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The purpose of this study is to explore the association of serum retinol and number of circulating inflammatory cells and disease activity in patients with ulcerative colitis.

A total of 60 patients with ulcerative colitis were enrolled in a cross-sectional pilot study. Patients were recruited from specialized clinic of Tabriz University of Medical Sciences, Iran between April and August 2015. Mayo clinic index was used to assess clinical disease activity score. Blood samples were collected. Serum retinol was assessed using HPLC to determine vitamin A status. Complete blood count and lymphocyte phenotyping were performed by automated hematology analyzer and flow-cytometric analysis, respectively.

According to Mayo scoring, 68.33 per cent of patients had mild and 31.66 per cent had moderate or severe disease activity. About 43.33 per cent of patients were vitamin A deficient, with 23.33 per cent having moderate to severe deficiency (serum retinol < 20 µg/dl). Lower levels of serum retinol and higher count and percentages of CD3+, CD8+ T cells and neutrophil to lymphocyte ratio were statistically associated with disease activity according to univariate analysis (p = 0.002, 0.037, <0.001, 0.031, 0.002 and 0.039); however, in binary logistic regression, only lower levels of serum retinol were independently associated with disease activity with a OR of 0.564 (p = 0.021; 95 per cent CI 0.35-0.92).

Vitamin A deficiency was detected in this study population. Patients with moderate to severe disease activity demonstrated lower serum retinol, higher CD8+ T cells and neutrophil to lymphocyte ratio compared to patients with mild disease activity.

This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) cytokine release in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls.

PBMCs isolated from whole blood of 50 patients with CAD and 48 healthy subjects aged 45 to 60 years were treated with 10 and 20 µM of betanin for 24 h. Real-time polymerase chain reaction was performed to assess gene expression levels of AMPK, SIRT1 and SIRT6. The supernatants of the cultured cells were used to assess the IL-6 and TNF-α protein levels by ELISA.

Treatment with both doses of betanin significantly increased AMPK, SIRT1 and SIRT6 expression in PBMCs of CAD patients compared to control non-treated cells (p < 0.05). In PBMCs of healthy subjects, only treatment with high dose of betanin showed significant increase in AMPK (p = 0.007), SIRT1 (p = 0.013) and SIRT6 (p = 0.024) expression compared to control non-treated cells. Betanin (20 µM) also significantly decreased TNF-α and IL-6 concentrations in the culture supernatants of the CAD patients compared to control non-treated cells (p < 0.001).

Betanin could enhance AMPK, SIRT1 and SIRT6 gene expressions in PBMCs and represent a useful complementary treatment to reduce the proinflammatory status accompanied with CAD.

This paper aims to determine the comparison between dietary habits and intakes and also anthropometric indices among adult patients with major depressive disorder (MDD) and healthy controls. MDD is a common psychiatric disorder with high prevalence in the world which imposes great economic pressure on the society and also the individual. Nutritional factors affect depressive symptoms by different mechanisms, so dietary modification would be inexpensive and somewhat conceivable.

This pilot case – control study was performed on 30 MDD patients and 30 age- and sex-matched healthy subjects. Demographic and anthropometric characteristics of the patients were recorded. Dietary intake and food habits were assessed by food records and using the food frequency questionnaire, respectively. Variables were compared between two groups using the independent t-test or Mann – Whitney test.

Nutrient intake (except for copper and vitamin D) was significantly higher among healthy subjects when compared to the MDD patients. Daily frequency of food consumption was significantly low among depressed patients in comparison to healthy participants in all seven food groups, except the bread and cereals group. Healthy subjects consumed more fish, about once during two months of a year, while this number was low for MDD patients.

The results of this case – control study revealed that dietary habits and consequently micronutrient and macronutrient intakes were significantly different between healthy and MDD patients.

This paper aims to describe food insecurity status, food consumption patterns of households and nutritional status of families residing along the baobab belt in Kitui and Kilifi counties of Kenya. It also explores associations between these and household socio-demographic characteristics.

A cross-sectional study design was performed with a sample of 216 caregiver/child pairs interviewed. Tablet-based semi-structured questions were used to obtain information on socio-demographic characteristics of children (6-13 years) and caregivers. Food insecurity status was assessed using the household food insecurity experience scale. Information on food consumption was obtained from qualitative 24-h recall as a basis for calculating a household dietary diversity score. Data were also obtained from a non-quantitative food frequency questionnaire. Anthropometric measurements of children and caregivers’ height and weight were taken to assess their nutritional status. Data were analyzed using Statistical Package for Social Science version 24 and WHO AnthroPlus 1.0.4.

The majority (98.2 per cent) of the households were food insecurity despite 81.5 and 57.4 per cent in Kitui and Kilifi counties, respectively, owning baobab trees. About 32.1 per cent of the households had poor dietary diversity scores (< 4). The prevalence of stunting (28.6 per cent), wasting (11.6 per cent) and underweight (25 per cent) rates among children were high. A significant association was observed between the children stunting rates with their age (p = 0.027), and also with household’s food security status (p < 0.001). Of the caregivers, 14.8 per cent were underweight, 18.1 per cent were overweight and 8.8 per cent were obese. There was significant association between the nutrition status of the caregivers and gender of the children (p < 0.001) and also with stunting rates of children (p = 0.047).

The study provides data on the current food security status and food consumption patterns of households and nutritional status of families residing along the baobab belt in Kenya which are mostly areas of marginal agricultural potential. The findings indicate a need for appropriate dietary improvements.