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The purpose of the paper is to report a case of bilateral inferior iridoschisis who underwent cataract surgery with intraocular lens implantation successfully with the help of iris hooks or pupillary expanders.

A 71-year-old male presented with inferior iridoschisis in both eyes, history of angle closure glaucoma (ACG), cataract and shallow anterior chamber (AC) angles inferiorly. A localized area of iris stroma is cleaved in two with anterior atrophic portion disintegrating into fibrils from the posterior stroma, and muscle layer is termed as iridoschisis. Iridoschisis is a rare condition associated with fibrillary iris degeneration, narrow drainage angles and cataract.

Preoperative and postoperative ocular examination, including visual acuity, intraocular pressure and degrees of iris damage, was evaluated. Cataract surgery was performed under topical anesthesia with flexible iris hooks. There were no intraoperative complications whereas marked corneal edema was shown at immediate postoperative period but subsided completely in two weeks’ time. Visual acuity improved from 20/60 to 20/25.

This case report demonstrates that while iridoschisis care during cataract surgery has been reported to be difficult, cataract extraction was managed using iris hooks.

This paper reports the successful management of cataract in a patient with bilateral inferior iridoschisis.

Glaucoma is a blinding disease which disproportionately affects some communities, particularly African‐Caribbeans. The ‘ReGAE’ project: Research into Glaucoma and Ethnicity was set up in 1999 and is based at the Birmingham and Midland Eye Centre. Among its aims are to provide ethnically‐sensitive evidence‐based information to help inform the future commissioning and training of glaucoma care with ethnic groups and to develop a national programme of glaucoma education.

The purpose of this study is to develop a domain independent, cost-effective, time-saving and semi-automated ontology generation framework that could extract taxonomic concepts from unstructured text corpus. In the human disease domain, ontologies are found to be extremely useful for managing the diversity of technical expressions in favour of information retrieval objectives. The boundaries of these domains are expanding so fast that it is essential to continuously develop new ontologies or upgrade available ones.

This paper proposes a semi-automated approach that extracts entities/relations via text mining of scientific publications. Text mining-based ontology (TmbOnt)-named code is generated to assist a user in capturing, processing and establishing ontology elements. This code takes a pile of unstructured text files as input and projects them into high-valued entities or relations as output. As a semi-automated approach, a user supervises the process, filters meaningful predecessor/successor phrases and finalizes the demanded ontology-taxonomy. To verify the practical capabilities of the scheme, a case study was performed to drive glaucoma ontology-taxonomy. For this purpose, text files containing 10,000 records were collected from PubMed.

The proposed approach processed over 3.8 million tokenized terms of those records and yielded the resultant glaucoma ontology-taxonomy. Compared with two famous disease ontologies, TmbOnt-driven taxonomy demonstrated a 60%–100% coverage ratio against famous medical thesauruses and ontology taxonomies, such as Human Disease Ontology, Medical Subject Headings and National Cancer Institute Thesaurus, with an average of 70% additional terms recommended for ontology development.

According to the literature, the proposed scheme demonstrated novel capability in expanding the ontology-taxonomy structure with a semi-automated text mining approach, aiming for future fully-automated approaches.

Atomoxetine has been approved for the treatment of attention deficit/hyperactivity disorder in both adults and children. However, it is also being examined for several off-label uses in adults including mood disorders, eating disorders, cognitive dysfunction, and the treatment of addictions. Prior to such use it is important to examine the reported adverse events to see if this represents an appropriate level of risk. This is particularly important in the light of recent warnings from several regulatory bodies about an increase in blood pressure in a significant percentage of patients taking atomoxetine. To understand the risks a literature review was performed, and which identified the following potential problems. The first is that this drug should not be given in patients with known cardiovascular problems, and that all adult patients who receive atomoxetine should be monitored for changes in blood pressure throughout treatment. Secondly, there are several clinical situations in which atomoxetine should be closely monitored, or avoided, including patients who have a history or risk of narrow angle glaucoma, epileptic seizures, Tourette's syndrome, a history of urinary outflow obstruction, or who are pregnant or lactating. In conclusion, the current literature suggests that atomoxetine can be safely used off-label provided the above precautions are taken.

The purpose of this paper is to determine the safety of substituting the first day post-operative review after routine cataract surgery (phacoemulsification) with a telephone survey.

Prospective non-randomised cohort study. A standardised questionnaire of five common ocular symptoms (general condition, vision, eye pain, headache, nausea or vomiting) was administered by a trained nurse on the first post-operative day. The patients were reviewed in clinic two to 14 days later. Patient charts were retrospectively reviewed for complications (endophthalmitis, raised intra-ocular pressure, wound leaks and uveitis) requiring deviation from standard treatment.

