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1 – 10 of 241C. De Maria, L. Grassi, F. Vozzi, A. Ahluwalia and G. Vozzi
This paper aims to develop a novel micro-ablation system to realise micrometric and well-defined hydrogel structures. To engineer a tissue it is necessary to evaluate several…
Abstract
Purpose
This paper aims to develop a novel micro-ablation system to realise micrometric and well-defined hydrogel structures. To engineer a tissue it is necessary to evaluate several aspects, such as cell-cell and cell-substrate interactions, its micro-architecture and mechanical stimuli that act on it. For this reason, it is important to fabricate a substrate which presents a microtopology similar to natural tissue and has chemical and mechanical properties able to promote cell functions. In this paper, well-defined hydrogel structures embedding cells were microfabricated using a purposely developed technique, micro-laser ablation, based on a thulium laser. Its working parameters (laser power emission, stepper motor velocity) were optimised to produce shaded “serpentine” pattern on a hydrogel film.
Design/methodology/approach
In this study, initially, swelling/contraction tests on agarose and alginate hydrogel in different solutions of main components of cell culture medium were performed and were compared with the MECpH model. This comparison matched with good approximation experimental measurements. Once known how hydrogel changed its topology, microstructures with a well-defined topology were realised using a purposely developed micro-laser ablation system design. S5Y5 neuroblastoma cell lines were embedded in hydrogel matrix and the whole structure was ablated with a laser microfabrication system. The cells did not show damages due to mechanical stress present in the hydrogel matrix and to thermal increase induced by the laser beam.
Findings
The hydrogel structure is able to reproduce extracellular matrix. Initially, the hydrogel swelling/contraction in different solutions, containing the main components of the most common cell culture media, was analysed. This analysis is important to evaluate if cell culture environment could alter microtopology of realised structures. Then, the same topology was realised on hydrogel film embedding neuronal cells and the cells did not show damages due to mechanical stress present in the hydrogel matrix and to thermal increase induced by the laser beam. The interesting obtained results could be useful to realise well-defined microfabricated hydrogel structures embedding cells to guide tissue formation
Originality/value
The originality of this paper is the design and realisation of a 3D microfabrication system able to microfabricate hydrogel matrix embedding cells without inducing cell damage. The ease of use of this system and its potential modularity render this system a novel potential device for application in tissue engineering and regenerative medicine area.
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Annalisa Tirella, Carmelo De Maria, Giuseppe Criscenti, Giovanni Vozzi and Arti Ahluwalia
The traditional tissue engineering approach employs rapid prototyping systems to realise microstructures (i.e. scaffolds) which recapitulate the function and organization of…
Abstract
Purpose
The traditional tissue engineering approach employs rapid prototyping systems to realise microstructures (i.e. scaffolds) which recapitulate the function and organization of native tissues. The purpose of this paper is to describe a new rapid prototyping system (PAM‐modular micro‐fabrication system, PAM2) able to fabricate microstructures using materials with different properties in a controlled environment.
Design/methodology/approach
Computer‐aided technologies were used to design multi‐scale biological models. Scaffolds with specific features were then designed using custom software and manufactured using suitable modules. In particular, several manufacturing modules were realised to enlarge the PAM2 processing material window, controlling physical parameters such as pressure, force, temperature and light. These modules were integrated in PAM2, allowing a precise control of fabrication parameters through a modular approach and hardware configuration.
Findings
Synthetic and natural polymeric solutions, thermo‐sensitive and photo‐sensitive materials can be used to fabricate 3D scaffolds. Both simple and complex architectures with high fidelity and spatial resolution ranging from ±15 μm to ±200μm (according to ink properties and extrusion module used) were realised.
Originality/value
The PAM2 system is a new rapid prototyping technique which operates in controlled conditions (for example temperature, pressure or light intensity) and integrates several manufacturing modules for the fabrication of complex or multimaterial microstructures. In this paper it is shown how the system can be configured and then used to fabricate scaffolds mimicking the extra‐cellular matrix, both in its properties (i.e. physic‐chemical and mechanical properties) and architecture.
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The objective of this study is to investigate the use of a fibre Bragg grating (FBG) sensor for measuring of curing strains that develop during the solidification of a…
Abstract
Purpose
The objective of this study is to investigate the use of a fibre Bragg grating (FBG) sensor for measuring of curing strains that develop during the solidification of a photocurable resin used in 3D microfabrication.
Design/methodology/approach
The followed approach consists of embedding a 1,300 nm FBG into a cylindrical specimen, fabricated into a transparent mould, being exposed to ultraviolet laser light. The further development of the cure induced strains under thermal treatment was also studied by post‐conditioning the cylindrical specimen in an oven at 70°C.
Findings
The experimental results demonstrate the capability of the FBG sensor to provide useful information on the strain build‐up during laser solidification and their post‐cure evolution under the presence of a thermal environment.
Research limitations/implications
Future work should involve the use of smaller diameter FBG sensors in microstereolithography built parts.
Practical implications
It is shown that considerable cure strains are developed at the end of the photo‐polymerisation process that eventually can affect the structural resolution of final parts fabricated by microstereolithography.
Originality/value
The presented method can be used to investigate other photopolymers used in micro‐stereolithography.
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Wenjun Liu and Bozhi Yang
The goal of this review paper is to provide information on several commonly used thermography techniques in semiconductor and micro‐device industry and research today.
Abstract
Purpose
The goal of this review paper is to provide information on several commonly used thermography techniques in semiconductor and micro‐device industry and research today.
