a retrospective design to collect data during 1998–2016 from VBDs endemic districts of Nepal. All data were reviewed and epidemiological information of the four VBDs were analyzed.

The number of malaria cases during 1998–2016 of the 13 affected districts was declined from 8,498 to 991 cases with no record of deaths since 2012. The number of cases and deaths in the 12 kala-azar (visceral leishmaniasis) affected districts in 1998 was 1,409 and 42 cases, respectively, but was dramatically decreased in 2016 to 213 and 2 cases, respectively. LF cases of the 61 affected districts in 2011, 2014 and 2016 were 28,855, 30,000 and 33,517 cases, respectively. In total, 25 districts achieved elimination target and the remaining are expected to complete the needful cycles by 2018. Dengue incidence of the 31 affected districts during 2006–2015 was under controlled with reported cases of 642, 356 and 136 cases in 2013, 2014 and 2015, respectively, and only one death in 2015. Implementation of control strategies particularly disease management and community peoples’ awareness significantly reduced the cases and deaths of the target VBDs.

The results of this study clearly suggest that the current control strategies have been worked effectively. However, in particular of the VBDs, health education in communities in the endemic areas should be adopted for better community participation in the context of the primary health care approach and increase the effectiveness of disease control.

VBDs, i.e., malaria, kala-azar (visceral leishmaniasis), LF and dengue fever/dengue hemorrhagic fever, are major causes of morbidity and mortality in the least developed countries which include Nepal. Globalization of travel and trading, unplanned urbanization, environmental and climate change are having a significant impact on disease transmission. Therefore, the Ministry of Health of Nepal had brought some changes in strategies based on activities for disease control, vector control, preventive and preparedness for outbreak response. Consequently, the cases and deaths due to malaria, kala-azar (visceral leishmaniasis), lymphatic filaiasis and dengue fever/dengue hemorrhagic fever have been brought down markedly.

The purpose of this paper is to evaluate the effectiveness of the intervention program for dengue fever prevention among people in rural communities.

A quasi-experimental study was designed for two groups. The intervention group received five weeks of dengue hemorrhagic prevention program consisted of knowledge broadcast, campaign, model house contest and group education. The control group received only the usual care of health promoting hospitals. The primary expected outcomes were changes in knowledge, perceived susceptibility, perceived severity, perceived benefit, perceived barriers and preventive action from baseline data, post-intervention and three-month follow-up, along with a comparison between the two groups. The secondary expected outcomes were changes in house index (HI) from baseline to post-intervention and three-month follow-up, along with a comparison between the two groups.

From the total of 64 participants, 32 were randomly assigned to the control group and 32 were randomly assigned to the intervention group. There were significant differences in knowledge, perceived susceptibility, perceived severity, perceived benefit, perceived barriers, preventive action and HI in the intervention group after received the five-week intervention program and at three-month follow-up (p<0.05).

Dengue hemorrhagic prevention program based on the Health Belief Model was effective in lowering HI and improving knowledge, perceived susceptibility, perceived severity, perceived benefit, perceived barriers and preventive action among people in rural communities. The intervention program may be beneficial in primary care in such a rural community.

The purpose of this chapter is to offer reflections on conventional theories concerning causes and determinants of diseases. It also intends to examine both theoretical and empirical bases for adopting an Integrated Social-Ecological Systems (ISES) lens as a tool for understanding complexities related to drivers, determinants and causes of diseases.

We assessed the theoretical underpinnings of a range of historical and contemporary lenses for viewing infectious disease drivers and the implications of their use when used to explain both personal (i.e. individual) and population health. We examined these issues within the empirical context of the City of Dhaka (Bangladesh) by adopting an ISES lens. Within this study an emphasis has been placed on illustrating how feedback loops and non-linearity functions in systems have a direct bearing upon various aspects of infectious disease occurrences.

A brief triumph over microbes during the last century stemmed in part from our improved understanding of disease causation which was built using disciplinary-specific, monocausal approaches to the study of disease emergence. Subsequently, empirical inquiries into the multi-factorial aetiology and the ‘web of causation’ of disease emergence have extended frameworks beyond simplistic, individualistic descriptions of disease causation. Nonetheless, much work is yet to be done to understand the roles of complex, intertwined, multi-level, social-ecological factors in affecting disease occurrence. We argue, a transdisciplinary-oriented, ISES lens is needed to explain the complexities of disease occurrence at various and interacting levels. More theoretical and empirical formulations, with evidence derived from various parts of the world, is also required to further the debate.

Our study advances the theoretical as well as empirical basis for considering an integrated human-nature systems approach to explaining disease occurrence at all levels so that factors at the individual, household/neighbourhood, local, regional and global levels are not treated in isolation.

This paper aims to review the potential application of surface plasmon resonance (SPR) in diagnosis of dengue virus (DENV-2) E-protein and the development of SPR to become an alternative DENV sensor.

In this review, the existing standard laboratory techniques to diagnosis of DENV are discussed, together with their drawbacks. To overcome these drawbacks, SPR has been aimed to be a valuable optical biosensor for identification of antibodies to the DENV antigen. The review also includes the future studies on three-dimensional poly(amidoamine) (PAMAM) dendrimer-surface-assembled monolayer (SAM)-Au multilayer thin films, which are envisaged to have high potential sensitive and selective detection ability toward target E-proteins.

Application of SPR in diagnosis of DENV emerged over recent years. A wide range of immobilized biorecognition molecules have been developed to combine with SPR as an effective sensor. The detection limit, sensitivity and selectivity of SPR sensing in DENV have been enhanced from time to time, until the present.

