Search results

This paper aims to investigate whether the interaction between vitamin D receptor (VDR) FokI polymorphism and dietary patterns is associated with metabolic syndrome (MetS) and its components.

In total, 304 Iranians were enrolled in this cross-sectional study. Dietary patterns were identified using factor analysis. Fasting serum glucose and lipid profile were also assessed. FokI polymorphism of the VDR gene was genotyped using the restriction fragment length polymorphism method.

Individuals in third tertile of “Unhealthy Patterns had greater odds for MetS (odds ratio: 2.9; 95 per cent CI: 1.3, 6.1; P for trend = 0.03) compared to those in first tertile. Significant results disappeared after controlling for covariates (p = 0.09). There was no significant relationship between adherence to ‘Healthy Pattern’ and odds of MetS (p = 0.55). There were not any interactions between FokI polymorphism and major dietary patterns associated with MetS.

No evidence found for the interaction between polymorphism FokI and major dietary patterns associated with MetS and its components in Iranian subjects. Genome-wide association techniques are needed to assess the direct effect of this polymorphism on MetS.

Fruits and vegetables (FVs) are a good source of substances that contributed to bone health. However, the relation of FVs consumption with inflammation and bone biomarkers is inconsistent. Thus, this paper aims to assess the association of FVs intake with inflammation and bone biomarkers in older adults.

This cross-sectional study was performed on 178 older adults in Tehran, with a mean age of 67.04. Biochemical measurements including serum osteocalcin, high sensitivity c-reactive protein, 25-hydroxyvitamin D 25(OH) D, parathormone and urine terminal telopeptide of Type I collagen (u-CTx) was done. The intake of FVs was calculated using a validated quantitative food frequency questionnaire.

Pearson correlation coefficients showed a positive relation between serum osteocalcin and total vegetables (r = 0.167, p = 0.026), juices group (r = 0.155, p = 0.035), starchy vegetables (r = 0.205, p = 0.006) and other vegetable group (r = 0.161, p = 0.032) even after controlling of potential confounders. Analysis of covariance showed that total vegetable were significantly associated with serum osteocalcin (p = 0.041) and PTH levels (p = 0.028). Additionally, no evidence of a significant relationship between total fruit intake and test variables was observed. However, subgroup analyses demonstrated a significant association between citrus fruits and serum 25(OH) D (p = 0.017). A significant relation between starchy vegetable and urine CTx-I was reported (p = 0.016). Moreover, other vegetable subgroup was strongly associated with serum osteocalcin (p = 0.003).

The results of this paper may provide insight for clinical interventions and also important to make policy for prevention or easing bone disorders and general inflammation related to fruit and vegetable intake.

Dietary patterns have been used to explore the association between dietary factors and risk of pancreatic cancer (PC) and renal cancer (RC); however, the association remains unclear. The purpose of this paper is to comprehensively review these associations.

Pertinent studies published prior to March 2016 were systematically searched and retrieved through PubMed and Scopus databases. Adjusted risk estimates were derived by comparing the highest with the lowest categories of dietary pattern scores and were combined by using the fixed-effects model when no substantial heterogeneity was observed; otherwise, the random-effects model was used.

A total of nine studies, five for PC (including 2,059 cases and 41,774 participants/controls) and four for RC (with 1,327 cases and 53,007 participants/controls), were included in this meta-analysis. A decreased risk of PC was shown for the highest compared with the lowest categories of the healthy dietary pattern (OR = 0.72, 95 per cent CI = 0.51-0.94, random effects (p-value for heterogeneity = 0.004)), whereas no significant association with Western dietary was observed (OR = 1.16, 95 per cent CI = 0.87-1.44, fixed effects). In the overall analysis, a significant association was found between the healthy dietary pattern and reduced risk of RC (OR = 0.59, 95 per cent CI = 0.48-0.71, fixed effects (p-value for heterogeneity = 0.459)), whereas the Western pattern was positively associated with risk of RC (OR = 1.42, 95 per cent CI = 1.14-1.69, fixed effects). For both cancers, the reduced risk associated with the healthy pattern was restricted to case-control, but not cohort, studies. Furthermore, drinking pattern was significantly related to reduced risk of RC (OR = 0.68, 95 per cent CI = 0.42-0.94).

To the authors’ knowledge, the present study is the first English document to summarize systematically the findings from observational studies in response to this question whether a posteriori dietary patterns are associated with susceptibility to the risk of renal and ovarian cancers.

Recently, evidences have suggested that healthy eating index (HEI), an index-based dietary pattern, may be a predictor for the risk of cancer. This paper aims to examine the association of HEI-2015 and its all components scores with the risk of breast cancer (BC), separately, among Iranian women.

In the present hospital-based, case-control study, 150 age-matched of cases (newly diagnosed female) and 150 controls were recruited. Data of dietary habits and anthropometric measures were obtained, and eventually, the HEI-2015 score was calculated. Multivariate odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship between the risk of BC across tertiles (Ts) of total HEI-2015 and its all component scores.

The results presented that in adjusted model, there was no significant difference between total HEI-2015 (p = 0.14) and its all component scores (p > 0.09) of healthy subjects and females with BC. Moreover, multivariable logistic regression analyses indicated that HEI-2015 score was not associated with the risk of BC in either crude (p-trend = 0.94) or adjusted (p-trend = 0.73) analyses. In the analyses of HEI-2015 components scores, it was observed that the scores of grains (OR, 0.53; 95% CI, 0.30–0.94) and total protein foods (OR, 0.13; 95% CI, 0.02–0.58) may have a relation with BC risk in crude model but after adjusting for BC risk factors, the mentioned associations changed to non-significant.