Design/methodology/approach
The temperature imaging or mapping techniques include thin coating methods such as liquid crystal thermography and fluorescence microthermography, contact mechanical methods such as scanning thermal microscopy, and optical techniques such as infrared microscopy and thermoreflectance. Their principles, characteristics and applications are discussed.
Findings
Thermal issues play an important part in optimizing the performance and reliability of high‐frequency and high‐packing density electronic circuits. To improve the performance and reliability of microelectronic devices and also to validate thermal models, accurate knowledge of local temperatures and thermal properties is required.
Originality/value
The paper provides readers, especially technical engineers in industry, a general knowledge of several commonly used thermography techniques in the semiconductor and micro‐device industries.
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Roger Main gives a four‐part report on the optical technologies which are playing an increasingly important role in sensor development.
Nestor L. Osorio and Gabriel E. Osorio
Mechatronics is a very important area of research in industrial applications. The purpose of this study is to find some of the most important components of the literature on this…
Abstract
Purpose
Mechatronics is a very important area of research in industrial applications. The purpose of this study is to find some of the most important components of the literature on this subject.
Design/methodology/approach
The analysis is based on the use of the database Compendex; it was searched in the broadest way for documents related to mechatronics. In addition, subject guides from libraries of universities with mechatronics programs were studied to find resources available in those areas.
Findings
The literature of mechatronics is extensive and multidisciplinary. Based on the results from Compendex, the following data were found: most productive authors, list of leading journals and conference proceedings, publishers and grant organizations, authors’ affiliations and other minor details. Based on the analysis of subject guides, the following types of resources were found: research databases, reference books and ebook collections.
Research limitations/implications
Part of the analysis is based on a search performed in one technical database, Compendex; it was the database that generated the largest number of citations as compared to Inspec and the Web of Science. The results have a strong English language focus. It is possible that by using the results from multiple data bases, some additional sources could be obtained.
Practical implications
Mechatronics is a relatively new technological field comprising a number of scientific and engineering areas. The results obtained summarized a significant amount of bibliographic information.
Originality/value
The work is original; to the best of the authors’ knowledge, no other study has analyzed the literature on this subject.
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Abstract
Purpose
Conventional machining methods for fabricating piezoelectric components such as ultrasound transducer arrays are time-consuming and limited to relatively simple geometries. The purpose of this paper is to develop an additive manufacturing process based on the projection-based stereolithography process for the fabrication of functional piezoelectric devices including ultrasound transducers.
Design/methodology/approach
To overcome the challenges in fabricating viscous and low-photosensitive piezocomposite slurry, the authors developed a projection-based stereolithography process by integrating slurry tape-casting and a sliding motion design. Both green-part fabrication and post-processing processes were studied. A prototype system based on the new manufacturing process was developed for the fabrication of green-parts with complex shapes and small features. The challenges in the sintering process to achieve desired functionality were also discussed.
Findings
The presented additive manufacturing process can achieve relatively dense piezoelectric components (approximately 95 per cent). The related property testing results, including X-ray diffraction, scanning electron microscope, dielectric and ferroelectric properties as well as pulse-echo testing, show that the fabricated piezo-components have good potentials to be used in ultrasound transducers and other sensors/actuators.
Originality/value
A novel bottom-up projection system integrated with tape casting is presented to address the challenges in the piezo-composite fabrication, including small curing depth and viscous ceramic slurry recoating. Compared with other additive manufacturing processes, this method can achieve a thin recoating layer (as small as 10 μm) of piezo-composite slurry and can fabricate green parts using slurries with significantly higher solid loadings. After post processing, the fabricated piezoelectric components become dense and functional.
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To predict the influence of inherent microfabrication and operating environmental influences on the performance of capacitive type sensors and actuators so that one can tune the…
Abstract
Purpose
To predict the influence of inherent microfabrication and operating environmental influences on the performance of capacitive type sensors and actuators so that one can tune the performance and carry out more realistic designs.
Design/methodology/approach
When the sensors and actuators are micromachined or microfabricated, they are subjected to special problems that are characteristic to microdimensions. The important concerns are the influence of microfabrication process on the material properties and influence of operating environment on the system behavior. Hence, this paper proposed a way of quantifying and modeling the influence of inherent limitations of microfabrication and operating environment for the better design of micromachined capacitive type sensors and actuators. The methodology applies the modeling the variation of the elastic property of the system due to above influences through elastic stiffening and weakening concepts. The approach includes the application of boundary conditioning concept through Rayleigh energy method.
Findings
The microfabrication process and electrostatic field can alter significantly both static and dynamic behavior of the device. The performance of the device could also be tuned through these influences.
Research limitations/implications
As the displacement of the sensors is expected to be small, linear approach is applied. The sensitivity, output range, operating limits and natural frequencies of the sensor can be easily controlled by varying the process and operating environmental influences.
Practical implications
Improved and more realistic design of microfabricated capacitive type sensors and actuators for many applications, such as, pressure sensors, microphones, microspeakers, etc.
Originality/value
A simple and easy way of modeling and quantifying the influence of process and operating environment was proposed for the betterment of design. The proposed design method can be applied for any micromachined or microfabricated capacitive type sensors and actuators so that varying sensitivities, output ranges and natural frequencies could be obtained. Over the last few years, newly emerging micro‐electro‐mechanical‐systems (MEMS) technology and micro‐fabrication techniques have gained popularity and importance in the miniaturization of a variety of sensors and actuators. The proposed technique is very useful in making the field of MEMS more matured as it attempts to model the problems that are unique to MEMS environment.
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