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Article
Publication date: 28 October 2022

Yaser Khajebishak, Sadra Madani, Amir Hossein Faghfouri, Ali Soleimani, Sara Ilaei, Said Peyrovi and Laleh Payahoo

Meteorin like-peptide (Metrnl) modulates energy hemostasis and relieves inflammation and oxidative stress. This study aims to investigate the relationship between Metrnl levels…

Abstract

Purpose

Meteorin like-peptide (Metrnl) modulates energy hemostasis and relieves inflammation and oxidative stress. This study aims to investigate the relationship between Metrnl levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in obese type 2 diabetic patients.

Design/methodology/approach

This analytical cross-sectional study was carried out between August 2020 and March 2021on 93 people (n = 32 obese type 2 diabetic patients, n = 31 healthy obese, n = 30 healthy normal weight). Serum Metrnl levels were measured by enzyme-linked immunosorbent assay. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde and total antioxidant capacity were measured using standard methods. Body composition was assessed by bioelectrical impedance analysis. p-Value less than 0.05 was considered significant.

Findings

Serum Metrnl levels were lower in obese diabetic patients than in healthy normal-weight subjects (82.5 [72.4–94.5] ng/mL compared to 154 [129–189] ng/mL). The difference in Metrnl levels between the two groups was significant (p < 0.001). The difference in Metrnl levels between the two groups was significant. Moreover, a significant correlation between Metrnl level and both TNF-a and hs-CRP was detected (p = 0.006 and p < 0.001, respectively) and the correlation between Metrnl and IL-6 was borderline (p = 0.051). A negative correlation was revealed between Metrnl level and anthropometric measurements and body composition (p < 0.05) with the exception of fat-free mass and skeletal muscle mass.

Originality/value

To discover sufficient evidence for the therapeutic function of Metrnl and its use as a prognostic biomarker in the management of type 2 diabetes mellitus, future clinical studies are needed to highlight other factors influencing Metrnl serum levels.

Details

Nutrition & Food Science, vol. 53 no. 5
Type: Research Article
ISSN: 0034-6659

Keywords

Open Access
Article
Publication date: 13 December 2022

Zeba Khanam and Sheema Tarab

Based on the theory of planned behavior (TPB) and stakeholder theory, the model proposes that responsible leadership (RL) is mediated by affective commitment (AC) on both outcome…

2791

Abstract

Purpose

Based on the theory of planned behavior (TPB) and stakeholder theory, the model proposes that responsible leadership (RL) is mediated by affective commitment (AC) on both outcome variables (organizational citizenship behavior [OCB] and patient satisfaction [PS]) while distributive justice (DJ) moderates the relationship among RL, OCB and PS through the mediator of AC.

Design/methodology/approach

Overall, data collected from 275 employees and patients in India’s healthcare sector support this model both in online and offline mode. SPSS 25, AMOS 22 and PROCESS macro were used to analyze the data.

Findings

The influence of RL, OCB and PS was seen insignificant in the Indian healthcare sector. This study examines the role of AC as a mediator which does not affect extra-role behavior and PS. The findings also show that the moderation-mediation effect of DJ through AC strengthened the link between RL and OCB, but not PS. Commitment does not affect extra-role behavior and PS.

Originality/value

Until now, there has been no research in the Indian context that has tested the effect of RL on extra-role behaviors and PS, as mediated by AC, according to researchers’ knowledge. Since RL and outcome variables are related through AC, the current study aims to understand how DJ acts as a moderator to that relationship.

Details

IIM Ranchi journal of management studies, vol. 2 no. 1
Type: Research Article
ISSN: 2754-0138

Keywords

Article
Publication date: 8 June 2018

Jan M.A. de Vries and Elizabeth A. Curtis

This paper aims to investigate nurses’ experiences of leadership within health care in the Republic of Ireland.

4843

Abstract

Purpose

This paper aims to investigate nurses’ experiences of leadership within health care in the Republic of Ireland.

Design/methodology/approach

This mainly qualitative study made use of a mail survey sent to a random national selection of registered nurses. Participants were asked to provide narrative descriptors of good nursing leadership and identify obstacles to such leadership.

Findings

Participants mainly provided examples of nursing leadership within a hierarchical context (concentrated leadership), such as meeting organisational goals and decision-making. While elements of distributed leadership were mentioned (good communication, providing help and support), they were mainly described as part of formal management roles, rather than leadership. Observed obstacles to developing nursing leadership included high workload, lack of support from management and peers, limited opportunities to gain experience, lack of education/training and poor work environments.

Research limitations/implications

The small sample (n = 72) limits generalisation. A wider interdisciplinary effort to address experiences with nursing leadership in Ireland may be needed to inform health services of the issues from a broader perspective.

Practical implications

The findings suggest that development of nursing leadership in Ireland may still be in its infancy, and that several obstacles need to be overcome.

Originality/value

Very few studies have addressed narratives from nurses regarding personal experiences with nursing leadership. The examples provided by participants have yielded significant insight into the issues they encounter, which are reflective of health care elsewhere.

Details

Leadership in Health Services, vol. 32 no. 3
Type: Research Article
ISSN: 1751-1879

Keywords

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