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Article
Publication date: 14 August 2020

Yasmina Bahlil, Djamil Krouf, Zoheir Mellouk, Nawal Taleb-Dida and Akila Guenzet

This study aims to examine whether Globularia alypum (Ga) lyophilized aqueous leaves extract treatment improves cardiometabolic syndromes such as hyperglycemia, lipid…

Abstract

Purpose

This study aims to examine whether Globularia alypum (Ga) lyophilized aqueous leaves extract treatment improves cardiometabolic syndromes such as hyperglycemia, lipid profiles and oxidative damage resulting from a high-fructose diet induced in hypertriglyceridemic rats.

Design/methodology/approach

A total of 24 male Wistar rats weighing 80 ± 5 g were first randomly divided into 2 groups. A total of 12 control rats (C) were fed a standard-diet (St-D) and 12 high fructose (HF) rats were fed a high-fructose diet (HF-D) containing St-D in which cornstarch was substituted by fructose (61.4%). After 15 weeks of feeding, body weight (BW) was about 320 ± 20 g and hypertriglyceridemia was noted in HF vs C group (2.69 ± 0.49 mmol/L) vs (1.25 ± 0.33 mmol/L). Each group of rats was then divided into two equal groups (n = 6) and fed during four weeks either a St-D or HF-D, treated or not with 1% of Ga extract (C-Ga) and (HF-Ga). After 28 days, fasting rats were anesthetized and blood and tissues were removed to measure biochemical parameters.

Findings

The results showed no significant differences in BW and insulinemia between all groups. Ga extract supplementation reduced glycemia (−36%), glycosylated hemoglobin (−37%), Homeostasis Model of Assessment-Insulin Resistance index (−34%) and triacylglycerol’s contents in plasma (−33%), very low density lipoproteins–low density lipoproteins (VLDL-LDL) (−48%), liver (−52%) and aorta (−39%); total cholesterol concentrations in aorta was 3.7-fold lower in HF-Ga vs HF group. Ga treatment reduced lipid peroxidation in plasma, VLDL-LDL, red blood cells (RBC), liver, muscle and kidney by improving superoxide dismutase (SOD) activity and glutathione peroxidase (GPx) in RBC and catalase (CAT) activity in kidney (p < 0.05). Moreover, Ga ameliorates glutathione (GSH) production in RBC (+41%) and kidney tissues (+35%).

Originality/value

Ga extract ameliorated cardiometabolic syndrome by its hypotriglyceridemic effect and prevented development of insulin resistance. It reduces lipid peroxidation by enhancing non-enzymatic (GSH) and enzymatic (SOD, GPx and CAT) antioxidant defense systems in high-fructose hypertriglyceridemic rats. Therefore, supplementation of Ga leaves extract as an adjuvant could be used for the treatment of hypertriglyceridemia and the prevention and/or the management of cardio-metabolic adverse effects.

Details

Nutrition & Food Science , vol. 51 no. 4
Type: Research Article
ISSN: 0034-6659

Keywords

Article
Publication date: 29 May 2020

Nawal Taleb-Dida, Djamil Krouf, Yasmina Bahlil, Sarra Dali, Fatima Zohra Alachaher and Akila Guenzet

This paper aims to investigate the preventive effects of a concomitant supplementation of a lyophilized aqueous extract of Globularia alypum (Ga) leaves in a high…

Abstract

Purpose

This paper aims to investigate the preventive effects of a concomitant supplementation of a lyophilized aqueous extract of Globularia alypum (Ga) leaves in a high cholesterol-diet (HC-D) on lipid profile and lecithin cholesterol acyltransferase (LCAT) activity in hypercholesterolemic rats.

Design/methodology/approach

Twenty-four male Wistar rats weighing 232 ± 10 g were divided into four groups (n = 6). Two control groups were fed a standard-diet (St-D) supplemented (C-Ga) or not (C) with 1.66% Ga leaf extract. The two others experimental groups were fed HC-D, which contains the St-D plus 1% of cholesterol and 0.5% of cholic acid supplemented (HC-Ga) or not (HC) with the same amount of Ga. At d28, feces were collected and fasting rats were anesthetized; bloods and livers were removed to measure biochemical parameters.

Findings

In hypercholesterolemic (HC) rats, Ga supplementation in HC-D induced a significant reduction in ALT (−64%, p = 0.002) and AST (−71%; p = 0.005) activities, in plasma TC (−55%; p = 0.03) and TG (−54%; p = 0.01) concentrations, in cholesterol contents of atherogenic lipoproteins VLDL (−78%; p = 0.004) and LDL-HDL1 (−64%; p = 0.003) and inversely, an increase in those of anti-atherogenic HDL2 (+14%; p = 0.002). Feeding the HC-D-Ga exhibited a reduction in atherogenic index Apo B/Apo A-I (−72%; p = 0.002), an increase in faecal lipids, cholesterol excretion and in plasma apo A-I (+60%; p = 0.002) and HDL2-cholesteryl esters (+32%, p = 0.04) and then improved LCAT activity (+31%; p = 0.03).

Originality/value

In hypercholesterolemic rats, Globularia alypum extract was effective in preventing lipid disorders by its hypolipidemic action, had an anti-atherogenic potential and a protective effect against cardiovascular risk by enhancing LCAT activity.

