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Coronary artery disease (CAD) is developed by an insufficient supply of oxygen-rich blood to the myocardium. Recent studies have shown that increased oxidative stress has implicated in the pathogenesis of coronary atherosclerosis. Anxiety and CAD have a mutual relationship, as the effect of long-lasting anxiety on atherosclerosis and CAD is well known. The purpose of this study is to investigate the relationship between dietary / serum total antioxidant capacity and CAD.

A total of 160 male patients were enrolled in this cross-sectional study. Diagnosis and analysis of angiograms were performed visually by a cardiologist. The subjects were categorized into CAD− (coronary artery obstruction <75 per cent) and CAD+ (coronary artery obstruction ≥ 75 per cent) groups. Anthropometric indices, blood pressure, blood sugar and lipid profile and physical activity (PA) were assessed. Information about anxiety was obtained by Spielberger questionnaire. Dietary total antioxidant capacity (TAC) was obtained by using a semi-quantitative food frequency questionnaire and an oxygen radical absorbance capacity of selected foods.

Mean of dietary TAC was significantly lower in CAD+ than CAD− group (P < 0.001). However, there was not any significant differences about serum TAC (P = 0.28). The mean of body mass index (BMI) (P = 0.04) and triglyceride (TG) level (P = 0.03) and the frequency of smoking (P = 0.03) were significantly higher in the CAD+ than the CAD− group. There was no significant relationship between CAD with apparent (P = 0.33) and hidden anxiety level (P = 0.16). Confounding factors such as smoking and medications were adjusted.

This study had certain limitations. Being a single center cross-sectional design does not permit analysis of causal relationships; the sample size was geographically limited. The authors could not exclude the medication of patients, which could affect the total antioxidant capacity levels. Measurement error in self-reported dietary consumption may results misclassification of exposure.

A diet high in total antioxidant capacity is inversely associated with CAD. Serum TAC does not vary between men with and without CAD when confounders including age, BMI, TG, smoking, SBP, DBP, energy intake, PA, HDL-C, LDL-C, T-C, FBS, family history of CAD, education and anxiety are taken into consideration.

High consumption of vegetables and fruits may play a major role in the prevention of CAD.

The study was approved by the ethics committee of Isfahan University of Medical Sciences (No:394888).

Coronary artery disease (CAD) is reported as one of the most common sources of death all over the world. The presence of stenosis (plaque) in the coronary arteries results in the restriction of blood supply, leading to myocardial infarction. The current study investigates the influence of multi stenosis on hemodynamic properties in a patient-specific left coronary artery.

A three-dimensional model of the patient-specific left coronary artery was reconstructed based on computed tomography (CT) scan images using MIMICS-20 software. The diseased model of the left coronary artery was investigated, having the narrowing of 90% and 70% of area stenosis (AS) at the left anterior descending (LAD) and left circumflex (LCX), respectively.

The results indicate that the upstream region of stenosis experiences very high pressure for 90% AS during the systolic period of the cardiac cycle. The pressure drops maximum as the flow travels into the stenotic zone, and the high flow velocities were observed across the 90% AS. The higher wall shear stresses occur at the stenosis region, and it increases with the increase in the flow rate. It is found that the maximum wall shear stress across 90% AS is at the highest risk for rupture. A recirculation region immediately after the stenosis results in the further development of stenosis.

The current study provides evidence that there is a strong effect of multi-stenosis on the blood flow in the left coronary artery.

A learning algorithm called CLILP2 (Cover Learning Using Integer Linear Programming) is applied to medical data to generate rules to recognize patients with coronary artery disease. The algorithm partitions a data set into subsets using features which best describe and distinguish a particular subset from all other subsets. These features are used to form the rules which can be used as the knowledge base of a diagnostic expert system. Results from the application of the algorithm to coronary artery stenosis data are compared with the results obtained from the existing expert system.

Reviews available literature on gender bias and the process of medical care. Current findings point to possible gender bias in treatment protocols for kidney and cardiac patients. Other clinical conditions have not been studied. Identifies methodological challenges to such research and discusses the need for further research.

