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As the Dutch East India Company expanded its presence in Asia during the seventeenth century, discovery of new products and medical materials was central to its continued success and survival. This new product innovation was difficult to manage directly however because the routine-driven, efficiency-focused organization was ill-suited to research and discovery required for bioprospecting and innovation. Instead, the Company tacitly allowed its employees in Asia to conduct this research on their own. Scientists became free riders, exploiting their administrative authority and corporate resources to further their private research projects. This symbiotic public–private partnership enabled employees to use Company resources to undertake large-scale economic and scientific surveys of its Asian domains. These decentralized, entrepreneurial projects cut across the boundaries of caste, language, religion, and theoretical orientation to assemble new, systematic views of Asian knowledge. While not centrally planned (nor always officially condoned), these surveying efforts had all of the hallmarks of a systematic colonial project to map out the sources of value in foreign colonies.

Archaeological evidence from the prehistoric Spondylus industry of coastal Ecuador is analyzed here to clarify how craft production was structured and the role that it played in the rise of social complexity. Many models of social development propose that elite cooption of specialized craft production can be a useful avenue through which aspiring elites can gain differential status. Contrary to the expectations of these models, data from coastal Ecuador indicates that craft production of sumptuary goods was an activity primarily carried out by household units for the benefit of the domestic economy. Increased trafficking with northern Peruvian states at ca. 750 seems to have promoted local social stratification by attracting large numbers of households to the restricted locales where they could exploit these resources, which in turn prompted a strengthening of the kinds of political conditions that facilitate orderly interaction and minimize internal social conflict.

The Epic of Gilgamesh is among the oldest stories remembered. One of its tales, “Journey to the Forests of Cedar,” illustrates early accounts of forest depletion (George, 1999, pp. 30–47). For timber, to expand the city of Uruk where he rules, Gilgamesh kills Humbaba, the forest guardian, who protected a great forest. Gilgamesh and his followers then stripped the forest. The gods warned Gilgamesh in dreams they sent to him on his forest journey that floods and droughts would follow his killing of Humbaba and the cutting of the cedar forests, and so it happened.

Purpose – Intravenous leiomyomatosis (IVL) is a very rare subtype of leiomyoma, involving the right obstruction of the heart, and is an unusual cause of outflow tract obstruction. The IVL grows from the vessel’s smooth muscle, protruding into the vessel’s lumen, and can expand to the right atrium and even beyond causing death due to blood flow obstruction into the right atrium and even to pulmonary artery.

Design/Methodology/Approach – We present a 33-year-old Indonesian woman with cardiopulmonary symptoms predominantly, and marked by an intravascular leiomyoma extending from inferior vena cava (IVC) to right chamber atrium, with the chief complaint being easily fatigued since seven months.

Findings – Echocardiography observations found a mass in the right atrium and the IVC that caused dynamics obstructed in tricuspid valve, right atrium and ventricle were dilated, no left ventricular (LV) hypertrophy, normal LV and right ventricular (RV) functions, and no valve abnormality except the tricuspid valve gradient being 21 mmHg with mild regurgitation. Venography resulted in a mobile tumor mass in IVC mouth which partially flew into the right atrium, and partially blocked the IVC mouth. Tumor size was 6.4 cm × 4.8 cm. Abdominal multislice computed tomography resulted in a residual soft tissue mass (leiomyoma) along the IVC extended to the right atrium. The tumor mass size in the IVC and the right atrium was bigger compared to tumor mass on July 2008. The correct diagnosis was established during surgery; therefore a two-stage resection was done.

Originality/Value – Surgical resection is the best treatment for intracardiac extension of intravenous leiomyoma. To remove the ilio-caval portion, iliac venotomy was recommended for the tumor in both stages of the surgeries.

Purpose – This chapter examines the expectation that because the developmental trajectories of cultural frontiers are often seen as being tied to that of their more complexly developed neighbors, increases in interregional interaction provide frontier communities with previously unavailable political-economic opportunities that promote social change.

Design/methodology/approach – This expectation is examined using data from archaeological excavations at the site of El Dornajo in southwestern Ecuador. Models based on external conditions like interregional interaction are considered alongside those based on internal conditions like environmental perturbations.

Findings – The results suggest that increased interregional interaction promoted the emergence of a regional prestige economy that symbolically legitimated (and perhaps made possible) the co-option of traditional risk buffering strategies during a time when the availability of subsistence resources had changed due to local conditions.

Practical implications – This chapter supports the notion that the emergence of institutionalized inequality requires control over both internal and external relationships. Furthermore, it suggests that examining models based on both internal and external conditions of change may help to explain the timing and pace of that change.

Originality/value – Much of the archaeological literature is dichotomized between models based on internal conditions and those based on external conditions. Few archaeologists would take exception to the notion that both conditions matter, but equally few archaeologists are looking at both kinds of conditions in the same case study.

Certain elements of Hayek’s work are prominent precursors to the modern field of complex adaptive systems, including his ideas on spontaneous order, his focus on market processes, his contrast between designing and gardening, and his own framing of complex systems. Conceptually, he was well ahead of his time, prescient in his formulation of novel ways to think about economies and societies. Technically, the fact that he did not mathematically formalize most of the notions he developed makes his insights hard to incorporate unambiguously into models. However, because so much of his work is divorced from the simplistic models proffered by early mathematical economics, it stands as fertile ground for complex systems researchers today. I suggest that Austrian economists can create a progressive research program by building models of these Hayekian ideas, and thereby gain traction within the economics profession. Instead of mathematical models the suite of techniques and tools known as agent-based computing seems particularly well-suited to addressing traditional Austrian topics like money, business cycles, coordination, market processes, and so on, while staying faithful to the methodological individualism and bottom-up perspective that underpin the entire school of thought.