The findings of current study suggested that there was no significant association of total HEI-2015 and its components scores, independently, with BC incidence among Iranian women.

This paper aims to evaluate the association between carbohydrate quality index (CQI) and nutrient adequacy in Iranian adults.

A total of 268 men and women with ages ranged from 18 to 70 years were evaluated in a cross-sectional study. The CQI was calculated by adding together the three components, namely, the ratio of solid to total carbohydrate, dietary fiber and glycemic index. The scores of three components were summed to calculate the CQI, with a higher score indicating a higher dietary carbohydrate quality. The odds ratios (ORs) of nutrient adequacy ratio (NAR), defined as the ratio of intake of a nutrient to the age- and gender-specific recommended dietary allowance, for the intake of energy and 10 nutrients across quartiles of the CQI were calculated by logistic regression analysis and expressed with 95% confidence intervals (CIs).

CQI ranged between 3 to 15 (mean ± SD: 9 ± 1.9). Being in top versus bottom quartile of the CQI was associated with a higher NAR of folic acid (OR: 3.20, 95% CI: 1.06–9.62; P-trend: <0.001), vitamin A (OR: 3.66; 95% CI: 1.46–9.17; P-trend: <0.001), magnesium (OR: 5.94; 95% CI; 1.71–20.53; P-trend: <0.001), vitamin C (OR: 7.85; 95% CI; 2.99–20.59; P-trend: <0.001).

A higher CQI was associated with greater micronutrient consumption adequacy in Iranian adults. The results suggest that increasing the consumption of total fiber and solid carbohydrates and decreasing the glycemic index of the diet and liquid carbohydrates can improve micronutrient intake adequacy.

Studies investigating the association between dietary inflammatory index (DII) and body mass index (BMI) have led to inconsistent findings. Therefore, to decisively conclude, this paper aims to clarify the relationship between DII and obesity by performing meta-analysis.

PubMed, Scopus and Google Scholar were searched up to July 2017 using key words selected from Medical Subject Headings and other related keywords to identify all relevant articles. In total, 22 articles were entered into the meta-analysis; 22 studies compared the mean of BMI among subjects with highest versus the lowest DII and 4 studies had data on the hazard risk (HR) or odds ratio (OR) for obesity.

A meta-analysis on included studies indicated a significant association on either mean differences (MD) in BMI (MD = 0.811; 95 per cent CI: 0.365-1.256; p: 0.0001) or obesity OR (OR: 1.310; 95 per cent CI: 1.144-1.500; p = 0.000) by comparing the highest and lowest DII categories. Between-study heterogeneity was high (Cochrane Q test, p < 0.001, I² = 98.1 per cent, df = 21, τ² = 0.9273), and only dietary assessment methods could explain the source of heterogeneity in which 24-h dietary recalls were homogeny (I² = 8.4 per cent, df = 2, p = 0.335).

The results of the present meta-analysis suggest that adherence to high DII score increased BMI and obesity. More prospective studies in different populations are needed to better clarify this relation.

This study aims to systematically review randomized clinical trials (RCTs) evaluated the effects of resveratrol on vascular flow-mediated dilation (FMD).

All published RCTs in English were systematically searched on PubMed and Scopus search engines up to October 2017. A total of 61 studies were found through search databases. The outcome variable of interest was FMD. Six articles which met inclusion criteria were included in this study.

From six studies, four showed a significant improvement in FMD after resveratrol supplementation acutely or chronically in subjects with cardio-metabolic risk factors. Two other studies did not show any significant effect of resveratrol on FMD.

The authors systematically reviewed the effectiveness of resveratrol supplementation on FMD for the first time. The findings suggest that pure resveratrol supplementation may have beneficial effects on endothelium dependent vasodilatation indicator, FMD.

This study aims to investigate the association of the dietary inflammatory index (DII), kidney function and high-sensitivity C-reactive protein (hs-CRP) among the senior population (60-83 years).

This cross-sectional study was conducted in 221 elderly subjects who are living in Tehran, Iran. The DII was calculated from validated semi-quantified food frequency questionnaire, combining putatively pro-inflammatory and anti-inflammatory effects of nutrients, vitamins and trace elements. Biochemical measurements of blood and urine samples were measured. The estimated glomerular filtration rate (eGFR) was assessed from serum creatinine.

A total of 221 subjects with mean BMI of 29.75 and age ranged 60-83 years old were included in the current study. Multiple linear regression analysis showed that eGFR (ß = –0.471; p = 0.48; 95 per cent CI: –2.90, 2.63), albumin/creatinine ratio (ACR) (ß = 0.041 p = 0.55; 95 per cent CI: –5.12, 9.46) and hs-CRP (ß = 0.004; p = 0.55; 95 per cent CI: –0.96, 1.79) were not associated with the DII before and after adjusting for potential confounders, including energy intake, age, sex, BMI, smoking status, physical activity, hypertension, diabetes, use of lipid-lowering medication, angiotensin II receptor blockers (ARB) and angiotensin-converting enzyme inhibitor (ACEI), steroidal and non- steroidal anti-inflammatory medications.

Due to the cross-sectional nature of this study, it is difficult to find the cause-and-effect relationship between the DII and the serum hs-CRP concentration. Another limitation of our study is concerning a possible overestimation or underestimation of dietary intakes, because the participants in the study were elderly and FFQ is a memory-based questionnaire.

Our findings suggest that the DII score is not associated with serum hs-CRP and kidney function markers in elderly people.