The purpose of this paper is to analyze changes in knowledge, attitudes and practices (KAP) regarding diet and life style related risk factors among male and female coronary artery disease (CAD) patients (30‐60 yrs), in Jaipur city.

All willing patients under medical supervision for CAD were included. A detailed pre‐tested and standardized interview schedule was used to elicit required information. In total, 100 subjects were assessed for KAP. Retrospective data were recorded for the information on KAP prior to the incidence of the disease.

The major findings revealed that there was a significant change in knowledge, attitudes and practices before and after the incidence of CAD. Knowledge and attitudes were found to have a strong association. Close association was statistically established between knowledge and smoking practice for male subjects and between attitudes and weight loss for female patients. No association could be established for other attributes.

The study explores the effect of CAD on the knowledge, attitude and practices of the patients regarding diet and life style related risk factors. It also observes and compares the data for prior to the frank expression of the disease and after the disease.

This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) cytokine release in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls.

PBMCs isolated from whole blood of 50 patients with CAD and 48 healthy subjects aged 45 to 60 years were treated with 10 and 20 µM of betanin for 24 h. Real-time polymerase chain reaction was performed to assess gene expression levels of AMPK, SIRT1 and SIRT6. The supernatants of the cultured cells were used to assess the IL-6 and TNF-α protein levels by ELISA.

Treatment with both doses of betanin significantly increased AMPK, SIRT1 and SIRT6 expression in PBMCs of CAD patients compared to control non-treated cells (p < 0.05). In PBMCs of healthy subjects, only treatment with high dose of betanin showed significant increase in AMPK (p = 0.007), SIRT1 (p = 0.013) and SIRT6 (p = 0.024) expression compared to control non-treated cells. Betanin (20 µM) also significantly decreased TNF-α and IL-6 concentrations in the culture supernatants of the CAD patients compared to control non-treated cells (p < 0.001).

Betanin could enhance AMPK, SIRT1 and SIRT6 gene expressions in PBMCs and represent a useful complementary treatment to reduce the proinflammatory status accompanied with CAD.

Increased levels of hostility are associated with the increased risk of coronary artery disease (CAD), and with poorer outcomes in CAD patients. The purpose of this paper is to estimate the level of hostility in CAD patients and in health care (HC) workers, as potential groups for intervention programmes.

A qualitative cross‐sectional study was undertaken. Hostility questionnaires were distributed in a non‐randomized fashion in a group of 236 CAD patients (187 men, 49 women), aged from 33 to 69 years (average 52 years) and 181 health care workers (52 men, 129 women), aged from 19 to 65 (average 31 years). The results of the survey were discussed in a focused group.

The results showed that the high level of hostility in both CAD patients and HC workers exceeded the risk value of 10 in 89 per cent of CAD patients and 95 per cent of HC workers. No difference was found in the hostility scores between CAD patients and HC workers. There was a tendency to higher scores of hostility or of its subcategories (cynicism, anger, aggression) in physicians and nurses of the invasive cardiology or the intensive care units.

This paper is of value by showing how increased level of hostility was the issue in both patients and HC workers, with potential consequences of health risk for individuals, as well as deteriorated interpersonal relations and a conflict‐generated corporate culture for organizations. Differently tailored programmes for hostility management for particular target groups may help to prevent negative developments.

The NHS Executive expects purchasers and providers to base their agreed patterns of care on evidence of clinical effectiveness. If this approach is to be successful it is necessary to reconcile conflicting published information about effectiveness and local professional opinion. In this study we have identified the type of interactions that occur when purchasers and providers were brought together to discuss how this policy could be implemented locally. Three geographically‐based multidisciplinary workshops were structured around three case studies: coronary artery disease, diabetes, and the management of clinical depression in general practice. The proceedings were transcribed and analysed using content analysis methods. Structured observation techniques were used to examine the interaction between providers and purchasers in the three groups that discussed coronary artery disease. While the overall pattern of interactions between purchasers and providers was similar among the workshops, there were significant differences within them. In two of the workshops providers dominated the discussions on clinical effectiveness, which may affect the purchaser's ability to implement a policy of clinical effectiveness. If a local policy of clinical effectiveness is to be successful there is a need to strengthen purchasers' ability to match the provider's knowledge and enthusiasm.