Over 13 months, 256 eyes of 238 patients underwent uncomplicated phacoemulsification by four consultant surgeons. Only one patient reported poor general condition, blurred vision and eye pain. She was subsequently found to have corneal oedema and raised intra-ocular pressure when recalled for an earlier review. Best corrected visual acuity better than 20/40 was achieved in 80.5 per cent of patients. There were no other post-operative complications noted from medical records review.

Non-randomised nature, skewed surgical expertise, lack of a control group and patient experience data. In all, 22 patients (9.2 per cent) were also uncontactable for the telephone interview.

A nurse-administered telephone survey seemed to be a safe and effective alternative to first day post-operative review after routine phacoemulsification. The survey also enabled the detection of serious post-operative complications. The first day post-operative hospital visit may be safely substituted in a selected patient population with greater patient convenience achieved and liberation of clinic resources.

This is the first study which utilises a standardised questionnaire as a form of post-operative review in an Asian population.

The purpose of this paper is to compare the fluid dynamic performance of two Aqueous Humor (AH) ocular drainage devices, the SOLX® Gold Micro Shunt (GMS) and the novel Silicon Shunt Device (SSD), implanted by surgeons in human eyes to reduce the IntraOcular Pressure towards physiological values, by draining the AH from the Anterior Chamber to the Suprachoroidal Space, to cure eyes with glaucoma.

The generalized porous medium model is solved to simulate the AH flow through the two ocular drainage devices and the surrounding porous tissues of the eye.

In the GMS, probable stagnation regions have been found, due to the very small AH velocity values inside the device and to the surrounding tissues, creating possible blockage and malfunction of the device. The simple microtubular geometry of the novel SSD allows to have a regular AH flow and to choose shunts with different diameters and/or with the presence of radial holes, based on patient needs, with consequent reduction of post-operative complications.

The present model will be further developed taking into account the insertion of the present drainage devices inside the anterior section of the eye. The present results show the comparative fluid dynamic performance of the two shunts considered, and can be useful for surgeons to choose the adequate shunt, based on the required AH flow rate for a specific patient.

The present numerical approach, employing the generalized porous medium model, represents a useful tool to study the fluid dynamics of ocular drainage devices and to design these shunts, to reduce post-operative complications.

The generalized porous medium model is here applied for the first time to simulate the interaction of ocular drainage devices with the surrounding porous tissues of the eye.

In the UK and elsewhere, accounting vocabularies and practices have come to permeate everyday life through their involvement in the management of hospitals, schools, universities, charities, trade unions, etc. This has been accompanied by an increase in the power of accountancy and the institutions of accountancy which increasingly function as quasi‐legislators. Such developments call for a (re)consideration of the role of accounting academics/intellectuals. Argues that, in a world where major business and professional interests are organized to advance sectional interests, to promote stereotyped images and to limit public debates, accounting academics/intellectuals have a responsibility to give visibility to such issues and thereby mobilize potentialities for gaining a fuller understanding of, and encouraging more democratic participation in, the design and operation of major social institutions. Suggests that, despite the constraints on academics, there are considerable opportunities to create, develop or become active in public policy debates through networks that comprise politicians, journalists, disaffected practitioners and concerned citizens – all of whom are potential allies in furthering a process in which accounting and its institutions are problematized and accounting professionals are rendered more accountable.

This paper aims to study the post-patent ethical drug market and simulate the impact of Patient Protection and Affordable Care Act (ACA) on individuals, health-care providers and pharmaceutical firms. US policymakers have been looking at various ways to curb rising health-care costs in USA, including ways to promote the use of generic drugs in lieu of brand drugs. In this broader context, the implementation of ACA in December 2013 will introduce major changes in the pharmaceutical market.

To fully understand the impact of such policy changes, we develop a structural model to study consumers’ buying behavior and firm competition in the post-patent ethical drug markets. We use the estimated model parameters to conduct four policy simulations to illustrate the effect of Obamacare on increasing the relative size of price-insensitive segment, reducing price sensitivity in the price-sensitive segment, providing brand price discount to Medicare patients previously in the “donut hole” and the effect of change in people’s attitude toward generics.

Our model estimation reveals two classes of consumers with different price sensitivities. This heterogeneity explains the increase in the brand price after generic entry. We identify consumers’ switching costs between generic and brand drugs, as well as among different generics. From the policy simulation, we find that except the closure of Medicare donut hole, all other policy changes lead to increased usage of the focal molecule, and the efforts to increase insurance coverage and reduce the out of pocket payment for prescription drugs lead to increase in firm profit.

This paper is the first to illustrate the potential policy effect of Obamacare through a structural model on post-patent ethical drug market.