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Population aging was a global trend, and the most obvious thing after aging was the change in skin appearance. Therefore, the active ingredients that delay skin aging were particularly noticed. Past studies had pointed out that Chinese herbal extracts can improve skin elasticity, reduce wrinkles and melanin precipitation. The purpose of this paper is to explore whether combining hydrolyzed collagen with Chinese herbal extracts can improve skin conditions and achieve anti-inflammatory effects.

Fifty subjects were randomly divided into collagen or placebo groups, and one bottle of collagen or placebo drink was used every day for four weeks, after which skin and inflammatory factors were tested.

In comparison with the baseline results, the skin parameters were improving after four-week intervention. In addition, the IL-6, IL-8, TNF-a were significantly decreased and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) was increased after four-week hydrolyzed collagen intervention.

This study showed that hydrolyzed collagen combined with Chinese herbal extracts can improve the condition of the skin, and can also reduce inflammatory associated factors, thereby achieving anti-aging effects.

Rambutan (Nephelium lappaceum), a ubiquitous fruit in Southeastern Asia, was rich in vitamins and phytochemicals, which were beneficial for improving of skin conditions. The fermentation process increased phytochemicals and antioxidant capacity. Thus, the purpose of this paper is to examine whether phytochemicals can be increased through the fermentation process of rambutan extracts to improve skin aging.

In this study, the authors used the three stages of fermentation with Saccharomyces cerevisiae, Lactobacillus plantarum TCI028 and Acetobacter aceti under red light to develop a fermented rambutan extract.

The level of polyphenols of red-light-based fermented rambutan extract (RLFRE) were significantly increased 108.9% (p < 0.01) and 97% (p < 0.01) compared with fermented rambutan extract (FRE) and pure rambutan extract (RE), respectively. The human skin fibroblasts treated with 0.03 or 0.06% of RLFRE can significantly decrease reactive oxygen species (ROS) levels by 0.74- (p < 0.001) and 0.84-fold (p < 0.001) compared with H₂O₂ group, respectively. And 0.03% of RLFRE can significantly increase in elastin content by 1.13-fold (p < 0.05). Also, ten compounds were identified including one new phenolic compound and nine known compounds from RLFRE. Moreover, red light could enhance the levels of compounds 4, 9 and 3 by 5, 2.5 and 2.5-fold, respectively, relative to the results of FRE. The last, RLFRE isolated compounds significantly facilitated the elastin content on fibroblast (compound 1, 7, 9, 10 compared with control: p < 0.001, compound 2 compared with control: p < 0.001).

In short, this was the first study to unveil that the red-light-based fermentation can enrich the antioxidant content in a rambutan extract and its product had the potential to be developed a functional product for health-promoting effects such as skin aging.