Details

Nutrition & Food Science , vol. 51 no. 1
Type: Research Article
ISSN: 0034-6659

Keywords

Article
Publication date: 6 February 2009

Hamid Reza Zakeri, Asal Ataie Jafari, Mohammad Rajabi and Saeed Hosseini

Reducing fat intake or inhibiting fat absorption is a useful solution for blood lipid reduction. It is shown that there are some proteins in wheat germ with pancreatic…

305

Abstract

Purpose

Reducing fat intake or inhibiting fat absorption is a useful solution for blood lipid reduction. It is shown that there are some proteins in wheat germ with pancreatic lipase inhibiting properties that have hypolipidemic effects. This paper aims to evaluate the possible beneficial effects of a daily intake of 30 g of raw wheat germ in a population of Iranian hyperlipidemic subjects with their special dietary habits.

Design/methodology/approach

This experimental trial was conducted on 15 hyperlipidemic patients with the average age of 45.7±7 years. They were not on lipid‐lowering drugs for the previous three months. They were asked to consume 30 g of raw wheat germ each day for four weeks, and continue their normal diet (follow‐up period) for the following four weeks. Dietary records were taken for three days prior to the study and at the end of a four weeks intervention and follow‐up period. Data were analysed using repeated measurement analysis. If the statistical significance was detected, a paired‐t‐test was used.

Findings

The consumption of wheat germ for four weeks lowered the serum total cholesterol (p<0.002), triglyceride (p<0.001) and VLDL‐C (p<0.001). These levels were significantly increased after the follow‐up period, but they did not reach the baseline level. HDL‐C level was not significantly changed.

Practical implications

Consumption of wheat germ may lower the risk of CHD by reducing the serum lipids.

Originality/value

The paper evaluates the possible beneficial effects of a daily intake of 30 g of raw wheat germ in a population of Iranian hyperlipidemic subjects with their special dietary habits.

Details

Nutrition & Food Science, vol. 39 no. 1
Type: Research Article
ISSN: 0034-6659

Keywords

Article
Publication date: 24 September 2019

Somayeh Tajik, Kevan Jacobson, Sam Talaei, Hamed Kord-Varkaneh, Zeinab Noormohammadi, Ammar Salehi-Sahlabadi, Mehran Pezeshki, Jamal Rahmani and Azita Hekmatdoost

The results of human studies evaluating the efficacy of plant Phytosterols on liver function were inconsistent. Therefore, the purpose of this paper is to eliminate these…

Abstract

Purpose

The results of human studies evaluating the efficacy of plant Phytosterols on liver function were inconsistent. Therefore, the purpose of this paper is to eliminate these controversies about the Phytosterols consumption on liver serum biochemistry in adult subjects.

Design/methodology/approach

The literatures systematically searched throughout PubMed and Scopus databases up to June 2018; it was conducted by using related keywords. Estimates of effect sizes were expressed based on weighted mean difference (WMD) and 95% CI from the random-effects model (erSimonian and Laird method). Heterogeneity across studies was assessed by using I2 index. Eighteen studies reported the effects of Phytosterols (PS) supplementation on liver serum biochemistry.

Findings

The current meta-analysis did not show a significant effect on ALT (MD: 0.165 U/L, 95% CI: −1.25, 1.58, p = 0.820), AST (MD: −0.375 IU/Liter, 95% CI: −1.362, 0.612, p = 0.457), ALP (MD: 0.804 cm, 95% CI: −1.757, 3.366, p = 0.538), GGT (MD: 0.431 U/L, 95% CI: −1.803, 2.665, p = 0.706) and LDH (MD: 0.619 U/L, 95% CI: −4.040, 5.277, p = 0.795) following PS consumption.

Originality/value

The authors found that no protective or toxic effects occur after the consumption of Phytosterols on liver enzymes including ALT, AST, ALP, LDH and GGT.

Article
Publication date: 9 May 2016

Harry Freitag Luglio, Anisa Lailatul Fitria, Dewi Ayu Kusumawardhani, Rinta Amalia, Desy Dwi Hapsari, Rina Susilowati and Sunarti Sunarti

This study aims to examine the effect of lesser yam-based cookies on glucagon-like peptide-1 (GLP-1), blood glucose and lipid profile in overweight and obese individuals.

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Abstract

Purpose

This study aims to examine the effect of lesser yam-based cookies on glucagon-like peptide-1 (GLP-1), blood glucose and lipid profile in overweight and obese individuals.

Design/methodology/approach

This was an experimental study on overweight or obese adults aged 21-50 years old. The intervention was done by giving 87g of cookies made with lesser yam flour in combination with wheat flour (80 and 20 per cent, respectively) for six weeks. Anthropometric measures, fasting plasma glucose, lipid and GLP-1 were measured before and after the intervention.

Findings

There were no changes in anthropometric measurements and glucose level after the intervention (p > 0.05). However, plasma low density lipoprotein (LDL) and total cholesterol decreased after the intervention (p = 0.033 and p = 0.035, respectively). Although fasting GLP-1 level (p = 0.121) was unchanged, we found that the slight changes in GLP-1 concentration was associated with changes in LDL and total cholesterol (p = 0.002 and p = 0.001, respectively).

Originality/value

The lesser yam-based cookies reduced fasting plasma LDL and total cholesterol, but not glucose level after six weeks of intervention. Additionally, reduction of LDL and total cholesterol level was negatively associated with the changes in GLP-1 level.

Details

Nutrition & Food Science, vol. 46 no. 3
Type: Research Article
ISSN: 0034-6659

Keywords

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