The main purpose of this review is to provide authors with up-to-date and useful information on sensing DENV using SPR and to introduce a novel three-dimensional PAMAM-SAM-Au multilayer thin films for future research on SPR sensing applications.

The purpose of this paper is to determine the factors associated with DF occurrence in recurrence villages in Chiang Rai, Thailand.

A case-control study was conducted between June 2017 and December 2017. A validated questionnaire was used to detect the factors associated with recurrence of DF. χ² and logistic regression were used to detect the associations between variables at α=0.05.

In total, 213 cases and 436 controls were recruited into the analysis. Cases were recruited from 20 DF recurring villages, while controls were recruited from 20 non-DF recurring villages in Chiang Rai province. At community level, three variables were associated with recurrence of DF; size of the village (p=0.007), number of villagers (p=0.009), tribe (p=0.043) and distance to a hospital (p=0.003). Three variables were associated with DF at personal and family levels in multivariate model: children whose parents worked as daily employees, and government officers and traders were more likely to have DF 1.56 (95%CI=1.22–2.48) and 4.31 (95%CI=4.66–9.38) times greater than of those whose parents’ worked as agriculturists, respectively; children aged less than one year were 2.89 (95%CI=2.17–4.33) times more likely to have DF than those aged=6 and children who were under standard growth and over standard growth were more likely to have DF than those standard growth 1.61 (95%CI=1.18–2.53) and 7.33 (95%CI=4.39–10.37) times, respectively.

This is the original research article which was conducted in detecting the factors associated with recurrence of DHF in Northern Thailand.

Since joining Bennett College in 2008, Dr. Oh has directed 17 undergraduate students’ research projects in applied mathematics. The National Science Foundation (NSF) awarded Dr. Oh grants from the Historically Black Colleges and Universities – Undergraduate Program (HBCU-UP). The grants allowed her to mentor eight mathematics majors/minors in summer research for four years (2009–2012). Based on the four years of successful undergraduate research (UGR) experiences, she, together with Dr. Jan Rychtar from the University of North Carolina at Greensboro (UNCG), received funding for two summers National Research Experience for Undergraduates (NREUP), an activity of Mathematical Association of America (MAA), funded by the NSF in 2013 and 2014. During the six years of funded UGR, Bennett students made 33 presentations at regional, state, and national conferences; two teams won the outstanding student presentation award and first place for presentation. Three papers were published; two of them by Dr. Oh and one of them with a UGR coauthor. Three projects resulted in manuscripts. As a result of the UGR experiences in 2015, Dr. Oh received three more grants: the MAA NREUP, the NSF’s Center for Undergraduate Research in Mathematics (CURM), and the NSF’s Preparation for Industrial Careers in Mathematical Sciences (PIC Math) program awarded grants. A grant was also submitted to HBC-UP-Targeted Infusion Projects: Computational Mathematics at Bennett College.

Overall, the six years of UGR at Bennett College attained the three goals of: (1) enhancing the quality of undergraduate STEM education and research for a deeper appreciation in those disciplines; (2) supporting increased graduation rates in STEM undergraduate education of females; and (3) broadening participation in the nation’s STEM workforce as well as enrollments in graduate schools.

This study examines mosquito-borne diseases and health hazard of using mosquito repellents in Bangladesh. This study also targets to explore the use of different mosquito repellents and associated health hazard between slum and residential people.

This study has applied a stratified systematic sampling technique taking 120 adult individuals from residential and slum areas covering users and non-users of mosquito repellents of Khulna city, Bangladesh. A structured questionnaire has been used to collect data from respondents.

Econometric techniques are exercised to examine the occurrence, severity and duration of different respiratory diseases. Results exhibit that poor and less-educated slum people are more prone to face respiratory diseases compared to residential people. The health cost of slum and residential people is estimated US$ 134 and US$ 9, respectively.

Relevant stakeholders under public health programs should spread awareness among people regarding the negative health effect of using mosquito repellent, encourage them to limit the use of harmful repellent and instead use herbal product (neem coil), avoid using repellent in living room rather use outside of room and close window and use proper bed net at night.

This study underpins arranging public health programs and taking averting actions as an impetus to raise consciousness toward the negative health effect of using mosquito repellents.

The purpose of this paper is to investigate the influence of breeding containers on the production of Aedes mosquitoes after a vector-control program in households that might support dengue transmission in tourist attraction areas of Bang Kachao Riverbend, Thailand.

A cross-sectional study was conducted in an ecotourism area of Bang Kachao Riverbend, Thailand, during the period October 2016 to September 2017. A total of 832 households from five villages participated in the study. Data collection employed an interview questionnaire, larval mosquito survey and measurements of the chemical properties of the water in each container. A binary logistic regression model was used to investigate the characteristics of water containers influencing the presence or absence of Aedes immatures.

The study found that water containers located inside households had a highly presence of Aedes immatures (2.22 times) compared with outdoor containers. Water containers without lids and water containers with ineffective had a high presence of Aedes immatures (3.69 and 2.54 times, respectively). In addition, the chemical properties of the water inside the containers, such as pH, influenced the presence of Aedes immatures (1.76 times) (OR=1.76, 95% CI=1.59–1.96).

The study results emphasized the characteristics of water containers in households located in a tourist attraction area. The findings may inform public health vector-control messages for households located in the tourist attraction area.

Over the last decades, there has been an increasing interest among scientists on the linkage between population health and climate and environmental factors, as well as health impacts of climate change and climate variability. Numerous studies have been done and substantial results achieved, but mostly in the developed countries, and not much quantitative evidence or assessment of the impacts at national and local levels has been provided for developing countries.