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Favorable effects of Globularia alypum on cardiometabolic markers in high fructose-fed rats

Yasmina Bahlil (Laboratory Clinical and Metabolic Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Université Oran1 Ahmed Ben Bella, Oran, Algeria)
Djamil Krouf (Laboratory Clinical and Metabolic Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Université Oran1 Ahmed Ben Bella, Oran, Algeria)
Zoheir Mellouk (Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, Université Oran1 Ahmed Ben Bella, Oran, Algeria)
Nawal Taleb-Dida (Laboratory Clinical and Metabolic Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Université Oran1 Ahmed Ben Bella, Oran, Algeria)
Akila Guenzet (Laboratory Clinical and Metabolic Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Université Oran1 Ahmed Ben Bella, Oran, Algeria)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 14 August 2020

Issue publication date: 2 June 2021

107

Abstract

Purpose

This study aims to examine whether Globularia alypum (Ga) lyophilized aqueous leaves extract treatment improves cardiometabolic syndromes such as hyperglycemia, lipid profiles and oxidative damage resulting from a high-fructose diet induced in hypertriglyceridemic rats.

Design/methodology/approach

A total of 24 male Wistar rats weighing 80 ± 5 g were first randomly divided into 2 groups. A total of 12 control rats (C) were fed a standard-diet (St-D) and 12 high fructose (HF) rats were fed a high-fructose diet (HF-D) containing St-D in which cornstarch was substituted by fructose (61.4%). After 15 weeks of feeding, body weight (BW) was about 320 ± 20 g and hypertriglyceridemia was noted in HF vs C group (2.69 ± 0.49 mmol/L) vs (1.25 ± 0.33 mmol/L). Each group of rats was then divided into two equal groups (n = 6) and fed during four weeks either a St-D or HF-D, treated or not with 1% of Ga extract (C-Ga) and (HF-Ga). After 28 days, fasting rats were anesthetized and blood and tissues were removed to measure biochemical parameters.

Findings

The results showed no significant differences in BW and insulinemia between all groups. Ga extract supplementation reduced glycemia (−36%), glycosylated hemoglobin (−37%), Homeostasis Model of Assessment-Insulin Resistance index (−34%) and triacylglycerol’s contents in plasma (−33%), very low density lipoproteins–low density lipoproteins (VLDL-LDL) (−48%), liver (−52%) and aorta (−39%); total cholesterol concentrations in aorta was 3.7-fold lower in HF-Ga vs HF group. Ga treatment reduced lipid peroxidation in plasma, VLDL-LDL, red blood cells (RBC), liver, muscle and kidney by improving superoxide dismutase (SOD) activity and glutathione peroxidase (GPx) in RBC and catalase (CAT) activity in kidney (p < 0.05). Moreover, Ga ameliorates glutathione (GSH) production in RBC (+41%) and kidney tissues (+35%).

Originality/value

Ga extract ameliorated cardiometabolic syndrome by its hypotriglyceridemic effect and prevented development of insulin resistance. It reduces lipid peroxidation by enhancing non-enzymatic (GSH) and enzymatic (SOD, GPx and CAT) antioxidant defense systems in high-fructose hypertriglyceridemic rats. Therefore, supplementation of Ga leaves extract as an adjuvant could be used for the treatment of hypertriglyceridemia and the prevention and/or the management of cardio-metabolic adverse effects.

Keywords

Acknowledgements

This work was supported by the Algerian Ministry of Higher Education and Scientific Research.

Conflict of interest: The authors declare that there are no financial/commercial conflicts of interest.

Citation

Bahlil, Y., Krouf, D., Mellouk, Z., Taleb-Dida, N. and Guenzet, A. (2021), "Favorable effects of Globularia alypum on cardiometabolic markers in high fructose-fed rats", Nutrition & Food Science, Vol. 51 No. 4, pp. 605-620. https://doi.org/10.1108/NFS-05-2020-0175

Publisher

:

Emerald Publishing Limited

Copyright © 2020, Emerald Publishing Limited

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