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A pandemic causes abrupt and unanticipated disruptions in many facets of society. A lot of authorities have quickly turned to online teaching methods. The best methods for online teaching have become a hot topic of discussion due to this urgent fast transmission. It was difficult to teach physiology to medical and paramedical students online because of concerns about how to give the students an effective interactive online teaching practice and how to guarantee successful outcomes. Therefore, three approaches have been individually applied to medical and nursing students for the first time in the physiology department of the Faculty of Medicine in Rabigh, King Abdulaziz University. Through online lectures and assignments, the strategies attempted to capture the students’ interest and interaction. The second-year nursing students were given a mind map project to complete after the lecture. The third-year medical students used a crossword puzzle game to test the students’ understanding. The third-year medical students were presented with short stories to better comprehend the physiological processes covered in the lectures. Overall, the three instructional strategies received positive feedback from the students. Incorporating such cutting-edge and imaginative educational approaches, in conclusion, could significantly aid in managing the pressures that arise during pandemics.