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Mucorales has been described to be widely distributed during the most recent COVID-19 pandemic, with a greater frequency of disease in India, particularly among those with immune deficiencies. This study aims to use computational tools to develop a vaccine.

The authors investigated at Mucorales proteins that had previously been associated to virulence factors. Recent research suggests that a vaccine based on high-level cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL) and B-cell lymphocyte (BCL) epitopes from diverse proteins might be developed. Furthermore, the vaccine assembly contains the targeted epitopes as well as PADRE peptides to induce an immune response. Computational approaches were used to analyze the immunological parameters used to build the suggested vaccine and validate its TLR-3 binding.

These studies show that the vaccination is capable of triggering a particular immune response. The authors offer a technique for developing and evaluating candidate vaccines using computational tools. To the best of their knowledge, this is the first immunoinformatic research of a prospective mucormycosis vaccine.

During this audit, a successful attempt was made to create a subunit MEV against black fungus. In the current study, MEV has been proposed as a suitable neutralizer candidate since it is immunogenic, secure, stable and interacts with human receptors. A stream study, on the other hand, is produced via a mixed vaccinosis approach. Following that, vaccinologists may perform more exploratory testing to evaluate whether the vaccine is effective.

The digital warehouse management system is an emergence that forms a critical part of the transformation of economic structure in Industry 4.0. In the present business scenario, the warehouse management system encounters a messy layout, poor damage control, unsatisfactory order management, lack of visibility and lack of technological interventions. Digital twin (DT) based warehouse system shows the ontology and knowledge graphs for competitive advantage by consolidating and transferring goods directly from an inbound supplier to an outbound customer on short notice and with no or limited storage. There remains a lack of clarity on how the DT can be implemented successfully in warehouse management.

The current literature remains largely unstructured and scattered due to a lack of a systematic approach to integrating the research implications and analysis. This paper probes the conceptualization of the DT with the help of theoretical analysis using the systematic literature analysis method.

The study explores essential concepts such as interoperability and integrability in implementing DT. Further, it analyzes the role of a supply chain control tower (SCCT) in modern supply chain management. A research framework is proposed for practitioners and academicians by incorporating the opportunities and challenges associated with DT implementation. The research findings are mainly threefold: Conceptualization of DT, Featuring SCCT and Exploration of cross-computer platform interfaces, scalability and maintenance strategies.

This study is among the first to analyze and review DT applications in warehouse management. Moreover, the study proposes a theoretical toolbox for the practitioners to successfully implement the DT in warehouse DT-based warehouse management system: A theoretical toolbox for future research and applications.